Robert J Mentz

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Heart Failure Clinical Trials in East and Southeast Asia: Understanding the Importance and Defining the Next Steps
    Robert J Mentz
    Duke Clinical Research Institute and the Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, North Carolina Electronic address
    JACC Heart Fail 4:419-27. 2016
  2. pmc Good Clinical Practice Guidance and Pragmatic Clinical Trials: Balancing the Best of Both Worlds
    Robert J Mentz
    From Duke Clinical Research Institute, Durham, NC R J M, A F H, L G B, T R, E C O B, J C I, L H C, E D P and Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, NC R J M, AF H, E C O B, E D P
    Circulation 133:872-80. 2016
  3. pmc Torsemide Versus Furosemide in Patients With Acute Heart Failure (from the ASCEND-HF Trial)
    Robert J Mentz
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina Electronic address
    Am J Cardiol 117:404-11. 2016
  4. pmc Prognostic significance of depression in blacks with heart failure: insights from Heart Failure: a Controlled Trial Investigating Outcomes of Exercise Training
    Robert J Mentz
    From the Duke University Medical Center, Durham, NC R J M, M A B, W E K, C M O C, J A B University of Alabama at Birmingham V B National Heart, Lung, and Blood Institute, Bethesda, MD J L F Henry Ford Hospital, Detroit, MI S J K University of Louisville, KY A M S Montefiore Einstein Medical Center, New York, NY I L P and Thomas Jefferson University, Philadelphia, PA D J W
    Circ Heart Fail 8:497-503. 2015
  5. pmc Ventricular conduction and long-term heart failure outcomes and mortality in African Americans: insights from the Jackson Heart Study
    Robert J Mentz
    From the Department of Medicine, Division of Cardiology, Duke University School of Medicine R J M, A D D, T A, P K, T C R, Z J E, E C O B, K L T, A F H, and Duke Clinical Research Institute R J M, M A G, A D D, T C R, Z J E, E C O B, K L T, L H C, A F H, Durham, NC Department of Medicine, Mayo Clinic, Rochester, MN S M D Vascular Research Laboratory, Providence VA Medical Center and Department of Medicine, Warren Alpert Medical School of Brown University, Providence, RI G C and Center of Biostatistics and Bioinformatics, University of Mississippi Medical Center, Jackson, MS M E G
    Circ Heart Fail 8:243-51. 2015
  6. pmc Noncardiac comorbidities in heart failure with reduced versus preserved ejection fraction
    Robert J Mentz
    Duke University, Durham, North Carolina Electronic address
    J Am Coll Cardiol 64:2281-93. 2014
  7. pmc Decongestion strategies and renin-angiotensin-aldosterone system activation in acute heart failure
    Robert J Mentz
    Duke Clinical Research Institute, Durham, North Carolina Electronic address
    JACC Heart Fail 3:97-107. 2015
  8. pmc The palliative care in heart failure trial: rationale and design
    Robert J Mentz
    Division of Cardiology, Duke University Medical Center, Durham, NC Electronic address
    Am Heart J 168:645-651.e1. 2014
  9. pmc Relation of dyspnea severity on admission for acute heart failure with outcomes and costs
    Robert J Mentz
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina Department of Medicine, Duke University School of Medicine, Durham, North Carolina Electronic address
    Am J Cardiol 115:75-81. 2015
  10. pmc Sleep-disordered breathing in patients with heart failure
    Robert J Mentz
    Duke University Medical Center, Duke Clinical Research Institute, 2301 Erwin Road, Durham, NC 27710, USA Electronic address
    Heart Fail Clin 10:243-50. 2014

Detail Information

Publications80

  1. pmc Heart Failure Clinical Trials in East and Southeast Asia: Understanding the Importance and Defining the Next Steps
    Robert J Mentz
    Duke Clinical Research Institute and the Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, North Carolina Electronic address
    JACC Heart Fail 4:419-27. 2016
    ..This review is based on discussions among scientists, clinical trialists, industry representatives, and regulatory representatives at the CardioVascular Clinical Trialist Asia Forum in Singapore on July 4, 2014. ..
  2. pmc Good Clinical Practice Guidance and Pragmatic Clinical Trials: Balancing the Best of Both Worlds
    Robert J Mentz
    From Duke Clinical Research Institute, Durham, NC R J M, A F H, L G B, T R, E C O B, J C I, L H C, E D P and Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, NC R J M, AF H, E C O B, E D P
    Circulation 133:872-80. 2016
    ....
  3. pmc Torsemide Versus Furosemide in Patients With Acute Heart Failure (from the ASCEND-HF Trial)
    Robert J Mentz
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina Electronic address
    Am J Cardiol 117:404-11. 2016
    ..55 and 180-day mortality hazard ratio 0.86, 95% CI 0.63 to 1.19, p = 0.37). In conclusion, these data are hypothesis-generating and randomized comparative effectiveness trials are needed to investigate the optimal diuretic choice...
  4. pmc Prognostic significance of depression in blacks with heart failure: insights from Heart Failure: a Controlled Trial Investigating Outcomes of Exercise Training
    Robert J Mentz
    From the Duke University Medical Center, Durham, NC R J M, M A B, W E K, C M O C, J A B University of Alabama at Birmingham V B National Heart, Lung, and Blood Institute, Bethesda, MD J L F Henry Ford Hospital, Detroit, MI S J K University of Louisville, KY A M S Montefiore Einstein Medical Center, New York, NY I L P and Thomas Jefferson University, Philadelphia, PA D J W
    Circ Heart Fail 8:497-503. 2015
    ..Although studies have shown that depression is associated with worse outcomes in patients with heart failure, most studies have been in white patients. The impact of depression on outcomes in blacks with heart failure has not been studied...
  5. pmc Ventricular conduction and long-term heart failure outcomes and mortality in African Americans: insights from the Jackson Heart Study
    Robert J Mentz
    From the Department of Medicine, Division of Cardiology, Duke University School of Medicine R J M, A D D, T A, P K, T C R, Z J E, E C O B, K L T, A F H, and Duke Clinical Research Institute R J M, M A G, A D D, T C R, Z J E, E C O B, K L T, L H C, A F H, Durham, NC Department of Medicine, Mayo Clinic, Rochester, MN S M D Vascular Research Laboratory, Providence VA Medical Center and Department of Medicine, Warren Alpert Medical School of Brown University, Providence, RI G C and Center of Biostatistics and Bioinformatics, University of Mississippi Medical Center, Jackson, MS M E G
    Circ Heart Fail 8:243-51. 2015
    ..We investigated the association between QRS duration and mortality in African Americans...
  6. pmc Noncardiac comorbidities in heart failure with reduced versus preserved ejection fraction
    Robert J Mentz
    Duke University, Durham, North Carolina Electronic address
    J Am Coll Cardiol 64:2281-93. 2014
    ..The basis for this review was discussions between scientists, clinical trialists, and regulatory representatives at the 10th Global CardioVascular Clinical Trialists Forum. ..
  7. pmc Decongestion strategies and renin-angiotensin-aldosterone system activation in acute heart failure
    Robert J Mentz
    Duke Clinical Research Institute, Durham, North Carolina Electronic address
    JACC Heart Fail 3:97-107. 2015
    ..The purpose of this study was to assess the relationship between biomarkers of renin-angiotensin-aldosterone system (RAAS) activation and decongestion strategies, worsening renal function, and clinical outcomes...
  8. pmc The palliative care in heart failure trial: rationale and design
    Robert J Mentz
    Division of Cardiology, Duke University Medical Center, Durham, NC Electronic address
    Am Heart J 168:645-651.e1. 2014
    ..Limited evidence exists from randomized, controlled trials supporting the use of interdisciplinary palliative care in HF...
  9. pmc Relation of dyspnea severity on admission for acute heart failure with outcomes and costs
    Robert J Mentz
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina Department of Medicine, Duke University School of Medicine, Durham, North Carolina Electronic address
    Am J Cardiol 115:75-81. 2015
    ..In conclusion, dyspnea at rest on presentation was associated with greater mortality, readmission, length of stay, and health care costs in patients hospitalized with acute HF. ..
  10. pmc Sleep-disordered breathing in patients with heart failure
    Robert J Mentz
    Duke University Medical Center, Duke Clinical Research Institute, 2301 Erwin Road, Durham, NC 27710, USA Electronic address
    Heart Fail Clin 10:243-50. 2014
    ..Ongoing research into the roles of comorbidities such as SDB as a treatment target may lead to better clinical outcomes and improved quality of life for patients with heart failure. ..
  11. pmc Heart failure with preserved ejection fraction: comparison of patients with and without angina pectoris (from the Duke Databank for Cardiovascular Disease)
    Robert J Mentz
    Department of Medicine, Duke University Medical Center, Durham, North Carolina Division of Cardiology, Duke University Medical Center, Durham, North Carolina Electronic address
    J Am Coll Cardiol 63:251-8. 2014
    ..This study investigated the characteristics and outcomes of patients with heart failure with preserved ejection fraction (HFpEF) and angina pectoris (AP)...
  12. pmc Learning from recent trials and shaping the future of acute heart failure trials
    Robert J Mentz
    Duke University, Durham, NC Electronic address
    Am Heart J 166:629-35. 2013
    ..This review is based on discussions between scientists, clinical trialists, and regulatory representatives at the 9th Global Cardio Vascular Clinical Trialists Forum in Paris, France, from November 30 to December 1, 2012. ..
  13. pmc Funding opportunities for clinical investigators in the early stages of career development in cardiovascular research
    Robert J Mentz
    Duke Clinical Research Institute, Duke University Medical Center, Duke University School of Medicine, 2400 Pratt Street, Durham, NC, 27705, USA
    J Thromb Thrombolysis 36:527-32. 2013
    ..This article highlights these opportunities in order to assist early career investigators in the development of a personalized research trajectory, which optimizes the potential for career success. ..
  14. pmc Race, exercise training, and outcomes in chronic heart failure: findings from Heart Failure - a Controlled Trial Investigating Outcomes in Exercise TraiNing (HF-ACTION)
    Robert J Mentz
    Duke University, Durham, NC Electronic address
    Am Heart J 166:488-95. 2013
    ..We aimed to investigate the association between race and outcomes and to explore interactions with exercise training in patients with ambulatory HF...
  15. pmc The past, present and future of renin-angiotensin aldosterone system inhibition
    Robert J Mentz
    Duke University Medical Center, Durham, NC 27710, USA
    Int J Cardiol 167:1677-87. 2013
    ..Finally, ongoing clinical trials, opportunities for future trials and issues related to the barriers and approvability of novel RAAS inhibitors are highlighted. ..
  16. pmc Noncardiac comorbidities and acute heart failure patients
    Robert J Mentz
    Division of Cardiology, Department of Medicine, Duke University Medical Center, 2301 Erwin Road, Durham, NC 27710, USA
    Heart Fail Clin 9:359-67, vii. 2013
    ..In some circumstances, careful attention to the diagnosis and management of these conditions in patients with AHF may help to improve patient outcomes. ..
  17. pmc Clinical characteristics, response to exercise training, and outcomes in patients with heart failure and chronic obstructive pulmonary disease: findings from Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing (HF-ACTION)
    Robert J Mentz
    Duke University Medical Center, Durham, NC, USA
    Am Heart J 165:193-9. 2013
    ..The aim of this study was to investigate the clinical characteristics, exercise training response, β-blocker selectivity, and outcomes in patients with heart failure (HF) and chronic obstructive pulmonary disease (COPD)...
  18. doi Association of beta-blocker use and selectivity with outcomes in patients with heart failure and chronic obstructive pulmonary disease (from OPTIMIZE-HF)
    Robert J Mentz
    Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, North Carolina, USA
    Am J Cardiol 111:582-7. 2013
    ..In conclusion, despite concerns regarding β blockers in patients with HF with COPD, there was no evidence that β-blocker selectivity was associated with differences in outcomes for patients with HF with COPD versus those without...
  19. doi Comparison of Clinical characteristics and long-term outcomes of patients with ischemic cardiomyopathy with versus without angina pectoris (from the Duke Databank for Cardiovascular Disease)
    Robert J Mentz
    Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, North Carolina, USA
    Am J Cardiol 109:1272-7. 2012
    ..03) (5-year event rates 85% vs 87% and 77% vs 73%, respectively). In conclusion, AP is common in patients with iCM despite medical therapy and previous revascularization and is associated with increased CV death or CV rehospitalization...
  20. doi Bronchodilators in heart failure patients with COPD: is it time for a clinical trial?
    Robert J Mentz
    Division of Cardiology, Department of Medicine, Duke Clinical Research Institute and Duke University Medical Center, Durham, North Carolina 27710, USA
    J Card Fail 18:413-22. 2012
    ....
  21. doi Implications of geographical variation on clinical outcomes of cardiovascular trials
    Robert J Mentz
    Duke University Medical Center, Durham, NC, USA
    Am Heart J 164:303-12. 2012
    ..This review is based on discussions between basic scientists and clinical trialists at the 8th Global Cardio Vascular Clinical Trialists Forum 2011 in Paris, France, from December 2 to 3...
  22. doi Clinical characteristics and outcomes of hospitalized heart failure patients with systolic dysfunction and chronic obstructive pulmonary disease: findings from OPTIMIZE-HF
    Robert J Mentz
    Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, NC 27710, USA
    Eur J Heart Fail 14:395-403. 2012
    ..We aimed to evaluate the clinical characteristics and outcomes of HF patients with systolic dysfunction and COPD in a large acute HF registry...
  23. doi Cardiorenal syndrome clinical trial end points
    Robert J Mentz
    Division of Cardiology, Department of Medicine, Duke University Medical Center, 2301 Erwin Road, Durham, NC 27705, USA
    Heart Fail Clin 7:519-28. 2011
    ..This article reviews the end points evaluated in key clinical trials of cardiorenal syndrome and synthesizes recent discussions about the appropriateness of end points for future trials...
  24. pmc Association between diabetes mellitus and post-discharge outcomes in patients hospitalized with heart failure: findings from the EVEREST trial
    Satyam Sarma
    Division of Cardiology, Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA
    Eur J Heart Fail 15:194-202. 2013
    ..DM is prevalent in patients hospitalized with HF, yet inconclusive data exist on the post-discharge outcomes of this patient population...
  25. doi Clinical profile and prognostic value of low systolic blood pressure in patients hospitalized for heart failure with reduced ejection fraction: insights from the Efficacy of Vasopressin Antagonism in Heart Failure: Outcome Study with Tolvaptan (EVEREST) t
    Andrew P Ambrosy
    Department of Medicine, Stanford University School of Medicine, CA, USA
    Am Heart J 165:216-25. 2013
    ..The prognostic value of SBP after initiating inhospital therapy and the mode of death and etiology of cardiovascular readmissions based on SBP have not been well characterized in HHF...
  26. pmc Influence of documented history of coronary artery disease on outcomes in patients admitted for worsening heart failure with reduced ejection fraction in the EVEREST trial
    Robert J Mentz
    Duke University Medical Center, Durham, NC, USA
    Eur J Heart Fail 15:61-8. 2013
    ..We describe the clinical characteristics and mode-specific outcomes of HF patients with reduced ejection fraction (EF) and documented CAD in a large randomized trial...
  27. pmc Hemodynamic Predictors of Heart Failure Morbidity and Mortality: Fluid or Flow?
    Lauren B Cooper
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA Electronic address
    J Card Fail 22:182-9. 2016
    ..Patients with advanced heart failure may continue for prolonged times with persistent hemodynamic abnormalities; intermediate- and long-term outcomes of these patients are unknown...
  28. pmc Predictors of early dyspnoea relief in acute heart failure and the association with 30-day outcomes: findings from ASCEND-HF
    Robert J Mentz
    Duke University Medical Center, Durham, NC, USA
    Eur J Heart Fail 15:456-64. 2013
    ..To examine the characteristics associated with early dyspnoea relief during acute heart failure (HF) hospitalization, and its association with 30-day outcomes...
  29. doi The impact of chronic obstructive pulmonary disease in patients hospitalized for worsening heart failure with reduced ejection fraction: an analysis of the EVEREST Trial
    Robert J Mentz
    Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, NC, USA
    J Card Fail 18:515-23. 2012
    ..We aimed to describe the characteristics and outcomes of patients with systolic dysfunction and COPD in a contemporary HF randomized trial...
  30. pmc The clinical course of health status and association with outcomes in patients hospitalized for heart failure: insights from ASCEND-HF
    Andrew P Ambrosy
    Duke University Medical Center, Durham, NC, USA
    Eur J Heart Fail 18:306-13. 2016
    ..A longitudinal and comprehensive analysis of health-related quality of life (HRQOL) was performed during hospitalization for heart failure (HF) or soon after discharge...
  31. doi Development and validation of a risk model for in-hospital worsening heart failure from the Acute Decompensated Heart Failure National Registry (ADHERE)
    Adam D DeVore
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC Department of Medicine, Duke University School of Medicine, Durham, NC Electronic address
    Am Heart J 178:198-205. 2016
    ..A subset of patients hospitalized with acute heart failure experiences in-hospital worsening heart failure, defined as persistent or worsening signs or symptoms requiring an escalation of therapy...
  32. doi Body Weight Change During and After Hospitalization for Acute Heart Failure: Patient Characteristics, Markers of Congestion, and Outcomes: Findings From ASCEND-HF
    Andrew P Ambrosy
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina Division of Cardiology, Duke Clinical Research Institute, Durham, North Carolina
    JACC Heart Fail . 2016
    ..This study sought to examine the relationships between in-hospital and post-discharge body weight changes and outcomes among patients hospitalized for acute heart failure (AHF)...
  33. pmc Relation of Angina Pectoris to Outcomes, Quality of Life, and Response to Exercise Training in Patients With Chronic Heart Failure (from HF-ACTION)
    Kishan S Parikh
    Duke Clinical Research Institute, Durham, North Carolina Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina Electronic address
    Am J Cardiol 118:1211-1216. 2016
    ..25 ml/kg/min, 95% CI 0.6 to 1.9). In conclusion, AP was associated with worse HRQoL and depressive symptoms. Despite greater peak VO2 improvement with exercise training, patients with AP experienced more adverse outcomes...
  34. doi Statins and Exercise Training Response in Heart Failure Patients: Insights From HF-ACTION
    Jacob P Kelly
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina Duke Clinical Research Institute, Durham, North Carolina Electronic address
    JACC Heart Fail 4:617-24. 2016
    ..The aim of this study was to assess for a treatment interaction between statin use and exercise training (ET) response...
  35. doi Influence of Clinical Trial Site Enrollment on Patient Characteristics, Protocol Completion, and End Points: Insights From the ASCEND-HF Trial (Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure)
    Stephen J Greene
    From the Division of Cardiology, Duke University Medical Center, Durham, NC S J G, A F H, A P A, C M O, R J M Duke Clinical Research Institute, Durham, NC A F H, J L S, A P A, P J S, C M O, R J M Cardiology, University of Brescia, Italy M M Division of Cardiology, Stony Brook University, NY J B Canadian VIGOUR Center, University of Alberta, Edmonton, Canada J A E, P W A Cleveland Clinic, OH R C S Section of Cardiology, San Francisco Veterans Affairs Medical Center, School of Medicine, University of California San Francisco J R T and Department of Cardiology, University Medical Center Groningen, The Netherlands A A V
    Circ Heart Fail 9:. 2016
    ..Most international acute heart failure trials have failed to show benefit with respect to key end points. The impact of site enrollment and protocol execution on trial performance is unclear...
  36. doi Comparative effectiveness of torsemide versus furosemide in heart failure patients: insights from the PROTECT trial
    Robert J Mentz
    Duke University, Durham, NC 27708, USA
    Future Cardiol 11:585-95. 2015
    ..The authors assessed the comparative effectiveness of torsemide versus furosemide in the PROTECT trial...
  37. pmc Worsening heart failure during hospitalization for acute heart failure: Insights from the Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure (ASCEND-HF)
    Jacob P Kelly
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC Electronic address
    Am Heart J 170:298-305. 2015
    ..Despite initial in-hospital treatment of acute heart failure (HF), some patients experience worsening HF (WHF). There are limited data about the outcomes and characteristics of patients who experience in-hospital WHF...
  38. pmc Clinical profile and prognostic value of anemia at the time of admission and discharge among patients hospitalized for heart failure with reduced ejection fraction: findings from the EVEREST trial
    Robert J Mentz
    From the Duke University Medical Center, Durham, NC R J M Northwestern University Feinberg School of Medicine, Chicago, IL S J G Stanford University School of Medicine, CA A P A Massachusetts General Hospital, Boston M V Center for Cardiovascular Innovation, Northwestern University Feinberg School of Medicine, Chicago, IL H P S, M G Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden K S Associazione Nazionale Medici Cardiologi Ospedalieri Research Center, Florence, Italy A P M University of Brescia, Brescia, Italy Klinika Kardiologii, Wroclaw, Poland S N, P P Center for Clinical and Basic Research, IRCCS San Raffaele, Rome, Italy S D A and Emory University, Atlanta, GA J B
    Circ Heart Fail 7:401-8. 2014
    ..Anemia has been associated with worse outcomes in patients with chronic heart failure (HF). We aimed to characterize the clinical profile and postdischarge outcomes of hospitalized HF patients with anemia at admission or discharge...
  39. doi Atrial fibrillation or flutter on initial electrocardiogram is associated with worse outcomes in patients admitted for worsening heart failure with reduced ejection fraction: findings from the EVEREST Trial
    Robert J Mentz
    Duke University Medical Center, Durham, NC, USA
    Am Heart J 164:884-92.e2. 2012
    ..However, the clinical profile and outcomes of patients following hospitalization for HF with AF/AFL on initial electrocardiogram (ECG) has not been well studied...
  40. doi Liver function tests in patients with acute heart failure and associated outcomes: insights from ASCEND-HF
    Marc D Samsky
    Duke University, Durham, NC, USA
    Eur J Heart Fail 18:424-32. 2016
    ..We aimed to characterize abnormal liver function tests in patients with heart failure (HF), as they are commonly encountered yet poorly defined...
  41. pmc Serum Bicarbonate in Acute Heart Failure: Relationship to Treatment Strategies and Clinical Outcomes
    Lauren B Cooper
    Duke Clinical Research Institute, Durham, North Carolina Electronic address
    J Card Fail 22:738-42. 2016
    ..Though commonly noted in clinical practice, it is unknown if decongestion in acute heart failure (AHF) results in increased serum bicarbonate...
  42. doi Serial high sensitivity cardiac troponin T measurement in acute heart failure: insights from the RELAX-AHF study
    G Michael Felker
    Duke Clinical Research Institute, DUMC Box 3850, Durham, NC, 27710, USA
    Eur J Heart Fail 17:1262-70. 2015
    ..We examined the association between serial measurements of high-sensitivity cardiac troponin T (hs-cTnT) and outcomes in RELAX-AHF...
  43. pmc Patient selection in heart failure with preserved ejection fraction clinical trials
    Jacob P Kelly
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina Electronic address
    J Am Coll Cardiol 65:1668-82. 2015
    ..This review reflects discussions between clinicians, scientists, trialists, regulators, and regulatory representatives at the 10th Global CardioVascular Clinical Trialists Forum in Paris, France, on December 6, 2013. ..
  44. doi International differences in clinical characteristics, management, and outcomes in acute heart failure patients: better short-term outcomes in patients enrolled in Eastern Europe and Russia in the PROTECT trial
    Robert J Mentz
    Duke University, Durham, NC, USA
    Eur J Heart Fail 16:614-24. 2014
    ..We investigated regional differences in an international acute HF trial...
  45. doi Changes in Dyspnea Status During Hospitalization and Postdischarge Health-Related Quality of Life in Patients Hospitalized for Heart Failure: Findings From the EVEREST Trial
    Andrew P Ambrosy
    From the Duke University Medical Center, Durham, NC A P A, R J M, S J G Department of Medicine, Emory University School of Medicine, Atlanta, GA H K Division of Cardiology, Tufts Medical Center and Tufts University School of Medicine, Boston, MA J E U, M A K Duke Clinical Research Institute, Durham, NC R J M Institute of Emergency for Cardiovascular Diseases Prof C C Iliescu, University of Medicine and Pharmacy Carol Davila, Bucuresti, Romania O C Division of Cardiology, Brigham and Women s Hospital, Boston, MA M V Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL H P S, M G Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden K S Department of Cardiology, INSERM, Nancy University, University de Lorraine, Nancy, France F Z Associazione Nazionale Medici Cardiologi Ospedalieri Research Center, Florence, Italy A P M and Stony Brook Heart Institute, Stony Brook, NY J B
    Circ Heart Fail 9:. 2016
    ..However, the association between short-term dyspnea relief and postdischarge clinical outcomes and health-related quality of life (HRQOL) remains uncertain...
  46. pmc Torsemide versus furosemide in heart failure patients: insights from Duke University Hospital
    Robert J Mentz
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC Department of Medicine, Duke University Medical Center, Durham, NC and Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    J Cardiovasc Pharmacol 65:438-43. 2015
    ..16; 95% CI: 0.98-1.38; P = 0.0864). Prospective trials are needed to investigate the effect of torsemide versus furosemide because of the potential for residual confounding. ..
  47. pmc Differences in health care use and outcomes by the timing of in-hospital worsening heart failure
    Lauren B Cooper
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC Department of Medicine, Duke University School of Medicine, Durham, NC Electronic address
    Am Heart J 170:1124-32. 2015
    ..In-hospital worsening heart failure is associated with worse in-hospital and postdischarge outcomes, but associations between the timing of worsening heart failure and outcomes are unknown...
  48. doi Loop diuretic dose adjustments after a hospitalization for heart failure: insights from ASCEND-HF
    Adam D DeVore
    Duke Clinical Research Institute, Durham, NC, USA Department of Medicine, Duke University School of Medicine, Durham, NC, USA
    Eur J Heart Fail 17:340-6. 2015
    ..This study was therefore conducted to determine these factors...
  49. pmc Relief and Recurrence of Congestion During and After Hospitalization for Acute Heart Failure: Insights From Diuretic Optimization Strategy Evaluation in Acute Decompensated Heart Failure (DOSE-AHF) and Cardiorenal Rescue Study in Acute Decompensated Heart
    Anuradha Lala
    From the Division of Cardiology, Brigham and Women s Hospital, Boston, MA A L, L W S The Zena and Michael A Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY A L Duke Clinical Research Institute, Durham, NC S E M, R J M, A D D, P K, K J A, G M F, A F H Mayo Clinic, Rochester, MN S M D, O F A, M M R Washington University School of Medicine, St Louis, MO J M V and Hennepin County Medical Center, Minneapolis, MN S R G, B A B
    Circ Heart Fail 8:741-8. 2015
    ..Although decongestion is a major goal of acute therapy, it is unclear how the clinical components of congestion (eg, peripheral edema, orthopnea) contribute to outcomes after discharge or how well decongestion is maintained...
  50. pmc Heart failure in elderly patients: distinctive features and unresolved issues
    Valentina Lazzarini
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA
    Eur J Heart Fail 15:717-23. 2013
    ..The clinical characteristics, treatment patterns, and outcomes of elderly HF patients are explored. Finally, the main gaps regarding HF therapies in the elderly and the opportunities for future trials are highlighted. ..
  51. doi Predictive value of low relative lymphocyte count in patients hospitalized for heart failure with reduced ejection fraction: insights from the EVEREST trial
    Muthiah Vaduganathan
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Circ Heart Fail 5:750-8. 2012
    ..Limited data exist regarding whether relative lymphocyte count correlates with postdischarge outcomes in patients hospitalized for HF...
  52. pmc Implications of Using Different Definitions on Outcomes in Worsening Heart Failure
    Jacob P Kelly
    From the Duke Clinical Research Institute, Duke Medicine, Durham, NC J P K, L B C, D G, K J A, C M O C, R J M, A F H, M F Division of Cardiology, Department of Medicine, Duke University School of Medicine, Durham, NC J P K, L B C, C M O C, R J M, A F H, M F Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN H H C, M M R and Inova Heart and Vascular Institute, Falls Church, VA C M O C
    Circ Heart Fail 9:. 2016
    ....
  53. pmc Response to Exercise Training and Outcomes in Patients With Heart Failure and Diabetes Mellitus: Insights From the HF-ACTION Trial
    Adam Z Banks
    Duke University Medical Center, Durham, North Carolina Electronic address
    J Card Fail 22:485-91. 2016
    ..Previous studies have suggested that diabetes mellitus (DM) may be associated with an attenuated response to exercise. We explored whether DM attenuated the improvement in functional capacity with exercise...
  54. pmc The Obesity and Heart Failure Epidemics Among African Americans: Insights From the Jackson Heart Study
    Arun Krishnamoorthy
    Duke Clinical Research Institute, Durham, North Carolina Department of Medicine, Duke University School of Medicine, Durham, North Carolina Electronic address
    J Card Fail 22:589-97. 2016
    ..We examined intermediate and long-term clinical implications of obesity in African Americans and associations between obesity and all-cause mortality, heart failure, and heart failure hospitalization...
  55. pmc Usefulness of Palliative Care to Complement the Management of Patients on Left Ventricular Assist Devices
    Nancy Luo
    Division of Cardiology, Department of Internal Medicine, Duke University Medical Center, Durham, North Carolina Electronic address
    Am J Cardiol 118:733-8. 2016
    ..Here, we describe the benefits of palliative care, barriers to use within HF, and specific applications to the integrated care of patients on mechanical circulatory support. ..
  56. doi Combination decongestion therapy in hospitalized heart failure: loop diuretics, mineralocorticoid receptor antagonists and vasopressin antagonists
    Muthiah Vaduganathan
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Expert Rev Cardiovasc Ther 13:799-809. 2015
    ....
  57. doi Relation of Elevated Heart Rate in Patients With Heart Failure With Reduced Ejection Fraction to One-Year Outcomes and Costs
    Adam D DeVore
    Duke Clinical Research Institute, Durham, North Carolina Department of Medicine, Duke University School of Medicine, Durham, North Carolina Electronic address
    Am J Cardiol 117:946-51. 2016
    ....
  58. doi The PROTECT in-hospital risk model: 7-day outcome in patients hospitalized with acute heart failure and renal dysfunction
    CHRISTOPHER M O'CONNOR
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27710, USA
    Eur J Heart Fail 14:605-12. 2012
    ..We aimed to identify the predictors of 7-day heart failure events or death in patients hospitalized with AHF...
  59. doi Efficacy and Safety of Tolvaptan in Patients Hospitalized with Acute Heart Failure
    G Michael Felker
    Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, NC Duke Clinical Research Institute, Durham, NC Electronic address
    J Am Coll Cardiol . 2016
    ..The oral vasopressin-2 receptor antagonist tolvaptan causes aquaresis in patients with volume overload, potentially facilitating decongestion and improving the clinical course of patients with acute heart failure (AHF)...
  60. doi Discharge heart rate and β-blocker dose in patients hospitalized with heart failure: Findings from the OPTIMIZE-HF registry
    Adam D DeVore
    Duke Clinical Research Institute, Durham, NC Department of Medicine, Duke University School of Medicine, Durham, NC Electronic address
    Am Heart J 173:172-8. 2016
    ..However, little is known about the proportion of patients with elevated heart rate despite β-blocker therapy...
  61. doi Tolvaptan in Patients Hospitalized With Acute Heart Failure: Rationale and Design of the TACTICS and the SECRET of CHF Trials
    G Michael Felker
    From the Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, NC G M F, R J M, C B P, M F, C M O C Department of Medicine, Division of Cardiology, University of North Carolina, Chapel Hill K F A Division of Cardiology, Emory University School of Medicine, Atlanta, GA R T C The Heart and Vascular Center, The Christ Hospital, Cincinnati, OH G F E Cardiovascular Clinical Science Foundation, Boston, MA D G, P W and The Cardiovascular Center, Tufts Medical Center, Boston, MA J E U, M A K
    Circ Heart Fail 8:997-1005. 2015
    ....
  62. pmc Psychosocial Factors, Exercise Adherence, and Outcomes in Heart Failure Patients: Insights From Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION)
    Lauren B Cooper
    From the Duke Clinical Research Institute L B C, R J M, J L S, P J S, C M O C, and Department of Medicine L B C, R J M, W E K, C M O C, Duke University School of Medicine, Durham, NC Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, Md J L F, L S C, E S L Division of Cardiology, Albert Einstein College of Medicine, Bronx, NY I L P Division of Cardiology, Jefferson Medical College, Philadelphia, PA D J W and Division of Cardiovascular Medicine, Henry Ford Hospital, Detroit, MI S J K
    Circ Heart Fail 8:1044-51. 2015
    ..Psychosocial factors may influence adherence with exercise training for heart failure (HF) patients. We aimed to describe the association between social support and barriers to participation with exercise adherence and clinical outcomes...
  63. doi Early vs. late worsening heart failure during acute heart failure hospitalization: insights from the PROTECT trial
    Robert J Mentz
    Duke University Hospital, Medicine, Division of Cardiology, 2301 Erwin Road, Durham, NC 27713, USA
    Eur J Heart Fail 17:697-706. 2015
    ..The association between the time of the WHF event and the intensity of WHF therapy with outcomes is unknown...
  64. pmc Decongestion in acute heart failure
    Robert J Mentz
    Duke University Medical Center, Durham, NC, USA
    Eur J Heart Fail 16:471-82. 2014
    ..This review is based on discussions among scientists, clinical trialists, and regulatory representatives at the 9th Global Cardio Vascular Clinical Trialists Forum in Paris, France, from 30 November to 1 December 2012. ..
  65. doi Persistent angina pectoris in ischaemic cardiomyopathy: increased rehospitalization and major adverse cardiac events
    Robert J Mentz
    Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, NC, USA
    Eur J Heart Fail 16:854-60. 2014
    ..The impact of refractory angina pectoris (AP) in patients with ischaemic cardiomyopathy (ICM) is unknown. We investigated the characteristics and outcomes of ICM patients with persistent AP following cardiac catheterization...
  66. doi Hospitalized Heart Failure in the United States: Lessons Learned from Clinical Trial Populations
    Stephen J Greene
    Division of Cardiology, Department of Medicine, Duke University Medical Center, 2301 Erwin Road, Durham, NC 27705, USA Electronic address
    Heart Fail Clin 11:591-601. 2015
    ....
  67. doi Identifying Barriers and Practical Solutions to Conducting Site-Based Research in North America: Exploring Acute Heart Failure Trials As a Case Study
    Andrew P Ambrosy
    Division of Cardiology, Duke University School of Medicine, 2301 Erwin Road Drive, Durham, NC 27710, USA Electronic address
    Heart Fail Clin 11:581-9. 2015
    ..This article uses AHF as a paradigm and identifies barriers and practical solutions to successfully conducting site-based research in North America. ..
  68. doi Angiotensin receptor neprilysin inhibition in heart failure: mechanistic action and clinical impact
    Jonathan Buggey
    Department of Medicine, Duke University Medical Center, Durham, North Carolina Electronic address
    J Card Fail 21:741-50. 2015
    ..In this paper, we review the preclinical and clinical data that led to the development of LCZ696, the understanding of the underlying mechanistic action, and the robust clinical impact that LCZ696 may have in the near future. ..
  69. pmc A reappraisal of loop diuretic choice in heart failure patients
    Jonathan Buggey
    Duke University Medical Center, Durham, NC Electronic address
    Am Heart J 169:323-33. 2015
    ....
  70. doi Global perspectives in hospitalized heart failure: regional and ethnic variation in patient characteristics, management, and outcomes
    Andrew P Ambrosy
    Division of Cardiology, Duke University Medical Center, Durham, NC, USA
    Curr Heart Fail Rep 11:416-27. 2014
    ..This paper aims to describe regional and ethnic variations in patient characteristics, management, and outcomes in hospitalized HF. ..
  71. pmc Dysphagia in the setting of left ventricular assist device hemolysis
    Robert J Mentz
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    ASAIO J 59:322-3. 2013
    ....
  72. pmc Charting a roadmap for heart failure biomarker studies
    Tariq Ahmad
    Division of Cardiology, Duke University Medical Center, Durham, North Carolina Duke Clinical Research Institute, Durham, North Carolina
    JACC Heart Fail 2:477-88. 2014
    ..Such a consortium could collaborate in sharing samples to identify biomarkers, undertake meta-analyses on completed trials, and spearhead clinical trials to test the clinical utility of new biomarkers. ..
  73. doi A crisis of the heart: an acute reversible cardiomyopathy bridged to recovery in a patient with Addison's disease
    Arun Krishnamoorthy
    From the Division of Cardiology and Division of Endocrinology, Duke University Medical Center, Durham, North Carolina Novant Health and Heart Vascular Institute, Charlotte, North Carolina and Division of Cardiothoracic Surgery, Duke University Medical Center, Durham, North Carolina
    ASAIO J 59:668-70. 2013
    ..The patient was successfully treated with corticosteroid replacement and bridged with temporary mechanical circulatory support to eventual complete the recovery of native myocardial function. ..
  74. doi Cardiac resynchronization therapy in heart failure patients with less severe left ventricular dysfunction
    Ofek Y Hai
    Division of Cardiovascular Medicine, Department of Medicine, State University of New York SUNY Downstate Medical Center, Brooklyn, NY, USA
    Eur J Heart Fail 17:135-43. 2015
    ..This review summarizes the currently available literature regarding the potential impact of CRT in patients with more modest reductions in LVEF. ..
  75. pmc Patient selection for advanced heart failure therapy referral
    Alexander C Fanaroff
    From the Department of Medicine, Duke University Medical Center, Durham, NC Division of Cardiology, Duke University Medical Center, Durham, NC and Division of Cardiothoracic Surgery, Duke University Medical Center, Durham, NC
    Crit Pathw Cardiol 13:1-5. 2014
    ..Decision making on referral to the heart transplant center is also summarized. ..
  76. doi Covariate adjustment in heart failure randomized controlled clinical trials: a case analysis of the HF-ACTION trial
    CHRISTOPHER M O'CONNOR
    Division of Cardiology, Duke University Medical Center, Durham, NC 27710, USA
    Heart Fail Clin 7:497-500. 2011
    ..This article reviews the HF-ACTION trial to better understand whether covariate adjustment should be prespecified as the primary end point in HF clinical trials...
  77. doi End-of-life Heart Failure Care in the United States
    Jonathan Buggey
    Department of Medicine, Duke University Medical Center, Duke Medical Hospital, Medical Residency Office Room 8254DN, 2301 Erwin Road, Durham, NC 27710, USA Electronic address
    Heart Fail Clin 11:615-23. 2015
    ..Improved palliative care services for patients with HF may improve quality of life and decrease health care resource use near the end of life. ..
  78. doi Pathophysiology and clinical evaluation of acute heart failure
    Robert J Mentz
    Duke Clinical Research Institute and Department of Medicine, Division of Cardiology, Duke University Medical Center, 2400 Pratt Street, Durham, NC 27705, USA
    Nat Rev Cardiol 13:28-35. 2016
    ..These potential causative mechanisms provide a framework for clinicians to evaluate and manage patients with AHF and highlight possible future targets for therapies designed to improve clinical outcomes. ..
  79. ncbi Natriuretic Peptide-guided therapy for heart failure
    Robert J Mentz
    Department of Cardiology, Duke Clinical Research Institute, Durham, NC, USA
    Circ J 75:2031-7. 2011
    ..This article reviews the rationale, accumulated data, and unanswered questions for BGT in chronic HF...
  80. doi Diuretics and ultrafiltration in acute decompensated heart failure
    G Michael Felker
    Division of Cardiology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA
    J Am Coll Cardiol 59:2145-53. 2012
    ..This review summarizes available data on the use of both diuretics and UF in ADHF patients and identifies challenges and unresolved questions for each approach...