Paula T Trzepacz

Summary

Affiliation: Eli Lilly and Company
Country: USA

Publications

  1. ncbi request reprint CYP2D6 metabolizer status and atomoxetine dosing in children and adolescents with ADHD
    Paula T Trzepacz
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Eur Neuropsychopharmacol 18:79-86. 2008
  2. doi request reprint Designing clinical trials for the treatment of delirium
    Paula T Trzepacz
    Lilly Research Laboratories, Neurosciences Platform Team, Indianapolis, IN 46285, USA
    J Psychosom Res 65:299-307. 2008
  3. pmc Frontolimbic atrophy is associated with agitation and aggression in mild cognitive impairment and Alzheimer's disease
    Paula T Trzepacz
    Lilly Research Laboratories, Indianapolis, IN, USA Indiana University School of Medicine, Indianapolis, IN, USA Electronic address
    Alzheimers Dement 9:S95-S104.e1. 2013
  4. pmc Subscale validation of the neuropsychiatric inventory questionnaire: comparison of Alzheimer's disease neuroimaging initiative and national Alzheimer's coordinating center cohorts
    Paula T Trzepacz
    Eli Lilly and Company, Indianapolis, IN 46285, USA
    Am J Geriatr Psychiatry 21:607-22. 2013
  5. pmc Mibampator (LY451395) randomized clinical trial for agitation/aggression in Alzheimer's disease
    Paula T Trzepacz
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA
    Int Psychogeriatr 25:707-19. 2013
  6. doi request reprint Phenotype of subsyndromal delirium using pooled multicultural Delirium Rating Scale--Revised-98 data
    Paula T Trzepacz
    Lilly Research Laboratories, Indianapolis, IN 46285, USA
    J Psychosom Res 73:10-7. 2012
  7. pmc Relationship between atomoxetine plasma concentration, treatment response and tolerability in attention-deficit/hyperactivity disorder and comorbid oppositional defiant disorder
    Philip Hazell
    Discipline of Psychological Medicine, Concord Clinical School, University of Sydney, Sydney, Australia
    Atten Defic Hyperact Disord 1:201-10. 2009
  8. doi request reprint PDI-4A: an augmented provisional screening instrument assessing 5 additional common anxiety-related diagnoses in adult primary care patients
    John P Houston
    Lilly USA, LLC, Indianapolis, IN 46285, USA
    Postgrad Med 123:89-95. 2011
  9. doi request reprint Comparison of neuroimaging modalities for the prediction of conversion from mild cognitive impairment to Alzheimer's dementia
    Paula T Trzepacz
    Eli Lilly and Company, Indianapolis, IN, USA Indiana University School of Medicine, Indianapolis, IN, USA Electronic address
    Neurobiol Aging 35:143-51. 2014
  10. pmc Florbetapir positron emission tomography and cerebrospinal fluid biomarkers
    Ann Hake
    Eli Lilly and Company, Indianapolis, IN, USA Department of Neurology Indiana University School of Medicine, Indianapolis, IN, USA Electronic address
    Alzheimers Dement 11:986-93. 2015

Detail Information

Publications31

  1. ncbi request reprint CYP2D6 metabolizer status and atomoxetine dosing in children and adolescents with ADHD
    Paula T Trzepacz
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Eur Neuropsychopharmacol 18:79-86. 2008
    ..Results suggest genotyping is unnecessary during routine clinical management, because investigators were able to dose atomoxetine to comparable efficacy and safety levels in EMs and PMs without knowledge of genotype metabolizer status...
  2. doi request reprint Designing clinical trials for the treatment of delirium
    Paula T Trzepacz
    Lilly Research Laboratories, Neurosciences Platform Team, Indianapolis, IN 46285, USA
    J Psychosom Res 65:299-307. 2008
    ....
  3. pmc Frontolimbic atrophy is associated with agitation and aggression in mild cognitive impairment and Alzheimer's disease
    Paula T Trzepacz
    Lilly Research Laboratories, Indianapolis, IN, USA Indiana University School of Medicine, Indianapolis, IN, USA Electronic address
    Alzheimers Dement 9:S95-S104.e1. 2013
    ..The neuroanatomy of agitation and aggression in Alzheimer's disease is not well understood...
  4. pmc Subscale validation of the neuropsychiatric inventory questionnaire: comparison of Alzheimer's disease neuroimaging initiative and national Alzheimer's coordinating center cohorts
    Paula T Trzepacz
    Eli Lilly and Company, Indianapolis, IN 46285, USA
    Am J Geriatr Psychiatry 21:607-22. 2013
    ..Based on existing exploratory literature, we report preliminary validation of three NPI Questionnaire (NPI-Q-10) subscales that measure clinically meaningful symptom clusters...
  5. pmc Mibampator (LY451395) randomized clinical trial for agitation/aggression in Alzheimer's disease
    Paula T Trzepacz
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA
    Int Psychogeriatr 25:707-19. 2013
    ..Mibampator, an amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor potentiator, was evaluated for treatment of agitation and aggression (A/A) in Alzheimer's disease (AD)...
  6. doi request reprint Phenotype of subsyndromal delirium using pooled multicultural Delirium Rating Scale--Revised-98 data
    Paula T Trzepacz
    Lilly Research Laboratories, Indianapolis, IN 46285, USA
    J Psychosom Res 73:10-7. 2012
    ..There is no consensus definition for the phenotype of subsyndromal delirium (SSD), a subthreshold state to full delirium. Without an a priori definition we applied advanced analytic techniques to discern SSD...
  7. pmc Relationship between atomoxetine plasma concentration, treatment response and tolerability in attention-deficit/hyperactivity disorder and comorbid oppositional defiant disorder
    Philip Hazell
    Discipline of Psychological Medicine, Concord Clinical School, University of Sydney, Sydney, Australia
    Atten Defic Hyperact Disord 1:201-10. 2009
    ..Results suggest atomoxetine plasma concentration does not predict ODD and ADHD symptom improvement. However, a higher atomoxetine dose may benefit some patients...
  8. doi request reprint PDI-4A: an augmented provisional screening instrument assessing 5 additional common anxiety-related diagnoses in adult primary care patients
    John P Houston
    Lilly USA, LLC, Indianapolis, IN 46285, USA
    Postgrad Med 123:89-95. 2011
    ..The PDI-4A may additionally help primary care physicians identify patients with PA, SP, OCD, hypochondriasis, and PTSD...
  9. doi request reprint Comparison of neuroimaging modalities for the prediction of conversion from mild cognitive impairment to Alzheimer's dementia
    Paula T Trzepacz
    Eli Lilly and Company, Indianapolis, IN, USA Indiana University School of Medicine, Indianapolis, IN, USA Electronic address
    Neurobiol Aging 35:143-51. 2014
    ..Individually, PIB-PET generated the best sensitivity, and fluorodeoxyglucose PET had the lowest. Among individual brain regions, the temporal cortex was found to be most predictive for MRI and PIB-PET...
  10. pmc Florbetapir positron emission tomography and cerebrospinal fluid biomarkers
    Ann Hake
    Eli Lilly and Company, Indianapolis, IN, USA Department of Neurology Indiana University School of Medicine, Indianapolis, IN, USA Electronic address
    Alzheimers Dement 11:986-93. 2015
    ..We evaluated the relationship between florbetapir-F18 positron emission tomography (FBP PET) and cerebrospinal fluid (CSF) biomarkers...
  11. doi request reprint Effect of atomoxetine on Tanner stage sexual development in children and adolescents with attention deficit/hyperactivity disorder: 18-month results from a double-blind, placebo-controlled trial
    Paula T Trzepacz
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Curr Med Res Opin 27:45-52. 2011
    ....
  12. doi request reprint Florbetapir F18 PET Amyloid Neuroimaging and Characteristics in Patients With Mild and Moderate Alzheimer Dementia
    Elisabeth K Degenhardt
    IU Health Physicians Group, Department of Psychiatry, Indiana University School of Medicine Collaboration, Indiana University Health, Indianapolis, IN
    Psychosomatics 57:208-16. 2016
    ..9%-87.3% sensitivity and 44.3%-70.8% specificity, compared with autopsy diagnosis. Florbetapir F18 positron emission tomography (FBP-PET) estimates beta-amyloid plaque density antemortem...
  13. pmc Empirically Defining Trajectories of Late-Life Cognitive and Functional Decline
    Helen Hochstetler
    Eli Lilly and Company or a Wholly Owned subsidiary, Indianapolis, IN, USA
    J Alzheimers Dis 50:271-82. 2016
    ..Alzheimer's disease (AD) is associated with variable cognitive and functional decline, and it is difficult to predict who will develop the disease and how they will progress...
  14. doi request reprint Relationship of Hippocampal Volume to Amyloid Burden across Diagnostic Stages of Alzheimer's Disease
    Paula T Trzepacz
    Indiana University School of Medicine, Indianapolis, Ind, USA
    Dement Geriatr Cogn Disord 41:68-79. 2016
    ..To assess how hippocampal volume (HV) from volumetric magnetic resonance imaging (vMRI) is related to the amyloid status at different stages of Alzheimer's disease (AD) and its relevance to patient care...
  15. pmc A review of the abuse potential assessment of atomoxetine: a nonstimulant medication for attention-deficit/hyperactivity disorder
    Himanshu P Upadhyaya
    Eli Lilly and Company, Indianapolis, IN 46285, USA
    Psychopharmacology (Berl) 226:189-200. 2013
    ..It was classified as an unscheduled medication indicating a low potential for abuse. However, the abuse potential of atomoxetine has not been reviewed...
  16. doi request reprint Rasch analysis of the orientation log and reconsideration of the latent construct during inpatient rehabilitation
    Jacob Kean
    Department of Physical Medicine and Rehabilitation, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Head Trauma Rehabil 26:364-74. 2011
    ....
  17. ncbi request reprint Efficacy of olanzapine combined with valproate or lithium in the treatment of dysphoric mania
    Robert W Baker
    Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Br J Psychiatry 185:472-8. 2004
    ..Few controlled studies examine the treatment of depressive features in mania...
  18. ncbi request reprint Improvement of Positive and Negative Syndrome Scale cognitive score associated with olanzapine treatment of acute mania
    Lizheng Shi
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Curr Med Res Opin 20:1371-6. 2004
    ....
  19. doi request reprint Time-to-onset and -resolution of adverse events before/after atomoxetine discontinuation in adult patients with ADHD
    Himanshu Upadhyaya
    a 1 Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, USA
    Postgrad Med 127:677-85. 2015
    ....
  20. pmc Relationship between the Montreal Cognitive Assessment and Mini-mental State Examination for assessment of mild cognitive impairment in older adults
    Paula T Trzepacz
    Indiana University School of Medicine, Indianapolis, IN, USA
    BMC Geriatr 15:107. 2015
    ..Clinicians need to better understand the relationship between MoCA and MMSE scores...
  21. doi request reprint Initial validation of a brief provisional diagnostic scale for delirium
    Jacob Kean
    Department of Speech and Hearing Sciences, Indiana University, Bloomington, IN, USA
    Brain Inj 24:1222-30. 2010
    ..This study evaluated its accuracy and validity in a population of participants with acquired brain injury (ABI)...
  22. doi request reprint Meta-analysis of suicide-related behavior events in patients treated with atomoxetine
    Mark E Bangs
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    J Am Acad Child Adolesc Psychiatry 47:209-18. 2008
    ..The present work examined suicide-related events in acute, double-blind, and placebo- or active comparator-controlled trials with atomoxetine...
  23. doi request reprint Comparison of diagnostic classification systems for delirium with new research criteria that incorporate the three core domains
    Paula T Trzepacz
    Indiana University School of Medicine, Indianapolis, IN, USA Tufts University Medical School, Boston, MA, USA
    J Psychosom Res 84:60-8. 2016
    ..We evaluated classification performances of novel Trzepacz, Meagher, and Franco research diagnostic criteria (TMF) that incorporate those domains and ICD-10, DSM-III-R, DSM-IV, and DSM-5...
  24. doi request reprint Executive function in adults with attention-deficit/hyperactivity disorder during treatment with atomoxetine in a randomized, placebo-controlled, withdrawal study
    Lenard Adler
    From the New York University School of Medicine and New York VA Harbor Healthcare System, New York, NY Eli Lilly and Company, Neuroscience, Indianapolis, IN inVentiv Health Clinical, LLC, Ann Arbor, MI University of Mississippi Medical School, Jackson, MS Tufts University School of Medicine, Boston, MA Indiana University School of Medicine, Indianapolis, IN and Lilly Research Laboratories, Kobe, Japan
    J Clin Psychopharmacol 34:461-6. 2014
    ....
  25. doi request reprint A provisional screening instrument for four common mental disorders in adult primary care patients
    John P Houston
    Lilly USA, LLC, Indianapolis, IN 46285, USA
    Psychosomatics 52:48-55. 2011
    ..To develop an adult self-report instrument for provisional diagnosis of four common mental disorders in primary care patients...
  26. doi request reprint Atomoxetine treatment of adults with ADHD and comorbid alcohol use disorders
    Timothy E Wilens
    Massachusetts General Hospital, 55 Fruit Street, YAW 6900, Boston, MA 02114, USA
    Drug Alcohol Depend 96:145-54. 2008
    ..The study aim was to determine if atomoxetine was superior to placebo in improving ADHD and alcohol use in recently abstinent adults with ADHD and comorbid alcohol use disorder...
  27. doi request reprint Motor symptoms in 100 patients with delirium versus control subjects: comparison of subtyping methods
    David J Meagher
    Department of Adult Psychiatry, Midwestern Regional Hospital and Health Systems Research Unit, Univ of Limerick, Limerick, Ireland
    Psychosomatics 49:300-8. 2008
    ..Different motor presentations of delirium may represent clinically meaningful subtypes...
  28. ncbi request reprint Phenomenological distinctions needed in DSM-V: delirium, subsyndromal delirium, and dementias
    David Meagher
    Department of Adult Psychiatry, Midwestern Regional Hospital, Limerick, Ireland
    J Neuropsychiatry Clin Neurosci 19:468-70. 2007
  29. ncbi request reprint Phenomenology of delirium. Assessment of 100 adult cases using standardised measures
    David J Meagher
    Department of Adult Psychiatry, Midwestern Regional Hospital, and Statistical Consulting Unit, University of Limerick, Ireland
    Br J Psychiatry 190:135-41. 2007
    ..Delirium phenomenology is understudied...
  30. ncbi request reprint Acute confusion following traumatic brain injury
    Risa Nakase-Thompson
    Department of Neurphyschology, Methodist Rehabilitation Center, Jackson, Mississippi 39216, USA
    Brain Inj 18:131-42. 2004
    ..To determine the incidence, duration and symptoms associated with acute confusion/delirium among traumatic brain injury (TBI) neuro-rehabilitation admissions...
  31. ncbi request reprint The delirium rating scale in children and adolescents
    Susan Beckwitt Turkel
    Department of Psychiatry, Childrens Hospital, University of Southern California Keck School of Medicine, USA
    Psychosomatics 44:126-9. 2003
    ..Therefore, the Delirium Rating Scale can be used to evaluate delirium in the pediatric population...