Affiliation: Duke University Medical Center
- High-throughput quantitative analysis of HIV-1 and SIV-specific ADCC-mediating antibody responsesJustin Pollara
Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
Cytometry A 79:603-12. 2011....
- Vaccine-induced plasma IgA specific for the C1 region of the HIV-1 envelope blocks binding and effector function of IgGGeorgia D Tomaras
Duke Human Vaccine Institute, and Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
Proc Natl Acad Sci U S A 110:9019-24. 2013..We show that monomeric Env-specific IgA, as part of postvaccination polyclonal antibody response, may modulate vaccine-induced immunity by diminishing ADCC effector function...
- Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2Hua Xin Liao
Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA
Immunity 38:176-86. 2013..Variation may signal sites of HIV-1 envelope vulnerability, providing vaccine designers with new options...
- Epitope specificity of human immunodeficiency virus-1 antibody dependent cellular cytotoxicity [ADCC] responsesJustin Pollara
Department of Surgery, Duke University Medical Center, P O Box 2926, Durham, NC 27710, USA
Curr HIV Res 11:378-87. 2013..Here we discuss the HIV-1 envelope epitopes targeted by ADCC antibodies in the context of the potential protective capacities of ADCC. ..
- HIV-1 vaccine-induced C1 and V2 Env-specific antibodies synergize for increased antiviral activitiesJustin Pollara
Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
J Virol 88:7715-26. 2014..This is a major step in understanding how these types of antibodies may have cooperatively contributed to reducing infection risk and should be considered in the context of prospective vaccine design...
- Mucosal immunization of lactating female rhesus monkeys with a transmitted/founder HIV-1 envelope induces strong Env-specific IgA antibody responses in breast milkGenevieve G A Fouda
Duke Human Vaccine Institute, Durham, North Carolina, USA
J Virol 87:6986-99. 2013..This study shows that systemic MVA prime followed by either intranasal or systemic protein boosts can elicit strong humoral responses in breast milk and may be a useful strategy to interrupt postnatal HIV-1 transmission...
- Isolation of HIV-1-neutralizing mucosal monoclonal antibodies from human colostrumJames Friedman
Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, United States
PLoS ONE 7:e37648. 2012..Therefore, characterization of HIV-specific antibodies produced by B cells in milk could guide the development of vaccines that elicit protective mucosal antibody responses...
- Antibody-dependent cellular cytotoxicity-mediating antibodies from an HIV-1 vaccine efficacy trial target multiple epitopes and preferentially use the VH1 gene familyMattia Bonsignori
Duke University Medical Center, Durham, North Carolina, USA
J Virol 86:11521-32. 2012..The polyclonality and low mutation frequency of these VH1 antibodies reveal fundamental differences in the regulation and maturation of these ADCC-mediating responses compared to VH1 bNAbs...
- Infant HIV type 1 gp120 vaccination elicits robust and durable anti-V1V2 immunoglobulin G responses and only rare envelope-specific immunoglobulin A responsesGenevieve G Fouda
Duke University, Durham, North Carolina
J Infect Dis 211:508-17. 2015..Infant responses to vaccines can be impeded by maternal antibodies and immune system immaturity. It is therefore unclear whether human immunodeficiency virus type 1 (HIV-1) vaccination would elicit similar responses in adults and infants...
- HIV-1 gp120 vaccine induces affinity maturation in both new and persistent antibody clonal lineagesM Anthony Moody
Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, USA
J Virol 86:7496-507. 2012..Improved vaccination strategies will be needed to drive persistent stimulation of antibody clonal lineages to induce affinity maturation that results in highly mutated HIV-1 Env-reactive antibodies...
- HIV-1 VACCINES. Diversion of HIV-1 vaccine-induced immunity by gp41-microbiota cross-reactive antibodiesWilton B Williams
Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA
Science 349:aab1253. 2015..Thus, HIV-1 Env DNA-rAd5 vaccine induced a dominant IM-polyreactive, non-neutralizing gp41-reactive Ab repertoire response that was associated with no vaccine efficacy. ..
- Vaccine-induced HIV-1 envelope gp120 constant region 1-specific antibodies expose a CD4-inducible epitope and block the interaction of HIV-1 gp140 with galactosylceramideS Moses Dennison
Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, USA
J Virol 88:9406-17. 2014..However, the MAb 17B itself did not block Env-Galcer binding, suggesting that the C1 antibody-induced gp120 conformational changes resulted in alteration in a Galcer binding site distant from the CD4i 17B MAb binding site...
- HIV-specific functional antibody responses in breast milk mirror those in plasma and are primarily mediated by IgG antibodiesGenevieve G Fouda
Duke Human Vaccine Institute, Duke University Medical Center, Box 103020, Durham, NC 27710, USA
J Virol 85:9555-67. 2011..These results suggest that plasma-derived IgG antibodies mediate the majority of the low-level HIV neutralization and ADCC activity in breast milk...
- Association of HIV-1 Envelope-Specific Breast Milk IgA Responses with Reduced Risk of Postnatal Mother-to-Child Transmission of HIV-1Justin Pollara
Department of Surgery, Duke University School of Medicine, Durham, North Carolina, USA
J Virol 89:9952-61. 2015..This finding supports further investigations into the mechanisms by which mucosal IgA reduces risk of HIV-1 transmission via breast milk and into immune interventions aimed at enhancing this response...
- An HIV-1 gp120 envelope human monoclonal antibody that recognizes a C1 conformational epitope mediates potent antibody-dependent cellular cytotoxicity (ADCC) activity and defines a common ADCC epitope in human HIV-1 serumGuido Ferrari
Duke University Medical Center, Department of Surgery, P O Box 2926, Durham, NC 27710, USA
J Virol 85:7029-36. 2011..These data demonstrate that the epitope defined by MAb A32 is a major target on gp120 for plasma ADCC activity...