Slave Petrovski

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. doi request reprint Phenomics and the interpretation of personal genomes
    Slave Petrovski
    Center for Human Genome Variation, Duke University School of Medicine, Durham, NC, 27708, USA Department of Medicine, The University of Melbourne, Austin Health and Royal Melbourne Hospital, Melbourne, Victoria 3050, Australia
    Sci Transl Med 6:254fs35. 2014
  2. pmc Genic intolerance to functional variation and the interpretation of personal genomes
    Slave Petrovski
    Center for Human Genome Variation, Duke University, School of Medicine, Durham, North Carolina, United States of America
    PLoS Genet 9:e1003709. 2013
  3. pmc Common human genetic variants and HIV-1 susceptibility: a genome-wide survey in a homogeneous African population
    Slave Petrovski
    Center for Human Genome Variation, School of Medicine, Duke University, Durham, North Carolina 27708, USA
    AIDS 25:513-8. 2011
  4. pmc The Intolerance of Regulatory Sequence to Genetic Variation Predicts Gene Dosage Sensitivity
    Slave Petrovski
    Institute for Genomic Medicine, Columbia University, New York, New York, United States of America Center for Human Genome Variation, Duke University, School of Medicine, Durham, North Carolina, United States of America Department of Medicine, The University of Melbourne, Austin Health and Royal Melbourne Hospital, Melbourne, Victoria, Australia
    PLoS Genet 11:e1005492. 2015
  5. pmc Sequencing studies in human genetics: design and interpretation
    David B Goldstein
    Center for Human Genome Variation, Duke University School of Medicine, 308 Research Drive, Box 91009, LSRC B Wing, Room 330, Durham, North Carolina 27708, USA
    Nat Rev Genet 14:460-70. 2013
  6. pmc A genome-wide comparison of the functional properties of rare and common genetic variants in humans
    Qianqian Zhu
    Center for Human Genome Variation, Duke University School of Medicine, Durham, NC 27708, USA
    Am J Hum Genet 88:458-68. 2011
  7. pmc Whole-exome sequencing in undiagnosed genetic diseases: interpreting 119 trios
    Xiaolin Zhu
    Center for Human Genome Variation, Duke University School of Medicine, Durham, North Carolina, USA
    Genet Med 17:774-81. 2015
  8. pmc Incorporating Functional Information in Tests of Excess De Novo Mutational Load
    Yu Jiang
    Department of Biostatistics and Bioinformatics, Duke University, Durham, NC 27710, USA
    Am J Hum Genet 97:272-83. 2015
  9. doi request reprint One gene, many neuropsychiatric disorders: lessons from Mendelian diseases
    Xiaolin Zhu
    Center for Human Genome Variation, Duke University School of Medicine, Durham, North Carolina, USA
    Nat Neurosci 17:773-81. 2014
  10. doi request reprint Unraveling the genetics of common epilepsies: approaches, platforms, and caveats
    Slave Petrovski
    Department of Medicine, University of Melbourne, Austin Health, Melbourne, Australia
    Epilepsy Behav 26:229-33. 2013

Collaborators

Detail Information

Publications11

  1. doi request reprint Phenomics and the interpretation of personal genomes
    Slave Petrovski
    Center for Human Genome Variation, Duke University School of Medicine, Durham, NC, 27708, USA Department of Medicine, The University of Melbourne, Austin Health and Royal Melbourne Hospital, Melbourne, Victoria 3050, Australia
    Sci Transl Med 6:254fs35. 2014
    ..In contemporary genomics research, phenotype-driven bioinformatics approaches hint at the potential of establishing a framework for quantifying phenotypic similarities among patients (Zemojtel et al., issue 252). ..
  2. pmc Genic intolerance to functional variation and the interpretation of personal genomes
    Slave Petrovski
    Center for Human Genome Variation, Duke University, School of Medicine, Durham, North Carolina, United States of America
    PLoS Genet 9:e1003709. 2013
    ..We conclude by showing that use of an intolerance ranking system can aid in interpreting personal genomes and identifying pathogenic mutations. ..
  3. pmc Common human genetic variants and HIV-1 susceptibility: a genome-wide survey in a homogeneous African population
    Slave Petrovski
    Center for Human Genome Variation, School of Medicine, Duke University, Durham, North Carolina 27708, USA
    AIDS 25:513-8. 2011
    ..We investigated whether common genetic variants associate with HIV-1 susceptibility in Africans...
  4. pmc The Intolerance of Regulatory Sequence to Genetic Variation Predicts Gene Dosage Sensitivity
    Slave Petrovski
    Institute for Genomic Medicine, Columbia University, New York, New York, United States of America Center for Human Genome Variation, Duke University, School of Medicine, Durham, North Carolina, United States of America Department of Medicine, The University of Melbourne, Austin Health and Royal Melbourne Hospital, Melbourne, Victoria, Australia
    PLoS Genet 11:e1005492. 2015
    ....
  5. pmc Sequencing studies in human genetics: design and interpretation
    David B Goldstein
    Center for Human Genome Variation, Duke University School of Medicine, 308 Research Drive, Box 91009, LSRC B Wing, Room 330, Durham, North Carolina 27708, USA
    Nat Rev Genet 14:460-70. 2013
    ..Here, we provide an overview of the basic workflow in next-generation sequencing studies and emphasize, where possible, measures and considerations that facilitate accurate inferences from human sequencing studies...
  6. pmc A genome-wide comparison of the functional properties of rare and common genetic variants in humans
    Qianqian Zhu
    Center for Human Genome Variation, Duke University School of Medicine, Durham, NC 27708, USA
    Am J Hum Genet 88:458-68. 2011
    ....
  7. pmc Whole-exome sequencing in undiagnosed genetic diseases: interpreting 119 trios
    Xiaolin Zhu
    Center for Human Genome Variation, Duke University School of Medicine, Durham, North Carolina, USA
    Genet Med 17:774-81. 2015
    ..Here, we extend this paradigm by evaluating novel bioinformatics approaches to aid identification of new gene-disease associations...
  8. pmc Incorporating Functional Information in Tests of Excess De Novo Mutational Load
    Yu Jiang
    Department of Biostatistics and Bioinformatics, Duke University, Durham, NC 27710, USA
    Am J Hum Genet 97:272-83. 2015
    ....
  9. doi request reprint One gene, many neuropsychiatric disorders: lessons from Mendelian diseases
    Xiaolin Zhu
    Center for Human Genome Variation, Duke University School of Medicine, Durham, North Carolina, USA
    Nat Neurosci 17:773-81. 2014
    ..Ultimately, we conclude that functional approaches will be critical for explaining the causes of nonspecific risk factors discovered by human genetic studies of neuropsychiatric disorders. ..
  10. doi request reprint Unraveling the genetics of common epilepsies: approaches, platforms, and caveats
    Slave Petrovski
    Department of Medicine, University of Melbourne, Austin Health, Melbourne, Australia
    Epilepsy Behav 26:229-33. 2013
    ..We briefly discuss the analytical options made available through rapid advances in sequencing and other genomic technologies...
  11. pmc Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways
    Elizabeth T Cirulli
    Center for Applied Genomics and Precision Medicine, Duke University School of Medicine, Durham, NC 27708, USA
    Science 347:1436-41. 2015
    ..These observations reveal a key role of the autophagic pathway in ALS and suggest specific targets for therapeutic intervention. ..