KENNETH MINNEMAN

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc Interaction of neuronal nitric oxide synthase with alpha1-adrenergic receptor subtypes in transfected HEK-293 cells
    Andre S Pupo
    Department of Pharmacology, Emory University, Atlanta, GA 30322, USA
    BMC Pharmacol 2:17. 2002
  2. ncbi request reprint Transcriptional responses to growth factor and G protein-coupled receptors in PC12 cells: comparison of alpha(1)-adrenergic receptor subtypes
    K P Minneman
    Department of Pharmacology, Emory University, Atlanta, GA 30322, USA
    J Neurochem 74:2392-400. 2000
  3. ncbi request reprint Splice variants of G protein-coupled receptors
    K P Minneman
    Department of Pharmacology, Emory University Medical School, Atlanta, GA 30322, USA
    Mol Interv 1:108-16. 2001
  4. pmc Heterodimerization and surface localization of G protein coupled receptors
    Kenneth P Minneman
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Biochem Pharmacol 73:1043-50. 2007
  5. ncbi request reprint Cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors
    Chris Hague
    Department of Pharmacology, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 279:15541-9. 2004
  6. ncbi request reprint Recent progress in alpha1-adrenergic receptor research
    Zhong Jian Chen
    Department of Pharmacology, School of Medicine, Emory University, Atlanta, GA 30322, USA
    Acta Pharmacol Sin 26:1281-7. 2005
  7. ncbi request reprint Selective inhibition of alpha1A-adrenergic receptor signaling by RGS2 association with the receptor third intracellular loop
    Chris Hague
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 280:27289-95. 2005
  8. pmc Olfactory receptor surface expression is driven by association with the beta2-adrenergic receptor
    Chris Hague
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 101:13672-6. 2004
  9. ncbi request reprint The N terminus of the human alpha1D-adrenergic receptor prevents cell surface expression
    Chris Hague
    Department of Pharmacology, Emory University Medical School, Rollins Research Building, 1510 Clifton Road, Atlanta, GA 30322, USA
    J Pharmacol Exp Ther 309:388-97. 2004
  10. ncbi request reprint Alpha(1)-adrenergic receptor subtypes: non-identical triplets with different dancing partners?
    Chris Hague
    Department of Pharmacology, Emory University, Atlanta, GA 30322, USA
    Life Sci 74:411-8. 2003

Research Grants

  1. STRUCTURE/FUNCTION OF ALPHA-1 ADRENERGIC RECEPTORS
    KENNETH MINNEMAN; Fiscal Year: 2002
  2. C-TERMINAL INTERACTIONS OF ALPHA1-ADRENOCEPTOR SUBTYPES
    KENNETH MINNEMAN; Fiscal Year: 2003

Collaborators

Detail Information

Publications25

  1. pmc Interaction of neuronal nitric oxide synthase with alpha1-adrenergic receptor subtypes in transfected HEK-293 cells
    Andre S Pupo
    Department of Pharmacology, Emory University, Atlanta, GA 30322, USA
    BMC Pharmacol 2:17. 2002
    ..The other two alpha1-AR subtypes have no sequence homology in this region, raising the possibility of subtype-specific protein-protein interactions...
  2. ncbi request reprint Transcriptional responses to growth factor and G protein-coupled receptors in PC12 cells: comparison of alpha(1)-adrenergic receptor subtypes
    K P Minneman
    Department of Pharmacology, Emory University, Atlanta, GA 30322, USA
    J Neurochem 74:2392-400. 2000
    ..These responses are not linearly related to second messenger production, and different subtypes show different patterns of activation...
  3. ncbi request reprint Splice variants of G protein-coupled receptors
    K P Minneman
    Department of Pharmacology, Emory University Medical School, Atlanta, GA 30322, USA
    Mol Interv 1:108-16. 2001
    ..However, GPCRs also appear to interact directly with many other intracellular proteins in addition to G proteins. Intriguingly, the domains involved in these interactions are the predominant sites of variation arising through splicing...
  4. pmc Heterodimerization and surface localization of G protein coupled receptors
    Kenneth P Minneman
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Biochem Pharmacol 73:1043-50. 2007
    ....
  5. ncbi request reprint Cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors
    Chris Hague
    Department of Pharmacology, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 279:15541-9. 2004
    ..These observations may be relevant to many other Class I G protein-coupled receptors, where the functional consequences of heterodimerization are still poorly understood...
  6. ncbi request reprint Recent progress in alpha1-adrenergic receptor research
    Zhong Jian Chen
    Department of Pharmacology, School of Medicine, Emory University, Atlanta, GA 30322, USA
    Acta Pharmacol Sin 26:1281-7. 2005
    ..Receptor heterodimerization has been shown to be important for cell surface expression, signaling and internalization. These new observations are likely to help elucidate the functional roles of individual alpha1-AR subtypes...
  7. ncbi request reprint Selective inhibition of alpha1A-adrenergic receptor signaling by RGS2 association with the receptor third intracellular loop
    Chris Hague
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 280:27289-95. 2005
    ..These findings demonstrate that certain RGS proteins can directly interact with preferred G-protein-coupled receptors to modulate their signaling with a high degree of specificity...
  8. pmc Olfactory receptor surface expression is driven by association with the beta2-adrenergic receptor
    Chris Hague
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 101:13672-6. 2004
    ..These data demonstrate the successful heterologous surface expression of a functional wild-type OR and reveal that persistent physical association with other GPCRs can control OR surface expression...
  9. ncbi request reprint The N terminus of the human alpha1D-adrenergic receptor prevents cell surface expression
    Chris Hague
    Department of Pharmacology, Emory University Medical School, Rollins Research Building, 1510 Clifton Road, Atlanta, GA 30322, USA
    J Pharmacol Exp Ther 309:388-97. 2004
    ..These findings demonstrate that the N-terminal region of alpha(1D)-ARs contain a transplantable signal that is critical for regulating formation of functional bindings, through regulating cellular localization...
  10. ncbi request reprint Alpha(1)-adrenergic receptor subtypes: non-identical triplets with different dancing partners?
    Chris Hague
    Department of Pharmacology, Emory University, Atlanta, GA 30322, USA
    Life Sci 74:411-8. 2003
    ..Thus, this subfamily represents a common phenomenon of a group of similar but non-identical receptor subtypes activated by the same neurotransmitter, whose individual functional roles remain to be clearly established...
  11. ncbi request reprint Heterodimers of alpha1B- and alpha1D-adrenergic receptors form a single functional entity
    Chris Hague
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Mol Pharmacol 69:45-55. 2006
    ..These data may help to explain why alpha(1D)-ARs are often pharmacologically undetectable in native tissues when they are coexpressed with alpha(1B)-ARs...
  12. ncbi request reprint Heterodimerization with beta2-adrenergic receptors promotes surface expression and functional activity of alpha1D-adrenergic receptors
    Michelle A Uberti
    Department of Pharmacology, Emory University School of Medicine, 5113 Rollins Research Center, 1510 Clifton Rd, Atlanta, GA 30322, USA
    J Pharmacol Exp Ther 313:16-23. 2005
    ....
  13. ncbi request reprint Specificity of olfactory receptor interactions with other G protein-coupled receptors
    Cristina F Bush
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 282:19042-51. 2007
    ..These studies shed light on the specificity of OR interactions with other GPCRs and the mechanisms governing olfactory receptor trafficking...
  14. ncbi request reprint N-terminal truncation of human alpha1D-adrenoceptors increases expression of binding sites but not protein
    Andre S Pupo
    Department of Pharmacology, 5017 Rollins Research Center, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322, USA
    Eur J Pharmacol 462:1-8. 2003
    ....
  15. ncbi request reprint Mutational uncoupling of alpha1A-adrenergic receptors from G proteins also uncouples mitogenic and transcriptional responses in PC12 cells
    Deborah Lee
    Department of Pharmacology, Emory University Medical School, Atlanta, GA 30322, USA
    J Pharmacol Exp Ther 306:471-7. 2003
    ..Overexpression of Galpha16 did not rescue any of these responses. These data suggest that known second messenger, mitogenic, and transcriptional effects of alpha1A-adrenergic receptors in PC12 cells all require G protein activation...
  16. ncbi request reprint Olfactory receptor localization and function: an emerging role for GPCR heterodimerization
    Chris Hague
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Mol Interv 4:321-2. 2004
    ..Together these findings may unlock the solution to a problem that has plagued the molecular study of olfaction since the cloning of the first olfactory G protein-coupled receptor over twelve years ago...
  17. ncbi request reprint Syntrophins regulate alpha1D-adrenergic receptors through a PDZ domain-mediated interaction
    Zhongjian Chen
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 281:12414-20. 2006
    ..This direct interaction may provide new information about the regulation of alpha1D-AR signaling and the role of syntrophins in modulating G protein-coupled receptor function...
  18. ncbi request reprint Subtype-specific dimerization of alpha 1-adrenoceptors: effects on receptor expression and pharmacological properties
    Michelle A Uberti
    Department of Pharmacology, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322, USA
    Mol Pharmacol 64:1379-90. 2003
    ..These studies demonstrate subtype-selective heterodimerization of alpha1-adrenoceptors, which does not change their pharmacological properties but seems to have functional consequences in regulating receptor expression and trafficking...
  19. ncbi request reprint Specific interactions between gC1qR and alpha1-adrenoceptor subtypes
    Andre S Pupo
    Department of Pharmacology, Rollins Research Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Recept Signal Transduct Res 23:185-95. 2003
    ..These studies suggest that gC1qR interacts specifically with alpha1B- and alpha1D-, but not alpha1A-ARs, and this interaction depends on the presence of an intact C-tail...
  20. ncbi request reprint Subtype-selective noncompetitive or competitive inhibition of human alpha1-adrenergic receptors by rho-TIA
    Zhongjian Chen
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 279:35326-33. 2004
    ..These differential interactions do not involve the receptor amino termini and are not because of the charged nature of the peptide, and isoleucine 8 is critical for its noncompetitive inhibition at alpha(1B)-ARs...
  21. ncbi request reprint Biochemistry and pharmacology of epitope-tagged alpha(1)-adrenergic receptor subtypes
    Aleksandra Vicentic
    Department of Pharmacology, 5017 Rollins Research Center, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322, USA
    J Pharmacol Exp Ther 302:58-65. 2002
    ..Because only monomers are detected by photoaffinity labeling, dimers and trimers observed on Western blots may be pharmacologically inactive...
  22. ncbi request reprint New pyrimido[5,4-b]indoles as ligands for alpha(1)-adrenoceptor subtypes
    Giuseppe Romeo
    Dipartimento di Scienze Farmaceutiche, Universita di Catania, Viale A Doria 6, 95125 Catania, Italy
    J Med Chem 46:2877-94. 2003
    ..This new model rationalized the relationships between structural properties and biological data of the pyrimido[5,4-b]indole compounds, as well as other compounds...
  23. ncbi request reprint Differential antagonism by conotoxin rho-TIA of contractions mediated by distinct alpha1-adrenoceptor subtypes in rat vas deferens, spleen and aorta
    Vanessa Lima
    Department of Pharmacology, Instituto de Biociencias, UNESP, Botucatu, SP 18618 000, Brazil
    Eur J Pharmacol 508:183-92. 2005
    ..It is concluded that rho-TIA will be useful for distinguishing the role of particular alpha1-adrenoceptor subtypes in native tissues...
  24. ncbi request reprint New 1,2,3,9-tetrahydro-4H-carbazol-4-one derivatives: analogues of HEAT as ligands for the alpha1-adrenergic receptor subtypes
    Giuseppe Romeo
    Dipartimento di Scienze Farmaceutiche, Universita di Catania, Viale A Doria 6, 95125 Catania, Italy
    Bioorg Med Chem 14:5211-9. 2006
    ..They showed moderate to good affinities, although their selectivity among the receptor subtypes hardly reached one order of magnitude...
  25. ncbi request reprint New pyrimido[5,4-b]indoles and [1]benzothieno[3,2-d]pyrimidines: high affinity ligands for the alpha(1)-adrenoceptor subtypes
    Giuseppe Romeo
    Dipartimento di Scienze Farmaceutiche, Universita di Catania, Viale A Doria 6, 95125 Catania, Italy
    Bioorg Med Chem Lett 16:6200-3. 2006
    ..They behaved as potent alpha(1)-AR antagonists. In binding experiments, some of them (RC24 and RC23) showed very high affinity for the alpha(1D)-AR subtype...

Research Grants2

  1. STRUCTURE/FUNCTION OF ALPHA-1 ADRENERGIC RECEPTORS
    KENNETH MINNEMAN; Fiscal Year: 2002
    ..These experiments will clarify mechanisms coupling AR activation to growth and differentiation, and provide important information on differences between closely-related subtypes. ..
  2. C-TERMINAL INTERACTIONS OF ALPHA1-ADRENOCEPTOR SUBTYPES
    KENNETH MINNEMAN; Fiscal Year: 2003
    ..These experiments will clarify the role of C-terminal interacting proteins in a1-AR function, and the significance of C-terminal splice variants. ..