William L Stone

Summary

Affiliation: East Tennessee State University
Country: USA

Publications

  1. ncbi request reprint Childhood obesity: a systems medicine approach
    William L Stone
    Department of Pediatrics, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, 37614, USA
    Front Biosci (Landmark Ed) 21:1061-75. 2016
  2. ncbi request reprint Drugs for the treatment of hyperlipidemia
    W L Stone
    Department of Pediatrics, East Tennessee State University, Johnson City, TN 37614 0578, USA
    IDrugs 4:788-94. 2001
  3. ncbi request reprint Retinopathy of prematurity: an oxidative stress neonatal disease
    William L Stone
    Department of Pediatrics, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, 37614, USA
    Front Biosci (Landmark Ed) 21:165-77. 2016
  4. pmc In vitro evaluation of novel N-acetylalaninate prodrugs that selectively induce apoptosis in prostate cancer cells
    Christopher A McGoldrick
    Department of Pediatrics, East Tennessee State University, Johnson City, TN 37614 0578, USA
    BMC Cancer 14:675. 2014
  5. pmc Identification of oxidized protein hydrolase as a potential prodrug target in prostate cancer
    Christopher A McGoldrick
    Department of Pediatrics, East Tennessee State University, P, O, Box 70579, Johnson City, TN 37614, USA
    BMC Cancer 14:77. 2014
  6. pmc The effect of walnut intake on factors related to prostate and vascular health in older men
    Kim J Spaccarotella
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    Nutr J 7:13. 2008
  7. ncbi request reprint Tocopherols and the treatment of colon cancer
    William L Stone
    East Tennessee State University, James H Quillen College of Medicine, Department of Pediatrics, Johnson City, TN 37614, USA
    Ann N Y Acad Sci 1031:223-33. 2004
  8. ncbi request reprint Therapeutic uses of antioxidant liposomes
    William L Stone
    Department of Pediatrics, East Tennessee State University, Johnson City, TN 37614, USA
    Mol Biotechnol 27:217-30. 2004
  9. ncbi request reprint The influence of dietary iron and tocopherols on oxidative stress and ras-p21 levels in the colon
    William L Stone
    Department of Pediatrics, James H Quillen College of Medicine, East Tennessee State University, Johnson City 37614 0578, USA
    Cancer Detect Prev 26:78-84. 2002
  10. pmc The influence of N-acetyl-L-cysteine on oxidative stress and nitric oxide synthesis in stimulated macrophages treated with a mustard gas analogue
    Victor Paromov
    Department of Pediatrics, College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    BMC Cell Biol 9:33. 2008

Research Grants

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Childhood obesity: a systems medicine approach
    William L Stone
    Department of Pediatrics, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, 37614, USA
    Front Biosci (Landmark Ed) 21:1061-75. 2016
    ..As discussed below, it is possible that some of the pathophysiological and epigenetic changes resulting from childhood obesity could become more irreversible the longer the obesity remains untreated. ..
  2. ncbi request reprint Drugs for the treatment of hyperlipidemia
    W L Stone
    Department of Pediatrics, East Tennessee State University, Johnson City, TN 37614 0578, USA
    IDrugs 4:788-94. 2001
    ..Treatments and issues specific to the elderly and to children are also described. The specific application of pharmacogenics to the problem of hyperlipidemia is presented as a likely direction for future research emphasis...
  3. ncbi request reprint Retinopathy of prematurity: an oxidative stress neonatal disease
    William L Stone
    Department of Pediatrics, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, 37614, USA
    Front Biosci (Landmark Ed) 21:165-77. 2016
    ..Proteomics has already identified a number of ROP serum biomarkers. This review will also suggest novel therapeutic approaches to ROP and other neonatal oxidative stress diseases (NOSDs) based on a systems medicine approach. ..
  4. pmc In vitro evaluation of novel N-acetylalaninate prodrugs that selectively induce apoptosis in prostate cancer cells
    Christopher A McGoldrick
    Department of Pediatrics, East Tennessee State University, Johnson City, TN 37614 0578, USA
    BMC Cancer 14:675. 2014
    ..4.19.1) yielding a quinone methide (QM) intermediate capable of depleting glutathione (GSH), a key intracellular antioxidant. OPH is a serine esterase/protease that is overexpressed in some human tumors and cancer cell lines...
  5. pmc Identification of oxidized protein hydrolase as a potential prodrug target in prostate cancer
    Christopher A McGoldrick
    Department of Pediatrics, East Tennessee State University, P, O, Box 70579, Johnson City, TN 37614, USA
    BMC Cancer 14:77. 2014
    ..In this study, we focused on the identification and characterization of differentially expressed esterases between non-tumorigenic and tumorigenic prostate epithelial cells...
  6. pmc The effect of walnut intake on factors related to prostate and vascular health in older men
    Kim J Spaccarotella
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    Nutr J 7:13. 2008
    ..Tocopherols may protect against prostate cancer and cardiovascular disease (CVD)...
  7. ncbi request reprint Tocopherols and the treatment of colon cancer
    William L Stone
    East Tennessee State University, James H Quillen College of Medicine, Department of Pediatrics, Johnson City, TN 37614, USA
    Ann N Y Acad Sci 1031:223-33. 2004
    ..VE is not a single molecule, but refers to at least eight different molecules, that is, four tocopherols and four tocotrienols...
  8. ncbi request reprint Therapeutic uses of antioxidant liposomes
    William L Stone
    Department of Pediatrics, East Tennessee State University, Johnson City, TN 37614, USA
    Mol Biotechnol 27:217-30. 2004
    ..These diseases and conditions include cancer, trauma, irradiation, retinotherapy or prematurity, respiratory distress syndrome, chemical weapon exposure, and pulmonary infections...
  9. ncbi request reprint The influence of dietary iron and tocopherols on oxidative stress and ras-p21 levels in the colon
    William L Stone
    Department of Pediatrics, James H Quillen College of Medicine, East Tennessee State University, Johnson City 37614 0578, USA
    Cancer Detect Prev 26:78-84. 2002
    ..The gamma-tocopherol may, therefore, play a significant role in preventing colon cancer. High levels of dietary iron were found to promote oxidative stress in feces and colonocytes...
  10. pmc The influence of N-acetyl-L-cysteine on oxidative stress and nitric oxide synthesis in stimulated macrophages treated with a mustard gas analogue
    Victor Paromov
    Department of Pediatrics, College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    BMC Cell Biol 9:33. 2008
    ....
  11. doi request reprint Preparation, characterization, and use of antioxidant-liposomes
    Hongsong Yang
    Department of Pediatrics, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA
    Methods Mol Biol 477:277-92. 2008
    ..The use of antioxidant liposomes in an in vitro situation will also be detailed...
  12. doi request reprint Sodium pyruvate modulates cell death pathways in HaCaT keratinocytes exposed to half-mustard gas
    Victor Paromov
    Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37604, USA
    Int J Toxicol 30:197-206. 2011
    ..However, the latter suggestion should be verified in animal models exposed to HD...
  13. pmc Comparative effects of RRR-alpha- and RRR-gamma-tocopherol on proliferation and apoptosis in human colon cancer cell lines
    Sharon E Campbell
    Department of Internal Medicine, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    BMC Cancer 6:13. 2006
    ..The RRR-gamma-tocopherol isoform is found primarily in the US diet, while RRR-alpha-tocopherol is highest in the plasma...
  14. pmc Gamma (gamma) tocopherol upregulates peroxisome proliferator activated receptor (PPAR) gamma (gamma) expression in SW 480 human colon cancer cell lines
    Sharon E Campbell
    Division of Hematology Oncology, Department of Internal Medicine, East Tennessee State University and James H, Quillen VA Medical Center, Johnson City, TN 37614, USA
    BMC Cancer 3:25. 2003
    ..We also measured the intracellular concentrations of vitamin E in SW 480 colon cancer cell lines...
  15. doi request reprint A specific molecular beacon probe for the detection of human prostate cancer cells
    Yu Lin Jiang
    Department of Chemistry, College of Arts and Sciences, East Tennessee State University, Johnson City, TN 37614, United States
    Bioorg Med Chem Lett 22:3632-8. 2012
    ....
  16. pmc Inhibition of inducible Nitric Oxide Synthase by a mustard gas analog in murine macrophages
    Min Qui
    Department of Pediatrics, East Tennessee State University, Johnson City, TN, USA
    BMC Cell Biol 7:39. 2006
    ..In particular, it is known that macrophage generated NO synthesised by iNOS plays a critical role in wound healing...
  17. ncbi request reprint Infants discriminate between natural and synthetic vitamin E
    William L Stone
    Department of Pediatrics, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614 0578, USA
    Am J Clin Nutr 77:899-906. 2003
    ..In adults, RRR-alpha-tocopheryl acetate (natural vitamin E) has approximately twice the biological activity of all-rac-alpha-tocopherol (synthetic vitamin E). Similar studies have not been done in term infants...
  18. ncbi request reprint Therapeutic uses of antioxidant liposomes
    William L Stone
    Department of Pediatrics, East Tennessee State University, Johnson City, TN, USA
    Methods Mol Biol 199:145-61. 2002
  19. doi request reprint γ-Tocotrienol induces growth arrest through a novel pathway with TGFβ2 in prostate cancer
    Sharon E Campbell
    Department of Biochemistry and Molecular Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Free Radic Biol Med 50:1344-54. 2011
    ..In addition, the latent precursor and the mature forms of TGFβ2 are down-regulated after treatment with GT3, with concomitant disruptions in TGFβ receptor I, SMAD-2, p38, and NF-κB signaling...
  20. pmc Protective effect of liposome-encapsulated glutathione in a human epidermal model exposed to a mustard gas analog
    Victor Paromov
    Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    J Toxicol 2011:109516. 2011
    ..This study provides a rationale for use of antioxidant liposomes against HD toxicity in the skin considering further verification in animal models exposed to HD...
  21. ncbi request reprint Synergistic growth inhibition of PC3 prostate cancer cells with low-dose combinations of simvastatin and alendronate
    Mailien Rogers
    Division of Hematology Oncology, Department of Internal Medicine, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN, U S A
    Anticancer Res 35:1851-9. 2015
    ..These two drugs cause a sequential blockade of the mevalonate pathway and significantly affect survival and apoptotic pathways by down-regulating phospho-AKT and activating c-JUN and ERK. ..
  22. ncbi request reprint Pediatric proteomics: an introduction
    Jeanne Young
    Department of Pediatrics, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37604, USA
    Front Biosci (Schol Ed) 4:1078-87. 2012
    ..The second article in this series will focus on the application of proteomics to neonatology with particular emphasis on diseases where oxidative stress plays a key pathophysiological role...
  23. pmc The uptake of tocopherols by RAW 264.7 macrophages
    Rong Gao
    Department of Pediatrics, East Tennessee State University, Johnson City, Tennessee 37614 0578, USA
    Nutr J 1:2. 2002
    ..7 macrophages. Similar studies were performed with alpha-tocopheryl quinone and gamma-tocopheryl quinone, which are oxidation products of tocopherols...
  24. ncbi request reprint Assays for nitric oxide expression
    William L Stone
    Department of Pediatrics, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA
    Methods Mol Biol 315:245-56. 2006
    ..In addition to reviewing the methodology associated with measuring NO itself, we will briefly touch upon some analytical methods important in characterizing the biochemical products formed from nitric oxide (e.g., 3-nitrotyrosine)...
  25. pmc Lipopolysaccharide enhances the cytotoxicity of 2-chloroethyl ethyl sulfide
    William L Stone
    Department of Pediatrics, East Tennessee State University, Johnson City, Tennessee 37614 0578, USA
    BMC Cell Biol 4:1. 2003
    ..The ability of LPS and other inflammatory agents (such as TNF-alpha and IL-1beta) to modulate the toxicity of CEES is likely to be an important factor in the design of effective treatments...
  26. pmc Myosin content of individual human muscle fibers isolated by laser capture microdissection
    Charles A Stuart
    Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee
    Am J Physiol Cell Physiol 310:C381-9. 2016
    ..These new observations suggest that the presence or absence of MYH6 and MYH7 proteins dictates the slow- or fast-twitch phenotype in skeletal muscle. ..
  27. ncbi request reprint The effects of acute exercise on neutrophils and plasma oxidative stress
    John C Quindry
    Department of Exercise and Sport Sciences and Physiology, Center for Exercise Science University of Florida, Gainesville, FL, USA
    Med Sci Sports Exerc 35:1139-45. 2003
    ..To investigate the influence of intensity versus total energy expenditure on neutrophilia and blood oxidative stress to acute exercise...

Research Grants1

  1. Antiatherogenic Properties of tert-Butylhydroquinone
    William Stone; Fiscal Year: 2004
    ..Commercial development should be accelerated since NIH has already conducted extensive toxicological studies with TBHQ. ..