R Mukherjee

Summary

Affiliation: DuPont Pharmaceuticals Company
Country: USA

Publications

  1. ncbi request reprint A selective peroxisome proliferator-activated receptor-gamma (PPARgamma) modulator blocks adipocyte differentiation but stimulates glucose uptake in 3T3-L1 adipocytes
    R Mukherjee
    Department of Pharmacology, Ligand Pharmaceuticals, Inc, San Diego, California 92121, USA
    Mol Endocrinol 14:1425-33. 2000
  2. ncbi request reprint RXR agonists activate PPARalpha-inducible genes, lower triglycerides, and raise HDL levels in vivo
    R Mukherjee
    Department of Pharmacology, Ligand Pharmaceuticals, Inc, San Diego, Calif 92121, USA
    Arterioscler Thromb Vasc Biol 18:272-6. 1998
  3. ncbi request reprint Identification, characterization, and tissue distribution of human peroxisome proliferator-activated receptor (PPAR) isoforms PPARgamma2 versus PPARgamma1 and activation with retinoid X receptor agonists and antagonists
    R Mukherjee
    Department of Cardiovascular Research, Ligand Pharmaceuticals, Inc, San Diego, California 92121, USA
    J Biol Chem 272:8071-6. 1997
  4. ncbi request reprint Peroxisome proliferator-activated receptor (PPAR) gamma and retinoid X receptor (RXR) agonists have complementary effects on glucose and lipid metabolism in human skeletal muscle
    B S Cha
    Veterans Affairs San Diego Healthcare System, San Diego and Department of Medicine, University of California, San Diego, California, USA
    Diabetologia 44:444-52. 2001
  5. ncbi request reprint Peroxisome proliferator-activated receptor subtype-specific regulation of hepatic and peripheral gene expression in the Zucker diabetic fatty rat
    S L Dana
    Department of Pharmacology, Ligand Pharmaceuticals, Inc, San Diego, CA 92121, USA
    Metabolism 50:963-71. 2001
  6. ncbi request reprint The human peroxisome proliferator-activated receptor (PPAR) subtype NUC1 represses the activation of hPPAR alpha and thyroid hormone receptors
    L Jow
    Department of Molecular Biology, Ligand Pharmaceuticals Inc, San Diego, California 92121
    J Biol Chem 270:3836-40. 1995

Collaborators

  • T P Ciaraldi
  • J R Paterniti
  • B S Cha
  • S L Dana
  • K M Ogilvie
  • R R Henry
  • L Carter
  • J M Bilakovics
  • S Mudaliar
  • R F Kauffman
  • S E Nikoulina
  • P A Hoener
  • D L Crombie
  • L Jow

Detail Information

Publications6

  1. ncbi request reprint A selective peroxisome proliferator-activated receptor-gamma (PPARgamma) modulator blocks adipocyte differentiation but stimulates glucose uptake in 3T3-L1 adipocytes
    R Mukherjee
    Department of Pharmacology, Ligand Pharmaceuticals, Inc, San Diego, California 92121, USA
    Mol Endocrinol 14:1425-33. 2000
    ..If selective PPARgamma modulators block adipogenesis in vivo, they may prevent obesity, lower insulin resistance, and delay the onset of type 2 diabetes...
  2. ncbi request reprint RXR agonists activate PPARalpha-inducible genes, lower triglycerides, and raise HDL levels in vivo
    R Mukherjee
    Department of Pharmacology, Ligand Pharmaceuticals, Inc, San Diego, Calif 92121, USA
    Arterioscler Thromb Vasc Biol 18:272-6. 1998
    ..This observation suggests the use of RXR-selective agonists, "rexinoids," either alone or in combination with a fibrate as a new therapeutic approach to treating patients with high triglyceride and low HDL cholesterol levels...
  3. ncbi request reprint Identification, characterization, and tissue distribution of human peroxisome proliferator-activated receptor (PPAR) isoforms PPARgamma2 versus PPARgamma1 and activation with retinoid X receptor agonists and antagonists
    R Mukherjee
    Department of Cardiovascular Research, Ligand Pharmaceuticals, Inc, San Diego, California 92121, USA
    J Biol Chem 272:8071-6. 1997
    ..Interestingly, a third protected band was detected with fat RNA indicating the possible existence of a third human PPARgamma isoform...
  4. ncbi request reprint Peroxisome proliferator-activated receptor (PPAR) gamma and retinoid X receptor (RXR) agonists have complementary effects on glucose and lipid metabolism in human skeletal muscle
    B S Cha
    Veterans Affairs San Diego Healthcare System, San Diego and Department of Medicine, University of California, San Diego, California, USA
    Diabetologia 44:444-52. 2001
    ....
  5. ncbi request reprint Peroxisome proliferator-activated receptor subtype-specific regulation of hepatic and peripheral gene expression in the Zucker diabetic fatty rat
    S L Dana
    Department of Pharmacology, Ligand Pharmaceuticals, Inc, San Diego, CA 92121, USA
    Metabolism 50:963-71. 2001
    ..The results of these studies suggest that activation of PPAR-alpha as well as PPAR-gamma in therapy for type 2 diabetes will enhance glucose and triglyceride control by combining actions in hepatic and peripheral tissues...
  6. ncbi request reprint The human peroxisome proliferator-activated receptor (PPAR) subtype NUC1 represses the activation of hPPAR alpha and thyroid hormone receptors
    L Jow
    Department of Molecular Biology, Ligand Pharmaceuticals Inc, San Diego, California 92121
    J Biol Chem 270:3836-40. 1995
    ..Our data further suggests convergence of thyroid hormone- and peroxisome-mediated fatty acid metabolism pathways. Overcoming hNUC1 repression could be a means of increasing the activity of these receptors...