Charles A Stuart

Summary

Affiliation: East Tennessee State University
Country: USA

Publications

  1. pmc Myosin content of individual human muscle fibers isolated by laser capture microdissection
    Charles A Stuart
    Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee
    Am J Physiol Cell Physiol 310:C381-9. 2016
  2. pmc Slow-twitch fiber proportion in skeletal muscle correlates with insulin responsiveness
    Charles A Stuart
    Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, P O Box 70622, Johnson City, Tennessee 37614 0622, USA
    J Clin Endocrinol Metab 98:2027-36. 2013
  3. pmc Insulin-stimulated translocation of glucose transporter (GLUT) 12 parallels that of GLUT4 in normal muscle
    Charles A Stuart
    Department of Internal Medicine, East Tennessee State University, Quillen College of Medicine, P O Box 70622, Johnson City, Tennessee 37614 0622, USA
    J Clin Endocrinol Metab 94:3535-42. 2009
  4. pmc Cycle training increased GLUT4 and activation of mammalian target of rapamycin in fast twitch muscle fibers
    Charles A Stuart
    Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Med Sci Sports Exerc 42:96-106. 2010
  5. pmc Brain glucose transporter (Glut3) haploinsufficiency does not impair mouse brain glucose uptake
    Charles A Stuart
    East Tennessee State University Quillen College of Medicine, Johnson City, TN, USA
    Brain Res 1384:15-22. 2011
  6. pmc Insulin responsiveness in metabolic syndrome after eight weeks of cycle training
    Charles A Stuart
    1Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 2Department of Exercise and Sport Science, Clemmer College of Education, East Tennessee State University, Johnson City, TN and 3Department of Allied Health, College of Clinical and Rehabilitative Health, East Tennessee State University, Johnson City, TN
    Med Sci Sports Exerc 45:2021-9. 2013
  7. pmc Impaired muscle AMPK activation in the metabolic syndrome may attenuate improved insulin action after exercise training
    Andrew S Layne
    Center of Excellence for Sport Science and Coach Education, Department of Kinesiology, Leisure, and Sports Science, Clemmer College of Education, East Tennessee State University, Johnson City, Tennessee 37614, USA
    J Clin Endocrinol Metab 96:1815-26. 2011
  8. ncbi request reprint Hexose transporter mRNAs for GLUT4, GLUT5, and GLUT12 predominate in human muscle
    Charles A Stuart
    Department of Internal Medicine, East Tennessee State University James H Quillen College of Medicine, Johnson City, Tennessee 37614 0622, USA
    Am J Physiol Endocrinol Metab 291:E1067-73. 2006
  9. pmc Pre-Training Muscle Characteristics of Subjects Who Are Obese Determine How Well Exercise Training Will Improve Their Insulin Responsiveness: Exercise training and muscle of obese subjects
    Charles A Stuart
    1Department of Internal Medicine, Quillen College of Medicine, 2Department of Allied Health, College of Clinical and Rehabilitative Health, and 3Department of Exercise and Sports Science, Clemmer College of Education, East Tennessee State University, Johnson City, Tennessee
    J Strength Cond Res . 2016
  10. ncbi request reprint Overexpression of GLUT5 in diabetic muscle is reversed by pioglitazone
    Charles A Stuart
    Department of Internal Medicine, East Tennessee State University, James H Quillen College of Medicine, Johnson City, Tennessee 37614 0622, USA
    Diabetes Care 30:925-31. 2007

Collaborators

Detail Information

Publications14

  1. pmc Myosin content of individual human muscle fibers isolated by laser capture microdissection
    Charles A Stuart
    Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee
    Am J Physiol Cell Physiol 310:C381-9. 2016
    ..These new observations suggest that the presence or absence of MYH6 and MYH7 proteins dictates the slow- or fast-twitch phenotype in skeletal muscle. ..
  2. pmc Slow-twitch fiber proportion in skeletal muscle correlates with insulin responsiveness
    Charles A Stuart
    Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, P O Box 70622, Johnson City, Tennessee 37614 0622, USA
    J Clin Endocrinol Metab 98:2027-36. 2013
    ..The metabolic syndrome, characterized by central obesity with dyslipidemia, hypertension, and hyperglycemia, identifies people at high risk for type 2 diabetes...
  3. pmc Insulin-stimulated translocation of glucose transporter (GLUT) 12 parallels that of GLUT4 in normal muscle
    Charles A Stuart
    Department of Internal Medicine, East Tennessee State University, Quillen College of Medicine, P O Box 70622, Johnson City, Tennessee 37614 0622, USA
    J Clin Endocrinol Metab 94:3535-42. 2009
    ..In GLUT4 null mice, insulin-stimulated glucose uptake into muscle was diminished but not eliminated, suggesting that another insulin-sensitive system was present...
  4. pmc Cycle training increased GLUT4 and activation of mammalian target of rapamycin in fast twitch muscle fibers
    Charles A Stuart
    Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Med Sci Sports Exerc 42:96-106. 2010
    ..To determine whether cycle training of sedentary subjects would increase the expression of the principle muscle glucose transporters, six volunteers completed 6 wk of progressively increasing intensity stationary cycle cycling...
  5. pmc Brain glucose transporter (Glut3) haploinsufficiency does not impair mouse brain glucose uptake
    Charles A Stuart
    East Tennessee State University Quillen College of Medicine, Johnson City, TN, USA
    Brain Res 1384:15-22. 2011
    ..We conclude that a 50% decrease in Glut3 is not limiting for the uptake of glucose into the mouse brain, since Glut3 haploinsufficiency does not impair brain glucose uptake or utilization...
  6. pmc Insulin responsiveness in metabolic syndrome after eight weeks of cycle training
    Charles A Stuart
    1Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 2Department of Exercise and Sport Science, Clemmer College of Education, East Tennessee State University, Johnson City, TN and 3Department of Allied Health, College of Clinical and Rehabilitative Health, East Tennessee State University, Johnson City, TN
    Med Sci Sports Exerc 45:2021-9. 2013
    ..Insulin resistance in obesity is decreased after successful diet and exercise. Aerobic exercise training alone was evaluated as an intervention in subjects with the metabolic syndrome...
  7. pmc Impaired muscle AMPK activation in the metabolic syndrome may attenuate improved insulin action after exercise training
    Andrew S Layne
    Center of Excellence for Sport Science and Coach Education, Department of Kinesiology, Leisure, and Sports Science, Clemmer College of Education, East Tennessee State University, Johnson City, Tennessee 37614, USA
    J Clin Endocrinol Metab 96:1815-26. 2011
    ..Strength training induces muscle remodeling and may improve insulin responsiveness...
  8. ncbi request reprint Hexose transporter mRNAs for GLUT4, GLUT5, and GLUT12 predominate in human muscle
    Charles A Stuart
    Department of Internal Medicine, East Tennessee State University James H Quillen College of Medicine, Johnson City, Tennessee 37614 0622, USA
    Am J Physiol Endocrinol Metab 291:E1067-73. 2006
    ..Immunofluorescent studies demonstrated that GLUT4 and GLUT12 were predominantly expressed in type I oxidative fibers; however, GLUT5 was expressed predominantly in type II (white) fibers...
  9. pmc Pre-Training Muscle Characteristics of Subjects Who Are Obese Determine How Well Exercise Training Will Improve Their Insulin Responsiveness: Exercise training and muscle of obese subjects
    Charles A Stuart
    1Department of Internal Medicine, Quillen College of Medicine, 2Department of Allied Health, College of Clinical and Rehabilitative Health, and 3Department of Exercise and Sports Science, Clemmer College of Education, East Tennessee State University, Johnson City, Tennessee
    J Strength Cond Res . 2016
    ..Our data suggest rather than responders being more fit, they may have been less fit, only catching up to the other half of subjects who are obese whose insulin responsiveness did not increase beyond their pre-training baseline...
  10. ncbi request reprint Overexpression of GLUT5 in diabetic muscle is reversed by pioglitazone
    Charles A Stuart
    Department of Internal Medicine, East Tennessee State University, James H Quillen College of Medicine, Johnson City, Tennessee 37614 0622, USA
    Diabetes Care 30:925-31. 2007
    ..This study was undertaken to quantify the expression of muscle GLUT in type 2 diabetes and to determine if treatment with an insulin-enhancing thiazolidenedione drug, pioglitazone, would alter its expression...
  11. doi request reprint Effects of Short-Term Free-Weight and Semiblock Periodization Resistance Training on Metabolic Syndrome
    Mark A South
    1Department of Exercise and Sport Science, Center of Excellence for Sport Science and Coach Education, East Tennessee State University, Johnson City, Tennessee Departments of 2Applied Physiology and Kinesiology 3Aging and Geriatric Research, University of Florida, Gainesville, Florida 4Department of Internal Medicine, Quillen School of Medicine, East Tennessee State University, Johnson City, Tennessee 5Department of Health and Exercise Science, Appalachian State University, Boone, North Carolina and 6Department of Coaching and Teaching Studies, College of Physical Activity and Sport Sciences, West Virginia University, Morgantown, West Virginia
    J Strength Cond Res 30:2682-96. 2016
    ..In summary, 8 weeks of semiblock free-weight resistance training improved several performance variables and some cardiovascular factors associated with MS. ..
  12. pmc Insulin resistance and muscle insulin receptor substrate-1 serine hyperphosphorylation
    Charles A Stuart
    Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee
    Physiol Rep 2:. 2014
    ..Excess fasting phosphorylation of muscle IRS-1 at Ser636 may be a major cause of the insulin resistance seen in obesity and might prevent improvement in insulin responsiveness when exercise training is not accompanied by weight loss...
  13. ncbi request reprint Angiopoietin-1 inhibits doxorubicin-induced human umbilical vein endothelial cell death by modulating fas expression and via the PI3K/Akt pathway
    Deling Yin
    Department of Internal Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    Endothelium 11:247-52. 2004
    ..Moreover, Ang-1 inhibits DOX-induced up-regulation of p53 through PI3K/Akt. Therefore, Ang-1 is a potent inhibitor for DOX-induced cell death through Fas and PI3K/Akt-mediated pathways...
  14. ncbi request reprint Gene silencing using small interference RNA in mast cells
    Deling Yin
    Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA
    Methods Mol Biol 315:333-9. 2006
    ..We have successfully applied the siRNA technique for silencing glucose transporter 3 in cultured L6 muscle cells. The siRNA technique has been used efficiently to silence RasGRP4 expression in mast cells...