David R Friend

Summary

Affiliation: Eastern Virginia Medical School
Country: USA

Publications

  1. doi Intravaginal rings: controlled release systems for contraception and prevention of transmission of sexually transmitted infections
    David R Friend
    Department of Obstetrics and Gynecology, CONRAD, Eastern Virginia Medical School, 1911 North Fort Myer Drive Suite 900, Arlington, VA, 22209, USA
    Drug Deliv Transl Res 1:185-93. 2011
  2. doi Assessment of topical microbicides to prevent HIV-1 transmission: concepts, testing, lessons learned
    David R Friend
    CONRAD, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Arlington, VA 22209, USA Electronic address
    Antiviral Res 99:391-400. 2013
  3. doi Multipurpose prevention technologies: products in development
    David R Friend
    CONRAD Program, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, 1911 N Fort Myer Drive, Suite 900, Arlington, VA 22209, United States Electronic address
    Antiviral Res 100:S39-47. 2013
  4. doi Drug delivery in multiple indication (multipurpose) prevention technologies: systems to prevent HIV-1 transmission and unintended pregnancies or HSV-2 transmission
    David R Friend
    Eastern Virginia Medical School, CONRAD, Department of Obstetrics and Gynecology, 1911 North Fort Myer Drive, Suite 900, Arlington, VA 22209, USA
    Expert Opin Drug Deliv 9:417-27. 2012
  5. doi Pharmaceutical development of microbicide drug products
    David R Friend
    CONRAD, Arlington, Virginia 22209, USA
    Pharm Dev Technol 15:562-81. 2010
  6. doi Combining prevention of HIV-1, other sexually transmitted infections and unintended pregnancies: Development of dual-protection technologies
    David R Friend
    CONRAD, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, 1911 North Fort Myer Drive, Arlington, VA 22209, USA
    Antiviral Res 88:S47-54. 2010
  7. doi Pharmacokinetics and topical vaginal effects of two tenofovir gels in rabbits
    Meredith R Clark
    CONRAD, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Arlington, Virginia, USA
    AIDS Res Hum Retroviruses 28:1458-66. 2012
  8. doi A hot-melt extruded intravaginal ring for the sustained delivery of the antiretroviral microbicide UC781
    Meredith R Clark
    CONRAD, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Arlington, Virginia 22209, USA
    J Pharm Sci 101:576-87. 2012
  9. pmc Evaluation of Rapidly Disintegrating Vaginal Tablets of Tenofovir, Emtricitabine and Their Combination for HIV-1 Prevention
    Meredith R Clark
    CONRAD, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Arlington, VA 22209, USA
    Pharmaceutics 6:616-631. 2014
  10. doi Preclinical evaluation of UC781 microbicide vaginal drug delivery
    Meredith R Clark
    CONRAD, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, 1911 North Fort Myer Drive, Suite 900, Arlington, VA, 22209, USA
    Drug Deliv Transl Res 1:175-82. 2011

Collaborators

Detail Information

Publications11

  1. doi Intravaginal rings: controlled release systems for contraception and prevention of transmission of sexually transmitted infections
    David R Friend
    Department of Obstetrics and Gynecology, CONRAD, Eastern Virginia Medical School, 1911 North Fort Myer Drive Suite 900, Arlington, VA, 22209, USA
    Drug Deliv Transl Res 1:185-93. 2011
    ..Another drug capable of blocking transmission of HIV-1 when released from IVRs is tenofovir. Finally, combinations of drugs with different indications (i.e., multipurpose prevention technologies) are actively being pursued. ..
  2. doi Assessment of topical microbicides to prevent HIV-1 transmission: concepts, testing, lessons learned
    David R Friend
    CONRAD, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Arlington, VA 22209, USA Electronic address
    Antiviral Res 99:391-400. 2013
    ..It is now clear that product adherence could be the greatest challenge to demonstrating topical (and to a similar extent oral) PrEP. Novel dosage forms should play a role in creating products that women will use correctly...
  3. doi Multipurpose prevention technologies: products in development
    David R Friend
    CONRAD Program, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, 1911 N Fort Myer Drive, Suite 900, Arlington, VA 22209, United States Electronic address
    Antiviral Res 100:S39-47. 2013
    ..It forms part of a special supplement to Antiviral Research...
  4. doi Drug delivery in multiple indication (multipurpose) prevention technologies: systems to prevent HIV-1 transmission and unintended pregnancies or HSV-2 transmission
    David R Friend
    Eastern Virginia Medical School, CONRAD, Department of Obstetrics and Gynecology, 1911 North Fort Myer Drive, Suite 900, Arlington, VA 22209, USA
    Expert Opin Drug Deliv 9:417-27. 2012
    ..The development of multiple indication (multipurpose) prevention technologies (MIPTs) is driven by overlapping relationships in the area of female reproductive health...
  5. doi Pharmaceutical development of microbicide drug products
    David R Friend
    CONRAD, Arlington, Virginia 22209, USA
    Pharm Dev Technol 15:562-81. 2010
    ..Dual protection systems are also under development. These systems include formulations capable of preventing HIV infection along with a second drug capable of preventing conception or other viral infections such as HSV...
  6. doi Combining prevention of HIV-1, other sexually transmitted infections and unintended pregnancies: Development of dual-protection technologies
    David R Friend
    CONRAD, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, 1911 North Fort Myer Drive, Arlington, VA 22209, USA
    Antiviral Res 88:S47-54. 2010
    ..This article forms part of a special supplement on a presentation covering DPTs, based on the symposium "Trends in Microbicide Formulations", held on 25 and 26 January 2010, Arlington, VA...
  7. doi Pharmacokinetics and topical vaginal effects of two tenofovir gels in rabbits
    Meredith R Clark
    CONRAD, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Arlington, Virginia, USA
    AIDS Res Hum Retroviruses 28:1458-66. 2012
    ..These data indicate that the reduced-glycerin TFV 1% gel may be a suitable alternative to TFV 1% gel...
  8. doi A hot-melt extruded intravaginal ring for the sustained delivery of the antiretroviral microbicide UC781
    Meredith R Clark
    CONRAD, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Arlington, Virginia 22209, USA
    J Pharm Sci 101:576-87. 2012
    ..Overall, UC781 was formulated in a stable PU IVR and provided controlled release of UC781 both in vitro and in vivo...
  9. pmc Evaluation of Rapidly Disintegrating Vaginal Tablets of Tenofovir, Emtricitabine and Their Combination for HIV-1 Prevention
    Meredith R Clark
    CONRAD, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Arlington, VA 22209, USA
    Pharmaceutics 6:616-631. 2014
    ..The data also support co-administration of FTC with TFV in a single vaginal tablet to create a combination microbicide in a simple and inexpensive dosage form...
  10. doi Preclinical evaluation of UC781 microbicide vaginal drug delivery
    Meredith R Clark
    CONRAD, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, 1911 North Fort Myer Drive, Suite 900, Arlington, VA, 22209, USA
    Drug Deliv Transl Res 1:175-82. 2011
    ..Based on these results, gels prepared with either form of UC781 led to tissue concentrations well in excess of UC781's EC50 under in vitro conditions (~3 ng/mL). ..
  11. doi Pharmacokinetics of UC781-loaded intravaginal ring segments in rabbits: a comparison of polymer matrices
    Meredith R Clark
    CONRAD, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, 1911 North Fort Myer Drive, Suite 900, Arlington, VA, 22209, USA
    Drug Deliv Transl Res 1:238-46. 2011
    ..8 ng/mL), with little influence by polymer matrix or UC781 loading. Moreover, these findings support the use of rabbit vaginal pharmacokinetic studies in preclinical testing of microbicide intravaginal rings. ..