Alexandros G Georgakilas

Summary

Affiliation: East Carolina University
Country: USA

Publications

  1. doi Oxidative stress, DNA damage and repair in carcinogenesis: have we established a connection?
    Alexandros G Georgakilas
    Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, NC 27858, USA
    Cancer Lett 327:3-4. 2012
  2. pmc DNA-PKcs deficiency leads to persistence of oxidatively induced clustered DNA lesions in human tumor cells
    Prakash Peddi
    Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, NC 27858, USA
    Free Radic Biol Med 48:1435-43. 2010
  3. doi BRCA1 role in the mitigation of radiotoxicity and chromosomal instability through repair of clustered DNA lesions
    Jessica M Hair
    Department of Biology, East Carolina University, Greenville, NC 27858, USA
    Chem Biol Interact 188:350-8. 2010
  4. doi Compromised repair of clustered DNA damage in the human acute lymphoblastic leukemia MSH2-deficient NALM-6 cells
    Stewart M Holt
    Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, NC 27858, USA
    Mutat Res 674:123-30. 2009
  5. doi Viral-induced human carcinogenesis: an oxidative stress perspective
    Alexandros G Georgakilas
    Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, NC 27858, USA
    Mol Biosyst 6:1162-72. 2010
  6. doi Processing of clustered DNA damage in human breast cancer cells MCF-7 with partial DNA-PKcs deficiency
    Prakash Peddi
    Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Howell Science Complex, Greenville, NC 27858, USA
    Cancer Lett 269:174-83. 2008
  7. ncbi Induction and processing of complex DNA damage in human breast cancer cells MCF-7 and nonmalignant MCF-10A cells
    Dave C Francisco
    Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, NC 27858, USA
    Free Radic Biol Med 44:558-69. 2008
  8. doi Measurement of oxidatively-induced clustered DNA lesions using a novel adaptation of single cell gel electrophoresis (comet assay)
    Alexandros G Georgakilas
    Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, North Carolina, USA
    Curr Protoc Cell Biol . 2010
  9. doi Accumulation of oxidatively induced clustered DNA lesions in human tumor tissues
    Somaira Nowsheen
    Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, NC 27858, USA
    Mutat Res 674:131-6. 2009
  10. doi BRCA1 involvement in toxicological responses and human cancer etiology
    Alexandros G Georgakilas
    Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, NC 27858, USA
    Toxicol Lett 188:77-83. 2009

Collaborators

Detail Information

Publications19

  1. doi Oxidative stress, DNA damage and repair in carcinogenesis: have we established a connection?
    Alexandros G Georgakilas
    Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, NC 27858, USA
    Cancer Lett 327:3-4. 2012
    ..Significant mechanistic insights are offered as well as connections with biological and clinical significance...
  2. pmc DNA-PKcs deficiency leads to persistence of oxidatively induced clustered DNA lesions in human tumor cells
    Prakash Peddi
    Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, NC 27858, USA
    Free Radic Biol Med 48:1435-43. 2010
    ..The information rendered will be important for understanding not only cancer etiology in the presence of an NHEJ deficiency but also cancer treatments based on the induction of oxidative stress and inhibition of cluster repair...
  3. doi BRCA1 role in the mitigation of radiotoxicity and chromosomal instability through repair of clustered DNA lesions
    Jessica M Hair
    Department of Biology, East Carolina University, Greenville, NC 27858, USA
    Chem Biol Interact 188:350-8. 2010
    ....
  4. doi Compromised repair of clustered DNA damage in the human acute lymphoblastic leukemia MSH2-deficient NALM-6 cells
    Stewart M Holt
    Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, NC 27858, USA
    Mutat Res 674:123-30. 2009
    ..Our studies suggest that MSH2 is probably involved in the processing of the biologically significant clustered DNA damages as well as the execution of apoptosis induced by ionizing radiation...
  5. doi Viral-induced human carcinogenesis: an oxidative stress perspective
    Alexandros G Georgakilas
    Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, NC 27858, USA
    Mol Biosyst 6:1162-72. 2010
    ..In this review, we discuss the current status of knowledge on viral-associated carcinogenesis with emphasis on the mechanisms of oxidative stress and DNA damage induction in humans by viruses as well as implications in cancer treatment...
  6. doi Processing of clustered DNA damage in human breast cancer cells MCF-7 with partial DNA-PKcs deficiency
    Prakash Peddi
    Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Howell Science Complex, Greenville, NC 27858, USA
    Cancer Lett 269:174-83. 2008
    ..These findings point to the important role of DNA-PKcs in the processing of complex DNA damage and its potential association with breast cancer development...
  7. ncbi Induction and processing of complex DNA damage in human breast cancer cells MCF-7 and nonmalignant MCF-10A cells
    Dave C Francisco
    Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, NC 27858, USA
    Free Radic Biol Med 44:558-69. 2008
    ..These findings point to the important role of complex DNA damage in breast cancer and its potential association with breast cancer development especially in the case of deficient BRCA1 expression...
  8. doi Measurement of oxidatively-induced clustered DNA lesions using a novel adaptation of single cell gel electrophoresis (comet assay)
    Alexandros G Georgakilas
    Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, North Carolina, USA
    Curr Protoc Cell Biol . 2010
    ....
  9. doi Accumulation of oxidatively induced clustered DNA lesions in human tumor tissues
    Somaira Nowsheen
    Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, NC 27858, USA
    Mutat Res 674:131-6. 2009
    ..These data suggest for the first time the importance of endogenous non-DSB clusters in human cancer and their potential use as cancer biomarkers...
  10. doi BRCA1 involvement in toxicological responses and human cancer etiology
    Alexandros G Georgakilas
    Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, NC 27858, USA
    Toxicol Lett 188:77-83. 2009
    ..Finally, we discuss the new insights in the exploitation of BRCA1 defects for the development of new therapeutic strategies in cancer treatment and clinical applications...
  11. doi Role of oxidative stress and DNA damage in human carcinogenesis
    Thomas B Kryston
    Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, NC 27858, USA
    Mutat Res 711:193-201. 2011
    ..At the same time, we discuss controversies related to potential artifacts inherent to specific methodologies used for the measurement of oxidatively induced DNA lesions in human cells or tissues...
  12. ncbi Processing of DNA damage clusters in human cells: current status of knowledge
    Alexandros G Georgakilas
    Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville NC 27858, USA
    Mol Biosyst 4:30-5. 2008
    ..We selectively review recently-obtained data on the processing of non-DSB DNA damage clusters in human cells and tissues and discuss the current status of knowledge in the field...
  13. pmc Systemic DNA damage accumulation under in vivo tumor growth can be inhibited by the antioxidant Tempol
    Alexandros G Georgakilas
    Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, NC 27858, USA Department of Physics, National Technical University of Athens, Zografou Campus, Athens GR 15773, Greece
    Cancer Lett 353:248-57. 2014
    ..These findings may be important for understanding the mechanisms of genomic instability and carcinogenesis caused by chronic stress-induced systemic DNA damage and for developing preventative strategies. ..
  14. doi Toxicity and adverse effects of Tamoxifen and other anti-estrogen drugs
    Geniey Yang
    Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, NC 27858, USA
    Pharmacol Ther 139:392-404. 2013
    ..In this review we focus on the role of Tamoxifen in breast cancer treatment including mechanisms and side-effects. Finally, we discuss in detail the exciting prospects that lie ahead. ..
  15. doi Induction and repair of clustered DNA lesions: what do we know so far?
    Alexandros G Georgakilas
    Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, North Carolina 27858, USA
    Radiat Res 180:100-9. 2013
    ....
  16. ncbi Detection of complex DNA damage in gamma-irradiated acute lymphoblastic leukemia Pre-b NALM-6 cells
    Stewart M Holt
    Biology Department, East Carolina University, Greenville, NC, USA
    Radiat Res 168:527-34. 2007
    ..These results point to the biological significance of clustered DNA lesions...
  17. ncbi Induction and processing of oxidative clustered DNA lesions in 56Fe-ion-irradiated human monocytes
    Doug Tsao
    Biology Department, East Carolina University, Greenville, North Carolina 27858 4353, USA
    Radiat Res 168:87-97. 2007
    ....
  18. doi Featuring the special issue editor: associate professor Alexandros G. Georgakilas
    Alexandros G Georgakilas
    Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, NC 27858, USA
    Cancer Lett 327:1-2. 2012
    ..His primary interests in research focus on various radiation and cancer biology aspects especially the involvement of clustered DNA lesions in carcinogenesis...
  19. ncbi Detection of oxidative clustered DNA lesions in X-irradiated mouse skin tissues and human MCF-7 breast cancer cells
    Esha Gollapalle
    Biology Department, East Carolina University, Greenville, North Carolina 27858, USA
    Radiat Res 167:207-16. 2007
    ..This may underscore the biological significance of clustered DNA lesions...