H Swartzwelder

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Effect of sub-chronic intermittent ethanol exposure on spatial learning and ethanol sensitivity in adolescent and adult rats
    H S Swartzwelder
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA Neurobiology Research Laboratory, Durham Veterans Affairs Medical Center, Durham, NC, USA Electronic address
    Alcohol 48:353-60. 2014
  2. ncbi request reprint Hippocampal function during adolescence: a unique target of ethanol effects
    Aaron M White
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann N Y Acad Sci 1021:206-20. 2004
  3. ncbi request reprint Self-reported ADHD and adjustment in college: cross-sectional and longitudinal findings
    Stacey L Blase
    Duke University, Durham, NC 27707, USA
    J Atten Disord 13:297-309. 2009
  4. pmc Developmental sensitivity of hippocampal interneurons to ethanol: involvement of the hyperpolarization-activated current, Ih
    Haidun Yan
    Department of Psychiatry, Duke University Medical Center, Durham, NC, USA
    J Neurophysiol 101:67-83. 2009
  5. pmc Differential sensitivity of hippocampal interneurons to ethanol in adolescent and adult rats
    Haidun Yan
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina, USA
    J Pharmacol Exp Ther 335:51-60. 2010
  6. ncbi request reprint Sedative and GABAergic effects of ethanol on male and female rats
    Young May Cha
    Neurobiology Research Laboratory, Veterans Affairs Medical Center, Durham, North Carolina 27705, USA
    Alcohol Clin Exp Res 30:113-8. 2006
  7. ncbi request reprint Prenatal choline supplementation protects against postnatal neurotoxicity
    Shirley X Guo-Ross
    Neurobiology Research Laboratory, Veterans Affairs Medical Center, Durham, North Carolina 27705, USA
    J Neurosci 22:RC195. 2002
  8. ncbi request reprint Differential anxiogenic, aversive, and locomotor effects of THC in adolescent and adult rats
    Nicole L Schramm-Sapyta
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Room 100B Research Park Bldg 2, P O Box 3813, Durham, NC 27710, USA
    Psychopharmacology (Berl) 191:867-77. 2007
  9. ncbi request reprint Executive function deficits in acute stroke
    Sandra Zinn
    Research and Development, Veterans Affairs Medical Center, Durham, NC 27705, USA
    Arch Phys Med Rehabil 88:173-80. 2007
  10. ncbi request reprint Magnitude and ethanol sensitivity of tonic GABAA receptor-mediated inhibition in dentate gyrus changes from adolescence to adulthood
    Rebekah L Fleming
    Department of Psychiatry, Duke University Medical Center, Durham, NC, USA
    J Neurophysiol 97:3806-11. 2007

Research Grants

Collaborators

Detail Information

Publications36

  1. pmc Effect of sub-chronic intermittent ethanol exposure on spatial learning and ethanol sensitivity in adolescent and adult rats
    H S Swartzwelder
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA Neurobiology Research Laboratory, Durham Veterans Affairs Medical Center, Durham, NC, USA Electronic address
    Alcohol 48:353-60. 2014
    ....
  2. ncbi request reprint Hippocampal function during adolescence: a unique target of ethanol effects
    Aaron M White
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann N Y Acad Sci 1021:206-20. 2004
    ..Studies of this type have yielded valuable information for prevention, education, and public policy efforts related to underage drinking...
  3. ncbi request reprint Self-reported ADHD and adjustment in college: cross-sectional and longitudinal findings
    Stacey L Blase
    Duke University, Durham, NC 27707, USA
    J Atten Disord 13:297-309. 2009
    ..To examine the association between self-reported ADHD and college adjustment...
  4. pmc Developmental sensitivity of hippocampal interneurons to ethanol: involvement of the hyperpolarization-activated current, Ih
    Haidun Yan
    Department of Psychiatry, Duke University Medical Center, Durham, NC, USA
    J Neurophysiol 101:67-83. 2009
    ..However, EtOH failed to affect sAP firing in the presence of ZD7288 or cesium chloride. These results suggest that Ih may be of mechanistic significance in the effect of EtOH on interneuron spontaneous firing...
  5. pmc Differential sensitivity of hippocampal interneurons to ethanol in adolescent and adult rats
    Haidun Yan
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina, USA
    J Pharmacol Exp Ther 335:51-60. 2010
    ..These results indicate that although EtOH promotes the firing of hippocampal interneurons, through promotion of I(h), the developmental expression of this effect differs between interneurons with somata located in the SO and SLM...
  6. ncbi request reprint Sedative and GABAergic effects of ethanol on male and female rats
    Young May Cha
    Neurobiology Research Laboratory, Veterans Affairs Medical Center, Durham, North Carolina 27705, USA
    Alcohol Clin Exp Res 30:113-8. 2006
    ....
  7. ncbi request reprint Prenatal choline supplementation protects against postnatal neurotoxicity
    Shirley X Guo-Ross
    Neurobiology Research Laboratory, Veterans Affairs Medical Center, Durham, North Carolina 27705, USA
    J Neurosci 22:RC195. 2002
    ..These data show that availability of a single nutrient, choline, during a brief period of prenatal development diminishes vulnerability to neurotoxicity in adolescent offspring...
  8. ncbi request reprint Differential anxiogenic, aversive, and locomotor effects of THC in adolescent and adult rats
    Nicole L Schramm-Sapyta
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Room 100B Research Park Bldg 2, P O Box 3813, Durham, NC 27710, USA
    Psychopharmacology (Berl) 191:867-77. 2007
    ..Unpleasant side effects of drugs of abuse often limit their repeated use; however, such effects may be attenuated in adolescents compared to adults...
  9. ncbi request reprint Executive function deficits in acute stroke
    Sandra Zinn
    Research and Development, Veterans Affairs Medical Center, Durham, NC 27705, USA
    Arch Phys Med Rehabil 88:173-80. 2007
    ..To establish the frequency of executive dysfunction during acute hospitalization for stroke and to examine the relationship of that dysfunction to stroke severity and premorbid characteristics...
  10. ncbi request reprint Magnitude and ethanol sensitivity of tonic GABAA receptor-mediated inhibition in dentate gyrus changes from adolescence to adulthood
    Rebekah L Fleming
    Department of Psychiatry, Duke University Medical Center, Durham, NC, USA
    J Neurophysiol 97:3806-11. 2007
    ....
  11. ncbi request reprint Differential sensitivity of GABA A receptor-mediated IPSCs to cannabinoids in hippocampal slices from adolescent and adult rats
    Maeng hee Kang-Park
    Department of Psychiatry, Durham Veterans Affairs Medical Center, Durham, NC 27705, USA
    J Neurophysiol 98:1223-30. 2007
    ..These results indicate that inhibitory synaptic function in the adolescent hippocampus is more sensitive to cannabinoid effects and may account, in part, for the greater sensitivity of adolescent animals to THC-induced memory impairment...
  12. ncbi request reprint Adjustment to college in students with ADHD
    David L Rabiner
    Duke University, Department of Psychology and Neuroscience, Center for Child and Family Policy, Durham, NC 27707, USA
    J Atten Disord 11:689-99. 2008
    ..To examine college adjustment in students reporting an ADHD diagnosis and the effect of medication treatment on students' adjustment...
  13. ncbi request reprint Motives and perceived consequences of nonmedical ADHD medication use by college students: are students treating themselves for attention problems?
    David L Rabiner
    Duke University, Durham, NC 27708, USA
    J Atten Disord 13:259-70. 2009
    ..This study examines why college students without a prescription take ADHD medication, what they perceive the consequences of this to be, and whether attention problems are associated with this behavior...
  14. ncbi request reprint The misuse and diversion of prescribed ADHD medications by college students
    David L Rabiner
    Center for Child and Family Policy, Department of Psychology and Neuroscience, Duke University, Durham, NC, USA
    J Atten Disord 13:144-53. 2009
    ..This study assesses the misuse and diversion of prescribed attention-deficit/hyperactivity disorder (ADHD) medications...
  15. pmc Predictors of nonmedical ADHD medication use by college students
    David L Rabiner
    Duke University, Durham, NC 27707, USA
    J Atten Disord 13:640-8. 2010
    ..To identify the predictors of nonmedical ADHD medication use by college students...
  16. pmc The synthetic cannabinoid WIN 55212-2 differentially modulates thigmotaxis but not spatial learning in adolescent and adult animals
    Shawn K Acheson
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, United States
    Neurosci Lett 487:411-4. 2011
    ..We suggest that the role of thigmotaxis be carefully evaluated in future neurodevelopmental studies of spatial learning, especially those investigating the endocannabinoid system...
  17. ncbi request reprint College students lack knowledge of standard drink volumes: implications for definitions of risky drinking based on survey data
    Aaron M White
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710, USA
    Alcohol Clin Exp Res 29:631-8. 2005
    ..The study also examined whether feedback regarding the accuracy of their definitions of standard drinks leads students to alter their self-reported levels of consumption...
  18. ncbi request reprint Age-related effects of alcohol on memory and memory-related brain function in adolescents and adults
    Aaron M White
    Duke University Medical Center, Neurobiology Research Labs, Veterans Affairs Medical Center, Durham, North Carolina 27710, USA
    Recent Dev Alcohol 17:161-76. 2005
    ..While research on this topic is still in its infancy, the findings clearly suggest that adolescence represents a unique stage of sensitivity to the impact of alcohol on behavior and brain function...
  19. ncbi request reprint Adolescent-onset nicotine self-administration modeled in female rats
    Edward D Levin
    Neurobehavioral Research Laboratory, Department of Psychiatry, Duke University Medical Center, 341 Bell Building, Box 3412, Durham, NC 27710, USA
    Psychopharmacology (Berl) 169:141-9. 2003
    ..Although the great majority of tobacco addiction begins during adolescence, little is known about differential nicotine effects in adolescents versus adults...
  20. ncbi request reprint Chronic-intermittent ethanol exposure during adolescence prevents normal developmental changes in sensitivity to ethanol-induced motor impairments
    Aaron M White
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710, USA
    Alcohol Clin Exp Res 26:960-8. 2002
    ..In the present study we examined the impact of repeated ethanol exposure during adolescence and adulthood on subsequent sensitivity to ethanol-induced motor impairments...
  21. ncbi request reprint Performance of recently detoxified patients with alcoholism on a neuropsychological screening test
    Sandra Zinn
    Health Services Research and Development, Building 16, Room 55, Durham Veterans Affairs Medical Center 152, 508 Fulton Street, Durham, NC 27705, USA
    Addict Behav 28:837-49. 2003
    ..Cognitive impairment in a sample of newly detoxified inpatients with alcoholism was examined using the Neurobehavioral Cognitive Status Examination (NCSE)...
  22. ncbi request reprint Do college students drink more than they think? Use of a free-pour paradigm to determine how college students define standard drinks
    Aaron M White
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710, USA
    Alcohol Clin Exp Res 27:1750-6. 2003
    ..This information is critical given the widespread reliance on survey data for assessing the correlates and consequences of college drinking...
  23. ncbi request reprint Differential effects of ethanol on motor coordination in adolescent and adult rats
    Aaron M White
    Department of Psychiatry, Duke University Medical Center, Durham, NC, USA
    Pharmacol Biochem Behav 73:673-7. 2002
    ..Given the critical role of motor coordination in the ability to operate motor vehicles and the central role of balance and coordination in field sobriety tests, these data could have important implications if extended to human subjects...
  24. ncbi request reprint Experiential aspects of alcohol-induced blackouts among college students
    Aaron M White
    Department of Psychiatry, Duke University Medical Center, Neurobiology Research, Durham VA Medical Center, Durham, North Carolina, USA
    Am J Drug Alcohol Abuse 30:205-24. 2004
    ..Characteristics of blackouts among college students in the present study are compared to the standard model of blackouts based on reports from alcoholics...
  25. ncbi request reprint Predictors of relapse during treatment and treatment completion among marijuana-dependent adolescents in an intensive outpatient substance abuse program
    Aaron M White
    Department of Psychiatry, Duke University Medical Center, Box 3374, Durham, NC 27710, USA
    Subst Abus 25:53-9. 2004
    ..These findings add to a slowly growing literature regarding adolescent substance abuse treatment, and may help clinicians identify marijuana-dependent adolescents at greater risk of relapse or noncompliance...
  26. ncbi request reprint Executive functioning early in abstinence from alcohol
    Sandra Zinn
    Research and Development, Health Services Research and Development, Durham Veterans Affairs Medical Center, Durham, North Carolina 27705, USA
    Alcohol Clin Exp Res 28:1338-46. 2004
    ..The type(s) and extent of executive dysfunction early in abstinence have not been well characterized, but they may have important implications for the evolution of behavioral treatment strategies...
  27. ncbi request reprint Differential effect of ethanol on NMDA EPSCs in pyramidal cells in the posterior cingulate cortex of juvenile and adult rats
    Qiang Li
    Department of Pharmacology and Cancer Biology, Neurology Research, Veterans Affairs Medical Center, 508 Fulton Street, Durham, North Carolina 27705, USA
    J Neurophysiol 87:705-11. 2002
    ..These results provide a cellular analysis of the enhanced potency of ethanol against NMDA receptor-mediated EPSCs in neocortical cells from juvenile animals compared with adults...
  28. ncbi request reprint Prevalence and correlates of alcohol-induced blackouts among college students: results of an e-mail survey
    Aaron M White
    Department of Psychiatry, Duke University, Durham, North Carolina 27710, USA
    J Am Coll Health 51:117-9, 122-31. 2002
    ..The female students who reported blackouts during the 2 weeks before the survey drank far less than male students did during this time period, supporting the use of gender-specific definitions of risky drinking...
  29. pmc Role of cannabinoid receptor type 1 desensitization in greater tetrahydrocannabinol impairment of memory in adolescent rats
    Nicole L T Moore
    Duke University Medical Center, Room 100B, Research Park II, Box 3813, Durham, NC 27710, USA
    J Pharmacol Exp Ther 335:294-301. 2010
    ..THC may impair learning in adolescents more than in adults because of delayed activation of cellular homeostatic adaptive mechanisms underlying cannabinoid tolerance in the hippocampus...
  30. ncbi request reprint Prenatal dietary choline availability alters postnatal neurotoxic vulnerability in the adult rat
    Shirley X Guo-Ross
    Neurobiology Research Laboratory, VA Medical Center, 27705, Durham, NC, USA
    Neurosci Lett 341:161-3. 2003
    ..These data show that availability of choline during a brief prenatal period diminishes vulnerability to neurotoxicity in adult offspring...
  31. pmc Early ethanol consumption predicts relapse-like behavior in adolescent male rats
    Nicole L Schramm-Sapyta
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Alcohol Clin Exp Res 32:754-62. 2008
    ..We assessed an array of behavioral and hormonal characteristics in adolescent (28-day-old) male rats before exposure to ethanol, and then determined which rats were most prone to high levels of alcohol drinking...
  32. ncbi request reprint Dietary prenatal choline supplementation alters postnatal hippocampal structure and function
    Qiang Li
    Neurobiology Research Laboratory, Veterans Affairs Medical Center, Durham 27705, USA
    J Neurophysiol 91:1545-55. 2004
    ..These data indicate that dietary supplementation with a single nutrient, choline, during a brief, critical period of prenatal development, alters the structure and function of hippocampal pyramidal cells...
  33. ncbi request reprint Adolescent vulnerabilities to chronic alcohol or nicotine exposure: findings from rodent models
    Susan Barron
    Psychology Department, University of Kentucky, Lexington, KY 40506 0044, USA
    Alcohol Clin Exp Res 29:1720-5. 2005
    ..Finally, Linda Spear provided some summary points and recommendations regarding unresolved issues and future directions...
  34. ncbi request reprint Cognitive deficits and CNS damage after a 4-day binge ethanol exposure in rats
    Jennifer A Obernier
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, 27599 7178, USA
    Pharmacol Biochem Behav 72:521-32. 2002
    ..The perseverative nature of the behavioral deficit could be related to both cognitive dysfunction and the behavioral components of the addiction process...
  35. ncbi request reprint Transformation of mu-opioid receptor agonists into biologically potent mu-opioid receptor antagonists
    Tingyou Li
    The Graduate School of Food and Medicinal Sciences, Kobe Gakuin University, Nishi ku, Kobe 651 2180, Japan
    Bioorg Med Chem 15:1237-51. 2007
    ..Thus, N-allylation of Dmt containing opioid peptides or opioidmimetics continues to provide a facile means to convert selective mu-opioid agonists into potent mu-opioid antagonists...
  36. ncbi request reprint Adolescence: booze, brains, and behavior
    Peter M Monti
    Veterans Affairs Medical Center, Brown University, Providence, Rhode Island 02912, USA
    Alcohol Clin Exp Res 29:207-20. 2005
    ..5) Alcohol-Induced Memory Impairments, Including Blackouts, and the Changing Adolescent Brain, by Aaron M. White and H. Scott Swartzwelder; and (6) Discussion, by Kenneth Sher...

Research Grants3

  1. LONG TERM EFFECTS OF ETHANOL EXPOSURE DURING ADOLESCENCE
    H Swartzwelder; Fiscal Year: 2004
    ..abstract_text> ..
  2. Ethanol and GABA Function: Developmental Sensitivity
    H Swartzwelder; Fiscal Year: 2008
    ..post-synaptic nature of the developmental sensitivity that we have observed, and directly test several candidate mechanisms which may underlie these developmental changes in ethanol sensitivity [unreadable] [unreadable]..
  3. Developmental THC Sensitivity in Male and Female Rats
    H Swartzwelder; Fiscal Year: 2008
    ..Specific Aims 2&3 will use electrophysiological and biochemical techniques to test specific mechanisms that may underlie the behavioral effects we have observed in our preliminary data. ..