Michael D Brown

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi request reprint Novel mtDNA mutations and oxidative phosphorylation dysfunction in Russian LHON families
    M D Brown
    Center for Molecular Medicine, Emory University School of Medicine, 420 B Dental Building, 1462 Clifton Road N E, Atlanta, GA 30322, USA
    Hum Genet 109:33-9. 2001
  2. ncbi request reprint Clinical, genetic, and biochemical characterization of a Leber hereditary optic neuropathy family containing both the 11778 and 14484 primary mutations
    M D Brown
    Center for Molecular Medicine, Emory University School of Medicine, 420 B Dental Building, 1462 Clifton Road N E, Atlanta, GA 30322, USA
    Am J Med Genet 104:331-8. 2001
  3. ncbi request reprint The role of mtDNA background in disease expression: a new primary LHON mutation associated with Western Eurasian haplogroup J
    Michael D Brown
    Center for Molecular Medicine, Emory University School of Medicine, 420B Dental Building, 1462 Clifton Road NE, Atlanta, GA 30322, USA
    Hum Genet 110:130-8. 2002
  4. ncbi request reprint Graduate medical education and knowledge translation: role models, information pipelines, and practice change thresholds
    Barry M Diner
    Emory University, Atlanta, GA, USA
    Acad Emerg Med 14:1008-14. 2007
  5. ncbi request reprint North American white mitochondrial haplogroups in prostate and renal cancer
    Lyra M Booker
    Department of Urology, Emory University, Atlanta, Georgia 30322, USA
    J Urol 175:468-72; discussion 472-3. 2006
  6. ncbi request reprint A novel recurrent mitochondrial DNA mutation in ND3 gene is associated with isolated complex I deficiency causing Leigh syndrome and dystonia
    Emmanuelle Sarzi
    INSERM U781, Department of Genetics, Hopital Necker Enfants Malades, Paris, France
    Am J Med Genet A 143:33-41. 2007
  7. pmc Mitochondrial DNA diversity in indigenous populations of the southern extent of Siberia, and the origins of Native American haplogroups
    Elena B Starikovskaya
    Laboratory of Human Molecular Genetics, Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, Novosibirsk 630090, Russia Federation
    Ann Hum Genet 69:67-89. 2005
  8. ncbi request reprint OPA1 mutations and mitochondrial DNA haplotypes in autosomal dominant optic atrophy
    Jian Han
    Department of Basic Medical Sciences, Mercer University School of Medicine, Macon, GA, USA
    Genet Med 8:217-25. 2006
  9. ncbi request reprint DNA sequence variation in the promoter region of the VEGF gene impacts VEGF gene expression and maximal oxygen consumption
    Steven J Prior
    Department of Kinesiology, University of Maryland, College Park, Maryland, USA
    Am J Physiol Heart Circ Physiol 290:H1848-55. 2006
  10. ncbi request reprint Sympathetic activity and the heterogenous blood pressure response to exercise training in hypertensives
    Michael D Brown
    Department of Internal Medicine, Division of Geriatric Medicine, University of Michigan Health System and Geriatric Research, Education, and Clinical Center, Ann Arbor Veterans Affairs Health System, Ann Arbor, Michigan 48105, USA
    J Appl Physiol (1985) 92:1434-42. 2002

Collaborators

  • D C Wallace
  • Fray F Marshall
  • Barry M Diner
  • Steven J Prior
  • N J Newman
  • Brian H Rowe
  • Peter C Wyer
  • J A Kline
  • Andrew G Clark
  • K Huoponen
  • Antonel Olckers
  • R H Lyles
  • Alan E Jones
  • Vincent Procaccio
  • Antonio Torroni
  • Robert E Ferrell
  • Steve D McCole
  • Jennifer M Jones
  • Joon Young Park
  • Vladimir Mayorov
  • Jung Jun Park
  • James M Hagberg
  • Andrew Worster
  • Emmanuelle Sarzi
  • Jian Han
  • Lyra M Booker
  • Dana A Phares
  • Valerie Biousse
  • Elena B Starikovskaya
  • Rem I Sukernik
  • Eduardo Ruiz-Pesini
  • Geoffrey E Moore
  • Sheri A Data
  • Andrea Huberty
  • Larry W Douglass
  • Dan Mishmar
  • Kenneth R Wilund
  • Stephen D Emond
  • Arnold Munnich
  • Agnes Rotig
  • Camala Smith
  • Dominique Chretien
  • Sophie Lebon
  • Shawna Silver
  • Thomas O Obisesan
  • Thomas C Dowling
  • Amanda K Baumann
  • Geoffrey M Habermacher
  • Angela J Thompson-Lowrey
  • John A Petros
  • So Dug Lim
  • Haomiao Jia
  • Carina Fernandez-Golarz
  • Qi Carrie Sun
  • Mahul Amin
  • Benjamin C Jessie
  • Alyson Reiss
  • Seyed H Hosseini
  • Marie T Lott
  • Olga A Derbeneva
  • Natalia V Volodko
  • Alan R Shuldiner
  • Vincent Macaulay
  • Mark H Roltsch
  • Brian Hand
  • Kirk Easley
  • Pawel Golik
  • Estella Chen
  • Martin Brandon
  • Seyed Hosseini
  • Carol H Spooner
  • William H Cordell

Detail Information

Publications25

  1. ncbi request reprint Novel mtDNA mutations and oxidative phosphorylation dysfunction in Russian LHON families
    M D Brown
    Center for Molecular Medicine, Emory University School of Medicine, 420 B Dental Building, 1462 Clifton Road N E, Atlanta, GA 30322, USA
    Hum Genet 109:33-9. 2001
    ....
  2. ncbi request reprint Clinical, genetic, and biochemical characterization of a Leber hereditary optic neuropathy family containing both the 11778 and 14484 primary mutations
    M D Brown
    Center for Molecular Medicine, Emory University School of Medicine, 420 B Dental Building, 1462 Clifton Road N E, Atlanta, GA 30322, USA
    Am J Med Genet 104:331-8. 2001
    ..Remarkably, spontaneous vision recovery occurred in the proband, highlighting the complexities encountered when associating mtDNA genotype and complex I function with LHON expression...
  3. ncbi request reprint The role of mtDNA background in disease expression: a new primary LHON mutation associated with Western Eurasian haplogroup J
    Michael D Brown
    Center for Molecular Medicine, Emory University School of Medicine, 420B Dental Building, 1462 Clifton Road NE, Atlanta, GA 30322, USA
    Hum Genet 110:130-8. 2002
    ..Thus, the 10663C mutation appears to be a new primary LHON mutation that is pathogenic when co-occurring with haplogroup J. These results strongly support a role for haplogroup J in the expression of certain LHON mutations...
  4. ncbi request reprint Graduate medical education and knowledge translation: role models, information pipelines, and practice change thresholds
    Barry M Diner
    Emory University, Atlanta, GA, USA
    Acad Emerg Med 14:1008-14. 2007
    ..This article is not an attempt to provide a complete overview of KT and GME, but, instead, aims to create a starting point for future work and discussions in the realm of KT and GM...
  5. ncbi request reprint North American white mitochondrial haplogroups in prostate and renal cancer
    Lyra M Booker
    Department of Urology, Emory University, Atlanta, Georgia 30322, USA
    J Urol 175:468-72; discussion 472-3. 2006
    ..We compared the mtDNA haplotype in patients with prostate and renal cancer to that in controls to determine if there is an association between mitochondrial genotype and cancer...
  6. ncbi request reprint A novel recurrent mitochondrial DNA mutation in ND3 gene is associated with isolated complex I deficiency causing Leigh syndrome and dystonia
    Emmanuelle Sarzi
    INSERM U781, Department of Genetics, Hopital Necker Enfants Malades, Paris, France
    Am J Med Genet A 143:33-41. 2007
    ..These results show that the 10197G>A mutation in the mitochondrial ND3 gene should be considered as a common mtDNA mutation responsible for LS and dystonia...
  7. pmc Mitochondrial DNA diversity in indigenous populations of the southern extent of Siberia, and the origins of Native American haplogroups
    Elena B Starikovskaya
    Laboratory of Human Molecular Genetics, Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, Novosibirsk 630090, Russia Federation
    Ann Hum Genet 69:67-89. 2005
    ....
  8. ncbi request reprint OPA1 mutations and mitochondrial DNA haplotypes in autosomal dominant optic atrophy
    Jian Han
    Department of Basic Medical Sciences, Mercer University School of Medicine, Macon, GA, USA
    Genet Med 8:217-25. 2006
    ..The purpose of this study was therefore to determine if the background mtDNA genotype acts as a genetic modifier for the expression of this disease...
  9. ncbi request reprint DNA sequence variation in the promoter region of the VEGF gene impacts VEGF gene expression and maximal oxygen consumption
    Steven J Prior
    Department of Kinesiology, University of Maryland, College Park, Maryland, USA
    Am J Physiol Heart Circ Physiol 290:H1848-55. 2006
    ..These results have potential implications for aerobic exercise training and may prove relevant in the study of pathological conditions that can be affected by angiogenesis, such as coronary artery disease and peripheral artery disease...
  10. ncbi request reprint Sympathetic activity and the heterogenous blood pressure response to exercise training in hypertensives
    Michael D Brown
    Department of Internal Medicine, Division of Geriatric Medicine, University of Michigan Health System and Geriatric Research, Education, and Clinical Center, Ann Arbor Veterans Affairs Health System, Ann Arbor, Michigan 48105, USA
    J Appl Physiol (1985) 92:1434-42. 2002
    ..Thus suppression of SNS activity may play a role in the reduction in MABP and account for a portion of the heterogeneity of the MABP response to aerobic exercise training in older hypertensive subjects...
  11. ncbi request reprint Procalcitonin test in the diagnosis of bacteremia: a meta-analysis
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28232 2861, USA
    Ann Emerg Med 50:34-41. 2007
    ..We seek to evaluate the diagnostic performance of the procalcitonin test for the diagnosis of bacteremia in the emergency department (ED) population...
  12. ncbi request reprint Evidence-based emergency medicine/critically appraised topic. Thrombolytic therapy for submassive pulmonary embolism?
    Andrew Worster
    Division of Emergency Medicine, McMaster University, Hamilton, Ontario, Canada
    Ann Emerg Med 50:78-84. 2007
    ..Patients with submassive pulmonary embolism were considered to be those with evidence of right ventricular dysfunction but without hemodynamic instability...
  13. pmc Differential aerobic exercise-induced changes in plasma aldosterone between African Americans and Caucasians
    Jennifer M Jones
    Department of Kinesiology, University of Maryland, College Park, MD, USA
    Exp Physiol 92:871-9. 2007
    ..The reduction in PA levels with AEX appeared to be driven by the change in PA levels in Caucasian participants. Fat distribution contributed to the ethnic differences in PA levels...
  14. ncbi request reprint Implementation of an emergency department based transient ischemic attack clinical pathway: a pilot study in knowledge translation
    Michael D Brown
    Grand Rapids MERC Michigan State University Program in Emergency Medicine, Grand Rapids, MI, USA
    Acad Emerg Med 14:1114-9. 2007
    ..To assess the feasibility of implementing an emergency department (ED)-based transient ischemic attack (TIA) clinical pathway that uses computer-based clinical support, and to evaluate measures of quality, safety, and efficiency...
  15. ncbi request reprint The role of the ND5 gene in LHON: characterization of a new, heteroplasmic LHON mutation
    Vladimir Mayorov
    Division of Basic Medical Sciences, Mercer University School of Medicine, Macon, GA 31207, USA
    Ann Neurol 58:807-11. 2005
    ..The 12848T mutation alters a highly conserved amino acid in the ND5 complex I gene, is not found in controls, and is heteroplasmic. Despite ND5 being the largest of the mtDNA complex I genes, ND5 mutations are quite rare in LHON...
  16. ncbi request reprint NADPH oxidase p22phox gene variants are associated with systemic oxidative stress biomarker responses to exercise training
    Joon Young Park
    Department of Kinesiology, University of Maryland, College Park, MD 20742 2611, USA
    J Appl Physiol (1985) 99:1905-11. 2005
    ..05). We found that p22phox polymorphisms, especially A640G, were associated with differential changes in systemic oxidative stress with aerobic exercise training...
  17. ncbi request reprint Evidence-based emergency medicine. Hypertonic versus isotonic crystalloid for fluid resuscitation in critically ill patients
    Michael D Brown
    Michigan State University Program in Emergency Medicine, Grand Rapids, MI, USA
    Ann Emerg Med 40:113-4. 2002
  18. ncbi request reprint Angiotensinogen M235T polymorphism associates with exercise hemodynamics in postmenopausal women
    Steve D McCole
    Division of Cardiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Physiol Genomics 10:63-9. 2002
    ....
  19. pmc Natural selection shaped regional mtDNA variation in humans
    Dan Mishmar
    Center for Molecular and Mitochondrial Medicine and Genetics, University of California, Irvine, 92697 3940, USA
    Proc Natl Acad Sci U S A 100:171-6. 2003
    ..From these analyses we conclude that selection may have played a role in shaping human regional mtDNA variation and that one of the selective influences was climate...
  20. ncbi request reprint Sequence variation in hypoxia-inducible factor 1alpha (HIF1A): association with maximal oxygen consumption
    Steven J Prior
    Department of Kinesiology, University of Maryland, College Park, Maryland 20742, USA
    Physiol Genomics 15:20-6. 2003
    ..Based on these findings, we conclude that HIF1A sequence variation is associated with VO2 max before and after aerobic exercise training in older humans...
  21. ncbi request reprint Evidence-based emergency medicine/skills for evidence-based emergency care. Interval likelihood ratios: another advantage for the evidence-based diagnostician
    Michael D Brown
    Grand Rapids MERC Michigan State University Program in Emergency Medicine, Grand Rapids, MI, USA
    Ann Emerg Med 42:292-7. 2003
    ..Authors and journals need to be encouraged to report the results of studies of performance of diagnostic tests using interval ranges rather than simple dichotomization when the tests involve continuous variables...
  22. ncbi request reprint eNOS T-786C genotype, physical activity, and peak forearm blood flow in females
    Sheri A Data
    Department of Kinesiology, University of Maryland, College Park 20742 2611, USA
    Med Sci Sports Exerc 35:1991-7. 2003
    ....
  23. ncbi request reprint Beta2- and beta3-adrenergic receptor polymorphisms and exercise hemodynamics in postmenopausal women
    Steve D McCole
    Division of Cardiology, University of Pittsburgh, Pennsylvania 15213, USA
    J Appl Physiol (1985) 96:526-30. 2004
    ....
  24. ncbi request reprint How relevant are the systematic reviews in the cochrane library to emergency medical practice?
    Stephen D Emond
    Department of Emergency Medicine, New York Presbyterian Hospital, New York, NY, USA
    Ann Emerg Med 39:153-8. 2002
    ..We conducted a study of the CDSR to evaluate the relevance of this database to emergency medical practice...
  25. ncbi request reprint Complete mitochondrial DNA sequence analysis in a family with early-onset dystonia and optic atrophy
    Michael D Brown
    Division of Basic Medical Sciences, Mercer University School of Medicine, Macon, Georgia 31207, USA
    Mov Disord 19:235-7. 2004
    ..Hence, it is unlikely that a mtDNA mutation accounts for the phenotype in this family...