Werner F Blum

Summary

Affiliation: Eli Lilly and Company
Country: USA

Publications

  1. ncbi Efficacy and tolerability of an individualized dosing regimen for adult growth hormone replacement therapy in comparison with fixed body weight-based dosing
    Andrew R Hoffman
    Medical Service, Veterans Affairs Palo Alto Health Care System and Stanford University, 3801 Miranda Avenue, Palo Alto, CA 94304, USA
    J Clin Endocrinol Metab 89:3224-33. 2004
  2. ncbi The growth response to growth hormone (GH) treatment in children with isolated GH deficiency is independent of the presence of the exon 3-minus isoform of the GH receptor
    Werner F Blum
    Eli Lilly and Co, Saalburgstrasse 153, D 61350 Bad Homburg, Germany
    J Clin Endocrinol Metab 91:4171-4. 2006
  3. ncbi Growth hormone is effective in treatment of short stature associated with short stature homeobox-containing gene deficiency: Two-year results of a randomized, controlled, multicenter trial
    Werner F Blum
    Lilly Research Laboratories, Eli Lilly and Company, Saalburgstrasse 153, D 61350 Bad Homburg, Germany
    J Clin Endocrinol Metab 92:219-28. 2007
  4. ncbi Cardiac and renal effects of growth hormone in volume overload-induced heart failure: role of NO
    Ines Pagel
    Franz Volhard Klinik at the Max Delbrück Center of Molecular Medicine, Charite, Germany
    Hypertension 39:57-62. 2002
  5. ncbi Decreased quality of life in adult patients with growth hormone deficiency compared with general populations using the new, validated, self-weighted questionnaire, questions on life satisfaction hypopituitarism module
    Werner F Blum
    Lilly Research Laboratories, Eli Lilly and Co, Indianapolis, Indiana 46285, USA
    J Clin Endocrinol Metab 88:4158-67. 2003
  6. ncbi Leptin: the voice of the adipose tissue
    W F Blum
    Lilly Research Laboratories, Giessen, Germany
    Horm Res 48:2-8. 1997
  7. doi Height gains in response to growth hormone treatment to final height are similar in patients with SHOX deficiency and Turner syndrome
    Werner F Blum
    Lilly Research Laboratories, Eli Lilly and Co, Bad Homburg, Germany
    Horm Res 71:167-72. 2009
  8. doi GH treatment to final height produces similar height gains in patients with SHOX deficiency and Turner syndrome: results of a multicenter trial
    Werner F Blum
    Eli Lilly and Company, Werner Reimers Strasse 2 4, D 61352 Bad Homburg, Germany
    J Clin Endocrinol Metab 98:E1383-92. 2013
  9. doi Growth hormone treatment for short stature in children born small for gestational age
    Heike Jung
    Medical Endocrinology Department, Lilly Research Laboratories, Eli Lilly and Company, Bad Homburg, Germany
    Adv Ther 25:951-78. 2008
  10. ncbi Long-term improvement of quality of life during growth hormone (GH) replacement therapy in adults with GH deficiency, as measured by questions on life satisfaction-hypopituitarism (QLS-H)
    Myriam Rosilio
    Lilly Research Laboratories, Eli Lilly and Co, Indianapolis, Indiana 46285, USA
    J Clin Endocrinol Metab 89:1684-93. 2004

Detail Information

Publications47

  1. ncbi Efficacy and tolerability of an individualized dosing regimen for adult growth hormone replacement therapy in comparison with fixed body weight-based dosing
    Andrew R Hoffman
    Medical Service, Veterans Affairs Palo Alto Health Care System and Stanford University, 3801 Miranda Avenue, Palo Alto, CA 94304, USA
    J Clin Endocrinol Metab 89:3224-33. 2004
    ..We conclude that GH replacement therapy should be initiated at a low dose and titrated to a dose producing maximal benefits without adverse side effects and an IGF-I level within the age- and sex-adjusted normal range...
  2. ncbi The growth response to growth hormone (GH) treatment in children with isolated GH deficiency is independent of the presence of the exon 3-minus isoform of the GH receptor
    Werner F Blum
    Eli Lilly and Co, Saalburgstrasse 153, D 61350 Bad Homburg, Germany
    J Clin Endocrinol Metab 91:4171-4. 2006
    ....
  3. ncbi Growth hormone is effective in treatment of short stature associated with short stature homeobox-containing gene deficiency: Two-year results of a randomized, controlled, multicenter trial
    Werner F Blum
    Lilly Research Laboratories, Eli Lilly and Company, Saalburgstrasse 153, D 61350 Bad Homburg, Germany
    J Clin Endocrinol Metab 92:219-28. 2007
    ....
  4. ncbi Cardiac and renal effects of growth hormone in volume overload-induced heart failure: role of NO
    Ines Pagel
    Franz Volhard Klinik at the Max Delbrück Center of Molecular Medicine, Charite, Germany
    Hypertension 39:57-62. 2002
    ..However, GH improved renal function by increasing diuresis and sodium excretion. The responsible mechanism might be the enhanced activity of the renal NO system...
  5. ncbi Decreased quality of life in adult patients with growth hormone deficiency compared with general populations using the new, validated, self-weighted questionnaire, questions on life satisfaction hypopituitarism module
    Werner F Blum
    Lilly Research Laboratories, Eli Lilly and Co, Indianapolis, Indiana 46285, USA
    J Clin Endocrinol Metab 88:4158-67. 2003
    ..This approach allows pooling of data from different cohorts and comparison with general populations. QLS-H scores in adults with GHD were significantly decreased at baseline and were almost normalized after 6-8 months of GH therapy...
  6. ncbi Leptin: the voice of the adipose tissue
    W F Blum
    Lilly Research Laboratories, Giessen, Germany
    Horm Res 48:2-8. 1997
    ..Finally, a possible role for leptin is presented...
  7. doi Height gains in response to growth hormone treatment to final height are similar in patients with SHOX deficiency and Turner syndrome
    Werner F Blum
    Lilly Research Laboratories, Eli Lilly and Co, Bad Homburg, Germany
    Horm Res 71:167-72. 2009
    ..If untreated, short patients with SHOX deficiency remain short in adulthood. Growth hormone (GH) treatment improves short-term linear growth; however, there are no data on GH treatment effects on final height...
  8. doi GH treatment to final height produces similar height gains in patients with SHOX deficiency and Turner syndrome: results of a multicenter trial
    Werner F Blum
    Eli Lilly and Company, Werner Reimers Strasse 2 4, D 61352 Bad Homburg, Germany
    J Clin Endocrinol Metab 98:E1383-92. 2013
    ..Because of the established effect of GH treatment on height in patients with Turner syndrome, we hypothesized that GH therapy would also stimulate growth in patients with SHOX deficiency...
  9. doi Growth hormone treatment for short stature in children born small for gestational age
    Heike Jung
    Medical Endocrinology Department, Lilly Research Laboratories, Eli Lilly and Company, Bad Homburg, Germany
    Adv Ther 25:951-78. 2008
    ..Further studies on individualized treatment regimens and long-term safety are ongoing...
  10. ncbi Long-term improvement of quality of life during growth hormone (GH) replacement therapy in adults with GH deficiency, as measured by questions on life satisfaction-hypopituitarism (QLS-H)
    Myriam Rosilio
    Lilly Research Laboratories, Eli Lilly and Co, Indianapolis, Indiana 46285, USA
    J Clin Endocrinol Metab 89:1684-93. 2004
    ..The authors suggest that evaluation of QoL should be a part of the routine clinical management of adult GH-deficient patients, complementing the measurement of surrogate biological markers or other clinical end points...
  11. doi Radiological Features in Patients with Short Stature Homeobox-Containing (SHOX) Gene Deficiency and Turner Syndrome before and after 2 Years of GH Treatment
    Christopher J Child
    Lilly Research Laboratories, Eli Lilly and Company, Windlesham, UK
    Horm Res Paediatr 84:14-25. 2015
    ..We investigated differences in radiological anomalies between patients with SHOX-D and Turner syndrome (TS) and the effect of 2 years of growth hormone (GH) treatment on these anomalies...
  12. doi Growth response to an individualized versus fixed dose GH treatment in short children born small for gestational age: the OPTIMA study
    Heike Jung
    Lilly Research Laboratories, D 61352 Bad Homburg, Germany
    Eur J Endocrinol 160:149-56. 2009
    ..This study compared the first year growth-promoting effect of an individually adjusted GH dose (IAD) versus a fixed high GH dose (FHD) in pre-pubertal children born SGA with severe short stature...
  13. ncbi Children with idiopathic short stature are poor eaters and have decreased body mass index
    Stefan A Wudy
    Department of General Pediatrics, Center of Child and Adolescent Medicine, Justus Liebig University, Giessen, Germany
    Pediatrics 116:e52-7. 2005
    ..In children with idiopathic short stature (ISS), studies investigating body mass index (BMI) or parameters of satiety regulation are scarce, and studies analyzing eating behavior are lacking...
  14. ncbi Vasoactive intestinal polypeptide/pituitary adenylate cyclase-activating peptide receptor 2 deficiency in mice results in growth retardation and increased basal metabolic rate
    Mark A Asnicar
    Division of Endocrine Research, Eli Lilly and Co, Indianapolis, Indiana 46285, USA
    Endocrinology 143:3994-4006. 2002
    ..Our results suggest that VPAC2R plays an important role in growth, basal energy expenditure, and male reproductive functions...
  15. ncbi Short-term safety and efficacy of human GH replacement therapy in 595 adults with GH deficiency: a comparison of two dosage algorithms
    Anne Kehely
    Lilly Research Centre, Erl Wood Manor, Windlesham, Surrey GU20 6PH, United Kingdom
    J Clin Endocrinol Metab 87:1974-9. 2002
    ..The lower starting dose with dose titration appeared more favorable, but differences in response between genders and onset of GH deficiency need to be taken into account when setting an individual dose regimen...
  16. ncbi Confirmation of severe GH deficiency after final height in patients diagnosed as GH deficient during childhood
    Andrea F Attanasio
    Eli Lilly Italia SPA, Via Gramsci 731 733, 50019 Sesto Fiorentino, Florence, Italy
    Clin Endocrinol (Oxf) 56:503-7. 2002
    ..At present, the diagnostic approach to these patients is not fully standardized. This study aimed to characterize a large group of previously GH-treated CO GHD patients and establish their GH status...
  17. doi Ten-year change in quality of life in adults on growth hormone replacement for growth hormone deficiency: an analysis of the hypopituitary control and complications study
    Daojun Mo
    Lilly Diabetes D M, R Q, Eli Lilly and Company, Indianapolis, Indiana 46285 Lilly Diabetes W F B, Eli Lilly and Company, Bad Homburg 61352, Germany Lilly France M R, 92521 Neuilly sur Seine, France Department of Endocrinology Medicine and CIBERER 747 S M W, Hospital S Pau, Universitat Autonoma de Barcelona, 08193 Cerdanyola del Valles, Barcelona, Spain Department of Endocrinology C J S, and Diabetes and Nutritional Medicine, Charite Universitatsmedizin, Campus Mitte, 13353 Berlin, Germany
    J Clin Endocrinol Metab 99:4581-8. 2014
    ..Previous studies showed improvement in impaired quality of life (QoL) in adult patients with growth hormone (GH) deficiency (GHD) who were treated with GH; improvement was sustained over a few years after GH therapy...
  18. ncbi Four novel mutations of the LHX3 gene cause combined pituitary hormone deficiencies with or without limited neck rotation
    Roland W Pfaeffle
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Medical Science Room 362A, 635 North Barnhill Drive, Indianapolis, IN 46202 5120, USA
    J Clin Endocrinol Metab 92:1909-19. 2007
    ..Human LHX3 gene mutations have been reported in five subjects with a phenotype consisting of GH, prolactin, TSH, LH, and FSH deficiency; abnormal pituitary morphology; and limited neck rotation...
  19. ncbi Auxological and endocrine phenotype in a population-based cohort of patients with PROP1 gene defects
    Jan Lebl
    Department of Paediatrics, 3 Faculty of Medicine, Charles University Parague, Czech Republic
    Eur J Endocrinol 153:389-96. 2005
    ..We aimed to establish the prevalence of HESX1, PROP1, and POU1F1 gene defects in a population-based cohort of patients with MPHD and to analyse the phenotype of affected individuals...
  20. ncbi The phenotype of short stature homeobox gene (SHOX) deficiency in childhood: contrasting children with Leri-Weill dyschondrosteosis and Turner syndrome
    Judith L Ross
    Department of Pediatrics, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Pediatr 147:499-507. 2005
    ..To evaluate the growth disorder and phenotype in prepubertal children with Leri-Weill dyschondrosteosis (LWD), a dominantly inherited skeletal dysplasia, and to compare the findings from girls with Turner syndrome (TS)...
  21. ncbi Serum insulin-like growth factor binding protein-2 levels as an indicator of functional ability in elderly men
    Annewieke W van den Beld
    Department of Internal Medicine III, Room D4, Erasmus University Medical Center, 40 Dr Molewaterplein, 3015 GD Rotterdam, The Netherlands
    Eur J Endocrinol 148:627-34. 2003
    ....
  22. ncbi Body composition, IGF-I and IGFBP-3 concentrations as outcome measures in severely GH-deficient (GHD) patients after childhood GH treatment: a comparison with adult onset GHD patients
    Andrea F Attanasio
    Eli Lilly and Co, Florence 50019, Italy
    J Clin Endocrinol Metab 87:3368-72. 2002
    ..001 within each gender) were significantly lower in the CO group. These results suggest that patients with CO GHD who were treated to final height suffer a significant maturational deficit despite GH replacement during childhood...
  23. ncbi Growth selection in mice reveals conserved and redundant expression patterns of the insulin-like growth factor system
    Andreas Hoeflich
    Lehrstuhl für Molekulare Tierzucht und Biotechnologie Genzentrum, Ludwig Maximilians Universitat, 81377 Munich, Germany
    Gen Comp Endocrinol 136:248-59. 2004
    ..The finding that serum but not tissue IGF-I levels were strictly positively correlated with growth during growth selection argues for an important role of endocrine IGF-I for postnatal growth in mice...
  24. ncbi Predicting the growth response to growth hormone (GH) treatment in prepubertal and pubertal children with isolated GH deficiency--model validation in an observational setting (GeNeSIS)
    Christof Land
    Children s Hospital, University of Cologne, Germany
    J Pediatr Endocrinol Metab 20:685-93. 2007
    ..Validation of a preexisting mathematical model for predicting height velocity in the first year of growth hormone (GH) treatment, using an independent cohort of pediatric patients with confirmed GH deficiency (GHD)...
  25. ncbi Evidence against a direct effect of leptin on insulin-like growth factor-I (IGF-I), IGFBP-2 and IGF-I receptor expression in human SK-N-MC neuroepithelioma cells
    Wieland Kiess
    Hospital for Children and Adolescents, University of Leipzig, Oststr 21 25, D 04317 Leipzig, Germany
    Regul Pept 130:35-41. 2005
    ..We hypothesize that leptin and the IGF system do not interact directly in a cell culture model of neuroepithelioma cells...
  26. ncbi Effect of growth hormone (GH) treatment on bone in postpubertal GH-deficient patients: a 2-year randomized, controlled, dose-ranging study
    Stephen M Shalet
    Department of Endocrinology, Christie Hospital NHS Trust, Manchester M20 4BX, United Kingdom
    J Clin Endocrinol Metab 88:4124-9. 2003
    ..Although there was a by-gender dose effect on IGF-I concentration, the treatment effect on bone was obtained in both males and females with the adult GH dose regimen...
  27. ncbi Effect of growth hormone treatment on adult height in peripubertal children with idiopathic short stature: a randomized, double-blind, placebo-controlled trial
    Ellen Werber Leschek
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development NIH, Building 10, Room 10N262, 10 Center Drive, MSC 1862, Bethesda, MD 20892 1862, USA
    J Clin Endocrinol Metab 89:3140-8. 2004
    ..52 SDS; 3.8 cm; P < 0.001; 95% confidence interval, 0.22-0.82 SDS) and no important dropout bias. In conclusion, GH treatment increases adult height in peripubertal children with marked idiopathic short stature...
  28. ncbi Continued growth hormone (GH) treatment after final height is necessary to complete somatic development in childhood-onset GH-deficient patients
    Andrea F Attanasio
    Lilly Research, Sesto Fiorentino, Italy
    J Clin Endocrinol Metab 89:4857-62. 2004
    ..Dose requirements may have to be adjusted by gender, with females requiring a higher dose than males...
  29. ncbi PROP1 mutations cause progressive deterioration of anterior pituitary function including adrenal insufficiency: a longitudinal analysis
    Antje Böttner
    University Hospital for Children and Adolescents, University of Leipzig, Oststrasse 21 25, 04317 Leipzig, Germany
    J Clin Endocrinol Metab 89:5256-65. 2004
    ....
  30. ncbi Reference values for insulin-like growth factor-binding protein-3 (IGFBP-3) and the ratio of insulin-like growth factor-I to IGFBP-3 throughout childhood and adolescence
    Chatarina Lofqvist
    Sahlgrenska Academy at Goteborg University, Institute for the Health of Women and Children, Goteborg Pediatric Growth Research Center, The Queen Silvia Children s Hospital, Goteborg, Sweden
    J Clin Endocrinol Metab 90:1420-7. 2005
    ..In late midpuberty (B = 4), the relationship with age was negative, and in late puberty values were relatively constant and higher than earlier in puberty...
  31. ncbi Pharmacokinetics and pharmacodynamics of GH: dependence on route and dosage of administration
    Alexandra Keller
    Hospital for Children and Adolescents, University of Leipzig, Oststr 21 25, D 04317 Leipzig, Germany
    Eur J Endocrinol 156:647-53. 2007
    ..We examined pharmacokinetics, pharmacodynamics, and 20 kDa GH after injection of rhGH at different doses and routes of administration...
  32. ncbi Lower serum leptin levels in female students of the nutritional sciences with eating disorders
    Joachim Frey
    Clinical Research Group, Department of Child and Adolescent Psychiatry, University of Marburg, Hans Sachs Str 6, 35033 Marburg, Germany
    Eur J Nutr 42:142-8. 2003
    ..It is unknown if these lower leptin levels represent a state or trait marker...
  33. ncbi IGFs and binding proteins in short children with intrauterine growth retardation
    Wayne S Cutfield
    Department of Pediatrics, University of Auckland, Auckland 92019, New Zealand
    J Clin Endocrinol Metab 87:235-9. 2002
    ..We speculate that hyperinsulinism secondary to insulin resistance may have led to these changes to the IGF-IGFBP axis in the IUGR group...
  34. ncbi Quality of life in childhood onset growth hormone-deficient patients in the transition phase from childhood to adulthood
    Andrea F Attanasio
    Casina del Rosone, Agliano Terme, Italy
    J Clin Endocrinol Metab 90:4525-9. 2005
    ..Quality of life (QoL) has not been specifically assessed in GH-deficient (GHD) transition patients...
  35. ncbi Collagen markers deoxypyridinoline and hydroxylysine glycosides: pediatric reference data and use for growth prediction in growth hormone-deficient children
    Frank Rauch
    Children s Hospital, University of Cologne, Josef Stelzmann Strasse 9, 50924 Cologne, Germany
    Clin Chem 48:315-22. 2002
    ..The aim of this study was to assess the relationship of the urinary collagen markers deoxypyridinoline (DPD) and hydroxylysine (Hyl) and its glycosides [galactosyl-Hyl (Gal-Hyl) and glucosyl-Gal-Hyl] with growth...
  36. pmc Identification of a major recombination hotspot in patients with short stature and SHOX deficiency
    Katja U Schneider
    Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany
    Am J Hum Genet 77:89-96. 2005
    ..We propose that the sequence present within this proximal deletion breakpoint "hotspot" region predisposes to recurrent breaks...
  37. doi A prospective study of body weight and serum leptin levels in patients treated with topiramate
    Frank M Theisen
    Department of Child and Adolescent Psychiatry, University of Marburg, Marburg, Germany
    Clin Neuropharmacol 31:226-30. 2008
    ..We prospectively studied 26 (10 women) patients (age, 37.4 +/- 10.3 years) with different types of refractory focal epilepsy who received topiramate as adjunctive treatment...
  38. doi Temporal changes in insulin-like growth factors I and II and in insulin-like growth factor binding proteins 1, 2, and 3 in human milk
    Stella R Milsom
    Fertility Associates, Ascot Integrated Hospital, Auckland, New Zealand
    Horm Res 69:307-11. 2008
    ..To evaluate the postpartum time course of changes in insulin-like growth factors (IGFs) and their binding proteins (IGFBPs)...
  39. pmc Three novel missense mutations within the LHX4 gene are associated with variable pituitary hormone deficiencies
    Roland W Pfaeffle
    University Children s Hospital, Leipzig, Germany
    J Clin Endocrinol Metab 93:1062-71. 2008
    ..The LHX4 LIM-homeodomain transcription factor has essential roles in pituitary gland and nervous system development. Heterozygous mutations in LHX4 are associated with combined pituitary hormone deficiency...
  40. ncbi IGF-binding protein-3 fragments in plasma of a child with acute renal failure
    Victoria Schebek-Fürstenberg
    Department of Biochemistry, Children s Hospital, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Pediatr Nephrol 19:1418-25. 2004
    ....
  41. ncbi Insulin-like growth factor binding protein-2 at diagnosis of childhood acute lymphoblastic leukemia and the prediction of relapse risk
    Peter Vorwerk
    Department of Pediatric Hematology Oncology, University Otto von Guericke Magdeburg, E Larisch Weg 17 19, D 39112 Magdeburg, Germany
    J Clin Endocrinol Metab 90:3022-7. 2005
    ....
  42. ncbi Validation of a calibrated prediction model for response to growth hormone treatment in an independent cohort
    Maria A J de Ridder
    Dutch Growth Foundation, Rotterdam, The Netherlands
    Horm Res 66:13-6. 2006
    ..We modified the prediction formula and now report validation of this modified model...
  43. ncbi Hypoglycemia due to paraneoplastic secretion of insulin-like growth factor-I in a patient with metastasizing large-cell carcinoma of the lung
    Michael A Nauck
    Diabeteszentrum Bad Lauterberg, Kirchberg 21, D 37431 Bad Lauterberg im Harz, Germany
    J Clin Endocrinol Metab 92:1600-5. 2007
    ..Multiple small lung nodules were detected by computed tomography scan. An undifferentiated large-cell carcinoma was diagnosed from an axillary lymph node metastasis...
  44. pmc Genotypes and phenotypes in children with short stature: clinical indicators of SHOX haploinsufficiency
    Gudrun Rappold
    Department of Molecular Human Genetics, University of Heidelberg, Heidelberg, Germany
    J Med Genet 44:306-13. 2007
    ....
  45. ncbi IGF-I and IGF-II stimulate directed cell migration of bone-marrow-derived human mesenchymal progenitor cells
    Jörg Fiedler
    Orthopaedic Department, Division for Biochemistry of Joint and Connective Tissue Diseases, University of Ulm, Ulm, Germany
    Biochem Biophys Res Commun 345:1177-83. 2006
    ..In conclusion, our results show that IGF-I and -II are chemotactic factors for MPC and indicate that IGFBP-5 both modulates the IGF-I effect and directly stimulates migration of human mesenchymal progenitor cells...
  46. ncbi Evidence for involvement of the vitamin D receptor gene in idiopathic short stature via a genome-wide linkage study and subsequent association studies
    Astrid Dempfle
    Institute of Medical Biometry and Epidemiology, Philipps University Marburg, Germany
    Hum Mol Genet 15:2772-83. 2006
    ..In conclusion, we identified significant linkage, which might be due to a functional SNP in the vitamin D receptor (VDR) gene and could be responsible for up to 34% of ISS cases in the population...
  47. ncbi Interaction of insulin-like growth factor II (IGF-II) with multiple plasma proteins: high affinity binding of plasminogen to IGF-II and IGF-binding protein-3
    Sandra Oesterreicher
    University Hospital Hamburg Eppendorf, Children s Hospital, Department of Biochemistry, Martinistrasse 52, D 20246 Hamburg, Germany
    J Biol Chem 280:9994-10000. 2005
    ....