CHRISTOPHER M O'CONNOR

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Combinatorial pharmacogenetic interactions of bucindolol and β1, α2C adrenergic receptor polymorphisms
    CHRISTOPHER M O'CONNOR
    Division of Cardiology, Duke University Medical Center Duke Clinical Research Institute, Durham, North Carolina, United States of America
    PLoS ONE 7:e44324. 2012
  2. pmc Safety and efficacy of sertraline for depression in patients with heart failure: results of the SADHART-CHF (Sertraline Against Depression and Heart Disease in Chronic Heart Failure) trial
    CHRISTOPHER M O'CONNOR
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Am Coll Cardiol 56:692-9. 2010
  3. pmc Worsening depressive symptoms are associated with adverse clinical outcomes in patients with heart failure
    Andrew Sherwood
    Duke University Medical Center, Durham, North Carolina 27710, USA
    J Am Coll Cardiol 57:418-23. 2011
  4. pmc Markers of decongestion, dyspnea relief, and clinical outcomes among patients hospitalized with acute heart failure
    Robb D Kociol
    Duke Clinical Research Institute, Durham, NC, USA
    Circ Heart Fail 6:240-5. 2013
  5. ncbi request reprint Racial differences in the characteristics of patients admitted for acute decompensated heart failure and their relation to outcomes: results from the OPTIME-CHF trial
    Melvin R Echols
    Duke Clinical Research Institute, Durham, North Carolina 27705, USA
    J Card Fail 12:684-8. 2006
  6. ncbi request reprint Systolic blood pressure at admission, clinical characteristics, and outcomes in patients hospitalized with acute heart failure
    Mihai Gheorghiade
    Division of Cardiology, Feinberg School of Medicine, Northwestern University, Chicago, Ill, USA
    JAMA 296:2217-26. 2006
  7. doi request reprint Comparison of medical therapy dosing in outpatients cared for in cardiology practices with heart failure and reduced ejection fraction with and without device therapy: report from IMPROVE HF
    J Thomas Heywood
    Division of Cardiology, Scripps Clinic Torrey Pines, La Jolla, Calif 92037, USA
    Circ Heart Fail 3:596-605. 2010
  8. doi request reprint Dosing of beta-blocker therapy before, during, and after hospitalization for heart failure (from Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure)
    Gregg C Fonarow
    Department of Medicine, UCLA Medical Center, Los Angeles, CA, USA
    Am J Cardiol 102:1524-9. 2008
  9. ncbi request reprint Influence of a performance-improvement initiative on quality of care for patients hospitalized with heart failure: results of the Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients With Heart Failure (OPTIMIZE-HF)
    Gregg C Fonarow
    Department of Medicine, University of California Los Angeles Medical Center, 10833 LeConte Ave, Room 47 123 CHS, Los Angeles, CA 90095 1679, USA
    Arch Intern Med 167:1493-502. 2007
  10. ncbi request reprint Relationship between depressive symptoms and long-term mortality in patients with heart failure
    Wei Jiang
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am Heart J 154:102-8. 2007

Collaborators

Detail Information

Publications116 found, 100 shown here

  1. pmc Combinatorial pharmacogenetic interactions of bucindolol and β1, α2C adrenergic receptor polymorphisms
    CHRISTOPHER M O'CONNOR
    Division of Cardiology, Duke University Medical Center Duke Clinical Research Institute, Durham, North Carolina, United States of America
    PLoS ONE 7:e44324. 2012
    ....
  2. pmc Safety and efficacy of sertraline for depression in patients with heart failure: results of the SADHART-CHF (Sertraline Against Depression and Heart Disease in Chronic Heart Failure) trial
    CHRISTOPHER M O'CONNOR
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Am Coll Cardiol 56:692-9. 2010
    ..The objective was to test the hypothesis that heart failure (HF) patients treated with sertraline will have lower depression scores and fewer cardiovascular events compared with placebo...
  3. pmc Worsening depressive symptoms are associated with adverse clinical outcomes in patients with heart failure
    Andrew Sherwood
    Duke University Medical Center, Durham, North Carolina 27710, USA
    J Am Coll Cardiol 57:418-23. 2011
    ..The purpose of this study was to assess the impact of changes in symptoms of depression over a 1-year period on subsequent clinical outcomes in heart failure (HF) patients...
  4. pmc Markers of decongestion, dyspnea relief, and clinical outcomes among patients hospitalized with acute heart failure
    Robb D Kociol
    Duke Clinical Research Institute, Durham, NC, USA
    Circ Heart Fail 6:240-5. 2013
    ....
  5. ncbi request reprint Racial differences in the characteristics of patients admitted for acute decompensated heart failure and their relation to outcomes: results from the OPTIME-CHF trial
    Melvin R Echols
    Duke Clinical Research Institute, Durham, North Carolina 27705, USA
    J Card Fail 12:684-8. 2006
    ..Recent data suggest that differences in response to therapy and survival exist between African Americans and Caucasians with heart failure. Whether these differences exist in acute decompensated heart failure (ADHF) is uncertain...
  6. ncbi request reprint Systolic blood pressure at admission, clinical characteristics, and outcomes in patients hospitalized with acute heart failure
    Mihai Gheorghiade
    Division of Cardiology, Feinberg School of Medicine, Northwestern University, Chicago, Ill, USA
    JAMA 296:2217-26. 2006
    ..The association between systolic blood pressure (SBP) at admission, clinical characteristics, and outcomes in patients hospitalized for heart failure who have reduced or relatively preserved systolic function has not been well studied...
  7. doi request reprint Comparison of medical therapy dosing in outpatients cared for in cardiology practices with heart failure and reduced ejection fraction with and without device therapy: report from IMPROVE HF
    J Thomas Heywood
    Division of Cardiology, Scripps Clinic Torrey Pines, La Jolla, Calif 92037, USA
    Circ Heart Fail 3:596-605. 2010
    ..Few data exist to characterize the delivery of evidence-based medical therapy for outpatients with heart failure who have received implantable cardioverter-defibrillators or cardiac resynchronization therapy (CRT) for systolic dysfunction...
  8. doi request reprint Dosing of beta-blocker therapy before, during, and after hospitalization for heart failure (from Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure)
    Gregg C Fonarow
    Department of Medicine, UCLA Medical Center, Los Angeles, CA, USA
    Am J Cardiol 102:1524-9. 2008
    ..In the first 60 to 90 days after hospital discharge, little up-titration in beta-blocker dosing occurs. Further efforts are needed to help understand and overcome this beta-blocker titration gap...
  9. ncbi request reprint Influence of a performance-improvement initiative on quality of care for patients hospitalized with heart failure: results of the Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients With Heart Failure (OPTIMIZE-HF)
    Gregg C Fonarow
    Department of Medicine, University of California Los Angeles Medical Center, 10833 LeConte Ave, Room 47 123 CHS, Los Angeles, CA 90095 1679, USA
    Arch Intern Med 167:1493-502. 2007
    ..We sought to evaluate the effect of a national hospital-based initiative on quality of care in patients hospitalized with HF...
  10. ncbi request reprint Relationship between depressive symptoms and long-term mortality in patients with heart failure
    Wei Jiang
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am Heart J 154:102-8. 2007
    ..The study sought to assess the association of depressive symptoms and long-term mortality of patients with HF and to explore the prognostic predictability of the Beck Depression Inventory (BDI) scale for patients with HF...
  11. ncbi request reprint Characteristics, treatments, and outcomes of patients with preserved systolic function hospitalized for heart failure: a report from the OPTIMIZE-HF Registry
    Gregg C Fonarow
    Ahmanson UCLA Cardiomyopathy Center, Department of Medicine, UCLA Medical Center, Los Angeles, California 90095 1679, USA
    J Am Coll Cardiol 50:768-77. 2007
    ..We sought to evaluate the characteristics, treatments, and outcomes of patients with preserved and reduced systolic function heart failure (HF)...
  12. ncbi request reprint Tezosentan in patients with acute heart failure and acute coronary syndromes: results of the Randomized Intravenous TeZosentan Study (RITZ-4)
    CHRISTOPHER M O'CONNOR
    Duke University Medical Center and Duke Clinical Research Institute, Durham, North Carolina 27705, USA
    J Am Coll Cardiol 41:1452-7. 2003
    ..We sought to determine the effect of tezosentan in patients with acute decompensated heart failure (HF) associated with acute coronary syndrome (ACS)...
  13. ncbi request reprint Demographics, clinical characteristics, and outcomes of patients hospitalized for decompensated heart failure: observations from the IMPACT-HF registry
    CHRISTOPHER M O'CONNOR
    Department of Medicine, Division of Cardiology, Duke University Medical Center and Clinical Research Institute, 2400 N Pratt Street, Durham, NC 27705, USA
    J Card Fail 11:200-5. 2005
    ....
  14. doi request reprint Predictors of mortality after discharge in patients hospitalized with heart failure: an analysis from the Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF)
    CHRISTOPHER M O'CONNOR
    Duke University Medical Center Duke Clinical Research Institute, Durham, NC 27705, USA
    Am Heart J 156:662-73. 2008
    ..We developed clinical models predictive of short-term clinical outcomes in a broad patient population discharged after hospitalization for HF...
  15. doi request reprint Predictors of in-hospital mortality in patients hospitalized for heart failure: insights from the Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF)
    William T Abraham
    Division of Cardiology, The Ohio State University, Columbus, Ohio, USA
    J Am Coll Cardiol 52:347-56. 2008
    ..The aim of this study was to develop a clinical model predictive of in-hospital mortality in a broad hospitalized heart failure (HF) patient population...
  16. doi request reprint Ischemia change in stable coronary artery disease is an independent predictor of death and myocardial infarction
    Afshin Farzaneh-Far
    Section of Cardiology, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA
    JACC Cardiovasc Imaging 5:715-24. 2012
    ..The aim of this study was to evaluate the independent prognostic significance of ischemia change in stable coronary artery disease (CAD)...
  17. pmc Galectin-3 in ambulatory patients with heart failure: results from the HF-ACTION study
    G Michael Felker
    Duke University Medical Center, Durham, NC 27710, USA
    Circ Heart Fail 5:72-8. 2012
    ..We evaluated the association between galectin-3 and long-term clinical outcomes in ambulatory heart failure patients enrolled in the HF-ACTION study...
  18. pmc Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial
    CHRISTOPHER M O'CONNOR
    Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA
    JAMA 301:1439-50. 2009
    ..Guidelines recommend that exercise training be considered for medically stable outpatients with heart failure. Previous studies have not had adequate statistical power to measure the effects of exercise training on clinical outcomes...
  19. pmc The effects of exercise on cardiovascular biomarkers in patients with chronic heart failure
    Tariq Ahmad
    Division of Cardiology, Duke University Medical Center, Durham, NC Duke Clinical Research Institute, Durham, NC
    Am Heart J 167:193-202.e1. 2014
    ..Whether exercise training leads to improvements in biomarkers and how such improvements relate to clinical outcomes are unclear...
  20. pmc Predictors of early dyspnoea relief in acute heart failure and the association with 30-day outcomes: findings from ASCEND-HF
    Robert J Mentz
    Duke University Medical Center, Durham, NC, USA
    Eur J Heart Fail 15:456-64. 2013
    ..To examine the characteristics associated with early dyspnoea relief during acute heart failure (HF) hospitalization, and its association with 30-day outcomes...
  21. ncbi request reprint Evaluation study of congestive heart failure and pulmonary artery catheterization effectiveness: the ESCAPE trial
    Cynthia Binanay
    Duke Clinical Research Institute, Durham, NC, USA
    JAMA 294:1625-33. 2005
    ..Pulmonary artery catheters (PACs) have been used to guide therapy in multiple settings, but recent studies have raised concerns that PACs may lead to increased mortality in hospitalized patients...
  22. ncbi request reprint Rationale and design of the pilot randomized study of nesiritide versus dobutamine in heart failure (PRESERVD-HF)
    Mihai Gheorghiade
    Division of Cardiology, Northwestern University, Feinberg School of Medicine, Chicago, Ill 60611, USA
    Am Heart J 145:S55-7. 2003
  23. pmc Factors related to morbidity and mortality in patients with chronic heart failure with systolic dysfunction: the HF-ACTION predictive risk score model
    CHRISTOPHER M O'CONNOR
    Duke Clinical Research Institute, Durham, NC, USA
    Circ Heart Fail 5:63-71. 2012
    ....
  24. doi request reprint Improving evidence-based care for heart failure in outpatient cardiology practices: primary results of the Registry to Improve the Use of Evidence-Based Heart Failure Therapies in the Outpatient Setting (IMPROVE HF)
    Gregg C Fonarow
    Department of Medicine, Ahmanson UCLA Cardiomyopathy Center, UCLA Medical Center, Los Angeles, CA 90095 1679, USA
    Circulation 122:585-96. 2010
    ....
  25. pmc Association of depression and survival in patients with chronic heart failure over 12 Years
    Julie Adams
    Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA
    Psychosomatics 53:339-46. 2012
    ..To examine the relationship between depression and survival in patients with chronic heart failure (HF) over a 12-year follow-up period...
  26. doi request reprint Factors identified as precipitating hospital admissions for heart failure and clinical outcomes: findings from OPTIMIZE-HF
    Gregg C Fonarow
    Department of Medicine, UCLA University of California, Los Angeles Medical Center, Los Angeles, CA 90095 1679, USA
    Arch Intern Med 168:847-54. 2008
    ..This study evaluated the association between precipitating factors identified at the time of HF hospital admission and subsequent clinical outcomes...
  27. ncbi request reprint Mortality risk associated with ejection fraction differs across resting nuclear perfusion findings
    Jamieson M Bourque
    Division of Cardiology, Department of Internal Medicine, Duke University Health System, Durham, NC, USA
    J Nucl Cardiol 14:165-73. 2007
    ..The purpose of this study was to determine whether the mortality risk associated with LVEF is the same across all values of SRS in a population undergoing evaluation for ischemic heart disease...
  28. pmc Outcomes, health policy, and managed care: relationships between patient-reported outcome measures and clinical measures in outpatients with heart failure
    Kathryn E Flynn
    Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC 27715, USA
    Am Heart J 158:S64-71. 2009
    ..We examined associations between patient-reported measures of health-related quality of life and clinical indicators of disease severity in a large, heterogeneous sample of patients with heart failure...
  29. ncbi request reprint Risk stratification after hospitalization for decompensated heart failure
    G Michael Felker
    Duke Clinical Research Institute, 2400 Pratt Street, Room 0311, Terrace Level, Durham, NC 27705, USA
    J Card Fail 10:460-6. 2004
    ..We used data from the Outcomes of a Prospective Trial of Intravenous Milrinone for Exacerbations of Chronic Heart Failure (OPTIME-CHF) study to develop a model that would predict outcomes in patients with decompensated HF...
  30. ncbi request reprint Prognosis of patients taking selective serotonin reuptake inhibitors before coronary artery bypass grafting
    Glen L Xiong
    Department of Internal Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Am J Cardiol 98:42-7. 2006
    ..26 to 1.70, p <0.0001, respectively). In conclusion, SSRI use before CABG was associated with a higher risk of long-term post-CABG mortality and rehospitalization. The explanation behind these findings requires further research...
  31. ncbi request reprint Clinical and economic implications of the Multicenter Automatic Defibrillator Implantation Trial-II
    Sana M Al-Khatib
    Duke Clinical Research Institute, Durham, North Carolina 27715, USA
    Ann Intern Med 142:593-600. 2005
    ..3 or less...
  32. ncbi request reprint Predischarge initiation of carvedilol in patients hospitalized for decompensated heart failure: results of the Initiation Management Predischarge: Process for Assessment of Carvedilol Therapy in Heart Failure (IMPACT-HF) trial
    Wendy A Gattis
    Division of Cardiology, Duke University Medical Center and Duke Clinical Research Institute, Durham, North Carolina, USA
    J Am Coll Cardiol 43:1534-41. 2004
    ....
  33. ncbi request reprint The Initiation Management Predischarge Process for Assessment of Carvedilol Therapy for Heart Failure (IMPACT-HF) Study: design and implications
    Wendy A Gattis
    Department of Medicine, Divisions of Clinical Pharmacology and Cardiology, Duke University Medical Center, Durham, North Carolina, USA
    Rev Cardiovasc Med 3:S48-54. 2002
    ..The trial data will determine if in-hospital initiation of beta-blocker therapy is effective at improving the long-term use of pharmacologic agents proven to reduce morbidity and mortality...
  34. pmc Clinical characteristics, response to exercise training, and outcomes in patients with heart failure and chronic obstructive pulmonary disease: findings from Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing (HF-ACTION)
    Robert J Mentz
    Duke University Medical Center, Durham, NC, USA
    Am Heart J 165:193-9. 2013
    ..The aim of this study was to investigate the clinical characteristics, exercise training response, β-blocker selectivity, and outcomes in patients with heart failure (HF) and chronic obstructive pulmonary disease (COPD)...
  35. doi request reprint Influence of beta-blocker continuation or withdrawal on outcomes in patients hospitalized with heart failure: findings from the OPTIMIZE-HF program
    Gregg C Fonarow
    Department of Medicine, University of California Los Angeles Medical Center, Los Angeles, California 90095 1679, USA
    J Am Coll Cardiol 52:190-9. 2008
    ..This study ascertains the relationship between continuation or withdrawal of beta-blocker therapy and clinical outcomes in patients hospitalized with systolic heart failure (HF)...
  36. pmc N-terminal pro-brain natriuretic peptide and exercise capacity in chronic heart failure: data from the Heart Failure and a Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION) study
    G Michael Felker
    Duke Clinical Research Institute, Durham, NC 27705, USA
    Am Heart J 158:S37-44. 2009
    ..To examine the relationship between N-terminal pro-brain natriuretic peptide (NT-proBNP) and exercise capacity in a large contemporary cohort of patients with chronic heart failure...
  37. ncbi request reprint Comparison of coronary artery bypass grafting versus medical therapy on long-term outcome in patients with ischemic cardiomyopathy (a 25-year experience from the Duke Cardiovascular Disease Databank)
    CHRISTOPHER M O'CONNOR
    Division of Cardiology, Department of Medicine, Duke University Medical Center and Duke Clinical Research Institute, Durham, North Carolina 27715, USA
    Am J Cardiol 90:101-7. 2002
    ..Thus, regardless of the severity of coronary disease, heart failure symptoms, or ventricular dysfunction, CABG provides extended event-free and survival advantage over medical therapy alone in patients with an ischemic cardiomyopathy...
  38. doi request reprint Day of admission and clinical outcomes for patients hospitalized for heart failure: findings from the Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients With Heart Failure (OPTIMIZE-HF)
    Gregg C Fonarow
    Department of Medicine, University of California Los Angeles Medical Center, Los Angeles, CA 90095 1679, USA
    Circ Heart Fail 1:50-7. 2008
    ..This study examined the relationship between the day of the week patients are hospitalized for HF and death rate, length of stay (LOS), and rehospitalization rate...
  39. doi request reprint B-type natriuretic peptide assessment in ambulatory heart failure patients: insights from IMPROVE HF
    Andrew P Ambrosy
    Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
    J Cardiovasc Med (Hagerstown) 13:360-7. 2012
    ....
  40. pmc Long-term survival of patients with ischemic cardiomyopathy treated by coronary artery bypass grafting versus medical therapy
    Eric J Velazquez
    Division of Cardiovascular Medicine, Department of Medicine, Duke University Medical Center, Duke Clinical Research Institute, Durham, North Carolina 27715, USA
    Ann Thorac Surg 93:523-30. 2012
    ....
  41. ncbi request reprint Predicting significant coronary artery disease in patients with left ventricular dysfunction
    David J Whellan
    Department of Medicine, Jefferson Medical College, Philadelphia, PA 19107, USA
    Am Heart J 152:340-7. 2006
    ..The objective of this study was to develop a model to assist clinicians in determining the likelihood of CAD before cardiac catheterization...
  42. ncbi request reprint Left ventricular assessment in myocardial infarction: the VALIANT registry
    Adrian F Hernandez
    Division of Cardiology, Department of Medicine, Duke University Medical Center and Duke Clinical Research Institute, Durham, NC 27715, USA
    Arch Intern Med 165:2162-9. 2005
    ..How often echocardiography and cardiac catheterization are used to evaluate left ventricular (LV) function in patients with myocardial infarction (MI) and how they are associated with quality of care is unknown...
  43. ncbi request reprint Racial differences in the outcomes of patients with diastolic heart failure
    Mark A East
    Outcomes Research and Assessment Group, Duke Clinical Research Institute, Durham, NC 27715, USA
    Am Heart J 148:151-6. 2004
    ..This is particularly common in African American patients, yet there have been few studies examining the long-term natural history of this disorder in African-American and white patients...
  44. ncbi request reprint Rationale and study design for a multicenter, randomized, double-blind, placebo-controlled study of the effects of tolvaptan on the acute and chronic outcomes of patients hospitalized with worsening congestive heart failure
    Mihai Gheorghiade
    Division of Cardiology, Northwestern University, Feinberg School of Medicine, Chicago, Ill 60611, USA
    Am Heart J 145:S51-4. 2003
  45. ncbi request reprint The prognostic importance of different definitions of worsening renal function in congestive heart failure
    Stephen S Gottlieb
    Division of Cardiology, University of Maryland School of Medicine and the D V A Medical Center, Baltimore, Maryland 21201, USA
    J Card Fail 8:136-41. 2002
    ..We therefore compared the prognostic importance of various definitions of worsening renal function in 1,002 patients hospitalized for congestive heart failure (CHF)...
  46. ncbi request reprint Improving the use of evidence-based heart failure therapies in the outpatient setting: the IMPROVE HF performance improvement registry
    Gregg C Fonarow
    Department of Medicine, Ahmanson UCLA Cardiomyopathy Center, Los Angeles, CA 90095 1679, USA
    Am Heart J 154:12-38. 2007
    ..Deidentified clinical data from the medical records of a planned 43,000 patients from 160 US cardiology practices will be included in this study...
  47. doi request reprint Factors associated with improvement in ejection fraction in clinical practice among patients with heart failure: findings from IMPROVE HF
    Jane E Wilcox
    Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Am Heart J 163:49-56.e2. 2012
    ..This study evaluated changes in LVEF and associated factors in outpatients with systolic HF or post-myocardial infarction with reduced LVEF during 24 months of follow-up...
  48. pmc New York Heart Association functional class predicts exercise parameters in the current era
    Stuart D Russell
    Department of Medicine, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Am Heart J 158:S24-30. 2009
    ..Using baseline data from the HF-ACTION (Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing) study, we examined this relationship...
  49. ncbi request reprint Impact of nonfatal myocardial infarction on outcomes in patients with advanced heart failure and the effect of bucindolol therapy
    CHRISTOPHER M O'CONNOR
    Duke University Medical Center, Durham, North Carolina, USA
    Am J Cardiol 95:558-64. 2005
    ..Beta-blocker therapy with bucindolol appears to attenuate the risk of nonfatal MI in this population...
  50. doi request reprint Atrial fibrillation or flutter on initial electrocardiogram is associated with worse outcomes in patients admitted for worsening heart failure with reduced ejection fraction: findings from the EVEREST Trial
    Robert J Mentz
    Duke University Medical Center, Durham, NC, USA
    Am Heart J 164:884-92.e2. 2012
    ..However, the clinical profile and outcomes of patients following hospitalization for HF with AF/AFL on initial electrocardiogram (ECG) has not been well studied...
  51. pmc Characteristics of depression remission and its relation with cardiovascular outcome among patients with chronic heart failure (from the SADHART-CHF Study)
    Wei Jiang
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Am J Cardiol 107:545-51. 2011
    ..5, Beck Depression Inventory scale 17.9 ± 6.5 vs 20.3 ± 7.2, p <0.001 for the 2 comparisons). In conclusion, this study indicates that remission from depression may improve the cardiovascular outcome of patients with heart failure...
  52. pmc Admission, discharge, or change in B-type natriuretic peptide and long-term outcomes: data from Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF) linked to Medicare claims
    Robb D Kociol
    Duke Clinical Research Institute, Department of Medicine, Duke University School of Medicine, Durham, NC, USA
    Circ Heart Fail 4:628-36. 2011
    ..It is unknown if admission, discharge, or change from admission to discharge BNP measure is the most important predictor of long-term outcomes...
  53. doi request reprint Early worsening heart failure in patients admitted with acute heart failure--a new outcome measure associated with long-term prognosis?
    Beth Davison Weatherley
    Momentum Research Inc, Durham, NC, USA
    Fundam Clin Pharmacol 23:633-9. 2009
    ..7-6.3). Early WHF is a common adverse event in patients admitted with AHF, and is associated with AHF severity and excessive 6-month mortality. WHF should be considered as a clinically important endpoint in AHF studies...
  54. doi request reprint Impact of serial troponin release on outcomes in patients with acute heart failure: analysis from the PROTECT pilot study
    CHRISTOPHER M O'CONNOR
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA
    Circ Heart Fail 4:724-32. 2011
    ..The degree and progression of cTnT release during hospitalization of patients with AHF is unclear. We evaluated the incidence of cTnT release during AHF hospitalization and the relationship of cTnT release with outcomes...
  55. doi request reprint Heart failure care in the outpatient cardiology practice setting: findings from IMPROVE HF
    Gregg C Fonarow
    Department of Medicine, Ahmanson UCLA Cardiomyopathy Center, UCLA Medical Center, Los Angeles, CA 90095 1679, USA
    Circ Heart Fail 1:98-106. 2008
    ..IMPROVE HF is a prospective cohort study designed to characterize current management of patients with chronic HF and ejection fraction < or =35% in a national registry of 167 US outpatient cardiology practices...
  56. pmc Effect of peripheral arterial disease on functional and clinical outcomes in patients with heart failure (from HF-ACTION)
    W Schuyler Jones
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Am J Cardiol 108:380-4. 2011
    ..62, p = 0.011). Patients with PAD and HF had deceased baseline exercise capacity and decreased response to exercise training. In conclusion, PAD is an independent predictor of all-cause death or hospitalization in patients with HF...
  57. pmc Antidepressant use, depression, and survival in patients with heart failure
    CHRISTOPHER M O'CONNOR
    Department of Medicine, Duke Clinical Research Institute, Duke University Medical Center, 2400 N Pratt St, Box 3356, Durham, NC 27705, USA
    Arch Intern Med 168:2232-7. 2008
    ..Because depression has also been shown to be associated with increased mortality in these patients, it remains unclear if this association is attributable to the use of antidepressants or to depression...
  58. pmc Myocardial perfusion, function, and dyssynchrony in patients with heart failure: baseline results from the single-photon emission computed tomography imaging ancillary study of the Heart Failure and A Controlled Trial Investigating Outcomes of Exercise Tr
    Allen E Atchley
    Duke University Medical Center, Durham, NC 27710, USA
    Am Heart J 158:S53-63. 2009
    ..This article addresses the Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing (HF-ACTION) gated SPECT imaging (gSPECT) substudy baseline results...
  59. pmc Long-term outcomes and costs of ventricular assist devices among Medicare beneficiaries
    Adrian F Hernandez
    Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA
    JAMA 300:2398-406. 2008
    ..In 2003, Medicare expanded coverage of ventricular assist devices as destination, or permanent, therapy for end-stage heart failure. Little is known about the long-term outcomes and costs associated with these devices...
  60. doi request reprint Medical resource use, costs, and quality of life in patients with acute decompensated heart failure: findings from ASCEND-HF
    Shelby D Reed
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina Department of Medicine, Duke University School of Medicine, Durham, North Carolina Electronic address
    J Card Fail 19:611-20. 2013
    ..We compared medical resource use, costs, and health utilities between the treatment groups...
  61. ncbi request reprint Pharmacoeconomic analysis of sertraline treatment of depression in patients with unstable angina or a recent myocardial infarction
    CHRISTOPHER M O'CONNOR
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    J Clin Psychiatry 66:346-52. 2005
    ....
  62. pmc Soluble ST2 in ambulatory patients with heart failure: Association with functional capacity and long-term outcomes
    G Michael Felker
    Division of Cardiology, Duke University Medical Center, Durham, NC
    Circ Heart Fail 6:1172-9. 2013
    ....
  63. ncbi request reprint Impact of mitral valve regurgitation evaluated by intraoperative transesophageal echocardiography on long-term outcomes after coronary artery bypass grafting
    Jacob N Schroder
    Division of Cardiovascular and Thoracic Surgery, Department of Surgery, Duke University Medical Center, Durham, NC 27703, USA
    Circulation 112:I293-8. 2005
    ..We sought to determine the long-term effect of uncorrected MR, measured by intraoperative transesophageal echocardiography (TEE), in CABG patients...
  64. pmc Influence of documented history of coronary artery disease on outcomes in patients admitted for worsening heart failure with reduced ejection fraction in the EVEREST trial
    Robert J Mentz
    Duke University Medical Center, Durham, NC, USA
    Eur J Heart Fail 15:61-8. 2013
    ..We describe the clinical characteristics and mode-specific outcomes of HF patients with reduced ejection fraction (EF) and documented CAD in a large randomized trial...
  65. ncbi request reprint The Pilot Randomized Study of Nesiritide Versus Dobutamine in Heart Failure (PRESERVD-HF)
    Mihai Gheorghiade
    Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Am J Cardiol 96:18G-25G. 2005
    ..Accordingly, therapies for AHFS that are aimed at improving hemodynamics may affect long-term prognosis by either injuring or salvaging myocardium...
  66. pmc Triage after hospitalization with advanced heart failure: the ESCAPE (Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness) risk model and discharge score
    CHRISTOPHER M O'CONNOR
    Duke Clinical Research Institute, Duke University Medical Center, 2400 North Pratt Street, Box 3356, Durham, North Carolina 27705, USA
    J Am Coll Cardiol 55:872-8. 2010
    ..Identifying high-risk heart failure (HF) patients at hospital discharge may allow more effective triage to management strategies...
  67. doi request reprint The impact of chronic obstructive pulmonary disease in patients hospitalized for worsening heart failure with reduced ejection fraction: an analysis of the EVEREST Trial
    Robert J Mentz
    Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, NC, USA
    J Card Fail 18:515-23. 2012
    ..We aimed to describe the characteristics and outcomes of patients with systolic dysfunction and COPD in a contemporary HF randomized trial...
  68. doi request reprint Comparison of Clinical characteristics and long-term outcomes of patients with ischemic cardiomyopathy with versus without angina pectoris (from the Duke Databank for Cardiovascular Disease)
    Robert J Mentz
    Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, North Carolina, USA
    Am J Cardiol 109:1272-7. 2012
    ..03) (5-year event rates 85% vs 87% and 77% vs 73%, respectively). In conclusion, AP is common in patients with iCM despite medical therapy and previous revascularization and is associated with increased CV death or CV rehospitalization...
  69. pmc Responses of mental stress-induced myocardial ischemia to escitalopram treatment: background, design, and method for the Responses of Mental Stress Induced Myocardial Ischemia to Escitalopram Treatment trial
    Wei Jiang
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Am Heart J 163:20-6. 2012
    ..Depression is a risk factor of MSIMI. The REMIT trial investigates whether selective serotonin reuptake inhibitor (SSRI) treatment can improve MSIMI. The rationale and outline of the study are described...
  70. doi request reprint The primary and secondary prevention of coronary artery disease: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
    Richard C Becker
    Duke Cardiovascular Thrombosis Center, Duke Clinical Research Institute, 2400 Pratt Street, Durham, NC 27705, USA
    Chest 133:776S-814S. 2008
    ..For primary prevention in patients with moderate risk for a coronary event, we recommend aspirin, 75-100 mg/d, over either no antithrombotic therapy or vitamin K antagonist (Grade 1A)...
  71. pmc Association of weight change with subsequent outcomes in patients hospitalized with acute decompensated heart failure
    Rajendra H Mehta
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA
    Am J Cardiol 103:76-81. 2009
    ..e., death and/or rehospitalization) in patients with HF in the design of treatment strategies for novel therapeutic agents in randomized controlled clinical trials...
  72. ncbi request reprint Anaemia and coronary artery disease severity in patients with heart failure
    G Michael Felker
    Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA
    Eur J Heart Fail 8:54-7. 2006
    ..Exacerbation of myocardial ischemia in patients with heart failure, coronary disease, and anaemia patients has been suggested as a potential mechanism underlying this association...
  73. doi request reprint A smoker's paradox in patients hospitalized for heart failure: findings from OPTIMIZE-HF
    Gregg C Fonarow
    Department of Medicine, UCLA Medical Center, Los Angeles, CA, USA
    Eur Heart J 29:1983-91. 2008
    ..This study aimed to ascertain the relationship between smoking and clinical outcomes in patients hospitalized with heart failure (HF)...
  74. ncbi request reprint Anemia in patients with heart failure and preserved systolic function
    G Michael Felker
    Duke Clinical Research Institute, Durham, NC 27705, USA
    Am Heart J 151:457-62. 2006
    ..Although heart failure in the setting of preserved systolic function (PSF) is an important clinical problem, the relationship between anemia and outcomes in patients with PSF has not been carefully evaluated...
  75. pmc Association between adrenergic receptor genotypes and beta-blocker dose in heart failure patients: analysis from the HF-ACTION DNA substudy
    Mona Fiuzat
    Duke University and the Duke Clinical Research Institute, Durham, NC, USA
    Eur J Heart Fail 15:258-66. 2013
    ..We examined whether the Arg389Gly polymorphism in ADRβ1 interacts with the dose requirements of beta-blockers in patients with systolic HF...
  76. pmc Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: a randomized clinical trial
    Margaret M Redfield
    Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    JAMA 309:1268-77. 2013
    ..Studies in experimental and human heart failure suggest that phosphodiesterase-5 inhibitors may enhance cardiovascular function and thus exercise capacity in heart failure with preserved ejection fraction (HFPEF)...
  77. doi request reprint Troponin I in acute decompensated heart failure: insights from the ASCEND-HF study
    G Michael Felker
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA
    Eur J Heart Fail 14:1257-64. 2012
    ..Circulating troponins are a prognostic marker in patients with ADHF. Contemporary assays with greater sensitivity require reassessment of the significance of troponin elevation in HF...
  78. pmc High mortality without ESCAPE: the registry of heart failure patients receiving pulmonary artery catheters without randomization
    Larry A Allen
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA
    J Card Fail 14:661-9. 2008
    ..The external validity of these findings is debated...
  79. doi request reprint Rationale and design of the Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure Trial (ASCEND-HF)
    Adrian F Hernandez
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA
    Am Heart J 157:271-7. 2009
    ..However, the effect of nesiritide on dyspnea at 6 or 24 hours is unknown, and no clinical outcome trials have been done to provide a reliable estimate of the effect of nesiritide on morbidity and mortality...
  80. pmc Relation between dose of loop diuretics and outcomes in a heart failure population: results of the ESCAPE trial
    Vic Hasselblad
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA
    Eur J Heart Fail 9:1064-9. 2007
    ..We examined the relation of maximal in-hospital diuretic dose to weight loss, changes in renal function, and mortality in hospitalised heart failure (HF) patients...
  81. doi request reprint Causes of death and rehospitalization in patients hospitalized with worsening heart failure and reduced left ventricular ejection fraction: results from Efficacy of Vasopressin Antagonism in Heart Failure Outcome Study with Tolvaptan (EVEREST) program
    CHRISTOPHER M O'CONNOR
    Duke University Medical Center, Durham, NC, USA
    Am Heart J 159:841-849.e1. 2010
    ..To the best of our knowledge, there has been no systematic analysis of the causes of death and rehospitalization in this patient population...
  82. pmc Effects of exercise training on health status in patients with chronic heart failure: HF-ACTION randomized controlled trial
    Kathryn E Flynn
    Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC 27715, USA
    JAMA 301:1451-9. 2009
    ..Findings from previous studies of the effects of exercise training on patient-reported health status have been inconsistent...
  83. ncbi request reprint Importance of echocardiography in patients with severe nonischemic heart failure: the second Prospective Randomized Amlodipine Survival Evaluation (PRAISE-2) echocardiographic study
    Christopher H Cabell
    Duke University School of Medicine, Durham, NC, USA
    Am Heart J 147:151-7. 2004
    ....
  84. doi request reprint Clinical characteristics and outcomes of hospitalized heart failure patients with systolic dysfunction and chronic obstructive pulmonary disease: findings from OPTIMIZE-HF
    Robert J Mentz
    Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, NC 27710, USA
    Eur J Heart Fail 14:395-403. 2012
    ..We aimed to evaluate the clinical characteristics and outcomes of HF patients with systolic dysfunction and COPD in a large acute HF registry...
  85. doi request reprint Clinical effectiveness of implantable cardioverter-defibrillators among medicare beneficiaries with heart failure
    Adrian F Hernandez
    Duke Clinical Research Institute, Department of Medicine, Duke University School of Medicine, Durham, NC, USA
    Circ Heart Fail 3:7-13. 2010
    ..The clinical effectiveness of implantable cardioverter-defibrillators (ICDs) in older patients with heart failure has not been established, and older patients have been underrepresented in previous studies...
  86. pmc Relationship of technetium-99m tetrofosmin-gated rest single-photon emission computed tomography myocardial perfusion imaging to death and hospitalization in heart failure patients: results from the nuclear ancillary study of the HF-ACTION trial
    Allen E Atchley
    Duke University Medical Center, Durham, NC 27710, USA
    Am Heart J 161:1038-45. 2011
    ....
  87. doi request reprint Safety of selective serotonin reuptake inhibitor use prior to coronary artery bypass grafting
    Glen L Xiong
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina, USA
    Clin Cardiol 33:E94-8. 2010
    ..Selective serotonin reuptake inhibitors (SSRIs) have been shown to increase bleeding risks. This study examined the association of perioperative coronary artery bypass grafting (CABG) bleeding risks and SSRI use prior to CABG...
  88. ncbi request reprint Relationship of depression to death or hospitalization in patients with heart failure
    Andrew Sherwood
    Department of Psychiatry, Duke University Medical Center, Durham, NC, USA
    Arch Intern Med 167:367-73. 2007
    ..However, patients with heart failure (HF) have been less frequently studied, and the effect of depression on prognosis, independent of disease severity, is uncertain...
  89. ncbi request reprint The association between depression and chronic kidney disease and mortality among patients hospitalized with congestive heart failure
    S Susan Hedayati
    Department of Medicine, Division of Nephrology, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA
    Am J Kidney Dis 44:207-15. 2004
    ..The point prevalence of depression and its relationship to poor outcomes among patients with chronic kidney disease (CKD) has not been fully characterized...
  90. ncbi request reprint Prognostic value of anxiety and depression in patients with chronic heart failure
    Wei Jiang
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Circulation 110:3452-6. 2004
    ..In a secondary analysis of data collected for a published study of depression and prognosis in patients with CHF, we examined the relations among anxiety, depression, and prognosis...
  91. doi request reprint patient and practice factors associated with improvement in use of guideline-recommended therapies for outpatients with heart failure (from the IMPROVE HF trial)
    CHRISTOPHER M O'CONNOR
    Duke University Medical Center, Durham, North Carolina, USA
    Am J Cardiol 107:250-8. 2011
    ..Other factors may be more important determinates of the magnitude of care improvements over time among cardiology practices participating in a performance improvement initiative...
  92. doi request reprint The PROTECT in-hospital risk model: 7-day outcome in patients hospitalized with acute heart failure and renal dysfunction
    CHRISTOPHER M O'CONNOR
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27710, USA
    Eur J Heart Fail 14:605-12. 2012
    ..We aimed to identify the predictors of 7-day heart failure events or death in patients hospitalized with AHF...
  93. pmc Relationship of beta-blocker dose with outcomes in ambulatory heart failure patients with systolic dysfunction: results from the HF-ACTION (Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training) trial
    Mona Fiuzat
    Duke University and the Duke Clinical Research Institute, Durham, North Carolina 27710, USA
    J Am Coll Cardiol 60:208-15. 2012
    ..This study sought to examine the association between baseline beta-blocker (BB) dose and outcomes in the HF-ACTION (Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training) trial...
  94. pmc Characterization of heart failure patients with preserved ejection fraction: a comparison between ADHERE-US registry and ADHERE-International registry
    Ryenn West
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA
    Eur J Heart Fail 13:945-52. 2011
    ..To characterize geographic differences in clinical characteristics and care of patients hospitalized with heart failure and preserved ejection fraction (HF-PEF)...
  95. doi request reprint Rapid clinical assessment of patients with acute heart failure: first blood pressure and oxygen saturation--is that all we need?
    Olga Milo-Cotter
    Momentum Research Inc, 3100 Tower Blvd, Suite 802, Durham, NC 27707, USA
    Cardiology 114:75-82. 2009
    ..Low oxygen saturation (SaO2) and systolic blood pressure (SBP) are signs of impending respiratory and circulatory failure that can be obtained quickly in patients with AHF...
  96. doi request reprint Troponin elevation in heart failure prevalence, mechanisms, and clinical implications
    Robb D Kociol
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA
    J Am Coll Cardiol 56:1071-8. 2010
    ..Ultimately, this information might allow physicians to guide therapy, choose appropriate therapeutics, and improve HF outcomes...
  97. ncbi request reprint Depression and ischemic heart disease: what have we learned so far and what must we do in the future?
    Wei Jiang
    Department of Internal Medicine and Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Am Heart J 150:54-78. 2005
  98. pmc Coping effectively with heart failure (COPE-HF): design and rationale of a telephone-based coping skills intervention
    Andrew Sherwood
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    J Card Fail 17:201-7. 2011
    ....
  99. pmc STICH (Surgical Treatment for Ischemic Heart Failure) trial enrollment
    Robert H Jones
    Division of Cardiothoracic Surgery Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    J Am Coll Cardiol 56:490-8. 2010
    ..The aim of this study was to assess the influence of enrolling site location and enrollment performance on the generalizability of STICH (Surgical Treatment for Ischemic Heart Failure) trial results...
  100. ncbi request reprint Overview of current noninodilator therapies for acute heart failure syndromes
    Wendy Gattis Stough
    Duke University Medical Center, Durham, North Carolina, USA
    Am J Cardiol 96:41G-6G. 2005
    ....
  101. doi request reprint Associations between outpatient heart failure process-of-care measures and mortality
    Gregg C Fonarow
    Department of Medicine, Ahmanson UCLA Cardiomyopathy Center, Los Angeles, CA 90095 1679, USA
    Circulation 123:1601-10. 2011
    ..However, this association has not been evaluated for current and emerging outpatient HF measures...