Allan I Levey

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc Development of transgenic rats producing human beta-amyloid precursor protein as a model for Alzheimer's disease: transgene and endogenous APP genes are regulated tissue-specifically
    Cansu Agca
    University of Missouri College of Veterinary Medicine, Department of Veterinary Pathobiology Columbia, MO 65211, USA
    BMC Neurosci 9:28. 2008
  2. ncbi request reprint Notch signaling inhibits PC12 cell neurite outgrowth via RBP-J-dependent and -independent mechanisms
    Oren A Levy
    Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Dev Neurosci 24:79-88. 2002
  3. pmc Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases
    Joungil Choi
    Department of Pharmacology, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 281:10816-24. 2006
  4. pmc Analysis of a membrane-enriched proteome from postmortem human brain tissue in Alzheimer's disease
    Laura E Donovan
    Department of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA
    Proteomics Clin Appl 6:201-11. 2012
  5. pmc Loss of LR11/SORLA enhances early pathology in a mouse model of amyloidosis: evidence for a proximal role in Alzheimer's disease
    Sara E Dodson
    Center for Neurodegenerative Disease, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 28:12877-86. 2008
  6. pmc Mint3/X11gamma is an ADP-ribosylation factor-dependent adaptor that regulates the traffic of the Alzheimer's Precursor protein from the trans-Golgi network
    Punya Shrivastava-Ranjan
    Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322 3050, USA
    Mol Biol Cell 19:51-64. 2008
  7. pmc Quantitative analysis of the detergent-insoluble brain proteome in frontotemporal lobar degeneration using SILAC internal standards
    Nicholas T Seyfried
    Department of Biochemistry, Center for Neurodegenerative Disease, School of Medicine, Emory University, Atlanta, Georgia 30322, USA
    J Proteome Res 11:2721-38. 2012
  8. pmc Selective enrichment of DJ-1 protein in primate striatal neuronal processes: implications for Parkinson's disease
    James A Olzmann
    Department of Pharmacology, Emory University, Atlanta, Georgia 30322, USA
    J Comp Neurol 500:585-99. 2007
  9. pmc Asparaginyl endopeptidase cleaves TDP-43 in brain
    Jeremy H Herskowitz
    Department of Neurology, Center for Neurodegenerative Diseases, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proteomics 12:2455-63. 2012
  10. pmc Rho kinase II phosphorylation of the lipoprotein receptor LR11/SORLA alters amyloid-beta production
    Jeremy H Herskowitz
    Department of Neurology, The Center for Neurodegenerative Diseases, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 286:6117-27. 2011

Research Grants

  1. MONAMINE TRANSPORTERS IN PARKINSONISM
    Allan Levey; Fiscal Year: 2001
  2. Muscarinic Receptors in Alzheimer's Disease
    Allan Levey; Fiscal Year: 2009

Detail Information

Publications97

  1. pmc Development of transgenic rats producing human beta-amyloid precursor protein as a model for Alzheimer's disease: transgene and endogenous APP genes are regulated tissue-specifically
    Cansu Agca
    University of Missouri College of Veterinary Medicine, Department of Veterinary Pathobiology Columbia, MO 65211, USA
    BMC Neurosci 9:28. 2008
    ..Some instances of FAD have been linked to mutations in the beta-amyloid protein precursor (APP). Although there are numerous mouse AD models available, few rat AD models, which have several advantages over mice, have been generated...
  2. ncbi request reprint Notch signaling inhibits PC12 cell neurite outgrowth via RBP-J-dependent and -independent mechanisms
    Oren A Levy
    Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Dev Neurosci 24:79-88. 2002
    ..Conversely, an activated form of RBP-J decreased neurite length but failed to reduce neurite number. In summary, Notch activation inhibited PC12 cell neurite outgrowth by both RBP-J-dependent and -independent pathways...
  3. pmc Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases
    Joungil Choi
    Department of Pharmacology, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 281:10816-24. 2006
    ..Our study provides new insights into the oxidative modifications of DJ-1 and indicates association of oxidative damage to DJ-1 with sporadic PD and AD...
  4. pmc Analysis of a membrane-enriched proteome from postmortem human brain tissue in Alzheimer's disease
    Laura E Donovan
    Department of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA
    Proteomics Clin Appl 6:201-11. 2012
    ..This study aims to validate a method to identify new proteins that could be involved in the pathogenesis of AD and potentially serve as disease biomarkers...
  5. pmc Loss of LR11/SORLA enhances early pathology in a mouse model of amyloidosis: evidence for a proximal role in Alzheimer's disease
    Sara E Dodson
    Center for Neurodegenerative Disease, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 28:12877-86. 2008
    ..The results of the current study support the hypothesis that control of LR11 expression may exert critical effects on Alzheimer's disease susceptibility in humans...
  6. pmc Mint3/X11gamma is an ADP-ribosylation factor-dependent adaptor that regulates the traffic of the Alzheimer's Precursor protein from the trans-Golgi network
    Punya Shrivastava-Ranjan
    Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322 3050, USA
    Mol Biol Cell 19:51-64. 2008
    ..Together, our data implicate Mint3 activity as a critical determinant of post-Golgi APP traffic...
  7. pmc Quantitative analysis of the detergent-insoluble brain proteome in frontotemporal lobar degeneration using SILAC internal standards
    Nicholas T Seyfried
    Department of Biochemistry, Center for Neurodegenerative Disease, School of Medicine, Emory University, Atlanta, Georgia 30322, USA
    J Proteome Res 11:2721-38. 2012
    ..However, in a subset of FTLD cases, PSF was aberrantly localized to the cytoplasm of oligodendrocytes. These data raise the possibility that PSF directed RNA processes in oligodendrocytes are altered in neurodegenerative disease...
  8. pmc Selective enrichment of DJ-1 protein in primate striatal neuronal processes: implications for Parkinson's disease
    James A Olzmann
    Department of Pharmacology, Emory University, Atlanta, Georgia 30322, USA
    J Comp Neurol 500:585-99. 2007
    ..Together, these findings indicate neuronal and synaptic expression of DJ-1 in primate subcortical brain regions and suggest a physiological role for DJ-1 in the survival and/or function of nigral-striatal neurons...
  9. pmc Asparaginyl endopeptidase cleaves TDP-43 in brain
    Jeremy H Herskowitz
    Department of Neurology, Center for Neurodegenerative Diseases, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proteomics 12:2455-63. 2012
    ..Moreover, these data highlight the utility of combining proteomic strategies in vitro and in vivo to provide insight into TDP-43 biology that will fuel the design of more detailed models of disease pathogenesis...
  10. pmc Rho kinase II phosphorylation of the lipoprotein receptor LR11/SORLA alters amyloid-beta production
    Jeremy H Herskowitz
    Department of Neurology, The Center for Neurodegenerative Diseases, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 286:6117-27. 2011
    ..These findings provide direct evidence that LR11 is phosphorylated in vivo and indicate that ROCK2 phosphorylation of LR11 may enhance LR11 mediated processing of APP and amyloid production...
  11. pmc Phosphoproteomic analysis reveals site-specific changes in GFAP and NDRG2 phosphorylation in frontotemporal lobar degeneration
    Jeremy H Herskowitz
    Department of Neurology, The Center for Neurodegenerative Diseases, Laboratory Medicine, and Proteomics Service Center, Emory University School of Medicine, Atlanta, Georgia 30322, United States
    J Proteome Res 9:6368-79. 2010
    ..These data highlight the utility of combining proteomic and phosphoproteomic strategies to characterize post-mortem human brain tissue...
  12. pmc Deletion of M1 muscarinic acetylcholine receptors increases amyloid pathology in vitro and in vivo
    Albert A Davis
    Center for Neurodegenerative Disease and Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 30:4190-6. 2010
    ..These results indicate that the M(1) mAChR is an important regulator of amyloidogenesis in the brain and provide strong support for targeting the M(1) mAChR as a therapeutic candidate in AD...
  13. pmc NF-κB activity is inversely correlated to RNF11 expression in Parkinson's disease
    Elaine Pranski
    Department of Neurology, Emory University, Atlanta, GA, USA
    Neurosci Lett 547:16-20. 2013
    ..Our data exemplifies the relevance of RNF11 and persistent NF-κB activation in PD...
  14. pmc RING finger protein 11 (RNF11) modulates susceptibility to 6-OHDA-induced nigral degeneration and behavioral deficits through NF-κB signaling in dopaminergic cells
    Elaine L Pranski
    Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neurobiol Dis 54:264-79. 2013
    ..This neuron-specific role of RNF11 in the brain has important implications for targeted therapeutics aimed at preventing neurodegeneration...
  15. pmc LR11/SorLA expression is reduced in sporadic Alzheimer disease but not in familial Alzheimer disease
    Sara E Dodson
    Center for Neurodegenerative Disease, Department of Neurology, Emory University Atlanta, Georgia 30322, USA
    J Neuropathol Exp Neurol 65:866-72. 2006
    ..We hypothesize that LR11 loss may be specific to sporadic AD and influence amyloid pathology through mechanisms independent of substrate-enzyme interactions regulated by FAD mutations...
  16. pmc Fas-associated factor 1 and Parkinson's disease
    Ranjita Betarbet
    Center for Neurodegenerative Disease, Emory University, Whitehead Biomedical Research Building, Room 505G, 615 Michael Street, Atlanta, Georgia 30322, USA
    Neurobiol Dis 31:309-15. 2008
    ..These studies, together with previous genetic linkage studies, highlight the potential significance of FAF1 in pathogenesis of idiopathic PD...
  17. pmc The lipoprotein receptor LR11 regulates amyloid beta production and amyloid precursor protein traffic in endosomal compartments
    Katrin Offe
    Center for Neurodegenerative Disease, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 26:1596-603. 2006
    ..The robust correlation between reduced LR11 expression and AD neuropathology and its potent effects on extracellular Abeta levels suggest that this neuronal lipoprotein receptor could play an important role in AD pathogenesis...
  18. pmc Coaggregation of RNA-binding proteins in a model of TDP-43 proteinopathy with selective RGG motif methylation and a role for RRM1 ubiquitination
    Eric B Dammer
    Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 7:e38658. 2012
    ..Together, these findings define some of the aggregation partners of TDP-43, and suggest that TDP-43 ubiquitination influences TDP-43 oligomerization...
  19. pmc Autosomal recessive causes likely in early-onset Alzheimer disease
    Thomas S Wingo
    Veterans Affairs Medical Center, Emory University School of Medicine, Atlanta, Georgia
    Arch Neurol 69:59-64. 2012
    ..To determine the genetic contribution to non-autosomal dominant early-onset Alzheimer disease (EOAD) (onset age ≤60 years) cases and identify the likely mechanism of inheritance in those cases...
  20. pmc Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-beta oligomers
    Sam Gandy
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Ann Neurol 68:220-30. 2010
    ..We sought to study the bioactivities of endogenously formed oAbeta/ADDLs generated in situ from the physiological processing of human amyloid precursor protein (APP) and presenitin1 (PS1) transgenes...
  21. pmc Proteomics analysis reveals novel components in the detergent-insoluble subproteome in Alzheimer's disease
    Yair M Gozal
    Department of Neurology, Emory University, Atlanta, Georgia 30322, USA
    J Proteome Res 8:5069-79. 2009
    ....
  22. pmc Polyubiquitin linkage profiles in three models of proteolytic stress suggest the etiology of Alzheimer disease
    Eric B Dammer
    Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 286:10457-65. 2011
    ..We conclude that different polyUb linkages play distinct roles under the three proteolytic stress conditions, and protein folding capacity in the heat shock responsive pathway might be more affected in Alzheimer disease...
  23. pmc Multiplex SILAC analysis of a cellular TDP-43 proteinopathy model reveals protein inclusions associated with SUMOylation and diverse polyubiquitin chains
    Nicholas T Seyfried
    Department of Human Genetics, School of Medicine, Emory University, Atlanta, Georgia 30322, USA
    Mol Cell Proteomics 9:705-18. 2010
    ....
  24. ncbi request reprint Phenylephrine and norepinephrine increase dopamine transporter ligand binding in striatum
    Michael Byas-Smith
    Department of Anesthesiology, Emory University School of Medicine, Atlanta, Georgia 30022, USA
    Mol Imaging Biol 5:217-26. 2003
    ..We tested the hypothesis that adrenergic receptor agonists increase the BP of [18F]FECNT for the DAT...
  25. pmc Neuron enriched nuclear proteome isolated from human brain
    Eric B Dammer
    Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Proteome Res 12:3193-206. 2013
    ..These comparative proteomic data sets also reveal a number of transcription and splicing factors that are selectively enriched in a cell-type-specific manner in human brain. ..
  26. pmc Reduced CSF p-Tau181 to Tau ratio is a biomarker for FTLD-TDP
    William T Hu
    From the Department of Neurology W T H, K W, J G, J J L, C H, M S, A I L, Center for Neurodegenerative Diseases Research W T H, K W, J G, J J L, C H, A I L, Alzheimer s Disease Research Center W T H, J G, J J L, C H, A I L, Emory University School of Medicine, Atlanta, GA and Departments of Neurology M G and Laboratory Medicine and Pathology V V D, J Q T, University of Pennsylvania, Philadelphia
    Neurology 81:1945-52. 2013
    ....
  27. pmc Abnormal gephyrin immunoreactivity associated with Alzheimer disease pathologic changes
    Chadwick M Hales
    From the Department of Neurology CMH, HR, AIL, JJL, TSW, Center for Neurodegenerative Disease CMH, HR, NTS, EBD, DMD, MG, AIL, JJL, TSW, Departments of Biochemistry NTS and Human Genetics EBD, TSW, and Pathology and Laboratory Medicine MG, Emory University School of Medicine, Atlanta, Georgia Department of Pathology, University of Washington, Seattle, Washington TJM Departments of Pathology and Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland JCT National Institute of Aging, National Institutes of Health, Bethesda, Maryland MT and Atlanta Veterans Administration Medical Center, Atlanta, Georgia TSW
    J Neuropathol Exp Neurol 72:1009-15. 2013
    ..Because gephyrin is involved in synaptic organization and synaptic dysfunction is an early event in AD, these findings point to its possible role in the pathogenesis of AD. ..
  28. pmc Neuronal RING finger protein 11 (RNF11) regulates canonical NF-κB signaling
    Elaine L Pranski
    Center for Neurodegenerative Disease, Department of Neurology, Emory University School of Medicine, 615 Michael St, Suite 500, Atlanta, GA 30322, USA
    J Neuroinflammation 9:67. 2012
    ....
  29. pmc GGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-β production
    Jeremy H Herskowitz
    Center for Neurodegenerative Disease, Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Mol Biol Cell 23:2645-57. 2012
    ..On basis of these results, we propose that GGA1 facilitates LR11 endocytic traffic and that LR11 modulates Aβ levels by promoting APP traffic to the endocytic recycling compartment...
  30. pmc Aberrant septin 11 is associated with sporadic frontotemporal lobar degeneration
    Yair M Gozal
    Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Mol Neurodegener 6:82. 2011
    ....
  31. pmc Proteomic identification of novel proteins associated with Lewy bodies
    Qiangwei Xia
    Department of Human Genetics, The Center for Neurodegenerative Diseases, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Front Biosci 13:3850-6. 2008
    ....
  32. pmc SPE-39 family proteins interact with the HOPS complex and function in lysosomal delivery
    Guang dan Zhu
    Graduate Program in Biochemistry, Cell, and Developmental Biology, Departments of Biology and Cell Biology, and Department of Neurology, Center for Neurodegenerative Disease, Emory University, Atlanta, GA 30322
    Mol Biol Cell 20:1223-40. 2009
    ..elegans spermatogenesis is an experimental system useful for identifying conserved regulators of metazoan lysosomal biogenesis...
  33. pmc Pharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer's disease mouse model
    Jeremy H Herskowitz
    Center for Neurodegenerative Disease, and Departments of Neurology, Cell Biology, and Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322, Medicinal Chemistry, Translational Research Institute, The Scripps Research Institute, Jupiter, Florida 33458, Department of Pathology, University of Washington, Seattle, Washington 98104, Departments of Pathology and Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, and Unit of Clinical and Translational Neuroscience and Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, Maryland 21224
    J Neurosci 33:19086-98. 2013
    ..Collectively, these findings highlight ROCK2 as a mechanism-based therapeutic target to combat Aβ production in AD. ..
  34. pmc Aggregates of small nuclear ribonucleic acids (snRNAs) in Alzheimer's disease
    Chadwick M Hales
    Center for Neurodegenerative Disease, Emory University, Atlanta, GA Department of Neurology, Emory University School of Medicine, Atlanta, GA
    Brain Pathol 24:344-51. 2014
    ..In combination with our previous results, these findings demonstrate that aggregates of U1 snRNA and U1 small nuclear ribonucleoproteins represent a new pathological hallmark of AD. ..
  35. pmc RNF11 modulates microglia activation through NF-κB signalling cascade
    Nirjari V Dalal
    Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, United States
    Neurosci Lett 528:174-9. 2012
    ..Thus our investigations clearly demonstrated that microglial RNF11 is a negative regulator of NF-κB signalling pathway and could be a strong potential target for modulating inflammatory responses in neurodegenerative diseases...
  36. pmc Phosphoproteomic analysis of human brain by calcium phosphate precipitation and mass spectrometry
    Qiangwei Xia
    Department of Human Genetics, The Center for Neurodegenerative Diseases, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Proteome Res 7:2845-51. 2008
    ..A majority of sites were not described previously. This study demonstrates the feasibility of combining calcium phosphate precipitation with mass spectrometry for phosphoproteome analysis of postmortem human brain tissue...
  37. ncbi request reprint Munc18 interacting proteins: ADP-ribosylation factor-dependent coat proteins that regulate the traffic of beta-Alzheimer's precursor protein
    Karen Hill
    Department of Biochemistry, School of Medicine, Emory University, Atlanta, Georgia 30322 3050, USA
    J Biol Chem 278:36032-40. 2003
    ..We propose that MINTs are a family of Arf-dependent, vesicle-coat proteins that can regulate the traffic of beta-APP...
  38. pmc A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly
    April J Ho
    Laboratory of Neuroimaging, Department of Neurology, University of California School of Medicine, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 107:8404-9. 2010
    ..These brain maps reveal that a commonly carried susceptibility allele for obesity is associated with structural brain atrophy, with implications for the health of the elderly...
  39. pmc Neuronal LR11/sorLA expression is reduced in mild cognitive impairment
    Kristen L Sager
    Center for Neurodegenerative Disease, Emory University, Atlanta, GA 30322, USA
    Ann Neurol 62:640-7. 2007
    ....
  40. doi request reprint Changes in the detergent-insoluble brain proteome linked to amyloid and tau in Alzheimer's Disease progression
    Chadwick M Hales
    Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA
    Proteomics 16:3042-3053. 2016
    ..Thus, proteins that cross-correlate with both Aβ and tau, including specific U1 snRNPs, may have potential mechanistic roles in linking Aβ plaques to tau tangle pathology during AD progression...
  41. ncbi request reprint Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases
    Joungil Choi
    Department of Pharmacology, Center for Neurodegenerative Disease, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322, USA
    J Biol Chem 279:13256-64. 2004
    ..Together, these results provide evidence supporting a direct link between oxidative damage to the neuronal ubiquitination/de-ubiquitination machinery and the pathogenesis of sporadic AD and PD...
  42. pmc An exploration of subgroups of mild cognitive impairment based on cognitive, neuropsychiatric and functional features: analysis of data from the National Alzheimer's Coordinating Center
    JOHN J HANFELT
    Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA, USA
    Am J Geriatr Psychiatry 19:940-50. 2011
    ....
  43. pmc Proteomic analysis of hippocampal dentate granule cells in frontotemporal lobar degeneration: application of laser capture technology
    Yair M Gozal
    Department of Neurology, School of Medicine, Emory University, Atlanta, GA, USA
    Front Neurol 2:24. 2011
    ..Application of LCM is a valuable tool in the molecular analysis of complex tissues, and its application in the proteomic characterization of neurodegenerative disorders such as FTLD-U may be used to identify proteins altered in disease...
  44. ncbi request reprint Loss of apolipoprotein E receptor LR11 in Alzheimer disease
    Clemens R Scherzer
    Department of Neurology, Emory University, Atlanta, GA, USA
    Arch Neurol 61:1200-5. 2004
    ..Genetic, epidemiologic, and biochemical evidence suggests that apolipoprotein E, low-density lipoprotein receptors, and lipid metabolism play important roles in sporadic Alzheimer disease (AD)...
  45. ncbi request reprint Proteomic characterization of postmortem amyloid plaques isolated by laser capture microdissection
    Lujian Liao
    Department of Human Genetics, Center for Neurodegenerative Disease, Enory University School of Medicine, Atlanta, GA 30322, USA
    J Biol Chem 279:37061-8. 2004
    ..Overall, our results revealed for the first time the sub-proteome of amyloid plaques that is important for further studies on disease biomarker identification and molecular mechanisms of AD pathogenesis...
  46. ncbi request reprint Altered striatal function and muscarinic cholinergic receptors in acetylcholinesterase knockout mice
    Laura A Volpicelli-Daley
    Emory University School of Medicine, Whitehead Biomedical Research Building, 615 Michael St, 5th Floor, Atlanta, GA 30322, USA
    Mol Pharmacol 64:1309-16. 2003
    ..mAChR downregulation in AChE-/- mice has important implications for the long-term use of cholinesterase inhibitors and other cholinomimetics in treating disorders characterized by perturbed cholinergic function...
  47. pmc U1 small nuclear ribonucleoproteins (snRNPs) aggregate in Alzheimer's disease due to autosomal dominant genetic mutations and trisomy 21
    Chadwick M Hales
    Department of Neurology, Emory University School of Medicine, Atlanta 30322, Georgia
    Mol Neurodegener 9:15. 2014
    ..However little is known about snRNP biology in early onset AD due to autosomal dominant genetic mutations or trisomy 21 in Down syndrome. Therefore we investigated snRNP biochemical and pathologic features in these disorders...
  48. pmc Association between polychlorinated biphenyls and Parkinson's disease neuropathology
    Jaime M Hatcher-Martin
    Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neurotoxicology 33:1298-304. 2012
    ..Furthermore, these data support epidemiological and laboratory studies reporting a link between PCB exposure and an increased risk for Parkinson's disease, including greater susceptibility of females...
  49. pmc Comparative distribution of protein components of the A20 ubiquitin-editing complex in normal human brain
    Elaine L Pranski
    Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, United States
    Neurosci Lett 520:104-9. 2012
    ..This study provides useful information about region specific expression of the A20 complex components that will be invaluable while determining the role of NF-κB signaling pathway in neuronal development and degeneration...
  50. ncbi request reprint Merger of laser capture microdissection and mass spectrometry: a window into the amyloid plaque proteome
    Yair M Gozal
    Department of Human Genetics, Center for Neurodegenerative Diseases, School of Medicine, Emory University, Atlanta, 30322, USA
    Methods Enzymol 412:77-93. 2006
    ..Finally, the data were corroborated by independent experiments using the approach of immunohistochemistry. Taken together, the merger of LCM and MS is a powerful tool to probe the proteome of any given pathological lesions...
  51. ncbi request reprint PARK10 candidate RNF11 is expressed by vulnerable neurons and localizes to Lewy bodies in Parkinson disease brain
    Leah R Anderson
    Center for Neurodegenerative Disease, Graduate Program in Neuroscience, Emory University, Atlanta, Georgia 30322, USA
    J Neuropathol Exp Neurol 66:955-64. 2007
    ..Collectively, these findings identify RNF11 as a strong candidate gene at the PARK10 locus and highlight its potential significance in the development of the common form of PD...
  52. ncbi request reprint Rab11a and myosin Vb regulate recycling of the M4 muscarinic acetylcholine receptor
    Laura A Volpicelli
    Center for Neurodegenerative Disease and Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 22:9776-84. 2002
    ..Both Rab11aS25N and the myosin Vb tail impair M4 recycling. The results demonstrate that GPCR recycling is mediated through a discrete pathway using both Rab11a and myosin Vb...
  53. pmc Mild cognitive impairment in Parkinson's disease: subtypes and motor characteristics
    Ann B Sollinger
    Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA
    Parkinsonism Relat Disord 16:177-80. 2010
    ..Future studies should focus on additional risk factors for MCI subtypes and their possible progression to frank dementia...
  54. ncbi request reprint Oxidative modifications and aggregation of Cu,Zn-superoxide dismutase associated with Alzheimer and Parkinson diseases
    Joungil Choi
    Department of Pharmacology, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, Georgia 30322 3090, USA
    J Biol Chem 280:11648-55. 2005
    ..This work suggests that AD, PD, and ALS may share a common or overlapping pathogenic mechanism(s) that could potentially be targeted by similar therapeutic strategies...
  55. pmc Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease
    Zhentao Zhang
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Nat Commun 6:8762. 2015
    ..Blockade of APP cleavage by AEP in mice alleviates pathological and behavioural deficits. Thus, AEP acts as a δ-secretase, contributing to the age-dependent pathogenic mechanisms in AD. ..
  56. pmc Exploring the potential of the platelet membrane proteome as a source of peripheral biomarkers for Alzheimer's disease
    Laura E Donovan
    Department of Neurology and Center for Neurodegenerative Disease, Emory University School of Medicine, 615 Michael Street NE, Atlanta, Georgia 30322, USA
    Alzheimers Res Ther 5:32. 2013
    ..Given parallels between neuron and platelet biology, we hypothesized platelet membrane-associated protein changes may differentiate patients clinically defined with probable AD from noncognitive impaired controls...
  57. pmc Aggregation properties of the small nuclear ribonucleoprotein U1-70K in Alzheimer disease
    Ian Diner
    From the Departments of Biochemistry and the Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, Georgia 30322
    J Biol Chem 289:35296-313. 2014
    ..Our results support a hypothesis that aberrant forms of U1-70K in AD can directly sequester soluble forms of U1-70K into insoluble aggregates. ..
  58. ncbi request reprint RGS2 binds directly and selectively to the M1 muscarinic acetylcholine receptor third intracellular loop to modulate Gq/11alpha signaling
    Leah S Bernstein
    Department of Pharmacology, Emory University School of Medicine, 1510 Clifton Road, Atlanta, Georgia 30322, USA
    J Biol Chem 279:21248-56. 2004
    ....
  59. ncbi request reprint Cell-specific extracellular signal-regulated kinase activation by multiple G protein-coupled receptor families in hippocampus
    Jennifer L Berkeley
    Department of Neurology and the Emory Center for Neurodegenerative Disease, Emory University, Atlanta, Georgia 30322, USA
    Mol Pharmacol 63:128-35. 2003
    ..Thus, we demonstrated that GPCR coupling to Gq, G(i/o), and Gs all activate ERK in the hippocampus, although each does so with unique properties and distributions...
  60. pmc Effects of hypertension and hypercholesterolemia on cognitive functioning in patients with alzheimer disease
    Felicia C Goldstein
    Department of Neurology, Emory University School of Medicine, Atlanta, GA 30329, USA
    Alzheimer Dis Assoc Disord 22:336-42. 2008
    ..The mechanisms likely involve the effects of VCs on cerebrovascular disease including white matter disruption. The results highlight the importance of controlling these risk factors in patients who carry the diagnosis of AD...
  61. pmc Quantitative phosphoproteomics of Alzheimer's disease reveals cross-talk between kinases and small heat shock proteins
    Eric B Dammer
    Department of Biochemistry, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA, USA
    Proteomics 15:508-19. 2015
    ..We further identified a network of phosphorylated kinases, which coenriched with phosphorylated small HSPs. This supports a hypothesis that a number of kinases are regulating and/or regulated by the small HSP folding network. ..
  62. pmc Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease
    Zhentao Zhang
    1 Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA 2 Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, China
    Nat Med 20:1254-62. 2014
    ..Together, these observations indicate that AEP acts as a crucial mediator of tau-related clinical and neuropathological changes. Inhibition of AEP may be therapeutically useful for treating tau-mediated neurodegenerative diseases. ..
  63. pmc Neurocognitive correlates of nocturnal oxygen desaturation in a memory clinic population
    Karim Yamout
    Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA
    J Clin Exp Neuropsychol 34:325-32. 2012
    ..Strength of associations was influenced by cardiovascular disease. Screening for nocturnal oxygen desaturation may be a useful procedure to assess for a potentially reversible cause of cognitive impairment...
  64. ncbi request reprint Production of antisera using fusion proteins
    Sara E Dodson
    Emory University, Atlanta, Georgia, USA
    Curr Protoc Neurosci . 2007
    ..Support protocols describe the purification of His-tagged insoluble fusion proteins for animal immunization and the construction and use of affinity columns for purifying antibodies using soluble fusion proteins...
  65. pmc High blood pressure and cognitive decline in mild cognitive impairment
    Felicia C Goldstein
    Department of Neurology, School of Medicine, Emory University, Atlanta, Georgia 30329, USA
    J Am Geriatr Soc 61:67-73. 2013
    ..To determine whether high blood pressure (BP) levels are associated with faster decline in specific cognitive domains...
  66. pmc Paraoxonase-1 polymorphisms in Alzheimer's disease, Parkinson's disease, and AD-PD spectrum diseases
    Thomas S Wingo
    Department of Neurology, Emory University, Atlanta, GA 30322 1047, USA
    Neurobiol Aging 33:204.e13-5. 2012
    ..Our results suggest that either these functional PON1 polymorphisms are not associated with AD and PD spectrum disorders, or that the relative risk conferred is small...
  67. pmc Evidence of shared risk for Alzheimer's disease and Parkinson's disease using family history
    Ami R Rosen
    Department of Neurology, Emory University, 1841 Clifton Rd, Atlanta, GA 30329, USA
    Neurogenetics 8:263-70. 2007
    ..These findings suggest the existence of common genetic and/or environmental factors that predispose to both AD and PD in the subset of cases with positive family history of both neurodegenerative diseases...
  68. pmc Development of a rapid screening instrument for mild cognitive impairment and undiagnosed dementia
    N Kyle Steenland
    Department of Environmental and Occupational Health, School of Public Health, Emory University, Atlanta, GA 30322, USA
    J Alzheimers Dis 15:419-27. 2008
    ....
  69. pmc Eye tracking during a visual paired comparison task as a predictor of early dementia
    Michael D Crutcher
    Yerkes National Primate Research Center, Emory University, Emory Alzheimer s Disease Research Center, Atlanta, Georgia, USA
    Am J Alzheimers Dis Other Demen 24:258-66. 2009
    ..05), while control participants and participants with Parkinson's disease remained above 70%. These findings demonstrate the usefulness of this task for assessing normal as well as impaired memory function...
  70. pmc Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's disease
    David A Wolk
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:10256-61. 2010
    ....
  71. ncbi request reprint Interaction of isoflurane with the dopamine transporter
    John Votaw
    Department of Radiology, Emory University School of Medicine, Atlanta, Georgia, USA
    Anesthesiology 98:404-11. 2003
    ..Because the dopamine transporter (DAT) is a key regulator of DA, it is likely affected by isoflurane. This study investigates the hypothesis that isoflurane inhibits DA reuptake by causing DAT to be trafficked into the cell...
  72. ncbi request reprint Very early activation of m-calpain in peripheral nerve during Wallerian degeneration
    Jonathan D Glass
    Department of Neurology, Emory University School of Medicine, 1639 Pierce Drive, Suite 6000, Atlanta, GA 30322, USA
    J Neurol Sci 196:9-20. 2002
    ..Calpain activation may be an early event in a proteolytic cascade that is initiated by axonal injury and culminates with axonal degeneration...
  73. pmc Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases
    Giovanni Coppola
    Department of Neurology, University of California, Los Angeles, CA, USA
    Hum Mol Genet 21:3500-12. 2012
    ....
  74. pmc White matter hyperintensities and changes in white matter integrity in patients with Alzheimer's disease
    Liya Wang
    Department of Radiology, Emory University School of Medicine, 1364 Clifton Road, Atlanta, GA 30329, USA
    Neuroradiology 53:373-81. 2011
    ..This study investigated the relationship between WMHs and white matter changes in AD using diffusion tensor imaging (DTI) and the sensitivity of each DTI index in distinguishing AD with WMHs...
  75. doi request reprint Implanted neural electrodes cause chronic, local inflammation that is correlated with local neurodegeneration
    George C McConnell
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology Emory University, Atlanta, 30332, USA
    J Neural Eng 6:056003. 2009
    ..These results also inform strategies to enhance our capability to attain reliable long-term recordings from implantable electrodes in the CNS...
  76. ncbi request reprint Muscarinic acetylcholine receptor subtypes in cerebral cortex and hippocampus
    Laura A Volpicelli
    Department of Neurology, Center for Neurodegenerative Disease, Emory University School of Medicine, Whitehead Biomedical Research Building, Suite 505, 615 Michael St, Atlanta, GA 30322, USA
    Prog Brain Res 145:59-66. 2004
    ....
  77. ncbi request reprint Altered hippocampal muscarinic receptors in acetylcholinesterase-deficient mice
    Laura A Volpicelli-Daley
    Center for Neurodegenerative Disease and Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Ann Neurol 53:788-96. 2003
    ..The alterations of mAChRs in AChE -/- mice suggest that mAChR downregulation may contribute to the limited efficacy of AChE inhibitors in Alzheimer's disease treatment...
  78. ncbi request reprint Synthesis and evaluation of two 18F-labeled imidazo[1,2-a]pyridine analogues as potential agents for imaging beta-amyloid in Alzheimer's disease
    Fanxing Zeng
    Department of Radiology, Division of Radiological Sciences, Emory University, Atlanta, GA 30322, USA
    Bioorg Med Chem Lett 16:3015-8. 2006
    ..Radiolabeling, in vitro film autoradiography, and micro-PET study were performed with [18F]FPPIP to determine its utility as a radioligand for amyloid plaque imaging in the brain of AD patients...
  79. ncbi request reprint Acute mitochondrial and chronic toxicological effects of 1-methyl-4-phenylpyridinium in human neuroblastoma cells
    Stacy E Stephans
    Department of Neurology, Center for Neurodegenerative Diseases, School of Medicine, Emory University, Atlanta, GA 30322, USA
    Neurotoxicology 23:569-80. 2002
    ..These immediate mitochondrial effects appear to be an accurate predictor of subsequent cell death...
  80. pmc Association of GSK3B with Alzheimer disease and frontotemporal dementia
    Barbara A J Schaffer
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, 2506 Gonda, 695 Charles E Young Dr S, Los Angeles, CA 90095 1761, USA
    Arch Neurol 65:1368-74. 2008
    ..As a known tau kinase, GSK3B is a promising candidate gene in the remaining cases of FTD and in AD, for which tau mutations have not been found...
  81. pmc 5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging
    Keith E Szulwach
    Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, USA
    Nat Neurosci 14:1607-16. 2011
    ..These data suggest that 5-hmC-mediated epigenetic modification is critical in neurodevelopment and diseases...
  82. ncbi request reprint The role of muscarinic acetylcholine receptor-mediated activation of extracellular signal-regulated kinase 1/2 in pilocarpine-induced seizures
    Jennifer L Berkeley
    Department of Neurology, Center for Neurodegenerative Disease, Emory University, Whitehead Biomedical Research Building, 615 Michael Street, Atlanta, GA 30322, USA
    J Neurochem 82:192-201. 2002
    ..In addition, ERK inhibition had no effect on the development of the long-term sequelae of status epilepticus (SE), including mossy fiber sprouting, neuronal death and spontaneous recurrent seizures...
  83. pmc Voxelwise genome-wide association study (vGWAS)
    Jason L Stein
    Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles School of Medicine, Neuroscience Research Building 225E, 635 Charles Young Drive, Los Angeles, CA 90095 1769, USA
    Neuroimage 53:1160-74. 2010
    ..These genes have high relevance to brain structure. This is the first voxelwise genome wide association study to our knowledge, and offers a novel method to discover genetic influences on brain structure...
  84. ncbi request reprint Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function
    James A Olzmann
    Departments of Pharmacology, Biochemistry, and Neurology, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, Georgia 30322 3090, USA
    J Biol Chem 279:8506-15. 2004
    ..Together these findings provide insights into the molecular mechanism by which loss-of-function mutations in DJ-1 lead to Parkinson's disease...
  85. ncbi request reprint Novel interaction between the M4 muscarinic acetylcholine receptor and elongation factor 1A2
    Daniel B McClatchy
    Center for Neurodegenerative Diseases, Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 277:29268-74. 2002
    ..eEF1A2 is an essential GTP-binding protein for protein synthesis. Thus, our data suggest a novel role for M4 in the regulation of protein synthesis through its interaction with eEF1A2...
  86. ncbi request reprint Huntingtin-associated protein 1 interacts with hepatocyte growth factor-regulated tyrosine kinase substrate and functions in endosomal trafficking
    Yankun Li
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322 3090, USA
    J Biol Chem 277:28212-21. 2002
    ..These findings implicate, for the first time, the involvement of HAP1 in the regulation of vesicular trafficking from early endosomes to the late endocytic compartments...
  87. ncbi request reprint Vesicular localization and activity-dependent trafficking of presynaptic choline transporters
    Shawn M Ferguson
    Neuroscience Graduate Program, Center for Molecular Neuroscience, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Neurosci 23:9697-709. 2003
    ....
  88. ncbi request reprint Regulation of muscarinic acetylcholine receptor function in acetylcholinesterase knockout mice
    Bin Li
    Eppley Institute, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Pharmacol Biochem Behav 74:977-86. 2003
    ..However, mRNA levels for muscarinic receptors were unchanged. These results indicate that one adaptation to the absence of AChE is downregulation of muscarinic receptors, thus reducing response to cholinergic stimulation...
  89. ncbi request reprint A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction
    Anna Helgadottir
    deCODE Genetics, Inc, Sturlugata 8, IS 101 Reykjavik, Iceland
    Nat Genet 38:68-74. 2006
    ..Interactions with other genetic or environmental risk factors that are more common in African Americans are likely to account for the greater relative risk conferred by HapK in this group...
  90. ncbi request reprint Evaluation of muscarinic agonist-induced analgesia in muscarinic acetylcholine receptor knockout mice
    Alokesh Duttaroy
    Laboratory of Bioorganic Chemistry, National Institute of Diabetes Digestive and Kidney Diseases, Bethesda, Maryland 20892 0810, USA
    Mol Pharmacol 62:1084-93. 2002
    ..These findings should be of considerable relevance for the development of receptor subtype-selective muscarinic agonists as novel analgesic drugs...
  91. ncbi request reprint Elongation factor 1A family regulates the recycling of the M4 muscarinic acetylcholine receptor
    Daniel B McClatchy
    Department of Cell Biology, Scripps Research Institute, 10550 North Torrey Pines Rd, SR 11, La Jolla, CA 92037, USA
    Neurochem Res 31:975-88. 2006
    ..Furthermore, eEF1A1 or eEF1A2 had no effect on the recovery of the M1 subtype in PC12 cells. These results demonstrate the novel ability of the eEF1A family to specifically regulate the M4 mAChR...
  92. ncbi request reprint A common variant on chromosome 9p21 affects the risk of myocardial infarction
    Anna Helgadottir
    deCODE Genetics, Sturlugata 8, IS 101 Reykjavik, Iceland
    Science 316:1491-3. 2007
    ..64 times as great as that of noncarriers. The corresponding risk is 2.02 times as great for early-onset cases. The population attributable risk is 21% for MI in general and 31% for early-onset cases...
  93. ncbi request reprint Daytime sleepiness and functional impairment in Alzheimer disease
    Jung Hie Lee
    Department of Psychiatry, Kangwon National University College of Medicine, Chunchon, Kangwon Do, South Korea
    Am J Geriatr Psychiatry 15:620-6. 2007
    ..The purpose of this study was to examine whether patient and spouse/caregiver reports of daytime sleepiness in AD were associated with lower functional status in those patients...
  94. ncbi request reprint Chronically mad as a hatter: anticholinergics and Alzheimer's disease pathology
    Allan I Levey
    Ann Neurol 54:144-6. 2003
  95. doi request reprint The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm
    Anna Helgadottir
    deCODE Genetics, Sturlugata 8, IS 101 Reykjavik, Iceland
    Nat Genet 40:217-24. 2008
    ..These findings extend our insight into the role of the sequence variant tagged by rs10757278-G and show that it is not confined to atherosclerotic diseases...
  96. ncbi request reprint Subpopulations of rat dorsal root ganglion neurons express active vesicular acetylcholine transporter
    Ada Maria Tata
    Dipartimento Biologia Cellulare e dello Sviluppo, Universita La Sapienza, Rome, Italy
    J Neurosci Res 75:194-202. 2004
    ....
  97. pmc Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats
    Carrie K Jones
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6600, USA
    J Neurosci 28:10422-33. 2008
    ..Together, these data suggest that selective activation of M(1) may provide a novel approach for the treatment of symptoms associated with schizophrenia and Alzheimer's disease...

Research Grants2

  1. MONAMINE TRANSPORTERS IN PARKINSONISM
    Allan Levey; Fiscal Year: 2001
    ....
  2. Muscarinic Receptors in Alzheimer's Disease
    Allan Levey; Fiscal Year: 2009
    ..The results of these studies should substantially advance the goal of developing more effective cholinergic therapies for AD and other neuropsychiatric disorders. ..