K S Kaye

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint Multidrug-resistant Pathogens: Mechanisms of Resistance and Epidemiology
    - Kaye
    Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Box 3152, Durham, NC 27710, USA
    Curr Infect Dis Rep 2:391-398. 2000
  2. ncbi request reprint Surgical site infection in the elderly population
    Keith S Kaye
    Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Clin Infect Dis 39:1835-41. 2004
  3. ncbi request reprint Risk factors for surgical site infections in older people
    Keith S Kaye
    Duke University Medical Center, Durham, North Carolina 27710, USA
    J Am Geriatr Soc 54:391-6. 2006
  4. ncbi request reprint Favorable impact of an infection control network on nosocomial infection rates in community hospitals
    Keith S Kaye
    Department of Medicine and Infection Control, Duke University Medical Center, Durham, NC 27710, USA
    Infect Control Hosp Epidemiol 27:228-32. 2006
  5. ncbi request reprint The case-case-control study design: addressing the limitations of risk factor studies for antimicrobial resistance
    Keith S Kaye
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Infect Control Hosp Epidemiol 26:346-51. 2005
  6. pmc Variety of beta-lactamases produced by amoxicillin-clavulanate-resistant Escherichia coli isolated in the northeastern United States
    Keith S Kaye
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Antimicrob Agents Chemother 48:1520-5. 2004
  7. pmc Reference group choice and antibiotic resistance outcomes
    Keith S Kaye
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Emerg Infect Dis 10:1125-8. 2004
  8. ncbi request reprint Pathogens resistant to antimicrobial agents: epidemiology, molecular mechanisms, and clinical management
    Keith S Kaye
    Department of Medicine, Duke University Medical Center, Box 3152, Durham, NC 27710, USA
    Infect Dis Clin North Am 18:467-511, viii. 2004
  9. ncbi request reprint The effect of increasing age on the risk of surgical site infection
    Keith S Kaye
    Division of Infectious Diseases, Department of Medicine, School of Medicine, Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Infect Dis 191:1056-62. 2005
  10. ncbi request reprint Utility of pulse oximetry in diagnosing pneumonia in nursing home residents
    Keith S Kaye
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Med Sci 324:237-42. 2002

Research Grants

  1. Hospital-Acquired Infections in the Elderly
    Keith Kaye; Fiscal Year: 2008

Detail Information

Publications77

  1. ncbi request reprint Multidrug-resistant Pathogens: Mechanisms of Resistance and Epidemiology
    - Kaye
    Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Box 3152, Durham, NC 27710, USA
    Curr Infect Dis Rep 2:391-398. 2000
    ..Azole resistance in Candida species. has also complicated the treatment of nosocomial infections. Resistance to antimicrobial drugs is a persistent and emerging problem and presents major therapeutic challenges...
  2. ncbi request reprint Surgical site infection in the elderly population
    Keith S Kaye
    Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Clin Infect Dis 39:1835-41. 2004
    ..Insights and opinions pertaining to modalities for SSI prevention in the elderly population and areas of import for future research are discussed...
  3. ncbi request reprint Risk factors for surgical site infections in older people
    Keith S Kaye
    Duke University Medical Center, Durham, North Carolina 27710, USA
    J Am Geriatr Soc 54:391-6. 2006
    ..To identify risk factors for surgical site infection (SSI) in older people and to test a priori hypotheses regarding particular variables and SSI risk...
  4. ncbi request reprint Favorable impact of an infection control network on nosocomial infection rates in community hospitals
    Keith S Kaye
    Department of Medicine and Infection Control, Duke University Medical Center, Durham, NC 27710, USA
    Infect Control Hosp Epidemiol 27:228-32. 2006
    ..To describe an infection control network (the Duke Infection Control Outreach Network [DICON]) and its impact on nosocomial infection rates in community hospitals...
  5. ncbi request reprint The case-case-control study design: addressing the limitations of risk factor studies for antimicrobial resistance
    Keith S Kaye
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Infect Control Hosp Epidemiol 26:346-51. 2005
    ..There are significant limitations of the standard case-control study design for identifying risk factors for resistant organisms. The objective of this study was to develop a study design to overcome these limitations...
  6. pmc Variety of beta-lactamases produced by amoxicillin-clavulanate-resistant Escherichia coli isolated in the northeastern United States
    Keith S Kaye
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Antimicrob Agents Chemother 48:1520-5. 2004
    ....
  7. pmc Reference group choice and antibiotic resistance outcomes
    Keith S Kaye
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Emerg Infect Dis 10:1125-8. 2004
    ..Cases were compared to uninfected patients and patients infected with the corresponding, susceptible organism. VRE and MRSA were associated with adverse outcomes. The effect was greater when uninfected control patients were used...
  8. ncbi request reprint Pathogens resistant to antimicrobial agents: epidemiology, molecular mechanisms, and clinical management
    Keith S Kaye
    Department of Medicine, Duke University Medical Center, Box 3152, Durham, NC 27710, USA
    Infect Dis Clin North Am 18:467-511, viii. 2004
    ..This article reviews the epidemiology, molecular mechanisms of resistance, and treatment options for pathogens resistant to antimicrobial drugs...
  9. ncbi request reprint The effect of increasing age on the risk of surgical site infection
    Keith S Kaye
    Division of Infectious Diseases, Department of Medicine, School of Medicine, Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Infect Dis 191:1056-62. 2005
    ..The objective of the present study was to determine the relationship between increasing age and risk of SSI...
  10. ncbi request reprint Utility of pulse oximetry in diagnosing pneumonia in nursing home residents
    Keith S Kaye
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Med Sci 324:237-42. 2002
    ..The differential diagnosis of acute infection in elderly nursing home patients is often difficult. This study evaluated pulse oximetry in pneumonia in this population...
  11. pmc Preoperative drug dispensing as predictor of surgical site infection
    K S Kaye
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Emerg Infect Dis 7:57-65. 2001
    ..The chronic disease score improved prediction of infection by the NNIS risk index and augmented the ASA score for risk adjustment...
  12. pmc Differential effects of levofloxacin and ciprofloxacin on the risk for isolation of quinolone-resistant Pseudomonas aeruginosa
    Keith S Kaye
    Duke University Medical Center, Durham, NC 27710, USA
    Antimicrob Agents Chemother 50:2192-6. 2006
    ..6; 95% CI = 0.4 to 0.9), whereas ciprofloxacin had no significant effect (OR = 1.0; 95% CI = 0.6 to 1.8). In conclusion, the use of levofloxacin, but not ciprofloxacin, was associated with isolation of QR P. aeruginosa...
  13. ncbi request reprint Surgical-site infection due to Staphylococcus aureus among elderly patients: mortality, duration of hospitalization, and cost
    Sarah A McGarry
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Infect Control Hosp Epidemiol 25:461-7. 2004
    ..aureus SSI...
  14. pmc Risk factors for recovery of ampicillin-sulbactam-resistant Escherichia coli in hospitalized patients
    K S Kaye
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA 02215, USA
    Antimicrob Agents Chemother 44:1004-9. 2000
    ..coli. Interestingly, exposure to piperacillin-tazobactam tended to protect against the isolation of E. coli strains resistant to ampicillin-sulbactam, but this did not reach statistical significance (OR = 0.13; P = 0.11)...
  15. ncbi request reprint Implementation of antibiotic rotation protocol improves antibiotic susceptibility profile in a surgical intensive care unit
    Kyla M Bennett
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Trauma 63:307-11. 2007
    ..We assessed the effect of an antibiotic rotation protocol on the antibiotic susceptibility profiles of three clinically relevant gram-negative microorganisms within our surgical intensive care unit (SICU)...
  16. ncbi request reprint Risk factors for postoperative mediastinitis due to methicillin-resistant Staphylococcus aureus
    E S Dodds Ashley
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Clin Infect Dis 38:1555-60. 2004
    ..Changes in perioperative antimicrobial prophylaxis, in addition to other interventions, should be considered for prevention of POM due to MRSA in targeted, high-risk populations...
  17. ncbi request reprint The impact of methicillin resistance in Staphylococcus aureus bacteremia on patient outcomes: mortality, length of stay, and hospital charges
    Sara E Cosgrove
    Division of Infectious Diseases, Johns Hopkins Medical Institutions, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Infect Control Hosp Epidemiol 26:166-74. 2005
    ..To evaluate the impact of methicillin resistance in Staphylococcus aureus on mortality, length of hospitalization, and hospital charges...
  18. ncbi request reprint Methicillin-resistant Staphylococcus aureus outbreak in an intensive care nursery: potential for interinstitutional spread
    Jay R McDonald
    Division of Infectious Diseases, Duke University Medical Center, Durham, NC, USA
    Pediatr Infect Dis J 26:678-83. 2007
    ..After surveillance surveys documented the absence of methicillin-resistant Staphylococcus aureus (MRSA) in our intensive care nursery, an outbreak of MRSA infection occurred there during a 7-month period in 2005...
  19. ncbi request reprint Control of nosocomial acquisition of vancomycin-resistant Enterococcus through active surveillance of hemodialysis patients
    R Neal Axon
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Infect Control Hosp Epidemiol 25:436-8. 2004
    ..05). To assess the effectiveness of active surveillance, patients undergoing active surveillance should be analyzed separately from other patients...
  20. doi request reprint Mortality and time to extubation in severe hospital-acquired pneumonia
    Sarah M Connelly
    Department of Internal Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Infect Control 37:143-9. 2009
    ..This study examined predictors of in-hospital mortality and time to extubation among patients with acute, severe hospital-acquired pneumonia (HAP) managed in the intensive care unit (ICU)...
  21. ncbi request reprint Health care--associated bloodstream infections in adults: a reason to change the accepted definition of community-acquired infections
    N Deborah Friedman
    Division of Infectious Diseases, Duke University Medical Center and Durham Regional Hospital, Box 3605, Durham, NC 27710, USA
    Ann Intern Med 137:791-7. 2002
    ..Bloodstream infections occurring in persons residing in the community, regardless of whether those persons have been receiving health care in an outpatient facility, have traditionally been categorized as community-acquired infections...
  22. ncbi request reprint Health and economic outcomes of the emergence of third-generation cephalosporin resistance in Enterobacter species
    Sara E Cosgrove
    Department of Medicine, The John Hopkins Hospital, 1830 E Monument St, Room 9020, Baltimore, MD 21287, USA
    Arch Intern Med 162:185-90. 2002
    ..This study evaluated the clinical and economic impact of the emergence of third-generation cephalosporin-resistant Enterobacter species...
  23. pmc Clinical and financial outcomes due to methicillin resistant Staphylococcus aureus surgical site infection: a multi-center matched outcomes study
    Deverick J Anderson
    Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Duke Infection Control Outreach Network, Durham, North Carolina, USA
    PLoS ONE 4:e8305. 2009
    ..The clinical and financial outcomes of SSIs directly attributable to MRSA and methicillin-resistance are largely uncharacterized. Previously published data have provided conflicting conclusions...
  24. pmc Spectrum of excess mortality due to carbapenem-resistant Klebsiella pneumoniae infections
    C Hauck
    Division of Infectious Diseases, University of North Carolina, Chapel Hill, NC, USA
    Clin Microbiol Infect 22:513-9. 2016
    ..Patients with BSI have slightly lower excess hospital mortality rates, whereas excess hospital mortality was not observed in hospitalized patients with UTI. ..
  25. doi request reprint Controlling antimicrobial resistance in the hospital
    Deverick J Anderson
    Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Infect Dis Clin North Am 23:847-64, vii-viii. 2009
    ..This article describes different infection control and antibiotic management strategies that can be used to control antimicrobial resistance in hospital settings...
  26. ncbi request reprint Analysis of two- and three-year trends in antimicrobial resistance in intensive care units using unit-specific antibiograms
    Tahaniyat Lalani
    Division of Infectious Diseases, Duke Clinical Research Institute, Durham, NC 27710, USA
    Scand J Infect Dis 40:672-4. 2008
    ..Three-y unit-specific antibiogram data may provide increased statistical power to detect changes in antimicrobial resistance...
  27. doi request reprint Infectious complications following endoscopic retrograde cholangiopancreatography: an automated surveillance system for detecting postprocedure bacteremia
    Deverick J Anderson
    Division of Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA
    Am J Infect Control 36:592-4. 2008
    ..Because invasive procedures are performed in various outpatient and inpatient settings, novel methods are needed to conduct effective surveillance for infection...
  28. doi request reprint Complex surgical site infections and the devilish details of risk adjustment: important implications for public reporting
    Deverick J Anderson
    Duke Infection Control Outreach Network, Duke University Medical Center, Durham, North Carolina 27710, USA
    Infect Control Hosp Epidemiol 29:941-6. 2008
    ..To validate the National Nosocomial Infection Surveillance (NNIS) risk index as a tool to account for differences in case mix when reporting rates of complex surgical site infection (SSI)...
  29. doi request reprint Clinical outcomes and costs among patients with Staphylococcus aureus bacteremia and orthopedic device infections
    Tahaniyat Lalani
    Duke Clinical Research Institute, 2400 Pratt Street, Cube 7545, Durham, NC 27710, USA
    Scand J Infect Dis 40:973-7. 2008
    ..Patients with ODI had higher relapse of S. aureus infection, compared to bacteremic patients without ODI. Costs and outcomes were similar among ODI patients undergoing device removal and those treated with debridement and retention...
  30. doi request reprint The deadly toll of invasive methicillin-resistant Staphylococcus aureus infection in community hospitals
    Keith S Kaye
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Clin Infect Dis 46:1568-77. 2008
    ..Data regarding the epidemiology, treatment, and outcomes of methicillin-resistant Staphylococcus aureus (MRSA) infections in rural and community hospitals are limited...
  31. doi request reprint Surgical volume and the risk of surgical site infection in community hospitals: size matters
    Deverick J Anderson
    Division of Infectious Disease, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Surg 247:343-9. 2008
    ..To determine if surgical volume affects the risk of surgical site infections (SSI) in community hospitals...
  32. doi request reprint Poor functional status as a risk factor for surgical site infection due to methicillin-resistant Staphylococcus aureus
    Deverick J Anderson
    Department of Medicine, Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina 27710, USA
    Infect Control Hosp Epidemiol 29:832-9. 2008
    ..To identify risk factors for surgical site infection (SSI) due to methicillin-resistant Staphylococcus aureus (MRSA)...
  33. ncbi request reprint Risk factors for surgical site infection complicating laminectomy
    N Deborah Friedman
    Division of Infectious Diseases, Department of Medicine, Duke University Hospital, Durham, NC 27710, USA
    Infect Control Hosp Epidemiol 28:1060-5. 2007
    ..To examine risk factors for surgical site infection (SSI) following spinal surgery and to analyze the associations between a surgeon's years of operating experience and surgical specialty and patients' SSI risk...
  34. pmc The effect of surgical site infection on older operative patients
    Keith S Kaye
    Duke University Medical Center, Durham, North Carolina, USA
    J Am Geriatr Soc 57:46-54. 2009
    ..To determine the effect of surgical site infection (SSI) on mortality, duration of hospitalization, and hospital cost in older operative patients...
  35. pmc Antibiotic resistance in urinary isolates of Escherichia coli from college women with urinary tract infections
    Ronald P Olson
    Duke Student Health, Duke University, Durham, North Carolina 27710, USA
    Antimicrob Agents Chemother 53:1285-6. 2009
    ..8%, compared to 1.8% among those without prior UTI. Nitrofurantoin should be considered for empirical therapy of lower tract UTI...
  36. doi request reprint Building a successful infection prevention program: key components, processes, and economics
    Evelyn Cook
    Department of Medicine, Duke Infection Control Outreach Network, Durham, NC, USA
    Infect Dis Clin North Am 25:1-19. 2011
    ..This article discusses the structure and responsibilities of an infection control program and the regulatory pressures and opportunities the program faces...
  37. doi request reprint Variation in the type and frequency of postoperative invasive Staphylococcus aureus infections according to type of surgical procedure
    Deverick J Anderson
    Division of Infectious Disease, Duke University Medical Center, Durham, North Carolina 27710, USA
    Infect Control Hosp Epidemiol 31:701-9. 2010
    ..To determine the epidemiological characteristics of postoperative invasive Staphylococcus aureus infection following 4 types of major surgical procedures.design. Retrospective cohort study...
  38. pmc Trends in antimicrobial resistance of Acinetobacter baumannii isolates from a metropolitan Detroit health system
    Tara Reddy
    Division of Infectious Diseases, Detroit Medical Center, Wayne State University, Detroit, Michigan 48201, USA
    Antimicrob Agents Chemother 54:2235-8. 2010
    ..The sharp rise mandates major multidisciplinary interventions to optimize management of this multidrug-resistant pathogen...
  39. doi request reprint Validating a 3-point prediction rule for surgical site infection after coronary artery bypass surgery
    Luke F Chen
    Division of Infectious Diseases and International Health, Duke University Medical Center, Durham, North Carolina, USA
    Infect Control Hosp Epidemiol 31:64-8. 2010
    ..Investigators from Australia proposed a new, 3-point scale that assesses SSI risk on the basis of diagnosis of diabetes mellitus and body mass index...
  40. pmc Predictors of mortality in patients with bloodstream infection due to ceftazidime-resistant Klebsiella pneumoniae
    Deverick J Anderson
    Duke University Medical Center, Division of Infectious Disease, DUMC Box 3824, Durham, NC 27710, USA
    Antimicrob Agents Chemother 50:1715-20. 2006
    ..07 to 10.3). Thus, among patients with BSI due to CAZ-R K. pneumoniae, a delay in the initiation of effective therapy of greater than 72 h after BSI was associated with a >3-fold increase in mortality risk...
  41. doi request reprint Pathogens resistant to antibacterial agents
    Luke F Chen
    Department of Medicine, Division of Infectious Diseases and International Health, Duke University Medical Center, Box 102359, Hanes House, Durham, NC 27710, USA
    Infect Dis Clin North Am 23:817-45, vii. 2009
    ..This article reviews the epidemiology, molecular mechanisms of resistance, and treatment options for pathogens resistant to antimicrobial drugs...
  42. doi request reprint Patient-days: a better measure of incidence of occupational bloodborne exposures
    Luke F Chen
    Division of Infectious Diseases, Duke Infection Control Outreach Network, Duke University Medical Center, Durham, NC 27710, USA
    Am J Infect Control 37:534-40. 2009
    ..There is currently no accepted standard denominator to calculate and to report the incidence of occupational exposures to bloodborne pathogens (OEBBPs) in health care...
  43. doi request reprint Staphylococcal surgical site infections
    Deverick J Anderson
    Division of Infectious Diseases, Duke University Medical Center, DUMC Box 3605, Durham, NC 27710, USA
    Infect Dis Clin North Am 23:53-72. 2009
    ..Other strategies, including decolonization and the use of vancomycin, remain controversial...
  44. ncbi request reprint Rocky mountain spotted fever
    Daniel J Sexton
    Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Med Clin North Am 86:351-60, vii-viii. 2002
    ..With prompt, appropriate antimicrobial therapy, patient outcomes are excellent. However, RMSF is often misdiagnosed, particularly during the initial stages of illness, and as a result, patient outcomes are sometimes suboptimal...
  45. ncbi request reprint Skin and soft tissue infections in older adults
    Deverick J Anderson
    Division of Infectious Diseases, Duke University Medical Center, Box 3605, Durham, NC 27710, USA
    Clin Geriatr Med 23:595-613, vii. 2007
    ..Specific community- and hospital-associated SSTIs are reviewed in this article with particular emphasis on the epidemiology, prevention, risk factors, and treatment of SSTIs in older patients...
  46. ncbi request reprint Risk factors for ineffective therapy in patients with bloodstream infection
    Jay R McDonald
    Division of Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA
    Arch Intern Med 165:308-13. 2005
    ..The objective of this study was to analyze the impact of health care-associated status on effectiveness of initial therapy in hospitalized patients with bloodstream infections...
  47. ncbi request reprint Virulence associated with outbreak-related strains of Burkholderia cepacia complex among a cohort of patients with bacteremia
    Christopher W Woods
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Clin Infect Dis 38:1243-50. 2004
    ..5; 95% confidence interval, 1.20-25.02). B. cenocepacia is an emerging nosocomial pathogen. Certain strains are associated with an enhanced capacity for interpatient spread and poor outcome...
  48. ncbi request reprint Severe surgical site infection in community hospitals: epidemiology, key procedures, and the changing prevalence of methicillin-resistant Staphylococcus aureus
    Deverick J Anderson
    Department of Medicine, Division of Infectious Diseases, Duke University Medical Center, Durham, NC, 27710, USA
    Infect Control Hosp Epidemiol 28:1047-53. 2007
    ..To characterize the epidemiology of severe (ie, nonsuperficial) surgical site infection (SSI) in community hospitals...
  49. doi request reprint Hand hygiene noncompliance and the cost of hospital-acquired methicillin-resistant Staphylococcus aureus infection
    Keith L Cummings
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Infect Control Hosp Epidemiol 31:357-64. 2010
    ..Hand hygiene noncompliance is a major cause of nosocomial infection. Nosocomial infection cost data exist, but the effect of hand hygiene noncompliance is unknown...
  50. ncbi request reprint Clinical outcomes and costs due to Staphylococcus aureus bacteremia among patients receiving long-term hemodialysis
    John J Engemann
    Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Infect Control Hosp Epidemiol 26:534-9. 2005
    ..To examine the clinical outcomes and costs associated with Staphylococcus aureus bacteremia among hemodialysis-dependent patients...
  51. ncbi request reprint Staphylococcus aureus bacteremia in patients with prosthetic devices: costs and outcomes
    Vivian H Chu
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Med 118:1416. 2005
    ..aureus bacteremia on patients with prosthetic devices. This investigation sought to define the clinical outcome, health care resource use, and infection-associated costs of S. aureus bacteremia in patients with prostheses...
  52. ncbi request reprint Staphylococcus aureus bacteremia after median sternotomy: clinical utility of blood culture results in the identification of postoperative mediastinitis
    Vance G Fowler
    Division of Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA
    Circulation 108:73-8. 2003
    ..Mediastinitis is a complication of coronary artery bypass graft surgery (CABG) that can be difficult to diagnose. This study evaluated the utility of blood culture results in identifying patients with mediastinitis...
  53. ncbi request reprint Adverse clinical and economic outcomes attributable to methicillin resistance among patients with Staphylococcus aureus surgical site infection
    John J Engemann
    Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Clin Infect Dis 36:592-8. 2003
    ..Methicillin resistance is independently associated with increased mortality and hospital charges among patients with S. aureus SSI...
  54. ncbi request reprint Underresourced hospital infection control and prevention programs: penny wise, pound foolish?
    Deverick J Anderson
    Division of Infectious Disease and International Health, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Infect Control Hosp Epidemiol 28:767-73. 2007
    ..To estimate the cost of healthcare-associated infections (HAIs) in a network of 28 community hospitals and to compare this sum to the amount budgeted for infection control programs at each institution and for the entire network...
  55. ncbi request reprint Surgical site infection in the elderly following orthopaedic surgery. Risk factors and outcomes
    Jeanne Lee
    Division of Infectious Diseases and Geriatrics, Department of Medicine, the Center for the Study of Aging, Duke University Medical Center, Box 3152, Durham, NC 27710, USA
    J Bone Joint Surg Am 88:1705-12. 2006
    ..The aim of this study was to identify risk factors for surgical site infections and to quantify the impact of these infections on health outcomes in elderly patients following orthopaedic surgery...
  56. ncbi request reprint Risk factors for 1-year mortality after postoperative mediastinitis
    Ravi Karra
    Department of Medicine, Division of Infectious Diseases, Duke University Medical Center, Durham, NC, USA
    J Thorac Cardiovasc Surg 132:537-43. 2006
    ..Postoperative mediastinitis after median sternotomy is associated with disability and mortality. The aim of this study was to identify risk factors for mortality 1 year after postoperative mediastinitis diagnosis...
  57. ncbi request reprint Utility of the Chronic Disease Score and Charlson Comorbidity Index as comorbidity measures for use in epidemiologic studies of antibiotic-resistant organisms
    Jessina C McGregor
    Department of Epidemiology and Preventive Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Am J Epidemiol 161:483-93. 2005
    ..05). A revised comorbidity measure specific to resistant infections would likely provide a better assessment of the comorbidity-attributable risk of antibiotic-resistant infections...
  58. pmc Fluoroquinolones protective against cephalosporin resistance in gram-negative nosocomial pathogens
    Mitchell J Schwaber
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Emerg Infect Dis 10:94-9. 2004
    ....
  59. doi request reprint Measuring acceptable treatment failure rates for community-acquired pneumonia: potential for reducing duration of treatment and antimicrobial resistance
    Keith S Kaye
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Infect Control Hosp Epidemiol 29:137-42. 2008
    ..Reducing the duration of antibiotic therapy is one strategy for reducing antibiotic exposure and thereby minimizing the potential for the emergence of antimicrobial resistance...
  60. pmc Risk factors for emergence of resistance to broad-spectrum cephalosporins among Enterobacter spp
    K S Kaye
    Division of Infectious Diseases and Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Antimicrob Agents Chemother 45:2628-30. 2001
    ..03). There were trends toward decreased risk for resistance among patients receiving broad-spectrum cephalosporins and either aminoglycosides or imipenem. Of the patients receiving broad-spectrum cephalosporins, 19% developed resistance...
  61. doi request reprint A compendium of strategies to prevent healthcare-associated infections in acute care hospitals
    Deborah S Yokoe
    Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Infect Control Hosp Epidemiol 29:S12-21. 2008
    ....
  62. pmc Tigecycline therapy for carbapenem-resistant Klebsiella pneumoniae (CRKP) bacteriuria leads to tigecycline resistance
    D van Duin
    Division of Infectious Diseases, University of North Carolina, Chapel Hill, NC, USA
    Clin Microbiol Infect 20:O1117-20. 2014
    ..13; 95% CI, 1.15-48.65; p 0.03). In conclusion, the use of tigecycline with CRKP bacteriuria is common, and is associated with the subsequent development of tigecycline resistance. ..
  63. ncbi request reprint A comparison of the effectiveness of lipid-lowering therapy between HIV- and non-HIV-infected subjects with hyperlipidaemia
    Mary L Townsend
    Department of Pharmacy Practice, Campbell University School of Pharmacy, Buies Creek, NC, USA
    Int J STD AIDS 18:851-5. 2007
    ..While non-HIV-infected subjects were more likely to achieve TC and TG goals than HIV-infected subjects, overall achievement of NCEP III goals was poor. This result was likely due to treatment with inappropriately low doses of statins...
  64. pmc Preventing surgical site infections after bariatric surgery: value of perioperative antibiotic regimens
    Teena Chopra
    Division of Infectious Diseases, Department of Medicine Wayne State University, Detroit Medical Center, 4201 Saint Antoine, Suite 2B, Box 331, Detroit, MI 48201, USA
    Expert Rev Pharmacoecon Outcomes Res 10:317-28. 2010
    ....
  65. ncbi request reprint Co-infection or co-colonization with vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus in a network of community hospitals
    Jay R McDonald
    Infect Control Hosp Epidemiol 25:622. 2004
  66. ncbi request reprint Costs and outcomes among hemodialysis-dependent patients with methicillin-resistant or methicillin-susceptible Staphylococcus aureus bacteremia
    Shelby D Reed
    Center for Clinical and Genetic Economics, USA
    Infect Control Hosp Epidemiol 26:175-83. 2005
    ..We compared costs and outcomes of methicillin resistance in patients with S. aureus bacteremia and a single chronic condition...
  67. ncbi request reprint Risk factors for Burkholderia cepacia complex bacteremia among intensive care unit patients without cystic fibrosis: a case-control study
    Adam M Bressler
    Infectious Disease Specialists of Atlanta and Clinical Microbiology Laboratory, DeKalb Medical Center, Atlanta, GA, USA
    Infect Control Hosp Epidemiol 28:951-8. 2007
    ..The Burkholderia cepacia complex is associated with colonization or disease in patients with cystic fibrosis (CF). For patients without CF, this complex is poorly understood apart from its presence in occasional point source outbreaks...
  68. ncbi request reprint Impact of severity of illness bias and control group misclassification bias in case-control studies of antimicrobial-resistant organisms
    Anthony D Harris
    Department of Epidemiology and Preventive Medicine, University of Maryland, College Park, USA
    Infect Control Hosp Epidemiol 26:342-5. 2005
    ..If this bias exists, these studies might be expected to report lower odds ratios (ORs) because control-patients would be more like case-patients...
  69. ncbi request reprint Methicillin-resistant Staphylococcus aureus in hospitals: time for a culture change
    Luke F Chen
    Med J Aust 188:62-3; author reply 63-4. 2008
  70. ncbi request reprint Physicians' acceptable treatment failure rates in antibiotic therapy for coagulase-negative staphylococcal catheter-associated bacteremia: implications for reducing treatment duration
    Eli N Perencevich
    Veterans Affairs Maryland Healthcare System, Baltimore, MD 21201, USA
    Clin Infect Dis 41:1734-41. 2005
    ..We aimed to identify acceptable failure rates among infectious disease consultants (IDCs) for treatment of central venous catheter-associated bacteremia...
  71. pmc Clinical and economic impact of bacteremia with extended- spectrum-beta-lactamase-producing Enterobacteriaceae
    Mitchell J Schwaber
    Division of Epidemiology, Tel Aviv Sourasky Medical Center, 6 Weizmann St, Tel Aviv 64239, Israel
    Antimicrob Agents Chemother 50:1257-62. 2006
    ..ESBL production was associated with severe adverse outcomes, including higher overall and infection-related mortality, increased LOS, DAT, discharge to chronic care, and higher costs...
  72. pmc Risk factors for piperacillin-tazobactam-resistant Pseudomonas aeruginosa among hospitalized patients
    Anthony D Harris
    Department of Epidemiology and Preventive Medicine, University of Maryland VA Maryland Health Care System, Baltimore, Maryland 21201, USA
    Antimicrob Agents Chemother 46:854-8. 2002
    ..aeruginosa. Our results suggest that the nosocomial isolation of piperacillin-tazobactam-resistant P. aeruginosa may be affected by multiple antibiotics...
  73. ncbi request reprint Methicillin-resistant Staphylococcus aureus bacteremia after isolation from urine
    Deverick J Anderson
    Clin Infect Dis 42:1504-5. 2006
  74. ncbi request reprint Control-group selection importance in studies of antimicrobial resistance: examples applied to Pseudomonas aeruginosa, Enterococci, and Escherichia coli
    Anthony D Harris
    Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, and VA Maryland Health Care System, Baltimore, MD, USA
    Clin Infect Dis 34:1558-63. 2002
    ..68). The selection of control patients from the potentially suboptimal control type 1 can falsely identify certain antibiotics and overestimate the OR of the resistance-defining antibiotic...
  75. ncbi request reprint Acceptable rates of treatment failure in osteomyelitis involving the diabetic foot: a survey of infectious diseases consultants
    Eli N Perencevich
    VA Maryland Healthcare System, Dept of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Clin Infect Dis 38:476-82. 2004
    ..4% to be acceptable. The methodology used in this study may prove useful in delineating acceptable treatment failure thresholds, an initial step in shortening durations of antimicrobial therapy...
  76. doi request reprint Surgical site infections after laparoscopic and open cholecystectomies in community hospitals
    Luke F Chen
    Infect Control Hosp Epidemiol 29:92-4; author reply 94-5. 2008
  77. ncbi request reprint The Cipro patent and bioterrorism
    Keith S Kaye
    Duke University Medical Center
    Am J Bioeth 2:41-2. 2002

Research Grants1

  1. Hospital-Acquired Infections in the Elderly
    Keith Kaye; Fiscal Year: 2008
    ..The risk factor identified for SSI and MDRB and the impact of SSI and MDRB on health outcomes will be used to design and implement future preventive interventions. ..