Affiliation: Emory University
- Neural stimulation successfully treats depression in patients with prior ablative cingulotomyJoseph S Neimat
Toronto Western Hospital, 399 Bathurst St, WW4 425, Toronto, Ontario M5T 2S8, Canada
Am J Psychiatry 165:687-93. 2008
- Deep brain stimulation for treatment-resistant depressionHelen S Mayberg
Rotman Research Institute at Baycrest Centre, and Departments of Psychiatry and Neurology, University of Toronto, Toronto, Ontario, M6A 2E1, Canada
Neuron 45:651-60. 2005....
- Posttraumatic stress disorder: a state-of-the-science reviewCharles B Nemeroff
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322 4990, USA
J Psychiatr Res 40:1-21. 2006....
- Changes in regional cerebral blood flow following mood challenge in drug-free, remitted patients with unipolar depressionMichael C Gemar
Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
Depress Anxiety 24:597-601. 2007..Previously reported mediofrontal changes in remitted patients are unlikely to be a consequence of maintenance medication and more likely are evidence of relapse vulnerability...
- Defining the neural circuitry of depression: toward a new nosology with therapeutic implicationsHelen S Mayberg
Biol Psychiatry 61:729-30. 2007
- Evaluation of a corticotropin releasing hormone type 1 receptor antagonist in women with posttraumatic stress disorder: study protocol for a randomized controlled trialBoadie W Dunlop
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 12 Executive Park Drive NE, 3rd Floor, Atlanta, GA, USA
Trials 15:240. 2014..This Phase II trial aims to evaluate the efficacy of a CRH type 1 receptor (CRHR1) antagonist in the treatment of PTSD...
- Predictors of remission in depression to individual and combined treatments (PReDICT): study protocol for a randomized controlled trialBoadie W Dunlop
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1256 Briarcliff Road, Building A, 3rd Floor, Atlanta, GA 30306, USA
Trials 13:106. 2012..Consequently, we initiated a randomized clinical trial designed to identify factors that moderate response to three treatments for MDD among patients never treated previously for the condition...
- Targeted electrode-based modulation of neural circuits for depressionHelen S Mayberg
Department of Psychiatry and Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Clin Invest 119:717-25. 2009..Discussed here are converging imaging findings that established a rationale for testing a targeted neuromodulation strategy, deep brain stimulation, for treatment-resistant major depression...
- Distributed self in episodic memory: neural correlates of successful retrieval of self-encoded positive and negative personality traitsPhilippe Fossati
Rotman Research Institute, Baycrest Centre for Geriatric Care, Toronto, Ontario, Canada M6A 2E1
Neuroimage 22:1596-604. 2004..Our results indicate that personally relevant words may signal important emotional clues and support the notion of a widely distributed set of brain regions involved in maintaining the concepts of self...
- Attending to the present: mindfulness meditation reveals distinct neural modes of self-referenceNorman A S Farb
Department of Psychology, University of Toronto, ON M5S 3G3, Canada
Soc Cogn Affect Neurosci 2:313-22. 2007..These results suggest a fundamental neural dissociation between two distinct forms of self-awareness that are habitually integrated but can be dissociated through attentional training: the self across time and in the present moment...
- The subcallosal cingulate gyrus in the context of major depressionClement Hamani
Division of Neurosurgery, Toronto Western Hospital, University of Toronto, University Health Network, Toronto, Canada
Biol Psychiatry 69:301-8. 2011..Particular attention is given to the regional and downstream structures that could be influenced by the application of deep brain stimulation in this region...
- Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinicKerry J Ressler
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 954 Gatewood Drive, Atlanta, Georgia 30329, USA
Nat Neurosci 10:1116-24. 2007..Although many of these approaches are experimental, the rapidly developing understanding of emotional circuit regulation is likely to provide exciting and powerful future treatments for debilitating mood and anxiety disorders...
- Subcallosal cingulate gyrus deep brain stimulation for treatment-resistant depressionAndres M Lozano
Division of Neurosurgery, University of Toronto, Toronto, Canada
Biol Psychiatry 64:461-7. 2008..We now report the results of these and an additional 14 patients with extended follow-up...
- VNS therapy in treatment-resistant depression: clinical evidence and putative neurobiological mechanismsCharles B Nemeroff
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
Neuropsychopharmacology 31:1345-55. 2006..Mechanisms that mediate the beneficial effects of VNS therapy for treatment-resistant depression remain obscure. Suggestions for future research directions are described...
- A tractography analysis of two deep brain stimulation white matter targets for depressionDavid A Gutman
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Biol Psychiatry 65:276-82. 2009..Connectivity patterns of these regions may inform on mechanisms of action for DBS of these targets...
- Exploratory structural equation modeling of resting-state fMRI: applicability of group models to individual subjectsG Andrew James
Biomedical Imaging Technology Center, Department of Biomedical Engineering, Georgia Institute of Technology Emory University, Atlanta, GA 30322 4600, USA
Neuroimage 45:778-87. 2009..These results suggest that exploratory SEM is a viable technique for neuroimaging connectivity analyses of individual subjects' resting-state fMRI data...
- Stuck in a rut: rethinking depression and its treatmentPaul E Holtzheimer
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle NE, Suite 4000, Atlanta, GA 30322, USA
Trends Neurosci 34:1-9. 2011..We also discuss the implications of this revised definition for future clinical and basic research...
- Tolerability of the dexamethasone-corticotropin releasing hormone test in major depressive disorderBoadie W Dunlop
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1256 Briarcliff Road NE, Building A, 3rd Floor, Atlanta, GA 30322, USA
J Psychiatr Res 45:24-8. 2011..However, a comprehensive analysis of the safety of this test in psychiatric patients has not previously been performed...
- Disease state prediction from resting state functional connectivityR Cameron Craddock
School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, USA
Magn Reson Med 62:1619-28. 2009..The proposed framework for applying support vector classification to functional connectivity data is applicable to other disease states beyond major depression...
- Treatment resistant depression as a failure of brain homeostatic mechanisms: implications for deep brain stimulationPeter Giacobbe
Department of Psychiatry, University Health Network, University of Toronto, Canada
Exp Neurol 219:44-52. 2009....
- Minding one's emotions: mindfulness training alters the neural expression of sadnessNorman A S Farb
Department of Psychology, University of Toronto, Toronto, Ontario, Canada
Emotion 10:25-33. 2010..Restoring balance between affective and sensory neural networks-supporting conceptual and body based representations of emotion-could be one path through which mindfulness reduces vulnerability to dysphoric reactivity...
- Modulating limbic-cortical circuits in depression: targets of antidepressant treatmentsHelen S Mayberg
Department of Psychiatry, University of Toronto, Ontario, Canada
Semin Clin Neuropsychiatry 7:255-68. 2002....
- Neuropsychological impact of Cg25 deep brain stimulation for treatment-resistant depression: preliminary results over 12 monthsHeather E McNeely
Schizophrenia Services, Neuropsychology Service, St Joseph s Healthcare, Hamilton, Ontario, Canada
J Nerv Ment Dis 196:405-10. 2008..Though the sample size is small, these results support cognitive safety of Cg25 DBS for TRD...
- Dopaminergic activity in depressed smokers: a positron emission tomography studyUsoa E Busto
Clinical Neuroscience Section, Neuroscience Research Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Synapse 63:681-9. 2009..Comorbid major depression and tobacco dependence exacerbates this effect, suggesting an altered dopamine system in comorbid patients...
- Modulation of cortical-limbic pathways in major depression: treatment-specific effects of cognitive behavior therapyKimberly Goldapple
Rotman Research Institute at Baycrest Centre, 3560 Bathurst Street, Toronto, Ontario, Canada M6A 2E1
Arch Gen Psychiatry 61:34-41. 2004..Functional imaging studies of major depressive disorder demonstrate response-specific regional changes following various modes of antidepressant treatment...
- Differences in brain glucose metabolism between responders to CBT and venlafaxine in a 16-week randomized controlled trialSidney H Kennedy
University Health Network, Institute of Medical Science, University of Toronto, Department of Psychiatry, and Toronto General Hospital, 200 Elizabeth St, Eaton North Wing 8 222, Toronto, Ontario M5G 2C4, Canada
Am J Psychiatry 164:778-88. 2007..In this study, the authors report changes in fluorine-18-fluorodeoxyglucose PET in responders to CBT or venlafaxine during a randomized controlled trial...
- Positron emission tomography imaging in depression: a neural systems perspectiveHelen S Mayberg
Department of Psychiatry and Medicine Neurology, Rotman Research Institute, Baycrest Centre, University of Toronto, 3560 Bathurst Street, Toronto, Ontario M6A 2E1, Canada
Neuroimaging Clin N Am 13:805-15. 2003..An additional goal is the development of routine, brain-based clinical algorithms that optimize diagnosis and treatment of individual depressed patients...
- Risk and resilience markers in bipolar disorder: brain responses to emotional challenge in bipolar patients and their healthy siblingsStephanie Krüger
Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
Am J Psychiatry 163:257-64. 2006..In this study, potential markers of bipolar risk and resilience were examined in a new cohort of lithium-responsive bipolar patients and their healthy siblings...
- Deep brain stimulation for Parkinson's disease dissociates mood and motor circuits: a functional MRI case studyTaresa Stefurak
Rotman Research Institute, University of Toronto, Toronto, Ontario, Canada
Mov Disord 18:1508-16. 2003....
- Personality influences limbic-cortical interactions during sad mood inductionMichelle L Keightley
Rotman Research Institute, Baycrest Centre for Geriatric Care, Toronto, Ontario, Canada
Neuroimage 20:2031-9. 2003....
- Functional neuroanatomical substrates of altered reward processing in major depressive disorder revealed by a dopaminergic probeLescia K Tremblay
Neuropsychopharmacology Research Program, Sunnybrook and Women s College Health Sciences Centre, Sunnybrook Campus, University of Toronto, Toronto, Ontario, Canada
Arch Gen Psychiatry 62:1228-36. 2005..The challenge is to elucidate the brain mechanisms of MDD behavioral symptoms, chiefly those of anhedonia...
- Persistent auditory hallucinations that are unresponsive to antipsychotic drugsStephen E Nicolson
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Suite 4000, Atlanta, GA 30322, USA
Am J Psychiatry 163:1153-9. 2006
- Modulating dysfunctional limbic-cortical circuits in depression: towards development of brain-based algorithms for diagnosis and optimised treatmentHelen S Mayberg
Department of Psychiatry and the Rotman Research Institute, University of Toronto, Ontario, Canada
Br Med Bull 65:193-207. 2003....
- Relationship between regional brain metabolism, illness severity and age in depressed subjectsJakub Z Konarski
Institute of Medical Science, University of Toronto, Toronto, ON, Canada
Psychiatry Res 155:203-10. 2007..The age-dependent changes documented herein may influence the distinct clinical presentation and treatment response described in older-age depression...
- The role of imaging in United States courtroomsPurvak Patel
Department of Radiology, Emory University Hospital, D 112, 1364 Clifton Road, NE, Atlanta, GA 30322, USA
Neuroimaging Clin N Am 17:557-67, x. 2007..This article reviews and discusses the current state of these issues...
- Unmasking disease-specific cerebral blood flow abnormalities: mood challenge in patients with remitted unipolar depressionMario Liotti
Division of Psychiatry, Faculty of Medicine, University of Nottingham, A Floor, South Block, Queens Medical Centre, Nottingham NG7 2UH, UK
Am J Psychiatry 159:1830-40. 2002....
- Penfield revisited? Understanding and modifying behavior by deep brain stimulation for PDHelen S Mayberg
Neurology 59:1298-9. 2002
- An fMRI study investigating cognitive modulation of brain regions associated with emotional processing of visual stimuliMichelle L Keightley
Rotman Research Institute, Baycrest Centre for Geriatric Care, 3560 Bathurst Street, Toronto, Ont, M6A 2E1 Canada
Neuropsychologia 41:585-96. 2003....
- State and trait influences on mood regulation in bipolar disorder: blood flow differences with an acute mood challengeStephanie Krüger
Department of Psychiatry SK, University of Dresden, Dresden, Germany
Biol Psychiatry 54:1274-83. 2003..Imitating such stressors by the controlled transient exposure to an emotional stimulus may help to identify brain regions modulating this sensitivity...
- Cerebral metabolic correlates as potential predictors of response to anterior cingulotomy for treatment of major depressionDarin D Dougherty
Department of Psychiatry, Radiology, Neurosurgery, and Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, USA
J Neurosurg 99:1010-7. 2003..The purpose of this study was to identify possible neuroimaging predictors of treatment response to anterior cingulotomy in patients with major depression...
- The functional neuroanatomy of the placebo effectHelen S Mayberg
Department of Psychiatry, University of Texas at San Antonio, USA
Am J Psychiatry 159:728-37. 2002..Administration of placebo can result in a clinical response indistinguishable from that seen with active antidepressant treatment. Functional brain correlates of this phenomenon have not been fully characterized...
- Neurobiological mechanisms of the placebo effectFabrizio Benedetti
Department of Neuroscience, University of Turin Medical School, 10125 Turin, Italy
J Neurosci 25:10390-402. 2005
- Imaging Predictors of Treatment Response for DepressionHelen Mayberg; Fiscal Year: 2009..Identification of such biomarkers has additional implications for future testing of novel therapies in patients with distinct brain signatures, including development of evidence-based treatment algorithms for individual patients. ..