Neel K Krishna

Summary

Affiliation: Eastern Virginia Medical School
Country: USA

Publications

  1. ncbi Human astrovirus coat protein: a novel C1 inhibitor
    Neel K Krishna
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Adv Exp Med Biol 632:237-51. 2008
  2. doi Role of molecular diagnostics in the management of infectious disease emergencies
    Neel K Krishna
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Med Clin North Am 96:1067-78. 2012
  3. doi Potent inhibition of the classical pathway of complement by a novel C1q-binding peptide derived from the human astrovirus coat protein
    Jenny Q Gronemus
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, 700 West Olney Road, Norfolk, VA 23507 1696, USA
    Mol Immunol 48:305-13. 2010
  4. pmc Peptide Inhibitor of Complement C1 (PIC1) Rapidly Inhibits Complement Activation after Intravascular Injection in Rats
    Julia A Sharp
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia, United States of America
    PLoS ONE 10:e0132446. 2015
  5. doi Therapeutic hypothermia modulates complement factor C3a and C5a levels in a rat model of hypoxic ischemic encephalopathy
    Tushar A Shah
    Department of Pediatrics, Eastern Virginia Medical School, Norfolk, VA, USA
    Pediatr Res . 2016
  6. doi Complement inhibition significantly decreases red blood cell lysis in a rat model of acute intravascular hemolysis
    Tushar A Shah
    Department of Pediatrics, Eastern Virginia Medical School, Norfolk, Virginia Children s Specialty Group, Norfolk, Virginia Children s Hospital of the King s Daughters, Norfolk, Virginia
    Transfusion 54:2892-900. 2014
  7. doi Eosinophil Quantitated Urine Kinetic: A novel assay for assessment of eosinophilic esophagitis
    Kenji M Cunnion
    Department of Pediatrics, Eastern Virginia Medical School, Norfolk, Virginia Children s Specialty Group, Norfolk, Virginia Children s Hospital of the King s Daughters, Norfolk, Virginia Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia Electronic address
    Ann Allergy Asthma Immunol 116:435-9. 2016
  8. pmc Hyperglycemia inhibits complement-mediated immunological control of S. aureus in a rat model of peritonitis
    Clifford T Mauriello
    Department of Pediatrics, Eastern Virginia Medical School, 855 West Brambleton Avenue, Norfolk, VA 23501 1980, USA
    J Diabetes Res 2014:762051. 2014
  9. pmc Hyperglycemic conditions inhibit C3-mediated immunologic control of Staphylococcus aureus
    Pamela S Hair
    Department of Pediatrics, Eastern Virginia Medical School, Norfolk, VA, USA
    J Transl Med 10:35. 2012
  10. doi Discriminating the hemolytic risk of blood type A plasmas using the complement hemolysis using human erythrocytes (CHUHE) assay
    Kenji M Cunnion
    Department of Pediatrics, Eastern Virginia Medical School, Norfolk, Virginia
    Transfusion . 2016

Research Grants

Collaborators

  • Pamela S Hair
  • Nicole M Thielens
  • Gerard J Arlaud
  • Julia A Sharp
  • Nenoo Rawal
  • Kenji M Cunnion
  • Tushar A Shah
  • Clifford T Mauriello
  • Haree K Pallera
  • Frank A Lattanzio
  • Alice L Werner
  • Laura A Sass
  • Pamela H Whitley
  • Parvathi S Kumar
  • Julius O Nyalwidhe
  • Jenny Q Gronemus
  • Rheba S Bonaparte
  • Antoinette F Hood
  • Patrick S Cottler
  • Brittany P Lassiter
  • George T Rodeheaver
  • Magdielis Gregory Rivera
  • Anca D Dobrian
  • Mary A Clements
  • Ryan Huyck
  • Angela Pineros-Fernandez
  • Jerry L Nadler
  • Jasmine E Nejad
  • Heather B Minto
  • W Thomas Bass
  • Corinne L Goldberg
  • Lauren K Willis
  • Megan A Sass
  • Rawad Farhat
  • Lanne Y Maes
  • Kelly M Maples
  • Clinton W Enos
  • Tanya C Burch
  • Amy M Perkins
  • Lou Ann Maes
  • Nicholas S Rister
  • Michael P Stolz
  • William Thomas Bass
  • Reuben D Rohn
  • Amandeep Sandhu
  • Cees van Kooten
  • Shizhi Qian
  • Pieter van der Pol
  • Jon L Woltmann
  • Katrina B Crawford
  • Dawn M Marshall
  • Deepa Banthia

Detail Information

Publications17

  1. ncbi Human astrovirus coat protein: a novel C1 inhibitor
    Neel K Krishna
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Adv Exp Med Biol 632:237-51. 2008
    ..Additionally, the properties of this compound are elucidated highlighting its potential as an anti-complement therapeutic for the many diseases associated with inappropriate complement activation...
  2. doi Role of molecular diagnostics in the management of infectious disease emergencies
    Neel K Krishna
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Med Clin North Am 96:1067-78. 2012
    ..An added advantage of rapid diagnostic tests often not emphasized is the capability to rule out certain diagnoses for which unnecessary antimicrobial therapy may otherwise be instituted and/or continued...
  3. doi Potent inhibition of the classical pathway of complement by a novel C1q-binding peptide derived from the human astrovirus coat protein
    Jenny Q Gronemus
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, 700 West Olney Road, Norfolk, VA 23507 1696, USA
    Mol Immunol 48:305-13. 2010
    ....
  4. pmc Peptide Inhibitor of Complement C1 (PIC1) Rapidly Inhibits Complement Activation after Intravascular Injection in Rats
    Julia A Sharp
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia, United States of America
    PLoS ONE 10:e0132446. 2015
    ....
  5. doi Therapeutic hypothermia modulates complement factor C3a and C5a levels in a rat model of hypoxic ischemic encephalopathy
    Tushar A Shah
    Department of Pediatrics, Eastern Virginia Medical School, Norfolk, VA, USA
    Pediatr Res . 2016
    ..The complement system plays a major role in the pathogenesis of ischemia-reperfusion injuries such as HIE. We have previously demonstrated that HT modulates complement activity in vitro...
  6. doi Complement inhibition significantly decreases red blood cell lysis in a rat model of acute intravascular hemolysis
    Tushar A Shah
    Department of Pediatrics, Eastern Virginia Medical School, Norfolk, Virginia Children s Specialty Group, Norfolk, Virginia Children s Hospital of the King s Daughters, Norfolk, Virginia
    Transfusion 54:2892-900. 2014
    ..Prevention of acute hemolytic transfusion reactions is a worldwide concern. The objective of this study was to develop a simple rat model of complement-mediated acute intravascular hemolysis...
  7. doi Eosinophil Quantitated Urine Kinetic: A novel assay for assessment of eosinophilic esophagitis
    Kenji M Cunnion
    Department of Pediatrics, Eastern Virginia Medical School, Norfolk, Virginia Children s Specialty Group, Norfolk, Virginia Children s Hospital of the King s Daughters, Norfolk, Virginia Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia Electronic address
    Ann Allergy Asthma Immunol 116:435-9. 2016
    ..Although markers of eosinophil degranulation correlate with symptoms, eosinophil counts do not correlate. Development of a noninvasive, cost-effective biomarker of eosinophil activation for the evaluation of EoE is an unmet medical need...
  8. pmc Hyperglycemia inhibits complement-mediated immunological control of S. aureus in a rat model of peritonitis
    Clifford T Mauriello
    Department of Pediatrics, Eastern Virginia Medical School, 855 West Brambleton Avenue, Norfolk, VA 23501 1980, USA
    J Diabetes Res 2014:762051. 2014
    ..aureus, suggesting that hyperglycemic inhibition of complement effectors may contribute to the increased risk and severity of S. aureus infections in diabetic patients...
  9. pmc Hyperglycemic conditions inhibit C3-mediated immunologic control of Staphylococcus aureus
    Pamela S Hair
    Department of Pediatrics, Eastern Virginia Medical School, Norfolk, VA, USA
    J Transl Med 10:35. 2012
    ..Diabetic patients are at increased risk for bacterial infections; these studies provide new insight into the role of the host defense complement system in controlling bacterial pathogens in hyperglycemic environments...
  10. doi Discriminating the hemolytic risk of blood type A plasmas using the complement hemolysis using human erythrocytes (CHUHE) assay
    Kenji M Cunnion
    Department of Pediatrics, Eastern Virginia Medical School, Norfolk, Virginia
    Transfusion . 2016
    ..The CHUHE assay is used to evaluate correlations between agglutination titers and complement-mediated hemolysis as well as the hemolytic potential of plasma from type A blood donors...
  11. pmc Complement Activation and STAT4 Expression Are Associated with Early Inflammation in Diabetic Wounds
    Kenji M Cunnion
    Department of Pediatrics, Eastern Virginia Medical School, Norfolk, VA, United States of America
    PLoS ONE 12:e0170500. 2017
    ..These changes were associated with a 76% increase in nucleated cells in the wounds of db/db mice vs...
  12. pmc Complement Effectors of Inflammation in Cystic Fibrosis Lung Fluid Correlate with Clinical Measures of Disease
    Laura A Sass
    Department of Pediatrics, Eastern Virginia Medical School, 700 West Olney Road, Norfolk, Virginia, United States of America
    PLoS ONE 10:e0144723. 2015
    ..77, P = 0.04). C3a, which has anti-inflammatory effects, correlated positively with FEV1% predicted (rs = 0.63, P = 0.02). These results suggest that complement effectors may significantly impact inflammation in CF lung fluid. ..
  13. pmc Clinical hypothermia temperatures increase complement activation and cell destruction via the classical pathway
    Tushar A Shah
    Department of Pediatrics, Eastern Virginia Medical School, 855 West Brambleton Avenue, Norfolk, VA 23510, USA
    J Transl Med 12:181. 2014
    ..Our goal was to measure the independent effect of temperature on complement activation, and more specifically, examine the relationship between clinical hypothermia temperatures (31-33°C), and complement activation...
  14. pmc A novel peptide inhibitor of classical and lectin complement activation including ABO incompatibility
    Clifford T Mauriello
    Department of Pediatrics, Eastern Virginia Medical School, 855 West Brambleton Avenue, Norfolk, VA 23510, United States
    Mol Immunol 53:132-9. 2013
    ....
  15. doi Human astrovirus coat protein binds C1q and MBL and inhibits the classical and lectin pathways of complement activation
    Pamela S Hair
    Department of Pediatrics, Eastern Virginia Medical School, 855 West Brambleton Avenue, Norfolk, VA 23510, United States
    Mol Immunol 47:792-8. 2010
    ..These findings suggest CP inhibits C1 and MBL activation via a novel mechanism of interference with the normal interaction of the recognition molecule with its cognate serine proteases...
  16. pmc Human astrovirus coat protein inhibits serum complement activation via C1, the first component of the classical pathway
    Rheba S Bonaparte
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, 700 West Olney Road, Norfolk, VA 23507 1696, USA
    J Virol 82:817-27. 2008
    ..Although diverse mechanisms of inhibition of complement activation have been described for many enveloped animal viruses, this is the first report of a nonenveloped icosahedral virus CP inhibiting classical pathway activation at C1...
  17. pmc Identification of structural domains involved in astrovirus capsid biology
    Neel K Krishna
    Department of Pediatrics and the Center for Pediatric Research, Norfolk, VA 23510, USA
    Viral Immunol 18:17-26. 2005
    ..Information derived from these structural predictions will serve as an important tool in designing experiments to understand astrovirus biology...

Research Grants1

  1. Molecular analysis of astrovirus capsid assembly
    NEEL KRISHNA; Fiscal Year: 2005
    ..In the long term, we expect that this work will add not only to the understanding of astrovirus particle biology, but also lead to the development of therapeutic drugs or vaccines to combat viral gastroenteritis in humans. ..