Alok Agrawal

Summary

Affiliation: East Tennessee State University
Country: USA

Publications

  1. pmc Atherosclerosis-related functions of C-reactive protein
    Alok Agrawal
    Department of Pharmacology, East Tennessee State University, Johnson City, TN 37614, USA
    Cardiovasc Hematol Disord Drug Targets 10:235-40. 2010
  2. doi request reprint Not only immunoglobulins, C-reactive protein too
    Alok Agrawal
    Department of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, P O Box 70577, Johnson City, TN 37614, USA Electronic address
    Mol Immunol 56:561-2. 2013
  3. pmc The protective function of human C-reactive protein in mouse models of Streptococcus pneumoniae infection
    Alok Agrawal
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Endocr Metab Immune Disord Drug Targets 8:231-7. 2008
  4. pmc Pattern recognition by pentraxins
    Alok Agrawal
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    Adv Exp Med Biol 653:98-116. 2009
  5. pmc The phosphocholine-binding pocket on C-reactive protein is necessary for initial protection of mice against pneumococcal infection
    Toh B Gang
    Department of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    J Biol Chem 287:43116-25. 2012
  6. pmc Identification of acidic pH-dependent ligands of pentameric C-reactive protein
    David J Hammond
    Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    J Biol Chem 285:36235-44. 2010
  7. pmc Binding of the monomeric form of C-reactive protein to enzymatically-modified low-density lipoprotein: effects of phosphoethanolamine
    Sanjay K Singh
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, United States
    Clin Chim Acta 406:151-5. 2009
  8. pmc Human C-reactive protein protects mice from Streptococcus pneumoniae infection without binding to pneumococcal C-polysaccharide
    Madathilparambil V Suresh
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    J Immunol 178:1158-63. 2007
  9. pmc Phosphoethanolamine-complexed C-reactive protein: a pharmacological-like macromolecule that binds to native low-density lipoprotein in human serum
    Sanjay K Singh
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Clin Chim Acta 394:94-8. 2008
  10. pmc Oct-1 acts as a transcriptional repressor on the C-reactive protein promoter
    Bhavya Voleti
    Department of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Mol Immunol 52:242-8. 2012

Collaborators

Detail Information

Publications22

  1. pmc Atherosclerosis-related functions of C-reactive protein
    Alok Agrawal
    Department of Pharmacology, East Tennessee State University, Johnson City, TN 37614, USA
    Cardiovasc Hematol Disord Drug Targets 10:235-40. 2010
    ....
  2. doi request reprint Not only immunoglobulins, C-reactive protein too
    Alok Agrawal
    Department of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, P O Box 70577, Johnson City, TN 37614, USA Electronic address
    Mol Immunol 56:561-2. 2013
    ..Thus, that the functions of a protein depend upon its alternate structural states, and therefore on the surrounding milieu, is a more general phenomenon for some ancient molecules of the immune system than previously thought. ..
  3. pmc The protective function of human C-reactive protein in mouse models of Streptococcus pneumoniae infection
    Alok Agrawal
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Endocr Metab Immune Disord Drug Targets 8:231-7. 2008
    ..Also, because CRP deficiency in humans has not yet been reported, it becomes important to investigate the deficiency of the mechanism of action of CRP in CRP-positive individuals...
  4. pmc Pattern recognition by pentraxins
    Alok Agrawal
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    Adv Exp Med Biol 653:98-116. 2009
    ..Thus, in conjunction with the other components of innate immunity, the pentraxins use their pattern-recognition property for the benefit of the host...
  5. pmc The phosphocholine-binding pocket on C-reactive protein is necessary for initial protection of mice against pneumococcal infection
    Toh B Gang
    Department of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    J Biol Chem 287:43116-25. 2012
    ..We conclude that the phosphocholine-binding pocket on CRP is necessary for CRP-mediated initial protection of mice against lethal pneumococcal infection...
  6. pmc Identification of acidic pH-dependent ligands of pentameric C-reactive protein
    David J Hammond
    Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    J Biol Chem 285:36235-44. 2010
    ..This ligand binding specificity of CRP in its acidic pH-induced pentameric state has implications for toxic conditions involving protein misfolding in acidic environments and favors the conservation of CRP throughout evolution...
  7. pmc Binding of the monomeric form of C-reactive protein to enzymatically-modified low-density lipoprotein: effects of phosphoethanolamine
    Sanjay K Singh
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, United States
    Clin Chim Acta 406:151-5. 2009
    ..The bioactivities of mCRP generated by spontaneous dissociation of CRP are largely unexplored...
  8. pmc Human C-reactive protein protects mice from Streptococcus pneumoniae infection without binding to pneumococcal C-polysaccharide
    Madathilparambil V Suresh
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    J Immunol 178:1158-63. 2007
    ....
  9. pmc Phosphoethanolamine-complexed C-reactive protein: a pharmacological-like macromolecule that binds to native low-density lipoprotein in human serum
    Sanjay K Singh
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Clin Chim Acta 394:94-8. 2008
    ..An important binding specificity of CRP is for the modified forms of low-density lipoprotein (LDL) in which the phosphocholine-binding sites of CRP participate. CRP, however, does not bind to native LDL...
  10. pmc Oct-1 acts as a transcriptional repressor on the C-reactive protein promoter
    Bhavya Voleti
    Department of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Mol Immunol 52:242-8. 2012
    ..We conclude that Oct-1 acts as a transcriptional repressor of CRP expression and it does so by occupying its cognate site on the promoter and also via other transcription factors by an as yet undefined mechanism...
  11. pmc Exposing a hidden functional site of C-reactive protein by site-directed mutagenesis
    Sanjay K Singh
    Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    J Biol Chem 287:3550-8. 2012
    ....
  12. pmc C-reactive protein-bound enzymatically modified low-density lipoprotein does not transform macrophages into foam cells
    Sanjay K Singh
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    J Immunol 180:4316-22. 2008
    ..Second, the function of CRP to prevent formation of foam cells may influence the process of atherogenesis...
  13. pmc Interaction of calcium-bound C-reactive protein with fibronectin is controlled by pH: in vivo implications
    Madathilparambil V Suresh
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    J Biol Chem 279:52552-7. 2004
    ..CRP, Fn, and the ECM all have been implicated in cancer. Taken together our data raise the possibility that CRP-Fn interactions may change the architecture of ECM to modify the development of tumors...
  14. pmc The connection between C-reactive protein and atherosclerosis
    Sanjay K Singh
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Ann Med 40:110-20. 2008
    ..Despite all this, at the end, the question whether CRP can protect humans from developing atherosclerosis remains unanswered...
  15. pmc A novel RBP-J kappa-dependent switch from C/EBP beta to C/EBP zeta at the C/EBP binding site on the C-reactive protein promoter
    Prem Prakash Singh
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    J Immunol 178:7302-9. 2007
    ..This process uses a novel phenomenon, that is, the incorporation of RBP-Jkappa into C/EBPzeta complexes solely to support the binding of C/EBPzeta to the C/EBP site...
  16. pmc Role of the property of C-reactive protein to activate the classical pathway of complement in protecting mice from pneumococcal infection
    Madathilparambil V Suresh
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, 37614, USA
    J Immunol 176:4369-74. 2006
    ....
  17. pmc Regulation of basal and induced expression of C-reactive protein through an overlapping element for OCT-1 and NF-kappaB on the proximal promoter
    Bhavya Voleti
    Department of Pharmacology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    J Immunol 175:3386-90. 2005
    ..This model for CRP expression favors the variation seen in baseline serum CRP levels in a normal healthy population...
  18. pmc Recognition functions of pentameric C-reactive protein in cardiovascular disease
    Alok Agrawal
    Department of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Mediators Inflamm 2014:319215. 2014
    ..There is no need to stop the biosynthesis of CRP...
  19. pmc C-reactive protein protects mice against pneumococcal infection via both phosphocholine-dependent and phosphocholine-independent mechanisms
    Toh B Gang
    Department of Biomedical Sciences, East Tennessee State University, Johnson City, Tennessee, USA
    Infect Immun 83:1845-52. 2015
    ..We conclude that both PCh-dependent and PCh-independent mechanisms are involved in the CRP-mediated decrease in bacteremia and the resulting protection of mice against pneumococcal infection. ..
  20. pmc Statins and nitric oxide reduce C-reactive protein production while inflammatory conditions persist
    Bhavya Voleti
    Department of Pharmacology, Quillen College of Medicine, P O Box 70577, East Tennessee State University, Johnson City, TN 37614, USA
    Mol Immunol 43:891-6. 2006
    ..Thus, the measurement of serum CRP levels alone in individuals on statin/NO-therapy is not as useful as was imagined...
  21. pmc CRP after 2004
    Alok Agrawal
    Department of Pharmacology, East Tennessee State University, P O Box 70577, Johnson City, TN 37614, USA
    Mol Immunol 42:927-30. 2005
    ..CRP is currently serving as an indicator of cardiovascular diseases, but to pinpoint the role of CRP in atherosclerosis, a drug that can lower cholesterol levels, but not the CRP levels, is needed for experimentation...
  22. ncbi request reprint Transcription factor c-Rel enhances C-reactive protein expression by facilitating the binding of C/EBPbeta to the promoter
    Alok Agrawal
    Department of Pharmacology, East Tennessee State University, Johnson City, TN 37614, USA
    Mol Immunol 40:373-80. 2003
    ..We conclude that c-Rel regulates CRP expression without the requirement of binding to a kappaB site, and binds directly to C/EBPbeta to facilitate the binding of C/EBPbeta to the CRP promoter...