John R Lynch
Affiliation: Duke University Medical Center
- A novel therapeutic derived from apolipoprotein E reduces brain inflammation and improves outcome after closed head injuryJohn R Lynch
The Multidisciplinary Neuroprotection Laboratories, Duke University Medical Center, Durham, NC 27710, USA
Exp Neurol 192:109-16. 2005..The development of an apoE-based intervention represents a novel therapeutic strategy in the management of acute brain injury...
- Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injuryHaichen Wang
Department of Medicine, Division of Neurology, Duke University Medical Center, Durham, NC 27710, USA
Exp Neurol 206:59-69. 2007..Furthermore, statin treatment improved cerebral hemodynamics following head injury. Thus, the administration of statins may represent a viable therapeutic strategy in the acute treatment of closed head injury...
- Simvastatin reduces vasospasm after aneurysmal subarachnoid hemorrhage: results of a pilot randomized clinical trialJohn R Lynch
Departments of Medicine Neurology, Duke University Medical Center, Durham, NC 27710, USA
Stroke 36:2024-6. 2005..Cerebral vasospasm remains a major source of morbidity after aneurysmal subarachnoid hemorrhage (SAH). We demonstrate that simvastatin reduces serum markers of brain injury and attenuates vasospasm after SAH...
- Levetiracetam is neuroprotective in murine models of closed head injury and subarachnoid hemorrhageHaichen Wang
Multidisciplinary Neuroprotection Laboratories, Duke University Medical Center, Durham, NC 27710, USA
Neurocrit Care 5:71-8. 2006..In the current study, we test the hypothesis that levetiracetam, an anticonvulsant with favorable interaction and adverse event profiles, is neuroprotective in clinically relevant models of SAH and closed head injury (CHI)...
- A novel apoE-derived therapeutic reduces vasospasm and improves outcome in a murine model of subarachnoid hemorrhageJunling Gao
Multidisciplinary Neuroprotection Laboratories, Durham, NC, USA
Neurocrit Care 4:25-31. 2006..We then test the hypothesis that an apoE-derived therapeutic peptide reduces vasospasm and improves functional recovery after SAH...
- APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory responseJohn R Lynch
Department of Medicine Neurology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 278:48529-33. 2003....
- Apolipoprotein E modifies the CNS response to injury via a histamine-mediated pathwayBrian E Mace
Department of Medicine Neurology, Duke University Medical Center, Durham, NC 27710, USA
Neurol Res 29:243-50. 2007..These results suggest that apoE modifies secondary neuronal injury caused by histamine release and are consistent with previous observations that apoE affects the CNS inflammatory response in an isoform-specific manner...
- Effects of a manganese (III) porphyrin catalytic antioxidant in a mouse closed head injury modelStephen B Leinenweber
Department of Pediatrics, Duke University Medical Center, Durham NC 27710, USA
Eur J Pharmacol 531:126-32. 2006..Closed head injury altered performance in both tests. No statistically significant effect of MnTE-2-PyP5+ was observed. We conclude that single dose MnTE-2-PyP5+ does not alter outcome in this mouse closed head injury model...
- Simvastatin increases endothelial nitric oxide synthase and ameliorates cerebral vasospasm resulting from subarachnoid hemorrhageMatthew J McGirt
Multidisciplinary Neuroprotection Laboratories, Duke University Medical Center, Duke University School of Medicine Duke University Medical Center, Durham, NC, USA
Stroke 33:2950-6. 2002..Simvastatin increases eNOS activity. We hypothesized that simvastatin would increase eNOS protein and ameliorate SAH-induced cerebral vasospasm...
- Apolipoprotein E affects the central nervous system response to injury and the development of cerebral edemaJohn R Lynch
Multidisciplinary Neuroprotection Laboratory, Duke University Medical Center, Durham, NC 27710, USA
Ann Neurol 51:113-7. 2002..Thus, modulation of the endogenous central nervous system inflammatory response may be one mechanism by which apolipoprotein E affects outcome following acute brain injury...
- Leukocytosis as an independent risk factor for cerebral vasospasm following aneurysmal subarachnoid hemorrhageMatthew J McGirt
Division of Neurology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
J Neurosurg 98:1222-6. 2003..The goal of this study was to assess whether clinical, radiographic, or serological variables could be used to identify patients at an increased risk for cerebral vasospasm...
- Novel diagnostic test for acute strokeJohn R Lynch
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Stroke 35:57-63. 2004..The objective of this study was to examine the feasibility of developing a diagnostic panel of blood-borne biochemical markers of cerebral ischemia...
- Effects of isoflurane versus fentanyl-nitrous oxide anesthesia on long-term outcome from severe forebrain ischemia in the ratHazem Elsersy
The Multidisciplinary Neuroprotection Laboratories, Duke University Medical Center, Durham, North Carolina, USA
Anesthesiology 100:1160-6. 2004..This study examined long-term outcome from severe forebrain ischemia in the rat, as a function of anesthetic given during the ischemic injury...
- Serum von Willebrand factor, matrix metalloproteinase-9, and vascular endothelial growth factor levels predict the onset of cerebral vasospasm after aneurysmal subarachnoid hemorrhageMatthew J McGirt
Multidisciplinary Neuroprotection Laboratory, Medical Center, Duke University School of Medicine, Durham, NC 27710, USA
Neurosurgery 51:1128-34; discussion 1134-5. 2002..We hypothesized that serum von Willebrand factor (vWF) (a marker of endothelial cell death), MMP-9, and VEGF levels could serve as prognostic markers in predicting the occurrence of cerebral vasospasm...
- Accurate patient history contributes to differentiating diabetes insipidus: a case studyDaiWai M Olson
Duke University Hospital North, Durham, NC, USA
J Neurosci Nurs 36:228-30. 2004..Thus successful treatment required that nephrogenic and neurogenic DI be treated concomitantly...
- Risk of cerebral vasopasm after subarachnoid hemorrhage reduced by statin therapy: A multivariate analysis of an institutional experienceMatthew J McGirt
Department of Neurosurgery, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
J Neurosurg 105:671-4. 2006..The authors hypothesized that patients chronically treated with statins would have a decreased risk of symptomatic vasospasm after SAH...
- Synthes Award for Resident Research in Spinal Cord & Spinal Column Injury: Statins for the treatment of neurological injury: a role beyond cholesterol loweringMatthew J McGirt
Department of Neurosurgery, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
Clin Neurosurg 51:320-8. 2004
- Galbraith Award: simvastatin attenuates experimental cerebral vasospasm and ameliorates serum markers of neuronal and endothelial injury in patients after subarachnoid hemorrhage: a dose-response effect dependent on endothelial nitric oxide synthaseMatthew J McGirt
Department of Neurosurgery, Johns Hopkins Hospital, Baltimore, Maryland, USA
Clin Neurosurg 52:371-8. 2005
- Correlation of serum brain natriuretic peptide with hyponatremia and delayed ischemic neurological deficits after subarachnoid hemorrhageMatthew J McGirt
Department of Neurosurgery, The Johns Hopkins Hospital, Baltimore, Maryland, USA
Neurosurgery 54:1369-73; discussion 1373-4. 2004..We examined the temporal relationship between serum BNP elevation, hyponatremia, and the onset of delayed ischemic neurological deficits and determined whether serum BNP levels correlated with the 2-week outcome after SAH...
- Interventional acute ischemic stroke therapy with intracranial self-expanding stentOsama O Zaidat
Stroke 39:2392-5. 2008..Newly available self-expanding intracranial atherosclerotic stents (SEIS), which can be deployed rapidly and safely, make acute stenting an option for treating AIS. We present the feasibility of this technique...