Wilson S Meng

Summary

Affiliation: Duquesne University
Country: USA

Publications

  1. ncbi request reprint Rational design of peptide-based tumor vaccines
    Wilson S Meng
    Division of Pharmaceutical Sciences, Duquesne University, Mylan School of Pharmacy, Pittsburgh, Pennsylvania 15282, USA
    Pharm Res 19:926-32. 2002
  2. ncbi request reprint Polymeric microspheres as stabilizing anchors for oligonucleotide delivery to dendritic cells
    Jeffrey R Kovacs
    Division of Pharmaceutical Sciences, Duquesne University, Mellon Hall 413, 600 Forbes Avenue, Pittsburgh, PA 15282, USA
    Biomaterials 26:6754-61. 2005
  3. ncbi request reprint Characterization of particles fabricated with poly(D, L-lactic-co-glycolic acid) and an ornithine-histidine peptide as carriers of oligodeoxynucleotide for delivery into primary dendritic cells
    Ying Zheng
    Division of Pharmaceutical Sciences, Duquesne University, Mellon Hall 413, 600 Forbes Avenue, Pittsburgh, PA 15282, USA
    J Biomater Sci Polym Ed 17:1389-403. 2006
  4. ncbi request reprint Activation of antigen-presenting cells by DNA delivery vectors
    Wilson S Meng
    Duquesne University, Division of Pharmaceutical Sciences, 600 Forbes Ave, Pittsburgh, PA 15282, USA
    Expert Opin Biol Ther 5:1019-28. 2005
  5. ncbi request reprint Expansion of Foxp3-expressing regulatory T cells in vitro by dendritic cells modified with polymeric particles carrying a plasmid encoding interleukin-10
    Liang Jia
    Division of Pharmaceutical Sciences, Duquesne University, PA 15282, USA
    Biomaterials 29:1250-61. 2008
  6. ncbi request reprint Attenuated alloreactivity of dendritic cells engineered with surface-modified microspheres carrying a plasmid encoding interleukin-10
    Liang Jia
    Division of Pharmaceutical Sciences, Duquesne University, 600 Forbes Ave, Mellon 413, Pittsburgh, PA, USA
    Biomaterials 27:2076-82. 2006
  7. doi request reprint Characterization of nickel-decorated PLGA particles anchored with a his-tagged polycation
    Jeffrey R Kovacs
    Division of Pharmaceutical Sciences, Duquesne University, Mellon Hall 413, Pittsburgh, PA 15282, USA
    J Biomater Sci Polym Ed 20:1307-20. 2009
  8. doi request reprint Local retention of antibodies in vivo with an injectable film embedded with a fluorogen-activating protein
    Wen Liu
    Division of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, United States
    J Control Release 230:1-12. 2016
  9. doi request reprint Retaining antibodies in tumors with a self-assembling injectable system
    Yi Wen
    Division of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282, USA
    Mol Pharm 10:1035-44. 2013
  10. pmc Secondary anchor substitutions in an HLA-A*0201-restricted T-cell epitope derived from Her-2/neu
    Matthew A Joseph
    Division of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, United States
    Mol Immunol 44:322-31. 2007

Research Grants

Collaborators

  • Hongmei Shen
  • Ying Zheng
  • Wen Liu
  • Eric C Freeman
  • Lisa H Butterfield
  • Suzanne Bertera
  • David A Johnson
  • Vicki L Davis
  • CHRISTOPHER SURRATT
  • Antoni Ribas
  • Yi Wen
  • Ellen S Gawalt
  • Jeffrey R Kovacs
  • Liang Jia
  • Gavin A Buckholtz
  • Nick Giannoukakis
  • Shana L Roudebush
  • Asako Tajima
  • Christina Bagia
  • Matthew J Saunders
  • Matthew A Joseph
  • Sai P Chamarthy
  • Yu Pei Liao
  • Nina A Reger
  • Patrick J Schimoler
  • William D Anderton
  • Sai Prasanth Chamarthy
  • Mark C Miller
  • Isha Pradhan
  • Yong Fan
  • Massimo Trucco
  • Mingfeng Bai
  • Jelena M Janjic
  • Thomas R Goehring
  • Shaojuan Zhang
  • Christopher Szent-Gyorgyi
  • Zachary Drennen
  • Kristen M Kruszewski
  • Harold R Kolonich
  • Alan S Waggoner
  • Jenny Tidball
  • Anthony Ross
  • Megan L Mitchell
  • Jeffrey D Evanseck
  • Steven M Firestine
  • Keisuke S Iwamoto
  • Karl R Anderson
  • James S Economou
  • William H McBride
  • Chun Chieh Wang
  • Diane Gattens
  • Erin McClelland

Detail Information

Publications23

  1. ncbi request reprint Rational design of peptide-based tumor vaccines
    Wilson S Meng
    Division of Pharmaceutical Sciences, Duquesne University, Mylan School of Pharmacy, Pittsburgh, Pennsylvania 15282, USA
    Pharm Res 19:926-32. 2002
    ..This review will discuss the basic and clinical aspects of modifying native TAA peptides as tumor vaccines...
  2. ncbi request reprint Polymeric microspheres as stabilizing anchors for oligonucleotide delivery to dendritic cells
    Jeffrey R Kovacs
    Division of Pharmaceutical Sciences, Duquesne University, Mellon Hall 413, 600 Forbes Avenue, Pittsburgh, PA 15282, USA
    Biomaterials 26:6754-61. 2005
    ..Accumulation of ODN in DC is greatly enhanced with the surface modified MS. Taken together, these data demonstrate that the self assembly system of MS(O10H6) is an effective delivery vehicle for DNA-based modulation of DC functions...
  3. ncbi request reprint Characterization of particles fabricated with poly(D, L-lactic-co-glycolic acid) and an ornithine-histidine peptide as carriers of oligodeoxynucleotide for delivery into primary dendritic cells
    Ying Zheng
    Division of Pharmaceutical Sciences, Duquesne University, Mellon Hall 413, 600 Forbes Avenue, Pittsburgh, PA 15282, USA
    J Biomater Sci Polym Ed 17:1389-403. 2006
    ..Taken together, these data suggest that combining PLGA and O10H6 is a feasible method to generate ODN-containing nano-sized particles for applications in DCs...
  4. ncbi request reprint Activation of antigen-presenting cells by DNA delivery vectors
    Wilson S Meng
    Duquesne University, Division of Pharmaceutical Sciences, 600 Forbes Ave, Pittsburgh, PA 15282, USA
    Expert Opin Biol Ther 5:1019-28. 2005
    ..This paper will summarise recent reports of adjuvant properties of viral and non-viral delivery systems...
  5. ncbi request reprint Expansion of Foxp3-expressing regulatory T cells in vitro by dendritic cells modified with polymeric particles carrying a plasmid encoding interleukin-10
    Liang Jia
    Division of Pharmaceutical Sciences, Duquesne University, PA 15282, USA
    Biomaterials 29:1250-61. 2008
    ..Collectively, the results raise the prospects of using PLGA(O10H6) as a vector for delivering anti-inflammatory cytokine genes to modulate T cell responses in vivo...
  6. ncbi request reprint Attenuated alloreactivity of dendritic cells engineered with surface-modified microspheres carrying a plasmid encoding interleukin-10
    Liang Jia
    Division of Pharmaceutical Sciences, Duquesne University, 600 Forbes Ave, Mellon 413, Pittsburgh, PA, USA
    Biomaterials 27:2076-82. 2006
    ..These data demonstrate that the self-assembled system of MS(O10H6) is an effectual delivery vehicle for plasmid-based modulation of DC-dependent allogeneic T cell responses...
  7. doi request reprint Characterization of nickel-decorated PLGA particles anchored with a his-tagged polycation
    Jeffrey R Kovacs
    Division of Pharmaceutical Sciences, Duquesne University, Mellon Hall 413, Pittsburgh, PA 15282, USA
    J Biomater Sci Polym Ed 20:1307-20. 2009
    ..These data suggest PLGA-Ni should be further explored as a nucleic acid carrier in the context of anti-sense gene down-regulation...
  8. doi request reprint Local retention of antibodies in vivo with an injectable film embedded with a fluorogen-activating protein
    Wen Liu
    Division of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, United States
    J Control Release 230:1-12. 2016
    ..The ability to track IgG binding sites and distribution simultaneously will aid the optimization of local antibody delivery systems. ..
  9. doi request reprint Retaining antibodies in tumors with a self-assembling injectable system
    Yi Wen
    Division of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282, USA
    Mol Pharm 10:1035-44. 2013
    ..These studies demonstrated that the immobilizing mechanism was effective in enhancing the retention of IgG locally in vivo. The injectable system may be used to enhance the delivery of immune modulatory antibodies in tumors...
  10. pmc Secondary anchor substitutions in an HLA-A*0201-restricted T-cell epitope derived from Her-2/neu
    Matthew A Joseph
    Division of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, United States
    Mol Immunol 44:322-31. 2007
    ..Priming HLA-A*0201 transgenic mice with G7F-loaded syngeneic dendritic cells stimulated mouse T cells to produce a higher level of INFgamma than mice immunized with GP2...
  11. ncbi request reprint Gene delivery to dendritic cells facilitated by a tumor necrosis factor alpha-competing peptide
    Sai P Chamarthy
    Division of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, PA 15282, USA
    Mol Immunol 41:741-9. 2004
    ..Exposing cells to the free peptide prior to transfection significantly diminished transgene expression. These results demonstrate that YTYQGKL can be used to facilitate gene transfer in DCs...
  12. pmc Antibody-functionalized peptidic membranes for neutralization of allogeneic skin antigen-presenting cells
    Yi Wen
    Division of Pharmaceutical Sciences, Duquesne University, PA, USA
    Acta Biomater 10:4759-67. 2014
    ..Taken together, the data indicate that the strategy has the potential to alter the natural course of rejection immune mechanisms in allogeneic transplant models...
  13. doi request reprint Reducing Escherichia coli growth on a composite biomaterial by a surface immobilized antimicrobial peptide
    Gavin A Buckholtz
    Department of Chemistry and Biochemistry, Duquesne University, Pittsburgh, PA 15282, USA
    Mater Sci Eng C Mater Biol Appl 65:126-34. 2016
    ..6% after 24h) and retained its activity against Escherichia coli based on N-phenylnaphthylamine uptake and bacterial turbidity tests. Overall, this simple scaffold system improves osteoblast activity and reduces bacterial activity. ..
  14. doi request reprint Coassembly of amphiphilic peptide EAK16-II with histidinylated analogues and implications for functionalization of β-sheet fibrils in vivo
    Yi Wen
    Division of Pharmaceutical Sciences, Duquesne University, 15282 PA, USA
    Biomaterials 35:5196-205. 2014
    ..By increasing coassembling efficiency, the likelihood of generating immunogenic aggregates outside the main fibrils could be minimized. These findings provide insights for rational functionalization of in situ self-gelling materials...
  15. doi request reprint A peptide-based material platform for displaying antibodies to engage T cells
    Ying Zheng
    Division of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, USA
    Biomaterials 32:249-57. 2011
    ..We report here the use of amphiphilic peptides to display Ab in vivo, the results indicating that the design can be used as a platform for engaging specific subsets of leukocytes for the purpose of immune modulation...
  16. doi request reprint Bioengineering mini functional thymic units with EAK16-II/EAKIIH6 self-assembling hydrogel
    Asako Tajima
    Institute of Cellular Therapeutics, Allegheny Health Network, Pittsburgh, PA, USA
    Clin Immunol 160:82-9. 2015
    ..These mini thymic units of TECs can be useful in clinical applications to reconstitute T-cell adaptive immunity. ..
  17. pmc Recent In Vivo Evidences of Particle-Based Delivery of Small-Interfering RNA (siRNA) into Solid Tumors
    Yi Wen
    Division of Pharmaceutical Sciences, Duquesne University, 600, Forbes Avenue, Pittsburgh, PA 15282, USA
    J Pharm Innov 9:158-173. 2014
    ..Physiochemical properties conducive to efficient siRNA delivery are summarized and directions for future research are discussed...
  18. pmc Modeling the proton sponge hypothesis: examining proton sponge effectiveness for enhancing intracellular gene delivery through multiscale modeling
    Eric C Freeman
    Department of Mechanical Engineering and Material Science, University of Pittsburgh, Pittsburgh, PA, USA
    J Biomater Sci Polym Ed 24:398-416. 2013
    ..Calibrated and validated using reported experimental data, the simulations offer insights into defining the properties of suitable dendrimers for enhancing gene delivery as a function of polymer structure...
  19. pmc Engineering fluorogen activating proteins into self-assembling materials
    Matthew J Saunders
    Molecular Biosensor and Imaging Center, Carnegie Mellon University, Pittsburgh, PA, USA
    Bioconjug Chem 24:803-10. 2013
    ..It is envisioned that dL5 membranes can be established in diseased locales to monitor infiltration and migration of inflammatory cells marked with antibodies conjugated to MG...
  20. ncbi request reprint A cationic peptide consists of ornithine and histidine repeats augments gene transfer in dendritic cells
    Sai Prasanth Chamarthy
    Division of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, PA 15282, USA
    Mol Immunol 40:483-90. 2003
    ..Taken together, these results indicate ornithine and histidine repeats are suitable building blocks of non-viral gene transfer vector for DC...
  21. pmc Development of a neuroscience-oriented "methods" course for graduate students of pharmacology and toxicology
    Christopher K Surratt
    Division of Pharmaceutical Sciences, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA 15282, USA
    CBE Life Sci Educ 5:188-96. 2006
    ....
  22. ncbi request reprint Ionizing radiation affects human MART-1 melanoma antigen processing and presentation by dendritic cells
    Yu Pei Liao
    Department of Radiation Oncology, Division of Surgical Oncology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Immunol 173:2462-9. 2004
    ..1/K(b) transgenic mice. Taken together, these results suggest that radiation modulates MHC class I-mediated antitumor immunity by functionally affecting DC Ag presentation pathways...
  23. ncbi request reprint T-cell responses to HLA-A*0201 immunodominant peptides derived from alpha-fetoprotein in patients with hepatocellular cancer
    Lisa H Butterfield
    Division of Surgical Oncology, University of California at Los Angeles, Los Angeles, California, USA
    Clin Cancer Res 9:5902-8. 2003
    ..We wished to test the hypothesis that AFP peptide-reactive T cells could be expanded in vivo in HCC patients immunized with these four AFP peptides...

Research Grants1

  1. Rational Design of Peptide-Based Tumor Vaccine
    WILSON MENG; Fiscal Year: 2004
    ..The research proposed will also benefit the development of peptide-based vaccines for viral and microbial infections. ..