Research Topics
 M C ReedSummaryAffiliation: Duke University Medical Center Country: USA Publications
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Publications
 Mathematical analysis of the regulation of competing methyltransferasesMichael C Reed
Department of Mathematics, Duke University, Durham, 27708, NC, USA
BMC Syst Biol 9:69. 2015..If the flux along one pathway is changed then the SAM concentration will change affecting all the other MT pathways, so it is difficult for the cell to regulate the pathways independently...  Mathematical modeling of the effects of glutathione on arsenic methylationSean D Lawley
Department of Mathematics, Duke University, Durham, NC 27708, USA
Theor Biol Med Model 11:20. 2014..In addition, in rats arsenicglutathione conjugates can be exported into the plasma and removed by the liver in the bile...  Computational studies of the role of serotonin in the basal gangliaMichael C Reed
Department of Mathematics, Duke University Durham, NC, USA
Front Integr Neurosci 7:41. 2013..There may be situations in which there are physiological reasons to "unbalance" the direct and indirect pathways, and we show that projections to the DRN from the cortex or other brain regions could accomplish this task...  Mathematical insights into the effects of levodopaMichael C Reed
Department of Mathematics, Duke University Durham, NC, USA
Front Integr Neurosci 6:21. 2012..Our results are consistent with and help explain results in the experimental literature and provide new predictions that can be tested experimentally...  The biochemistry of acetaminophen hepatotoxicity and rescue: a mathematical modelRotem BenShachar
Program in Computational Biology and Bioinformatics, Duke University, Durham, NC, USA
Theor Biol Med Model 9:55. 2012..The standard treatment for overdose is Nacetylcysteine (NAC), which is given to stimulate the production of glutathione...  Mathematical model insights into arsenic detoxificationSean D Lawley
Department of Mathematics, Duke University, 130 Science Drive, Durham, NC 27708, USA
Theor Biol Med Model 8:31. 2011....  In silico experimentation with a model of hepatic mitochondrial folate metabolismH Frederik Nijhout
Department of Biology, Duke University, Durham, NC 27708, USA
Theor Biol Med Model 3:40. 2006....  Homeostatic mechanisms in dopamine synthesis and release: a mathematical modelJanet A Best
Department of Mathematics, The Ohio State University, Columbus, OH 43210, USA
Theor Biol Med Model 6:21. 2009....  Serotonin synthesis, release and reuptake in terminals: a mathematical modelJanet Best
Department of Mathematics, The Ohio State University, Columbus, OH 43210, USA
Theor Biol Med Model 7:34. 2010..The scientific issues are daunting but important for human health because of the use of selective serotonin reuptake inhibitors and other pharmacological agents to treat disorders in the serotonergic signaling system...  A mathematical model for LH release in response to continuous and pulsatile exposure of gonadotrophs to GnRHTalitha M Washington
Department of Mathematics, College of New Rochelle, USA
Theor Biol Med Model 1:9. 2004..The mathematical model allows us to assess the effects of internalization and desensitization on the shapes and time courses of LH response curves...  The biological significance of substrate inhibition: a mechanism with diverse functionsMichael C Reed
Department of Mathematics, Duke University, Durham, NC 27708, USA
Bioessays 32:4229. 2010..Substrate inhibition of DNA methyltransferase serves to faithfully copy DNA methylation patterns when cells divide while preventing de novo methylation of methylfree promoter regions...  A mathematical model of glutathione metabolismMichael C Reed
Department of Mathematics, Duke University, Durham, NC 27708, USA
Theor Biol Med Model 5:8. 2008..Deficits in glutathione have been implicated in aging and a host of diseases including Alzheimer's disease, Parkinson's disease, cardiovascular disease, cancer, Down syndrome and autism...  Model calculations of steady state responses to binaural stimuli in the dorsal nucleus of the lateral lemniscusM C Reed
Department of Mathematics, Duke University, Durham, NC 27708 0320, USA
Hear Res 136:1328. 1999..Furthermore, we propose a simple mechanism by which the cells of the DNLL and LSO could create a topographic place map in the inferior colliculus...  Precision of neural timing: effects of convergence and timewindowingMichael C Reed
Department of Mathematics, Duke University, Durham, NC 27708, USA
J Comput Neurosci 13:3547. 2002..For appropriate choices of m, epsilon, and f, the standard deviation sigma(n,m,epsilon) may be as low as 1/n. Thus, depending on these variables, remarkable improvements in timing accuracy of such a stochastic system may occur...  A mathematical model of the methionine cycleMichael C Reed
Department of Mathematics, Duke University, Durham, NC 27708, USA
J Theor Biol 226:3343. 2004..We conduct computational "experiments" that give understanding of the regulatory behavior of the methionine cycle under normal conditions and the behavior in the presence of genetic variation and dietary deficiencies...  Model calculations of time dependent responses to binaural stimuli in the dorsal nucleus of the lateral lemniscusJ J Blum
Division of Physiology, Department of Cell Biology, Duke University Medical Center, Durham, NC 27708 0320, USA
Hear Res 149:7790. 2000....  A mathematical model gives insights into nutritional and genetic aspects of folatemediated onecarbon metabolismMichael C Reed
Department of Mathematics, Duke University, Durham, NC 27708, USA
J Nutr 136:265361. 2006..These mathematical simulations of folatemediated 1carbon metabolism provide a costefficient approach to in silico experimentation that can complement and help guide laboratory studies...  Robustness of a neural network model for differencingA Solodovnikov
Department of Mathematics, Duke University, Durham, NC 27708, USA
J Comput Neurosci 11:16573. 2001..There is some evidence that the network exists in the neural tissue of the auditory brainstem...  A mathematical model quantifying GnRHinduced LH secretion from gonadotropesJ J Blum
Department of Cell Biology, Duke University Medical Center, Durham 27710, North Carolina, USA
Am J Physiol Endocrinol Metab 278:E26372. 2000..Despite these and other simplifications, the model explains the qualitative features of LH release in response to GnRH pulses of various durations and different concentrations in the presence and absence of external Ca(2+)...  Longrange allosteric interactions between the folate and methionine cycles stabilize DNA methylation reaction rateH Frederik Nijhout
Department of Biology, Duke University, Durham, North Carolina 27708, USA
Epigenetics 1:817. 2006..In silico experimentation allows us to evaluate the independent effects of various combinations of the longrange interactions, and thereby propose a plausible evolutionary scenario...  A mathematical model of the folate cycle: new insights into folate homeostasisH Frederik Nijhout
Departments of Biology and Mathematics, Duke University, Durham, NC 27708, USA
J Biol Chem 279:5500816. 2004..In the presence of folate binding and allosteric inhibition, the velocities show a remarkable constancy as total folate is decreased...  A mathematical model gives insights into the effects of vitamin B6 deficiency on 1carbon and glutathione metabolismH Frederik Nijhout
Department of Biology, Duke University, Durham, NC 27708, USA
J Nutr 139:78491. 2009..Our simulations showed that the primary function of SHMT was to increase the rate by which the glycineserine balance was reequilibrated after a perturbation...  A mathematical model for the regulation of juvenile hormone titersH Frederik Nijhout
Department of Biology, Duke University, Durham, NC 27708, USA
J Insect Physiol 54:25564. 2008..These analyses suggest that there is a critical need to develop a better understanding of the in vivo role of synthesis, sequestration and degradation in JH titer regulation...  Mathematical models of folatemediated onecarbon metabolismH F Nijhout
Department of Biology, Duke University, Durham, North Carolina 27705, USA
Vitam Horm 79:4582. 2008....  Propagation of fluctuations in biochemical systems, I: linear SSC networksDavid F Anderson
Department of Mathematics, Duke University, Durham, NC 27708, USA
Bull Math Biol 69:1791813. 2007..We also investigate the asymptotic behavior of the system as one reaction becomes fast relative to the others...  The role of skeletal muscle in liver glutathione metabolism during acetaminophen overdoseL M Bilinsky
Department of Mathematics, Duke University, United States Electronic address
J Theor Biol 376:11833. 2015..Finally, we explain why supplementation with Gln, a Glu precursor, assists in the preservation of liver GSH during APAP overdose despite the fact that under normal conditions only Cys is ratelimiting for GSH formation. ..  Neural tube defects and folate pathway genes: familybased association tests of genegene and geneenvironment interactionsAbee L Boyles
Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
Environ Health Perspect 114:154752. 2006..Most studies addressed these genes individually, often with different populations providing conflicting results...  Flavindependent thymidylate synthase ThyX activity: implications for the folate cycle in bacteriaDamien Leduc
Inserm Avenir Group, Institut de Génétique et de Microbiologie, CNRS UMR8621, F 91405 Orsay, France
J Bacteriol 189:853745. 2007..In addition, our observations suggest that the presence of flavindependent thymidylate synthase X provides growth benefits under conditions in which the level of reduced folate derivatives is compromised...