Randy Hall

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi request reprint GABAB receptor association with the PDZ scaffold Mupp1 alters receptor stability and function
    Srividya Balasubramanian
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 282:4162-71. 2007
  2. pmc Adhesion G protein-coupled receptors: signaling, pharmacology, and mechanisms of activation
    Kevin J Paavola
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Mol Pharmacol 82:777-83. 2012
  3. ncbi request reprint Beta-adrenergic receptors and their interacting proteins
    Randy A Hall
    Department of Pharmacology, Rollins Research Center, Emory University School of Medicine, 5113 Rollins Research Center, 1510 Clifton Rd, Atlanta, GA 30322, USA
    Semin Cell Dev Biol 15:281-8. 2004
  4. ncbi request reprint Olfactory receptor interactions with other receptors
    Randy A Hall
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Ann N Y Acad Sci 1170:147-9. 2009
  5. ncbi request reprint Autonomic modulation of olfactory signaling
    Randy A Hall
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Sci Signal 4:pe1. 2011
  6. ncbi request reprint LPA2 receptor mediates mitogenic signals in human colon cancer cells
    C Chris Yun
    Department of Medicine, Division of Digestive Diseases, Emory University School of Medicine, Whitehead Bldg, Suite 201, 615 Michael St, Atlanta, Georgia 30322, USA
    Am J Physiol Cell Physiol 289:C2-11. 2005
  7. pmc P2Y1 receptor signaling is controlled by interaction with the PDZ scaffold NHERF-2
    Sami R Fam
    Department of Pharmacology, Yerkes National Primate Research Center, and Division of Digestive Disease, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 102:8042-7. 2005
  8. pmc MAGI-3 regulates LPA-induced activation of Erk and RhoA
    Huanchun Zhang
    Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Cell Signal 19:261-8. 2007
  9. pmc Olfactory receptor surface expression is driven by association with the beta2-adrenergic receptor
    Chris Hague
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 101:13672-6. 2004
  10. ncbi request reprint GABA(B) receptors in the centromedian/parafascicular thalamic nuclear complex: an ultrastructural analysis of GABA(B)R1 and GABA(B)R2 in the monkey thalamus
    Rosa M Villalba
    Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30322, USA
    J Comp Neurol 496:269-87. 2006

Research Grants

Collaborators

Detail Information

Publications46

  1. ncbi request reprint GABAB receptor association with the PDZ scaffold Mupp1 alters receptor stability and function
    Srividya Balasubramanian
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 282:4162-71. 2007
    ....
  2. pmc Adhesion G protein-coupled receptors: signaling, pharmacology, and mechanisms of activation
    Kevin J Paavola
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Mol Pharmacol 82:777-83. 2012
    ..For this reason, understanding the mechanisms of activation for these receptors and elucidating their downstream signaling pathways can provide insights with the potential to lead to novel therapeutic agents...
  3. ncbi request reprint Beta-adrenergic receptors and their interacting proteins
    Randy A Hall
    Department of Pharmacology, Rollins Research Center, Emory University School of Medicine, 5113 Rollins Research Center, 1510 Clifton Rd, Atlanta, GA 30322, USA
    Semin Cell Dev Biol 15:281-8. 2004
    ..Moreover, the differential tissue expression patterns of many of the beta AR-interacting proteins may contribute to tissue-specific regulation of beta AR function...
  4. ncbi request reprint Olfactory receptor interactions with other receptors
    Randy A Hall
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Ann N Y Acad Sci 1170:147-9. 2009
    ..These studies provide evidence that olfactory receptors can interact with other G protein-coupled receptors and that these interactions can promote olfactory receptor surface expression and functionality in heterologous cells...
  5. ncbi request reprint Autonomic modulation of olfactory signaling
    Randy A Hall
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Sci Signal 4:pe1. 2011
    ..The emerging view is that the stimulation of odorant receptor signaling by odorants, which is the earliest step in olfaction, can be substantially regulated by the autonomic nervous system...
  6. ncbi request reprint LPA2 receptor mediates mitogenic signals in human colon cancer cells
    C Chris Yun
    Department of Medicine, Division of Digestive Diseases, Emory University School of Medicine, Whitehead Bldg, Suite 201, 615 Michael St, Atlanta, Georgia 30322, USA
    Am J Physiol Cell Physiol 289:C2-11. 2005
    ..We conclude that LPA2 is the major LPA receptor in colon cancer cells and cellular signals by LPA2 are largely mediated through its ability to interact with NHERF2...
  7. pmc P2Y1 receptor signaling is controlled by interaction with the PDZ scaffold NHERF-2
    Sami R Fam
    Department of Pharmacology, Yerkes National Primate Research Center, and Division of Digestive Disease, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 102:8042-7. 2005
    ..These findings reveal that NHERF-2 is a key regulator of the cellular activity of P2Y(1)R and may therefore determine cell-specific differences in P2Y(1)R-mediated signaling...
  8. pmc MAGI-3 regulates LPA-induced activation of Erk and RhoA
    Huanchun Zhang
    Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Cell Signal 19:261-8. 2007
    ..These results demonstrate that MAGI-3 interacts directly with LPA(2) and regulates the ability of LPA(2) to activate Erk and RhoA...
  9. pmc Olfactory receptor surface expression is driven by association with the beta2-adrenergic receptor
    Chris Hague
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 101:13672-6. 2004
    ..These data demonstrate the successful heterologous surface expression of a functional wild-type OR and reveal that persistent physical association with other GPCRs can control OR surface expression...
  10. ncbi request reprint GABA(B) receptors in the centromedian/parafascicular thalamic nuclear complex: an ultrastructural analysis of GABA(B)R1 and GABA(B)R2 in the monkey thalamus
    Rosa M Villalba
    Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30322, USA
    J Comp Neurol 496:269-87. 2006
    ..Overall, these findings provide evidence for multiple sites where GABA(B) receptors could modulate GABAergic and glutamatergic transmission in the primate CM/PF complex...
  11. ncbi request reprint Agonist-induced polarized trafficking and surface expression of the adenosine 2b receptor in intestinal epithelial cells: role of SNARE proteins
    Lixin Wang
    Division of Digestive Diseases, Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Am J Physiol Gastrointest Liver Physiol 287:G1100-7. 2004
    ....
  12. ncbi request reprint An electron microscope immunocytochemical study of GABA(B) R2 receptors in the monkey basal ganglia: a comparative analysis with GABA(B) R1 receptor distribution
    Ali Charara
    Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30322, USA
    J Comp Neurol 476:65-79. 2004
    ....
  13. pmc GPR37 surface expression enhancement via N-terminal truncation or protein-protein interactions
    Jill H Dunham
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Biochemistry 48:10286-97. 2009
    ....
  14. pmc The protein scaffold NHERF-1 controls the amplitude and duration of localized protein kinase D activity
    Maya T Kunkel
    Department of Pharmacology, University of California, San Diego, La Jolla, California 92093 0721, USA
    J Biol Chem 284:24653-61. 2009
    ..Thus, live cell imaging of PKD activity demonstrates ultrasensitive control of kinase signaling at the scaffold compared with bulk activity in the cytosol or at the plasma membrane...
  15. ncbi request reprint Hetero-oligomerization between GABAA and GABAB receptors regulates GABAB receptor trafficking
    Srividya Balasubramanian
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 279:18840-50. 2004
    ..These findings reveal that the GABA(B)R1/gamma2S interaction results in the regulation of multiple aspects of GABA(B) receptor trafficking, allowing for cross-talk between these two distinct classes of GABA receptor...
  16. ncbi request reprint Cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors
    Chris Hague
    Department of Pharmacology, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 279:15541-9. 2004
    ..These observations may be relevant to many other Class I G protein-coupled receptors, where the functional consequences of heterodimerization are still poorly understood...
  17. ncbi request reprint Novel interaction between the M4 muscarinic acetylcholine receptor and elongation factor 1A2
    Daniel B McClatchy
    Center for Neurodegenerative Diseases, Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 277:29268-74. 2002
    ..eEF1A2 is an essential GTP-binding protein for protein synthesis. Thus, our data suggest a novel role for M4 in the regulation of protein synthesis through its interaction with eEF1A2...
  18. ncbi request reprint Heterodimerization with beta2-adrenergic receptors promotes surface expression and functional activity of alpha1D-adrenergic receptors
    Michelle A Uberti
    Department of Pharmacology, Emory University School of Medicine, 5113 Rollins Research Center, 1510 Clifton Rd, Atlanta, GA 30322, USA
    J Pharmacol Exp Ther 313:16-23. 2005
    ....
  19. pmc Astrocytic and neuronal localization of the scaffold protein Na+/H+ exchanger regulatory factor 2 (NHERF-2) in mouse brain
    Maryse Paquet
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Comp Neurol 494:752-62. 2006
    ....
  20. ncbi request reprint The PDZ scaffold NHERF-2 interacts with mGluR5 and regulates receptor activity
    Maryse Paquet
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 281:29949-61. 2006
    ..These observations reveal that NHERF-2 can selectively modulate mGluR5 signaling, which may contribute to cell-specific regulation of mGluR5 activity...
  21. pmc Differential synaptology of vGluT2-containing thalamostriatal afferents between the patch and matrix compartments in rats
    Dinesh V Raju
    Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30322, USA
    J Comp Neurol 499:231-43. 2006
    ..These observations pave the way for understanding differential regulatory mechanisms of striatal outflow from the patch and matrix compartments by thalamostriatal afferents...
  22. ncbi request reprint Specificity of olfactory receptor interactions with other G protein-coupled receptors
    Cristina F Bush
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 282:19042-51. 2007
    ..These studies shed light on the specificity of OR interactions with other GPCRs and the mechanisms governing olfactory receptor trafficking...
  23. ncbi request reprint Syntrophins regulate alpha1D-adrenergic receptors through a PDZ domain-mediated interaction
    Zhongjian Chen
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 281:12414-20. 2006
    ..This direct interaction may provide new information about the regulation of alpha1D-AR signaling and the role of syntrophins in modulating G protein-coupled receptor function...
  24. ncbi request reprint Cell cycle-dependent phosphorylation of Disabled-2 by cdc2
    Junqi He
    Department of Pharmacology, Rollins Research Center, Emory University School of Medicine, Atlanta, GA 30322, USA
    Oncogene 22:4524-30. 2003
    ..These findings reveal that Dab2 is differentially phosphorylated during the cell cycle by cdc2 and provide a potential feedback mechanism by which Dab2 inhibition of cell growth and proliferation may be regulated...
  25. ncbi request reprint Studying protein-protein interactions via blot overlay or Far Western blot
    Randy A Hall
    Department of Pharmacology, Emory University, Atlanta, GA, USA
    Methods Mol Biol 261:167-74. 2004
    ....
  26. ncbi request reprint Cocaine- and amphetamine-regulated transcript (CART) peptide activates the extracellular signal-regulated kinase (ERK) pathway in AtT20 cells via putative G-protein coupled receptors
    Anita Lakatos
    Yerkes National Primate Research Center of Emory University, 954 Gatewood Road, NE, Atlanta, GA 30329, USA
    Neurosci Lett 384:198-202. 2005
    ..Overall, these data strongly support the existence of a specific receptor for CART peptide that is a G-protein coupled receptor utilizing a Gi/o mechanism involving MEK1 and 2...
  27. ncbi request reprint Regulation of G protein-coupled receptor signaling by scaffold proteins
    Randy A Hall
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA, USA
    Circ Res 91:672-80. 2002
    ..This review focuses on several specific examples of G protein-coupled receptor-associated scaffolds and the roles they may play in organizing receptor-initiated signaling pathways in the cardiovascular system and other tissues...
  28. ncbi request reprint Interaction with cystic fibrosis transmembrane conductance regulator-associated ligand (CAL) inhibits beta1-adrenergic receptor surface expression
    Junqi He
    Department of Pharmacology, Rollins Research Center, Emory University, School of Medicine, Atlanta, GA 30322, USA
    J Biol Chem 279:50190-6. 2004
    ....
  29. ncbi request reprint Subcellular and subsynaptic localization of group I metabotropic glutamate receptors in the monkey subthalamic nucleus
    Masaaki Kuwajima
    Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30322, USA
    J Comp Neurol 474:589-602. 2004
    ..These findings demonstrate that mGluR1a and mGluR5 exhibit a similar pattern of subsynaptic localization in monkey STN neurons, with both receptor subtypes exhibiting substantial extrasynaptic and perisynaptic localization...
  30. pmc Enhancement of the surface expression of G protein-coupled receptors
    Jill H Dunham
    Department of Pharmacology, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322, USA
    Trends Biotechnol 27:541-5. 2009
    ....
  31. ncbi request reprint Differential synaptic plasticity of the corticostriatal and thalamostriatal systems in an MPTP-treated monkey model of parkinsonism
    Dinesh V Raju
    Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA
    Eur J Neurosci 27:1647-58. 2008
    ..These findings provide striking evidence that suggests a differential degree of plasticity of the corticostriatal and thalamostriatal system in PD...
  32. ncbi request reprint Glycosylation of beta(1)-adrenergic receptors regulates receptor surface expression and dimerization
    Junqi He
    Department of Pharmacology, 5113 Rollins Research Center, Emory University School of Medicine, 1510 Clifton Rd, Atlanta, GA 30322, USA
    Biochem Biophys Res Commun 297:565-72. 2002
    ..These data reveal that the beta(1)AR is glycosylated on Asn15 and that this glycosylation plays a role in regulating beta(1)AR surface expression and dimerization...
  33. pmc Fine-tuning of GPCR activity by receptor-interacting proteins
    Stefanie L Ritter
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Nat Rev Mol Cell Biol 10:819-30. 2009
    ..Furthermore, GPCR-interacting proteins can have a big impact on the regulation of GPCR trafficking, localization and/or pharmacological properties...
  34. ncbi request reprint Evidence against enhanced glutamate transport in the anticonvulsant mechanism of the ketogenic diet
    Kristopher J Bough
    Department of Pharmacology, Emory University, Atlanta, GA, USA
    Epilepsy Res 74:232-6. 2007
    ..These multiple studies suggest that the anticonvulsant nature of the KD does not stem from enhanced glutamate re-uptake...
  35. ncbi request reprint Erbin enhances voltage-dependent facilitation of Ca(v)1.3 Ca2+ channels through relief of an autoinhibitory domain in the Ca(v)1.3 alpha1 subunit
    Irina Calin-Jageman
    Department of Pharmacology and Center for Neurodegenerative Disease, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 27:1374-85. 2007
    ..Our findings reveal a novel mechanism by which PDZ interactions and alternative splicing of alpha1 1.3 may influence activity-dependent regulation of Ca(v)1.3 channels at the synapse...
  36. ncbi request reprint Olfactory receptor localization and function: an emerging role for GPCR heterodimerization
    Chris Hague
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Mol Interv 4:321-2. 2004
    ..Together these findings may unlock the solution to a problem that has plagued the molecular study of olfaction since the cloning of the first olfactory G protein-coupled receptor over twelve years ago...
  37. ncbi request reprint Heterodimerization of g protein-coupled receptors: specificity and functional significance
    Steven C Prinster
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Pharmacol Rev 57:289-98. 2005
    ..Understanding the specificity and functional significance of GPCR heterodimerization is of tremendous clinical importance since GPCRs are the molecular targets for numerous therapeutic drugs...
  38. ncbi request reprint Localization and expression of group I metabotropic glutamate receptors in the mouse striatum, globus pallidus, and subthalamic nucleus: regulatory effects of MPTP treatment and constitutive Homer deletion
    Masaaki Kuwajima
    Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 27:6249-60. 2007
    ..Thus, nigrostriatal dopaminergic lesion and Homer deletion lead to changes in the trafficking of group I mGluRs in vivo that are specific to receptor subtypes and brain areas...
  39. ncbi request reprint Design of a selective chemical probe for class I PDZ domains
    Naoaki Fujii
    Department of Chemical Biology and Therapeutics, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Bioorg Med Chem Lett 17:546-8. 2007
    ..A chemical probe (2) that contained this moiety alkylated diverse PDZ domains, including NHERF-1 PDZ2, and differentially visualized the cellular proteome...
  40. pmc Interaction between metabotropic glutamate receptor 7 and alpha tubulin
    Julie A Saugstad
    Robert S Dow Neurobiology Laboratories, Legacy Research, Portland, Oregon, USA
    J Neurochem 80:980-8. 2002
    ....
  41. pmc Monitoring protein-protein interactions between the mammalian integral membrane transporters and PDZ-interacting partners using a modified split-ubiquitin membrane yeast two-hybrid system
    Serge M Gisler
    Institute of Physiology and Center for Integrative Human Physiology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Mol Cell Proteomics 7:1362-77. 2008
    ..In summary, our study establishes the MYTH 2.0 system as a novel tool for interactive proteomics studies of membrane protein complexes...
  42. ncbi request reprint A C-terminal class I PDZ binding motif of EspI/NleA modulates the virulence of attaching and effacing Escherichia coli and Citrobacter rodentium
    Sau Fung Lee
    Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia
    Cell Microbiol 10:499-513. 2008
    ..rodentium expressing full-length EspI. Overall, these results suggested that EspI may modulate the virulence of A/E pathogens by binding host PDZ-domain proteins...
  43. ncbi request reprint kappa Opioid receptor interacts with Na(+)/H(+)-exchanger regulatory factor-1/Ezrin-radixin-moesin-binding phosphoprotein-50 (NHERF-1/EBP50) to stimulate Na(+)/H(+) exchange independent of G(i)/G(o) proteins
    Peng Huang
    Department of Pharmacology and Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Biol Chem 279:25002-9. 2004
    ..This study provides the first direct evidence that a G protein-coupled receptor through association with NHERF-1/EBP-50 stimulates NHE3...
  44. ncbi request reprint Identification of novel G protein-coupled receptor-interacting proteins
    Richard T Premont
    Liver Center, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Methods Enzymol 343:611-21. 2002
    ..Undoubtedly, it is likely that all G protein-coupled receptors have their own unique constellations of associated cytoplasmic proteins, and the techniques described here should prove useful in identifying these...
  45. ncbi request reprint Proteomic analysis of beta1-adrenergic receptor interactions with PDZ scaffold proteins
    Junqi He
    Department of Biochemistry and Molecular Biology, Capital University of Medical Sciences, Beijing 100054, China
    J Biol Chem 281:2820-7. 2006
    ....
  46. ncbi request reprint The association of NHERF adaptor proteins with g protein-coupled receptors and receptor tyrosine kinases
    Edward J Weinman
    Department of Medicine, University of Maryland School of Medicine, and Medical Service, Department of Veterans Affairs Medical Center, Baltimore, Maryland 21201, USA
    Annu Rev Physiol 68:491-505. 2006
    ..This review summarizes the emerging data on the biochemical mechanisms, physiologic outcomes, and potential clinical implications of the assembly and disassembly of receptor/NHERF complexes...

Research Grants3

  1. MAGI-2 IN BETA-1-ADRENERGIC RECEPTOR FUNCTION
    Randy Hall; Fiscal Year: 2004
    ..These studies will provide mechanistic insight into localization and regulation of the beta1AR, a receptor that is a common target for therapeutics used in the treatment of heart disease and other disorders. ..
  2. Direct Interaction Between GABA-A and GABA-B Receptors
    Randy Hall; Fiscal Year: 2007
    ..abstract_text> ..
  3. NHERF IN BETA-2-ADRENERGIC RECEPTOR SIGNALING
    Randy Hall; Fiscal Year: 2003
    ..These studies will provide insight into hovel signaling pathways activated by the beta2AR, a receptor that is a common target for therapeutics used in the treatment of hypertension, heart disease and other disorders. ..