Robert L Coffman

Summary

Affiliation: Dynavax Technologies
Country: USA

Publications

  1. ncbi request reprint Origins of the T(H)1-T(H)2 model: a personal perspective
    Robert L Coffman
    Dynavax Technologies, Berkeley, California 94710, USA
    Nat Immunol 7:539-41. 2006
  2. pmc Nonhuman primate models of asthma
    Robert L Coffman
    Dynavax Technologies, Berkeley, CA 94710, USA
    J Exp Med 201:1875-9. 2005
  3. pmc TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus
    Cristiana Guiducci
    Dynavax Technologies Corporation, 2929 Seventh Street, Suite 100, Berkeley, California 94710, USA
    Nature 465:937-41. 2010
  4. ncbi request reprint Inhibitors of TLR-9 act on multiple cell subsets in mouse and man in vitro and prevent death in vivo from systemic inflammation
    Omar Duramad
    Dynavax Technologies, Berkeley, CA 94710, USA
    J Immunol 174:5193-200. 2005
  5. pmc Immunostimulatory oligonucleotides block allergic airway inflammation by inhibiting Th2 cell activation and IgE-mediated cytokine induction
    Edith M Hessel
    Dynavax Technologies, Berkeley, CA 94710, USA
    J Exp Med 202:1563-73. 2005
  6. ncbi request reprint Superior activity of the type C class of ISS in vitro and in vivo across multiple species
    Jason D Marshall
    Dynavax Technologies Corporation, Berkeley, California 94710, USA
    DNA Cell Biol 24:63-72. 2005
  7. pmc Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus
    Franck J Barrat
    Dynavax Technologies Corporation, Berkeley, CA 94710, USA
    J Exp Med 202:1131-9. 2005
  8. pmc A limited CpG-containing oligodeoxynucleotide therapy regimen induces sustained suppression of allergic airway inflammation in mice
    John D Campbell
    Dynavax Technologies, Berkeley, California, USA
    Thorax 69:565-73. 2014
  9. pmc Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation
    Cristiana Guiducci
    Dynavax Technologies Corporation, Berkeley, CA 94710, USA
    J Exp Med 203:1999-2008. 2006
  10. pmc Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9
    Cristiana Guiducci
    Dynavax Technologies Corporation, Berkeley, CA 94710, USA
    J Exp Med 207:2931-42. 2010

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Origins of the T(H)1-T(H)2 model: a personal perspective
    Robert L Coffman
    Dynavax Technologies, Berkeley, California 94710, USA
    Nat Immunol 7:539-41. 2006
    ..Robert L. Coffman recounts how his work on immunoglobulin E regulation along with data from Tim Mosmann on the functional heterogeneity of T cell clones led to the T helper type 1-T helper type 2 hypothesis...
  2. pmc Nonhuman primate models of asthma
    Robert L Coffman
    Dynavax Technologies, Berkeley, CA 94710, USA
    J Exp Med 201:1875-9. 2005
    ..We advocate more extensive use of nonhuman primate asthma models to reconcile these differences between man and mouse...
  3. pmc TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus
    Cristiana Guiducci
    Dynavax Technologies Corporation, 2929 Seventh Street, Suite 100, Berkeley, California 94710, USA
    Nature 465:937-41. 2010
    ..These findings unveil a new role for self nucleic acid recognition by TLRs and indicate that inhibitors of TLR7 and 9 signalling could prove to be effective corticosteroid-sparing drugs...
  4. ncbi request reprint Inhibitors of TLR-9 act on multiple cell subsets in mouse and man in vitro and prevent death in vivo from systemic inflammation
    Omar Duramad
    Dynavax Technologies, Berkeley, CA 94710, USA
    J Immunol 174:5193-200. 2005
    ..IRS can also inhibit a complex pathological response to ISS, as shown by protection from death after massive systemic inflammation induced by a CpG-containing oligodeoxynucleotides...
  5. pmc Immunostimulatory oligonucleotides block allergic airway inflammation by inhibiting Th2 cell activation and IgE-mediated cytokine induction
    Edith M Hessel
    Dynavax Technologies, Berkeley, CA 94710, USA
    J Exp Med 202:1563-73. 2005
    ..Thus, inhibition by ISS of allergic responses can be explained by two novel mechanisms that culminate in the inhibition of the principal sources of type 2 cytokines in the airways...
  6. ncbi request reprint Superior activity of the type C class of ISS in vitro and in vivo across multiple species
    Jason D Marshall
    Dynavax Technologies Corporation, Berkeley, California 94710, USA
    DNA Cell Biol 24:63-72. 2005
    ..In conclusion, we have shown CpG-C to exert several types of immune functions across multiple species, and this novel class is thus an attractive candidate for ISS-based therapeutic strategies...
  7. pmc Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus
    Franck J Barrat
    Dynavax Technologies Corporation, Berkeley, CA 94710, USA
    J Exp Med 202:1131-9. 2005
    ..These inhibitors of TLR signaling thus represent novel therapeutic agents with potential for the treatment of lupus...
  8. pmc A limited CpG-containing oligodeoxynucleotide therapy regimen induces sustained suppression of allergic airway inflammation in mice
    John D Campbell
    Dynavax Technologies, Berkeley, California, USA
    Thorax 69:565-73. 2014
    ..A single treatment has transient effects but a limited series of treatments has potential to achieve clinically meaningful sustained inhibition of allergic airway disease...
  9. pmc Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation
    Cristiana Guiducci
    Dynavax Technologies Corporation, Berkeley, CA 94710, USA
    J Exp Med 203:1999-2008. 2006
    ..This establishes that the primary determinant of TLR9 signaling is not valency but endosomal location and demonstrates a strict compartmentalization of the biological response to TLR9 activation in PDCs...
  10. pmc Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9
    Cristiana Guiducci
    Dynavax Technologies Corporation, Berkeley, CA 94710, USA
    J Exp Med 207:2931-42. 2010
    ..These data suggest that inhibitors of TLR7 and TLR9 signaling have potential therapeutic application for the treatment of interface dermatitis...
  11. ncbi request reprint Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms
    Franck J Barrat
    Dynavax Technologies Corporation, Berkeley, CA 94710, USA
    Eur J Immunol 37:3582-6. 2007
    ..These data demonstrate that in addition to its ability to block IFN-alpha, IRS 954 can reduce symptoms in a lupus model and thus represents a promising therapeutic agent for the treatment of SLE...
  12. pmc CpG-containing immunostimulatory DNA sequences elicit TNF-alpha-dependent toxicity in rodents but not in humans
    John D Campbell
    Dynavax Technologies Corporation, Berkeley, California 94710, USA
    J Clin Invest 119:2564-76. 2009
    ..These data demonstrate that ISS induce rodent-specific TNF-alpha-dependent toxicity that is absent in humans and reflective of differential TLR9 expression patterns in rodents versus humans...
  13. ncbi request reprint IL-10 regulates plasmacytoid dendritic cell response to CpG-containing immunostimulatory sequences
    Omar Duramad
    Dynavax Technologies, 717 Potter St, Ste 100, Berkeley, CA 94710, USA
    Blood 102:4487-92. 2003
    ..The 3 distinct classes of ISS differed with respect to induction of PDC maturation and T-cell priming capacity. IL-10 regulated PDC activation but did not inhibit the subsequent T-cell-priming ability of PDCs already activated by ISS...
  14. ncbi request reprint A minimal human immunostimulatory CpG motif that potently induces IFN-gamma and IFN-alpha production
    Karen Fearon
    Dynavax Technologies Corporation, Berkeley, CA 94710, USA
    Eur J Immunol 33:2114-22. 2003
    ..These results describe a novel technique for formulating active, but very short, ISS oligodeoxynucleotide that allows for the dissection and characterization of minimal immunostimulatory CpG motifs...
  15. pmc RNA recognition by human TLR8 can lead to autoimmune inflammation
    Cristiana Guiducci
    Dynavax Technologies Corporation, Berkeley, CA 94710
    J Exp Med 210:2903-19. 2013
    ....
  16. doi request reprint Development of TLR inhibitors for the treatment of autoimmune diseases
    Franck J Barrat
    Dynavax Technologies Corporation, Berkeley, CA 94710, USA
    Immunol Rev 223:271-83. 2008
    ..We describe novel inhibitors of these receptors and provide evidence to support their use as novel therapeutic agents for autoimmunity...
  17. pmc A CpG-Ficoll Nanoparticle Adjuvant for Anthrax Protective Antigen Enhances Immunogenicity and Provides Single-Immunization Protection against Inhaled Anthrax in Monkeys
    Melissa A Kachura
    Dynavax Technologies, Berkeley, CA 94710 and
    J Immunol 196:284-97. 2016
    ..These findings support the development of DV230-Ficoll as an adjuvant platform, particularly for vaccines such as for anthrax, for which rapid induction of protective immunity and memory with a single injection is very important. ..
  18. pmc PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation
    Cristiana Guiducci
    Dynavax Technologies Corporation, Berkeley, CA 94710, USA
    J Exp Med 205:315-22. 2008
    ..Thus, PI3K selectively controls type I IFN production by regulating IRF-7 nuclear translocation in human pDCs and could serve as a novel target to inhibit pathogenic type I IFN in autoimmune diseases...
  19. ncbi request reprint Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists
    Holger Kanzler
    Dynavax Technologies, 2929 Seventh Street, Suite 100, Berkeley, California 94710, USA
    Nat Med 13:552-9. 2007
    ..As recognition grows of the role of inappropriate Toll-like receptor stimulation in inflammation and autoimmunity, significant efforts have begun to develop antagonists to Toll-like receptors as well...
  20. pmc Optimization, Production, and Characterization of a CpG-Oligonucleotide-Ficoll Conjugate Nanoparticle Adjuvant for Enhanced Immunogenicity of Anthrax Protective Antigen
    Bob Milley
    Dynavax Technologies Corporation, 2929 Seventh Street, Suite 100, Berkeley, California 94710, United States
    Bioconjug Chem 27:1293-304. 2016
    ..The processes described here establish a reproducible and robust process for the synthesis of a novel, size-controlled, and stable CpG-ODN nanoparticle adjuvant suitable for manufacture and use in vaccines. ..
  21. ncbi request reprint Identification of a novel CpG DNA class and motif that optimally stimulate B cell and plasmacytoid dendritic cell functions
    Jason D Marshall
    Dynavax Technologies Corporation, Berkeley, California, USA
    J Leukoc Biol 73:781-92. 2003
    ....
  22. pmc In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines
    Franck J Barrat
    DNAX Research Institute, Department of Immunology, Palo Alto, CA 94304, USA
    J Exp Med 195:603-16. 2002
    ..Generating homogeneous populations of IL-10-producing T cells in vitro will thus facilitate the use of regulatory T cells in immunotherapy...
  23. pmc Intratumoral injection of a CpG oligonucleotide reverts resistance to PD-1 blockade by expanding multifunctional CD8+ T cells
    Shu Wang
    Discovery, Dynavax Technologies Corporation, Berkeley, CA 94710
    Proc Natl Acad Sci U S A 113:E7240-E7249. 2016
    ..These findings suggest that a CpG oligonucleotide given intratumorally may increase the response of cancer patients to PD-1 blockade, increasing the quantity and the quality of tumor-specific CD8+ T cells...
  24. doi request reprint Biomarkers measuring the activity of Toll-like receptor ligands in clinical development programs
    Paul Sims
    Dynavax Technologies, Berkeley, CA 94710, USA
    Methods Mol Biol 517:415-40. 2009
    ....
  25. pmc Vaccine adjuvants: putting innate immunity to work
    Robert L Coffman
    Dynavax Technologies Corporation, Berkeley, CA 94710, USA
    Immunity 33:492-503. 2010
    ..However, the larger challenge is to develop vaccines that generate strong T cell immunity with purified or recombinant vaccine antigens...
  26. pmc Novel chimeric immunomodulatory compounds containing short CpG oligodeoxyribonucleotides have differential activities in human cells
    Jason D Marshall
    Dynavax Technologies Corporation, 717 Potter Street, Suite 100, Berkeley, CA 94710, USA
    Nucleic Acids Res 31:5122-33. 2003
    ....
  27. ncbi request reprint Role of the chemokine stromal cell-derived factor 1 in autoantibody production and nephritis in murine lupus
    Karl Balabanian
    Institut National de la Santé et de la Recherche Médicale Unité 131, Institut Paris Sud sur les Cytokines, Clamart, France
    J Immunol 170:3392-400. 2003
    ..Therefore, PerB1a lymphocytes are abnormally sensitive to the combined action of SDF-1 and IL-10 in NZB/W mice, and SDF-1 is key in the development of autoimmunity in this murine model of lupus...
  28. pmc Transgenic mice expressing human interleukin-10 in the antigen-presenting cell compartment show increased susceptibility to infection with Mycobacterium avium associated with decreased macrophage effector function and apoptosis
    Carl G Feng
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Infect Immun 70:6672-9. 2002
    ..Together, these data indicate that APC-derived IL-10 can exert a major inhibitory effect on control of mycobacterial infection by a mechanism involving the suppression of macrophage effector function and apoptosis...
  29. ncbi request reprint Human TLR-7-, -8-, and -9-mediated induction of IFN-alpha/beta and -lambda Is IRAK-4 dependent and redundant for protective immunity to viruses
    Kun Yang
    Laboratory of Human Genetics of Infectious Diseases, University of Paris René Descartes INSERM U550, Necker Medical School, 75015 Paris, France
    Immunity 23:465-78. 2005
    ..The TLR-7-, TLR-8-, and TLR-9-dependent induction of IFN-alpha/beta and -lambda is strictly IRAK-4 dependent and paradoxically redundant for protective immunity to most viruses in humans...
  30. pmc Gender differences in the allergic response of mice neonatally exposed to environmental tobacco smoke
    Brian W P Seymour
    Department of Immunobiology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA
    Dev Immunol 9:47-54. 2002
    ..These data demonstrate that female animals are significantly more susceptible than males to the influence of ETS on the allergic response...
  31. pmc Interleukin-10 (IL-10) in experimental visceral leishmaniasis and IL-10 receptor blockade as immunotherapy
    Henry W Murray
    Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    Infect Immun 70:6284-93. 2002
    ..IL-10's deactivating effects regulate outcome in experimental visceral leishmaniasis, and IL-10R blockade represents a potential immuno- and/or immunochemotherapeutic approach in this infection...
  32. ncbi request reprint New IL-17 family members promote Th1 or Th2 responses in the lung: in vivo function of the novel cytokine IL-25
    Stephen D Hurst
    DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA
    J Immunol 169:443-53. 2002
    ..Further, these data demonstrate the heterogeneity of function within the IL-17 cytokine family and suggest that IL-25 may be an important mediator of allergic disease via production of IL-4, IL-5, IL-13, and eotaxin...
  33. ncbi request reprint Friend of GATA is expressed in naive Th cells and functions as a repressor of GATA-3-mediated Th2 cell development
    Hirokazu Kurata
    Department of Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA
    J Immunol 168:4538-45. 2002
    ..Our results clearly indicate that 1) FOG is a repressor of GATA-3 in naive T cells and 2) the down-regulation of FOG induces Th2 cell differentiation by releasing GATA-3 from its repression...
  34. ncbi request reprint A restricted subset of dendritic cells captures airborne antigens and remains able to activate specific T cells long after antigen exposure
    Valerie Julia
    DNAX Research Institute, Immunology Department, 901 California Avenue, Palo Alto, CA 94304, USA
    Immunity 16:271-83. 2002
    ..Taken together, our results may explain the chronic Th2 airway inflammation characteristic of allergic asthma...
  35. doi request reprint CpG oligodeoxynucleotides alter lymphocyte and dendritic cell trafficking in humans
    W Nicholas Haining
    Department of Hematology Oncology, Children s Hospital, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Clin Cancer Res 14:5626-34. 2008
    ..CpG-ODN also induce PDC to secrete chemokines that alter lymphocyte migration. Whether CpG-ODN TLR signals enhance antigen-specific immunity and/or trafficking in humans is unknown...
  36. ncbi request reprint Surface phenotype of Peyer's patch germinal center cells: implications for the role of germinal centers in B cell differentiation. 1982
    Eugene C Butcher
    J Immunol 175:1363-72. 2005
  37. ncbi request reprint Immunostimulatory sequences regulate interferon-inducible genes but not allergic airway responses
    Gail M Gauvreau
    McMaster University, Hamilton, ON, Canada
    Am J Respir Crit Care Med 174:15-20. 2006
    ..1018 ISS is a synthetic oligonucleotide containing immunostimulatory CpG motifs. In animal studies, 1018 ISS effectively inhibited Th2-mediated lung inflammation, including eosinophil infiltration, and airway hyperresponsiveness...
  38. ncbi request reprint Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. 1986
    Timothy R Mosmann
    J Immunol 175:5-14. 2005
  39. pmc T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells
    Linda Fahlén
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, England, UK
    J Exp Med 201:737-46. 2005
    ..Importantly, the function of TGF-beta1(-/-) T reg cells was abrogated by anti-TGF-beta monoclonal antibody, indicating that functional TGF-beta can be provided by a non-T reg cell source...
  40. ncbi request reprint Toll-like receptor recognition regulates immunodominance in an antimicrobial CD4+ T cell response
    Felix Yarovinsky
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Immunity 25:655-64. 2006
    ..These findings support a major influence of TLR recognition in antigen presentation by DC in vivo and establish a mechanism by which TLR ligand association regulates the immunogenicity of microbial antigens...
  41. ncbi request reprint Combination immunotherapy with a CpG oligonucleotide (1018 ISS) and rituximab in patients with non-Hodgkin lymphoma: increased interferon-alpha/beta-inducible gene expression, without significant toxicity
    Jonathan W Friedberg
    James P Wilmot Cancer Center, University of Rochester, Rochester, NY 14642, USA
    Blood 105:489-95. 2005
    ..CpG treatment resulted in no significant toxicity, providing rationale for further testing of this exciting combination immunotherapy approach to NHL...
  42. ncbi request reprint Differential regulation of lymphoproliferative responses to Trypanosoma cruzi antigen in patients with the cardiac or indeterminate form of Chagas disease
    Silvia de Barros-Mazon
    Departamento de Patologia Clinica, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, 13083 970, SP, Brazil
    Clin Immunol 111:137-45. 2004
    ..The results evidence that IL-10 regulates parasite-specific T cell responses in patients with the cardiac form, whereas regulation by prostaglandins (PG) occurs in patients with either cardiac or indeterminate form of the disease...
  43. pmc Second-hand smoke increases bronchial hyperreactivity and eosinophilia in a murine model of allergic aspergillosis
    Brian W P Seymour
    Department of Pathology, Microbiology and Immunology, 1126 Haring Hall, School of Veterinary Medicine, University of California, One Shields Avenue, Davis, CA 95616, USA
    Clin Dev Immunol 10:35-42. 2003
    ..Thus, ETS can cause exacerbation of asthma in ABPA as demonstrated by functional airway hyperresponsiveness and elevated levels of blood eosinophilia...
  44. doi request reprint Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections
    Judith N Mandl
    Graduate Program in Population Biology, Ecology and Evolution, Emory University, 1510 Clifton Road, Atlanta, Georgia 30322, USA
    Nat Med 14:1077-87. 2008
    ..Such a vicious cycle of continuous virus replication and immunopathology is absent in natural sooty mangabey hosts...
  45. pmc Microarray profile of differentially expressed genes in a monkey model of allergic asthma
    Jun Zou
    Department of Allergy, Schering Plough Research Institute, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA
    Genome Biol 3:research0020. 2002
    ..suum antigen or given interleukin-4 (IL-4) treatment; lung tissue was collected at 4, 18 or 24 h after antigen challenge or 24 h after IL-4. Each challenged monkey lung was compared to a pool of normal, unchallenged monkey lungs...

Research Grants2

  1. Immunostimulatory DNA Priming of Lung Innate Immunity
    Robert Coffman; Fiscal Year: 2005
    ..abstract_text> ..
  2. Development of an Inhibitory Oligonucleotide for the Treatment of Lupus
    Robert Coffman; Fiscal Year: 2006
    ..We propose to develop a novel drug that specifically inhibits Interferon-alpha, a key factor in the disease. [unreadable] [unreadable] [unreadable]..