Chuanfu Li

Summary

Affiliation: East Tennessee State University
Country: USA

Publications

  1. ncbi request reprint Early activation of IKKbeta during in vivo myocardial ischemia
    C Li
    Department of Surgery, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    Am J Physiol Heart Circ Physiol 280:H1264-71. 2001
  2. pmc Scavenger receptor class-A has a central role in cerebral ischemia-reperfusion injury
    Chen Lu
    Department of Surgery, East Tennessee State University, Johnson City, Tennessee, USA
    J Cereb Blood Flow Metab 30:1972-81. 2010
  3. pmc TLR2 ligands induce cardioprotection against ischaemia/reperfusion injury through a PI3K/Akt-dependent mechanism
    Tuanzhu Ha
    Department of Surgery, James H Quillen College of Medicine, East Tennessee State University, PO Box 70575, Johnson City, TN 37614 0575, USA
    Cardiovasc Res 87:694-703. 2010
  4. ncbi request reprint Protection against myocardial ischemia/reperfusion injury in TLR4-deficient mice is mediated through a phosphoinositide 3-kinase-dependent mechanism
    Fang Hua
    Department of Surgery, East Tennessee State University, Johnson City, TN 37614, USA
    J Immunol 178:7317-24. 2007
  5. pmc Glucan phosphate attenuates myocardial HMGB1 translocation in severe sepsis through inhibiting NF-κB activation
    Tuanzhu Ha
    Department of Surgery, East Tennessee State University, Johnson City, Tennessee 37614 0575, USA
    Am J Physiol Heart Circ Physiol 301:H848-55. 2011
  6. doi request reprint Lipopolysaccharide-induced myocardial protection against ischaemia/reperfusion injury is mediated through a PI3K/Akt-dependent mechanism
    Tuanzhu Ha
    Department of Surgery, James H Quillen College of Medicine, East Tennessee State University, Johnson City, PO Box 70575, TN 37614 0575, USA
    Cardiovasc Res 78:546-53. 2008
  7. pmc Scavenger receptor class a plays a central role in mediating mortality and the development of the pro-inflammatory phenotype in polymicrobial sepsis
    Tammy R Ozment
    Department of Surgery, East Tennessee State University, Quillen College of Medicine, Johnson City, Tennessee, USA
    PLoS Pathog 8:e1002967. 2012
  8. pmc Activation of Toll-like receptor 4 signaling contributes to hippocampal neuronal death following global cerebral ischemia/reperfusion
    Fang Hua
    Department of Surgery, East Tennessee State University, Johnson City, TN 37614, USA
    J Neuroimmunol 190:101-11. 2007
  9. pmc TLR2 ligands attenuate cardiac dysfunction in polymicrobial sepsis via a phosphoinositide 3-kinase-dependent mechanism
    Tuanzhu Ha
    Dept of Surgery, East Tennessee State Univ, Johnson City, TN 37614 0575, USA
    Am J Physiol Heart Circ Physiol 298:H984-91. 2010
  10. pmc Differential roles of TLR2 and TLR4 in acute focal cerebral ischemia/reperfusion injury in mice
    Fang Hua
    Department of Surgery, East Tennessee State University, Johnson City, TN 37614, USA
    Brain Res 1262:100-8. 2009

Collaborators

Detail Information

Publications68

  1. ncbi request reprint Early activation of IKKbeta during in vivo myocardial ischemia
    C Li
    Department of Surgery, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    Am J Physiol Heart Circ Physiol 280:H1264-71. 2001
    ..The results suggest that in vivo I/R rapidly induces IKKbeta activity and increases IkappaBalpha phosphorylation and degradation, resulting in NF-kappaB activation in the myocardium...
  2. pmc Scavenger receptor class-A has a central role in cerebral ischemia-reperfusion injury
    Chen Lu
    Department of Surgery, East Tennessee State University, Johnson City, Tennessee, USA
    J Cereb Blood Flow Metab 30:1972-81. 2010
    ..These data suggest that SR-A has a central role in cerebral I/R injury and that suppression of SR-A may be a useful approach for ameliorating brain injury in stroke patients...
  3. pmc TLR2 ligands induce cardioprotection against ischaemia/reperfusion injury through a PI3K/Akt-dependent mechanism
    Tuanzhu Ha
    Department of Surgery, James H Quillen College of Medicine, East Tennessee State University, PO Box 70575, Johnson City, TN 37614 0575, USA
    Cardiovasc Res 87:694-703. 2010
    ..We hypothesized that the modulation of TLR2 would induce cardioprotection against I/R injury via activation of the PI3K/Akt signalling...
  4. ncbi request reprint Protection against myocardial ischemia/reperfusion injury in TLR4-deficient mice is mediated through a phosphoinositide 3-kinase-dependent mechanism
    Fang Hua
    Department of Surgery, East Tennessee State University, Johnson City, TN 37614, USA
    J Immunol 178:7317-24. 2007
    ..These data also suggest that modulation of TLR4/PI3K/Akt-dependent signaling pathways may be a viable strategy for reducing myocardial I/R injury...
  5. pmc Glucan phosphate attenuates myocardial HMGB1 translocation in severe sepsis through inhibiting NF-κB activation
    Tuanzhu Ha
    Department of Surgery, East Tennessee State University, Johnson City, Tennessee 37614 0575, USA
    Am J Physiol Heart Circ Physiol 301:H848-55. 2011
    ..These data suggest that attenuation of HMGB1 translocation by GP is mediated through inhibition of NF-κB activation in CLP-induced sepsis and that activation of NF-κB is required for HMGB1 translocation...
  6. doi request reprint Lipopolysaccharide-induced myocardial protection against ischaemia/reperfusion injury is mediated through a PI3K/Akt-dependent mechanism
    Tuanzhu Ha
    Department of Surgery, James H Quillen College of Medicine, East Tennessee State University, Johnson City, PO Box 70575, TN 37614 0575, USA
    Cardiovasc Res 78:546-53. 2008
    ..We hypothesized that activation of PI3K/Akt signalling plays a critical role in LPS-induced cardioprotection...
  7. pmc Scavenger receptor class a plays a central role in mediating mortality and the development of the pro-inflammatory phenotype in polymicrobial sepsis
    Tammy R Ozment
    Department of Surgery, East Tennessee State University, Quillen College of Medicine, Johnson City, Tennessee, USA
    PLoS Pathog 8:e1002967. 2012
    ..Mechanistically, SRA interacts with TLR4 to enhance the development of the pro-inflammatory phenotype and mediate the morbidity and mortality of sepsis/septic shock...
  8. pmc Activation of Toll-like receptor 4 signaling contributes to hippocampal neuronal death following global cerebral ischemia/reperfusion
    Fang Hua
    Department of Surgery, East Tennessee State University, Johnson City, TN 37614, USA
    J Neuroimmunol 190:101-11. 2007
    ..These data suggest that activation of TLR4 signaling contributes to ischemia-induced hippocampal neuronal death. In addition, these data suggest that modulation of TLR4 signaling may attenuate ischemic injury in hippocampal neurons...
  9. pmc TLR2 ligands attenuate cardiac dysfunction in polymicrobial sepsis via a phosphoinositide 3-kinase-dependent mechanism
    Tuanzhu Ha
    Dept of Surgery, East Tennessee State Univ, Johnson City, TN 37614 0575, USA
    Am J Physiol Heart Circ Physiol 298:H984-91. 2010
    ..More significantly, Pam3 therapeutic treatment will have a potential clinical relevance...
  10. pmc Differential roles of TLR2 and TLR4 in acute focal cerebral ischemia/reperfusion injury in mice
    Fang Hua
    Department of Surgery, East Tennessee State University, Johnson City, TN 37614, USA
    Brain Res 1262:100-8. 2009
    ..Specifically, TLR4 contributes to cerebral I/R injury, while TLR2 appears to be neuroprotective by enhancing the activation of protective signaling in response to cerebral I/R...
  11. pmc Scavenger receptor A (SR-A) is required for LPS-induced TLR4 mediated NF-κB activation in macrophages
    Honghui Yu
    Department of Surgery, James Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Biochim Biophys Acta 1823:1192-8. 2012
    ..The data suggests that SR-A is needed for LPS-induced inflammatory responses in macrophages...
  12. pmc Toll-like receptor 3 plays a central role in cardiac dysfunction during polymicrobial sepsis
    Ming Gao
    Department of Surgery, Internal Medicine, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA
    Crit Care Med 40:2390-9. 2012
    ..To determine the role of Toll-like receptor 3 in cardiac dysfunction during polymicrobial sepsis...
  13. ncbi request reprint Glucan phosphate attenuates cardiac dysfunction and inhibits cardiac MIF expression and apoptosis in septic mice
    Tuanzhu Ha
    Dept of Surgery, East Tennessee State Univ, Campus Box 70575, Johnson City, TN 37614 0575, USA
    Am J Physiol Heart Circ Physiol 291:H1910-8. 2006
    ..GP administration also activates the phosphoinositide 3-kinase/Akt pathway, decreases myocardial MIF expression, and reduces cardiomyocyte apoptosis...
  14. ncbi request reprint Blocking the MyD88-dependent pathway protects the myocardium from ischemia/reperfusion injury in rat hearts
    Fang Hua
    Department of Surgery, East Tennessee State University, Johnson City, TN 37614, USA
    Biochem Biophys Res Commun 338:1118-25. 2005
    ..The results demonstrate that both inhibition of the NFkappaB activation pathway and activation of the Akt signaling pathway may be responsible for the protective effect of transfection of dominant negative MyD88...
  15. ncbi request reprint Attenuation of cardiac hypertrophy by inhibiting both mTOR and NFkappaB activation in vivo
    Tuanzhu Ha
    Department of Surgery, Campus Box 70575, East Tennessee State University, Johnson City, TN 37614, USA
    Free Radic Biol Med 39:1570-80. 2005
    ..Similar results were observed in aortic-banding-induced cardiac hypertrophy in mice. Our results suggest that both NFkappaB activation and the PI3K/Akt signaling pathway participate in the development of cardiac hypertrophy in vivo...
  16. pmc Toll-like receptor 3 plays a role in myocardial infarction and ischemia/reperfusion injury
    Chen Lu
    Department of Surgery, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Biochim Biophys Acta 1842:22-31. 2014
    ..The mechanisms involve activation of apoptotic signaling and NF-κB binding activity. Modulation of TLR3 may be an effective approach for ameliorating heart injury in heart attack patients. ..
  17. pmc Activation of myocardial phosphoinositide-3-kinase p110α ameliorates cardiac dysfunction and improves survival in polymicrobial sepsis
    Chuanfu Li
    Department of Surgery, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, United States of America
    PLoS ONE 7:e44712. 2012
    ..Finally, these data suggest that modulation of the PI3K/p110α signaling pathway may be beneficial in the prevention and/or management of septic cardiomyopathy and septic shock...
  18. pmc Increased expression of microRNA-146a decreases myocardial ischaemia/reperfusion injury
    Xiaohui Wang
    Department of Surgery, James H Quillen College of Medicine, East Tennessee State University, Campus Box 70575, Johnson City, TN 37614 0575, USA
    Cardiovasc Res 97:432-42. 2013
    ..This study examined the role of microRNA-146a in myocardial I/R injury...
  19. pmc The Toll-like receptor 9 ligand, CpG oligodeoxynucleotide, attenuates cardiac dysfunction in polymicrobial sepsis, involving activation of both phosphoinositide 3 kinase/Akt and extracellular-signal-related kinase signaling
    Ming Gao
    Department of Surgery, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614 0575, USA
    J Infect Dis 207:1471-9. 2013
    ..Toll-like receptors (TLRs) play a role in the pathophysiology of sepsis and multiple organ failure. This study examined the effect of CpG oligodeoxynucleotide (CpG-ODN), the TLR9 ligand, on polymicrobial sepsis-induced cardiac dysfunction...
  20. pmc TLR2 ligand induces protection against cerebral ischemia/reperfusion injury via activation of phosphoinositide 3-kinase/Akt signaling
    Chen Lu
    Department of Surgery, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    J Immunol 187:1458-66. 2011
    ..Of greater significance, these data indicate that therapy with a TLR2-specific agonist during cerebral ischemia is effective in reducing injury...
  21. pmc Preconditioning with a TLR2 specific ligand increases resistance to cerebral ischemia/reperfusion injury
    Fang Hua
    Department of Surgery, East Tennessee State University, Johnson City, TN 37614, United States
    J Neuroimmunol 199:75-82. 2008
    ..These results suggest that TLR2 is a new target of ischemic preconditioning in the brain and preconditioning with a TLR2 specific ligand will protect the brain from I/R injury...
  22. pmc Attenuation of Cardiac Dysfunction in Polymicrobial Sepsis by MicroRNA-146a Is Mediated via Targeting of IRAK1 and TRAF6 Expression
    Ming Gao
    Department of Surgery, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614
    J Immunol 195:672-82. 2015
    ....
  23. pmc CpG-ODN, the TLR9 agonist, attenuates myocardial ischemia/reperfusion injury: involving activation of PI3K/Akt signaling
    Zhijuan Cao
    Department of Surgery, East Tennessee State University, Johnson City, TN 37614, USA
    Biochim Biophys Acta 1832:96-104. 2013
    ..Toll-like receptors (TLRs) have been implicated in myocardial ischemia/reperfusion (I/R) injury. The TLR9 ligand, CpG-ODN has been reported to improve cell survival. We examined effect of CpG-ODN on myocardial I/R injury...
  24. ncbi request reprint Modulating Toll-like receptor mediated signaling by (1-->3)-beta-D-glucan rapidly induces cardioprotection
    Chuanfu Li
    Department of Surgery, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Cardiovasc Res 61:538-47. 2004
    ..In the present study, we report that GP rapidly induced cardioprotection against I/R injury in vivo...
  25. pmc SR-A deficiency reduces myocardial ischemia/reperfusion injury; involvement of increased microRNA-125b expression in macrophages
    Danyang Ren
    Department of Surgery, East Tennessee State University, Johnson City, TN 37614, USA
    Biochim Biophys Acta 1832:336-46. 2013
    ..SR-A(-/-) macrophages contain high levels of miR-125b which may play a role in the protective effect of SR-A deficiency on myocardial I/R injury and H/R-induced cell damage...
  26. pmc Restraint stress induces lymphocyte reduction through p53 and PI3K/NF-kappaB pathways
    Yi Zhang
    Department of Internal Medicine, College of Medicine, East Tennessee State University, Johnson City, TN 37614, United States
    J Neuroimmunol 200:71-6. 2008
    ..Our study thus demonstrates that restraint stress promotes lymphocyte reduction through p53 and PI3K/NF-kappaB pathways...
  27. ncbi request reprint Anterior pituitary cells express pattern recognition receptors for fungal glucans: implications for neuroendocrine immune involvement in response to fungal infections
    Kevin F Breuel
    Department of Obstetrics and Gynecology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Neuroimmunomodulation 11:1-9. 2004
    ..Recent evidence confirms the existence of glucan-specific receptors on cells outside the immune system. We hypothesized that glucans may directly interact with pituitary cells as an early signaling event in fungal infections...
  28. ncbi request reprint NF-kappaB activation is required for the development of cardiac hypertrophy in vivo
    Yuehua Li
    Dept of Surgery, James H Quillen College of Medicine, East Tennessee State University, Campus Box 70575, Johnson City, TN 37614 0575, USA
    Am J Physiol Heart Circ Physiol 287:H1712-20. 2004
    ..Our results suggest that NF-kappaB activation is required for the development of cardiac hypertrophy in vivo and that NF-kappaB could be an important target for inhibiting the development of cardiac hypertrophy in vivo...
  29. ncbi request reprint The development of a novel mouse model of transient global cerebral ischemia
    Fang Hua
    Department of Surgery, East Tennessee State University, Johnson City, TN 37614 0575, USA
    Neurosci Lett 400:69-74. 2006
    ....
  30. ncbi request reprint Blockade of MyD88 attenuates cardiac hypertrophy and decreases cardiac myocyte apoptosis in pressure overload-induced cardiac hypertrophy in vivo
    Tuanzhu Ha
    Department of Surgery, East Tennessee State University, Campus Box 70575, Johnson City, Tennessee 37614 0575, USA
    Am J Physiol Heart Circ Physiol 290:H985-94. 2006
    ..Blockade of MyD88 significantly reduced cardiac hypertrophy, cardiac myocyte apoptosis, and improved cardiac function in vivo...
  31. ncbi request reprint Reduced cardiac hypertrophy in toll-like receptor 4-deficient mice following pressure overload
    Tuanzhu Ha
    Department of Surgery, East Tennessee State University, Johnson City, 37614 0575, USA
    Cardiovasc Res 68:224-34. 2005
    ..NFkappaB is a downstream transcription factor in the Toll-like receptor (TLR)-mediated signaling pathway; therefore, we investigated a role of TLR4 in cardiac hypertrophy in vivo...
  32. doi request reprint MicroRNA-214 protects against hypoxia/reoxygenation induced cell damage and myocardial ischemia/reperfusion injury via suppression of PTEN and Bim1 expression
    Xiaohui Wang
    Department of Surgery, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA
    Oncotarget . 2016
    ..Activation of PI3K/Akt signaling protects the myocardium from I/R injury. This study investigated the role of miR-214 in hypoxia/reoxygenation (H/R)-induced cell damage in vitro and myocardial I/R injury in vivo...
  33. pmc MicroRNA-125b protects against myocardial ischaemia/reperfusion injury via targeting p53-mediated apoptotic signalling and TRAF6
    Xiaohui Wang
    Department of Surgery, James H Quillen College of Medicine, East Tennessee State University, Campus Box 70575, Johnson City, TN 37614 0575, USA
    Cardiovasc Res 102:385-95. 2014
    ..The present study examined the role of microRNA-125b (miR-125b) in myocardial ischaemia/reperfusion (I/R) injury. We constructed lentivirus-expressing miR-125b (LmiR-125b) and developed transgenic mice with overexpression of miR-125b...
  34. pmc The toll-like receptor 9 agonist, CpG-oligodeoxynucleotide 1826, ameliorates cardiac dysfunction after trauma-hemorrhage
    Xia Zhang
    Department of Surgery, James H Quillen College of Medicine, East Tennessee State University, Johnson City 37614, Tennessee, USA
    Shock 38:146-52. 2012
    ..The mechanisms involve activation of both PI3K/Akt and ERK signaling pathways. The TLR9 agonist, CpG-ODN 1826, may provide a novel treatment strategy for preventing or managing cardiac dysfunction and enhancing recovery in T-H patients...
  35. ncbi request reprint Modulation of the phosphoinositide 3-kinase pathway alters innate resistance to polymicrobial sepsis
    David L Williams
    Department of Surgery, James H Quillen College of Medicine, East Tennessee State University, PO Box 70575, Johnson City, TN 37614, USA
    J Immunol 172:449-56. 2004
    ..This suggests that stimulation of the PI3K pathway may be an effective approach for preventing or treating sepsis and/or septic shock...
  36. pmc Attenuation of cardiac dysfunction and remodeling of myocardial infarction by microRNA-130a are mediated by suppression of PTEN and activation of PI3K dependent signaling
    Chen Lu
    Department of Surgery, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, United States
    J Mol Cell Cardiol 89:87-97. 2015
    ..In this study, we examined whether miR-130a will attenuate cardiac dysfunction and remodeling after myocardial infarction (MI) via PI3K/Akt dependent mechanism...
  37. pmc Poly (I:C) therapy decreases cerebral ischaemia/reperfusion injury via TLR3-mediated prevention of Fas/FADD interaction
    Xia Zhang
    Department of Surgery, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA
    J Cell Mol Med 19:555-65. 2015
    ..We conclude that TLR3 modulation by Poly (I:C) could be a potential approach for protection against ischaemic stroke...
  38. pmc Toll-like receptor 4 plays a central role in cardiac dysfunction during trauma hemorrhage shock
    Xia Zhang
    Departments of Surgery and Biometry and Medical Computing, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee
    Shock 42:31-7. 2014
    ..Toll-like receptor 4 antagonism may be a new and novel approach for the treatment and management of cardiac dysfunction in TH patients...
  39. pmc Phosphoinositide-3-kinase/akt - dependent signaling is required for maintenance of [Ca(2+)](i), I(Ca), and Ca(2+) transients in HL-1 cardiomyocytes
    Bridget M Graves
    Departments of Surgery, James H Quillen College of Medicine, East Tennessee State Universitycpr, Johnson City, TN 37614, USA
    J Biomed Sci 19:59. 2012
    ..We conclude that the PI3K/Akt pathway is required for normal maintenance of [Ca(2+)](i) in HL-1 cardiomyocytes. Thus, myocardial PI3K/Akt-PKB signaling sustains [Ca(2+)](i) required for excitation-contraction coupling in cardiomyoctyes...
  40. ncbi request reprint Angiopoietin-1 inhibits doxorubicin-induced human umbilical vein endothelial cell death by modulating fas expression and via the PI3K/Akt pathway
    Deling Yin
    Department of Internal Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    Endothelium 11:247-52. 2004
    ..Moreover, Ang-1 inhibits DOX-induced up-regulation of p53 through PI3K/Akt. Therefore, Ang-1 is a potent inhibitor for DOX-induced cell death through Fas and PI3K/Akt-mediated pathways...
  41. pmc Toll-like receptors: new players in myocardial ischemia/reperfusion injury
    Tuanzhu Ha
    Department of Surgery, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Antioxid Redox Signal 15:1875-93. 2011
    ..Understanding how TLRs contribute to myocardial I/R injury could provide basic scientific knowledge for the development of new therapeutic approaches for the treatment and management of patients with heart attack...
  42. ncbi request reprint Chronic restraint stress modulates expression of genes in murine spleen
    Deling Yin
    Department of Internal Medicine, James Quillen College of Medicine, East Tennessee State University, P O Box 70622, Johnson City, TN 37614, United States
    J Neuroimmunol 177:11-7. 2006
    ..In this study, we identify a potentially important component of pro-apoptotic activity in restraint stress and suggest a possible target for anti-apoptotic therapy to protect splenocytes against stress-induced apoptosis...
  43. ncbi request reprint Overexpression of TLR2 and TLR4 susceptibility to serum deprivation-induced apoptosis in CHO cells
    Wei Fan
    Department of Surgery, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Biochem Biophys Res Commun 337:840-8. 2005
    ..Our results suggest that overexpression of TLR2 and TLR4 in CHO cells sensitizes the cells to serum deprivation-induced apoptosis and that the mechanisms are involved in the death receptor-mediated signaling pathway...
  44. pmc The TLR9 ligand, CpG-ODN, induces protection against cerebral ischemia/reperfusion injury via activation of PI3K/Akt signaling
    Chen Lu
    Department of Surgery, East Tennessee State University, Johnson City, 37614, TN
    J Am Heart Assoc 3:e000629. 2014
    ..Toll-like receptors (TLRs) have been shown to be involved in cerebral ischemia/reperfusion (I/R) injury. TLR9 is located in intracellular compartments and recognizes CpG-DNA. This study examined the effect of CpG-ODN on cerebral I/R injury...
  45. pmc Lipopolysaccharide prolongs action potential duration in HL-1 mouse cardiomyocytes
    Robert Wondergem
    Department of Biomedical Science, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614 1708, USA
    Am J Physiol Cell Physiol 303:C825-33. 2012
    ..This protracted time course points toward an intermediary metabolic event, which either decreases available mouse ether-a-go-go (mERG) and Na(+) channels or potentiates their inactivation...
  46. ncbi request reprint Modulation of tissue Toll-like receptor 2 and 4 during the early phases of polymicrobial sepsis correlates with mortality
    David L Williams
    Department of Surgery, James H Quillen College of Medicine, East Tennessee State University, PO Box 70575, Johnson City, TN 37614 1708, USA
    Crit Care Med 31:1808-18. 2003
    ..To determine whether there was a correlation between induction of polymicrobial sepsis, modulation of tissue Toll-like receptor (TLR) gene, and protein expression and survival outcome...
  47. ncbi request reprint Activation of nuclear factor-kappaB
    Chuanfu Li
    Department of Surgery, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA
    Methods Mol Biol 315:141-50. 2006
    ..Lipopolysaccharide caused a rapid and significant increase in NF-kappaB binding activity...
  48. ncbi request reprint Mast cell activation by lipoproteins
    Jim Kelley
    Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA
    Methods Mol Biol 315:341-8. 2006
    ..IL-8 mRNA levels were measured by reverse-transcription polymerase chain reaction and protein levels by enzyme-linked immunoassay...
  49. pmc Lipopolysaccharides directly decrease Ca2+ oscillations and the hyperpolarization-activated nonselective cation current If in immortalized HL-1 cardiomyocytes
    Robert Wondergem
    Dept of Physiology, James H Quillen College of Medicine, East Tennessee State Univ, P O Box 70576, Johnson City, TN 37614 1708, USA
    Am J Physiol Cell Physiol 299:C665-71. 2010
    ..We conclude that LPS inhibits activation of I(f), enhances its deactivation, and impairs regulation of [Ca2+]i in HL-1 cardiomyocytes via TLR-4 and other mechanisms...
  50. pmc Zymosan-Induced Peritonitis: Effects on Cardiac Function, Temperature Regulation, Translocation of Bacteria, and Role of Dectin-1
    Lizzie L Monroe
    Department of Biomedical Sciences, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee Department of Surgery, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee Center of Excellence in Inflammation, Infectious Disease and Immunity, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee
    Shock 46:723-730. 2016
    ..The data suggest that dectin-1-dependent and -independent mechanisms are involved. Although zymosan treatment causes translocation of bacteria, this effect does not have a major role in the overall systemic response to zymosan...
  51. pmc Scavenger receptor-A (CD204): a two-edged sword in health and disease
    Jim L Kelley
    Departments of Internal Medicine, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614
    Crit Rev Immunol 34:241-61. 2014
    ..These observations of both harmful and beneficial effects of SR-A are discussed here in the framework of inflammation, innate immunity, and endoplasmic reticulum stress. ..
  52. pmc Enhanced effects of cigarette smoke extract on inflammatory cytokine expression in IL-1β-activated human mast cells were inhibited by Baicalein via regulation of the NF-κB pathway
    David S Chi
    Department of Internal Medicine, James H, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    Clin Mol Allergy 10:3. 2012
    ..The goal of the present study was to examine the effect of BAI on IL-6 and IL-8 production from CSE-treated and IL-1β-activated HMC-1...
  53. pmc Leukocyte Dectin-1 expression is differentially regulated in fungal versus polymicrobial sepsis
    Tammy R Ozment-Skelton
    Departments of Surgery, Microbiology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA
    Crit Care Med 37:1038-45. 2009
    ..To examine peripheral leukocyte Dectin-1 regulation in clinically relevant models of fungal and polymicrobial sepsis...
  54. ncbi request reprint Regulation of nitric oxide production from macrophages by lipopolysaccharide and catecholamines
    David S Chi
    Department of Internal Medicine, James H Quillen College of Medicine, East Tennessee State University, P O Box 70622, Johnson City, TN 37614 1709, USA
    Nitric Oxide 8:127-32. 2003
    ....
  55. pmc Impaired heart rate regulation and depression of cardiac chronotropic and dromotropic function in polymicrobial sepsis
    Donald B Hoover
    Department of Biomedical Sciences, Department of Surgery, and Center for Inflammation, Infectious Disease and Immunity, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee
    Shock 43:185-91. 2015
    ....
  56. pmc Baicalein inhibits IL-1beta- and TNF-alpha-induced inflammatory cytokine production from human mast cells via regulation of the NF-kappaB pathway
    Chia Jung Hsieh
    Departments of Internal Medicine, James H, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    Clin Mol Allergy 5:5. 2007
    ..We examined its effects and mechanisms on the expression of inflammatory cytokines in an IL-1beta- and TNF-alpha-activated human mast cell line, HMC-1...
  57. ncbi request reprint Molecular regulation of interleukin-13 and monocyte chemoattractant protein-1 expression in human mast cells by interleukin-1beta
    Steven A Lee
    Department of Internal Medicine, East Tennessee State University, Johnson City, Tennessee 37614 1709, USA
    Am J Respir Cell Mol Biol 31:283-91. 2004
    ....
  58. pmc Coadministration of adenoviral vascular endothelial growth factor and angiopoietin-1 enhances vascularization and reduces ventricular remodeling in the infarcted myocardium of type 1 diabetic rats
    Samson Mathews Samuel
    Molecular Cardiology and Angiogenesis Laboratory, Department of Surgery, University of Connecticut Health Center, Farmington, Connecticut, USA
    Diabetes 59:51-60. 2010
    ..The present study evaluates the reversal of diabetes-mediated impairment of angiogenesis in the infarcted diabetic rat myocardium by proangiogenic gene therapy...
  59. doi request reprint Cellular cardiomyoplasty: what have we learned?
    Race L Kao
    Department of Surgery, James H Quillen College of Medicine, East Tennessee State University, Johnson City
    Asian Cardiovasc Thorac Ann 17:89-101. 2009
    ..Cellular cardiomyoplasty has progressed rapidly in the last decade. A critical review may help us to better plan the future direction...
  60. doi request reprint Impaired autophagosome clearance contributes to local anesthetic bupivacaine-induced myotoxicity in mouse myoblasts
    Rongrong Li
    From the Departments of Anesthesiology R L, H M, J X, T L, Z D and Geriatrics X Z, Y M, L L, First Affiliated Hospital with Nanjing Medical University, Nanjing, China Department of Surgery, East Tennessee State University, Johnson City, Tennessee C L and Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China J D
    Anesthesiology 122:595-605. 2015
    ..The current study examined the role(s) of autophagy in myotoxicity induced by bupivacaine in mouse myoblast C2c12 cells...
  61. ncbi request reprint Human vascular endothelial cells express pattern recognition receptors for fungal glucans which stimulates nuclear factor kappaB activation and interleukin 8 production. Winner of the Best Paper Award from the Gold Medal Forum
    Elizabeth P Lowe
    Department of Surgery, James H Quillen College of Medicine, East Tennessee State University, Johnson City 37614 0575, USA
    Am Surg 68:508-17; discussion 517-8. 2002
    ..These results provide new insights into the mechanisms by which the host recognizes and responds to fungal cell wall products and suggests that the response to glucans may not be confined to leukocytes...
  62. ncbi request reprint Over-expression of heat shock protein 27 attenuates doxorubicin-induced cardiac dysfunction in mice
    Li Liu
    Department of Geriatrics, First Affiliated Hospital with Nanjing Medical University, Nanjing, China
    Eur J Heart Fail 9:762-9. 2007
    ..Heat shock protein 27 (Hsp27) has been found to confer resistance to oxidative stress in cultured cells; however, the role of Hsp27 in in-vivo hearts remains to be determined...
  63. ncbi request reprint Synergistically therapeutic effects of VEGF165 and angiopoietin-1 on ischemic rat myocardium
    Xiang Liu
    The First Affiliate Hospital of Nanjing Medical University, Nanjing, P R China
    Scand Cardiovasc J 41:95-101. 2007
    ....
  64. ncbi request reprint HIV-1 Tat protein-induced VCAM-1 expression in human pulmonary artery endothelial cells and its signaling
    Kai Liu
    Department of Medicine, Tulane Univ School of Medicine, New Orleans, LA 70112 2699, USA
    Am J Physiol Lung Cell Mol Physiol 289:L252-60. 2005
    ....
  65. ncbi request reprint Erythropoietin enhances the angiogenic potency of autologous bone marrow stromal cells in a rat model of myocardial infarction
    Dingguo Zhang
    First Affiliated Hospital, Nanjing Medical University, Nanjing, People s Republic of China
    Cardiology 108:228-36. 2007
    ..Erythropoietin (EPO) is capable of inducing angiogenesis and inhibiting cell apoptosis. The aim of this study was to investigate the effect of EPO on the therapeutic potency of MSC transplantation in a rat model of myocardial infarction...
  66. ncbi request reprint Grey-scale contrast enhancement in rabbit liver with SonoVue at different doses
    Jie Li
    Department of Ultrasound, Qilu Hospital, Shandong University, Jinan, China
    Ultrasound Med Biol 31:185-90. 2005
    ..The parameters of time-intensity curve were influenced intensely by different contrast agent doses...
  67. ncbi request reprint Ultrasonographic portography with low mechanical index gray-scale imaging in hepatic VX2 tumor
    Jie Li
    Department of Ultrasound, Qilu Hospital, Shandong University, Jinan, China
    Ultrasound Med Biol 32:641-7. 2006
    ..However, applicability of the method to human may be problematic because of high invasiveness and great difficulty in administering contrast medium...
  68. doi request reprint 17beta-estradiol attenuates cardiac dysfunction and decreases NF-kappaB binding activity in mechanically stretched rat hearts
    Jing Li
    Department of Pathophysiology, Nanjing Medical University, Nanjing 210029, China
    Steroids 73:720-6. 2008
    ..The results suggest that pharmacological dose of 17beta-estradiol will attenuate stretching-induced cardiac dysfunction in an isolated heart model. The mechanisms could involve in blunting p38 MAPK and NF-kappaB signaling...