DAVID GUY KIRSCH
Affiliation: Duke University Medical Center
- Efficacy of phosphatidylinositol-3 kinase inhibitors in a primary mouse model of undifferentiated pleomorphic sarcomaSuzy Kim
Department of Radiation Oncology, Duke University Medical Center, Box 91006, Durham, NC 27710, USA
Sarcoma 2012:680708. 2012..1%. Combining BEZ235 with doxorubicin (n = 10) increased the complete response rate to 50% (P = 0.035). These studies demonstrate that PI3K pathway inhibition is a viable and attractive target for soft-tissue sarcomas...
- Intraoperative detection and removal of microscopic residual sarcoma using wide-field imagingJeffrey K Mito
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27708, USA
Cancer 118:5320-30. 2012..To help identify these patients, the authors developed an in vivo imaging system to investigate the suitability of molecular imaging for intraoperative visualization...
- Cross species genomic analysis identifies a mouse model as undifferentiated pleomorphic sarcoma/malignant fibrous histiocytomaJeffrey K Mito
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, United States of America
PLoS ONE 4:e8075. 2009..These results suggest that genomic alterations present in human MFH are conserved in the LSL-Kras(G12D); p53(Flox/Flox) mouse model of soft tissue sarcoma and demonstrate the utility of this pre-clinical model...
- Generation of primary tumors with Flp recombinase in FRT-flanked p53 miceChang Lung Lee
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Box 91006, Durham, NC 27708, USA
Dis Model Mech 5:397-402. 2012..p53(FRT) mice will enable dual recombinase technology to study cancer biology because Cre is available to modify genes specifically in stromal cells to investigate their role in tumor development, progression and response to therapy...
- NF1 deletion generates multiple subtypes of soft-tissue sarcoma that respond to MEK inhibitionRebecca D Dodd
Corresponding Author David G Kirsch, Duke University Medical Center, Box 91006, Durham, NC 27708
Mol Cancer Ther 12:1906-17. 2013..These studies suggest that MEK inhibitors should be further explored as potential sarcoma therapies in patients with tumors containing NF1 deletion...
- Using genetically engineered mice for radiation researchDavid G Kirsch
Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
Radiat Res 176:275-9. 2011..These advances in genetic engineering provide a powerful model system to dissect both the mechanisms of normal tissue injury after irradiation and the mechanisms by which radiation cures cancer...
- Imaging primary lung cancers in mice to study radiation biologyDavid G Kirsch
The David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA
Int J Radiat Oncol Biol Phys 76:973-7. 2010..To image a genetically engineered mouse model of non-small-cell lung cancer with micro-computed tomography (micro-CT) to measure tumor response to radiation therapy...
- p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosisDavid G Kirsch
David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Science 327:593-6. 2010..These results suggest that the GI syndrome is caused by the death of GI epithelial cells and that these epithelial cells die by a mechanism that is regulated by p53 but independent of apoptosis...
- Dicer1 functions as a haploinsufficient tumor suppressorMadhu S Kumar
Massachusetts Institute of Technology Koch Institute for Integrative Cancer Research, Cambridge, Massachusetts 02139, USA
Genes Dev 23:2700-4. 2009..These findings suggest Dicer1 may be an important haploinsufficient tumor suppressor gene and, furthermore, that other factors controlling miRNA biogenesis may also function in this manner...
- A spatially and temporally restricted mouse model of soft tissue sarcomaDavid G Kirsch
Center for Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
Nat Med 13:992-7. 2007..Therefore, the intrinsic pathway of apoptosis seems sufficient to mediate p53 tumor suppression in an epithelial cancer, but not in this model of soft tissue sarcoma...
- Future of early detection of lung cancer: the role of mouse modelsAlice T Shaw
Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA
Clin Cancer Res 11:4999s-5003s. 2005..The application of innovative technologies to accurate mouse models promises to accelerate the discovery of new molecular targets and imaging biomarkers for the early detection of lung cancer...