Kim M Huffman

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Molecular alterations in skeletal muscle in rheumatoid arthritis are related to disease activity, physical inactivity, and disability
    Kim M Huffman
    Department of Medicine, Duke Molecular Physiology Institute, Duke School of Medicine, Durham, NC, USA
    Arthritis Res Ther 19:12. 2017
  2. pmc Metabolite signatures of exercise training in human skeletal muscle relate to mitochondrial remodelling and cardiometabolic fitness
    Kim M Huffman
    Physical Medicine and Rehabilitation Service, Veterans Affairs Medical Center, Durham, NC, USA
    Diabetologia 57:2282-95. 2014
  3. pmc Impact of baseline physical activity and diet behavior on metabolic syndrome in a pharmaceutical trial: results from NAVIGATOR
    Kim M Huffman
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA Veteran Affairs Medical Center, Durham, NC, USA Electronic address
    Metabolism 63:554-61. 2014
  4. pmc Caloric restriction alters the metabolic response to a mixed-meal: results from a randomized, controlled trial
    Kim M Huffman
    Physical Medicine and Rehabilitation, Veterans Affairs Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 7:e28190. 2012
  5. pmc Relationships between circulating metabolic intermediates and insulin action in overweight to obese, inactive men and women
    Kim M Huffman
    Physical Medicine and Rehabilitation, Veterans Affairs Medical Center, Durham, North Carolina, USA
    Diabetes Care 32:1678-83. 2009
  6. pmc Dietary carbohydrate intake and high-sensitivity C-reactive protein in at-risk women and men
    Kim M Huffman
    Division of Rheumatology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am Heart J 154:962-8. 2007
  7. pmc Relationships between adipose tissue and cytokine responses to a randomized controlled exercise training intervention
    Kim M Huffman
    Division of Rheumatology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Metabolism 57:577-83. 2008
  8. pmc Impact of hormone replacement therapy on exercise training-induced improvements in insulin action in sedentary overweight adults
    Kim M Huffman
    Division of Rheumatology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Metabolism 57:888-95. 2008
  9. pmc Relations of a marker of endothelial activation (s-VCAM) to function and mortality in community-dwelling older adults
    Kim M Huffman
    Department of Physical Medicine and Rehabilitation, Veterans Affairs Medical Center, Durham, NC, USA
    J Gerontol A Biol Sci Med Sci 66:1369-75. 2011
  10. pmc Exercise-induced changes in metabolic intermediates, hormones, and inflammatory markers associated with improvements in insulin sensitivity
    Kim M Huffman
    Physical Medicine and Rehabilitation, Veterans Affairs Medical Center, Durham, North Carolina, USA
    Diabetes Care 34:174-6. 2011

Collaborators

Detail Information

Publications30

  1. pmc Molecular alterations in skeletal muscle in rheumatoid arthritis are related to disease activity, physical inactivity, and disability
    Kim M Huffman
    Department of Medicine, Duke Molecular Physiology Institute, Duke School of Medicine, Durham, NC, USA
    Arthritis Res Ther 19:12. 2017
    ..To identify molecular alterations in skeletal muscle in rheumatoid arthritis (RA) that may contribute to ongoing disability in RA...
  2. pmc Metabolite signatures of exercise training in human skeletal muscle relate to mitochondrial remodelling and cardiometabolic fitness
    Kim M Huffman
    Physical Medicine and Rehabilitation Service, Veterans Affairs Medical Center, Durham, NC, USA
    Diabetologia 57:2282-95. 2014
    ..We hypothesised that changes in mitochondrial metabolic intermediates would predict improvements in clinical risk factors, thereby offering novel insights into potential mechanisms...
  3. pmc Impact of baseline physical activity and diet behavior on metabolic syndrome in a pharmaceutical trial: results from NAVIGATOR
    Kim M Huffman
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA Veteran Affairs Medical Center, Durham, NC, USA Electronic address
    Metabolism 63:554-61. 2014
    ..Each can be affected by physical activity and diet. Our objective was to determine whether determine whether baseline physical activity and/or diet behavior impact MS in the course of a large pharmaceutical trial...
  4. pmc Caloric restriction alters the metabolic response to a mixed-meal: results from a randomized, controlled trial
    Kim M Huffman
    Physical Medicine and Rehabilitation, Veterans Affairs Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 7:e28190. 2012
    ....
  5. pmc Relationships between circulating metabolic intermediates and insulin action in overweight to obese, inactive men and women
    Kim M Huffman
    Physical Medicine and Rehabilitation, Veterans Affairs Medical Center, Durham, North Carolina, USA
    Diabetes Care 32:1678-83. 2009
    ..To determine whether circulating metabolic intermediates are related to insulin resistance and beta-cell dysfunction in individuals at risk for type 2 diabetes...
  6. pmc Dietary carbohydrate intake and high-sensitivity C-reactive protein in at-risk women and men
    Kim M Huffman
    Division of Rheumatology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am Heart J 154:962-8. 2007
    ..Our objective was to determine if GL is related to hsCRP and other measures of CVD risk in a population of sedentary, overweight, dyslipidemic middle-aged women and men enrolled in an exercise intervention trial (STRRIDE)...
  7. pmc Relationships between adipose tissue and cytokine responses to a randomized controlled exercise training intervention
    Kim M Huffman
    Division of Rheumatology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Metabolism 57:577-83. 2008
    ..In contradiction to our hypothesis, despite significant alterations in body composition, exercise training produced limited cytokine responses...
  8. pmc Impact of hormone replacement therapy on exercise training-induced improvements in insulin action in sedentary overweight adults
    Kim M Huffman
    Division of Rheumatology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Metabolism 57:888-95. 2008
    ..These findings have implications for the relative utility of ET for improving insulin action in middle-aged men and women, particularly in the setting of differences in HRT use...
  9. pmc Relations of a marker of endothelial activation (s-VCAM) to function and mortality in community-dwelling older adults
    Kim M Huffman
    Department of Physical Medicine and Rehabilitation, Veterans Affairs Medical Center, Durham, NC, USA
    J Gerontol A Biol Sci Med Sci 66:1369-75. 2011
    ....
  10. pmc Exercise-induced changes in metabolic intermediates, hormones, and inflammatory markers associated with improvements in insulin sensitivity
    Kim M Huffman
    Physical Medicine and Rehabilitation, Veterans Affairs Medical Center, Durham, North Carolina, USA
    Diabetes Care 34:174-6. 2011
    ..To understand relationships between exercise training-mediated improvements in insulin sensitivity (S(I)) and changes in circulating concentrations of metabolic intermediates, hormones, and inflammatory mediators...
  11. pmc Is diabetes associated with poorer self-efficacy and motivation for physical activity in older adults with arthritis?
    K M Huffman
    Division of Rheumatology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Scand J Rheumatol 39:380-6. 2010
    ..A further objective was to determine whether the added burden of diabetes contributes to a further reduction in these PA determinants and types...
  12. pmc The impact of self-reported arthritis and diabetes on response to a home-based physical activity counselling intervention
    K M Huffman
    Division of Rheumatology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Scand J Rheumatol 39:233-9. 2010
    ..Our objective was to explore whether persons with arthritis alone or those with both arthritis and diabetes could improve amounts of PA with a home-based counselling intervention...
  13. ncbi request reprint Response of high-sensitivity C-reactive protein to exercise training in an at-risk population
    Kim M Huffman
    Division of Rheumatology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am Heart J 152:793-800. 2006
    ..Our objective was to determine if modulating fitness with exercise training imposes changes in high-sensitivity C-reactive protein in a mixed-sex population at risk for cardiovascular disease...
  14. pmc A novel inflammatory biomarker, GlycA, associates with disease activity in rheumatoid arthritis and cardio-metabolic risk in BMI-matched controls
    David B Bartlett
    Department of Medicine and Duke Molecular Physiology Institute, Duke School of Medicine, Durham, NC, USA
    Arthritis Res Ther 18:86. 2016
    ....
  15. pmc Enhanced fitness: a randomized controlled trial of the effects of home-based physical activity counseling on glycemic control in older adults with prediabetes mellitus
    Miriam C Morey
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Medical Center, Durham, North Carolina 27705, USA
    J Am Geriatr Soc 60:1655-62. 2012
    ..To determine whether a home-based multicomponent physical activity counseling (PAC) intervention is effective in reducing glycemic measures in older outpatients with prediabetes mellitus...
  16. pmc Exercise effects on lipids in persons with varying dietary patterns-does diet matter if they exercise? Responses in Studies of a Targeted Risk Reduction Intervention through Defined Exercise I
    Kim M Huffman
    Division of Rheumatology, Duke University Medical Center, Durham, NC, USA
    Am Heart J 164:117-24. 2012
    ..The purpose of the current study was to determine if, across a range of dietary patterns, there were variable lipoprotein responses to an aerobic exercise training intervention...
  17. pmc Effects of exercise training intensity on pancreatic beta-cell function
    Cris A Slentz
    Division of Cardiovascular Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Diabetes Care 32:1807-11. 2009
    ..Insulin resistance and beta-cell dysfunction both are important contributors to the pathogenesis of type 2 diabetes. Exercise training improves insulin sensitivity, but its effects on beta-cell function are less well studied...
  18. pmc Lessons learned when innovations go awry: a baseline description of a behavioral trial-the Enhancing Fitness in Older Overweight Veterans with Impaired Fasting Glucose study
    Katherine S Hall
    Veterans Affairs Medical Center, Durham, NC, USA
    Transl Behav Med 1:573-587. 2011
    ..This study presents baseline participant characteristics and discusses unwelcome adaptations to a highly innovative study design to increase PA and enhance glucose metabolism when the best-laid plans went awry...
  19. pmc Effects of exercise training alone vs a combined exercise and nutritional lifestyle intervention on glucose homeostasis in prediabetic individuals: a randomised controlled trial
    Cris A Slentz
    Duke Molecular Physiology Institute, Department of Medicine, Duke University School of Medicine, 300 North Duke Street, Durham, NC, 27701, USA
    Diabetologia 59:2088-98. 2016
    ..The primary outcome was improvement in fasting plasma glucose, with improvement in plasma glucose AUC response to an OGTT as the major secondary outcome...
  20. ncbi request reprint Physical Performance Across the Adult Life Span: Correlates With Age and Physical Activity
    Katherine S Hall
    Duke Claude D Pepper Older Americans Independence Center, Duke Center for the Study of Aging and Human Development, and Department of Medicine, Duke University, Durham, North Carolina Geriatric Research, Education, and Clinical Center, Veterans Affairs Medical Center, Durham, North Carolina
    J Gerontol A Biol Sci Med Sci . 2016
    ..We developed a mobility-focused physical performance screener designed to be appropriate for the adult life span...
  21. pmc Impact of combined resistance and aerobic exercise training on branched-chain amino acid turnover, glycine metabolism and insulin sensitivity in overweight humans
    Erin L Glynn
    Sarah W Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC, USA
    Diabetologia 58:2324-35. 2015
    ..The purpose of this study was to investigate the relationship between BCAA metabolism and IS in overweight (OW) individuals during exercise intervention...
  22. pmc Sex-specific alterations in mRNA level of key lipid metabolism enzymes in skeletal muscle of overweight and obese subjects following endurance exercise
    Ira J Smith
    Center for the Study of Aging, Duke University Medical Center, Durham, North Carolina 27710, USA
    Physiol Genomics 36:149-57. 2009
    ..Future studies should determine whether these adaptations in mRNA levels translate into changes in protein function...
  23. pmc Plasma acylcarnitines are associated with physical performance in elderly men
    Helen Lum
    Department of Medicine, Division of Geriatrics, Gerontology and Palliative Medicine, University of Texas Health Science Center, San Antonio, USA
    J Gerontol A Biol Sci Med Sci 66:548-53. 2011
    ..Metabolic profiling might provide insight into the biologic underpinnings of disability in older adults...
  24. pmc Adipose depots, not disease-related factors, account for skeletal muscle insulin sensitivity in established and treated rheumatoid arthritis
    Hiba Abouassi
    From the Divisions of Endocrinology, Rheumatology and Immunology, Cardiology, Geriatrics, Department of Medicine and Duke Molecular Physiology Institute, Duke University Medical Center Durham Veterans Affairs Medical Center, Durham, North Carolina, USA H AbouAssi, MD, Division of Endocrinology K N Tune, BA, Division of Rheumatology and Immunology B Gilmore, BS L A Bateman, MS, Division of Cardiology G McDaniel, PA, Division of Rheumatology and Immunology, Department of Medicine, Duke University Medical Center M Muehlbauer, PhD J L Huebner, MS, Duke Molecular Physiology Institute, Duke University Medical Center H M Hoenig, MD, Division of Geriatrics, Department of Medicine, Duke University Medical Center, Veterans Affairs Medical Center V B Kraus, MD, PhD, Division of Rheumatology and Immunology, Department of Medicine, Duke Molecular Physiology Institute, Duke University Medical Center E W St Clair, MD, Division of Rheumatology and Immunology, Department of Medicine, Duke University Medical Center W E Kraus, MD, Division of Cardiology, Department of Medicine, Duke Molecular Physiology Institute, Livilands Gate
    J Rheumatol 41:1974-9. 2014
    ..Our objectives were to carefully assess, compare, and determine predictors of skeletal muscle insulin sensitivity in RA, accounting for adiposity and physical activity...
  25. pmc Effects of aerobic vs. resistance training on visceral and liver fat stores, liver enzymes, and insulin resistance by HOMA in overweight adults from STRRIDE AT/RT
    Cris A Slentz
    Div of Cardiology, Dept of Medicine, PO Box 3022, Duke Univ Medical Center, Durham, NC 27710, USA
    Am J Physiol Endocrinol Metab 301:E1033-9. 2011
    ....
  26. pmc Critical appraisal of four IL-6 immunoassays
    Dana K Thompson
    Division of Rheumatology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 7:e30659. 2012
    ..Serial plasma samples from intravenous glucose tolerance tests (IVGTTs), with expected rises in IL-6 concentrations, were used to test the face validity of the various assays...
  27. pmc Alpha C-telopeptide of type I collagen is associated with subchondral bone turnover and predicts progression of joint space narrowing and osteophytes in osteoarthritis
    Janet L Huebner
    Duke University School of Medicine, Durham, North Carolina
    Arthritis Rheumatol 66:2440-9. 2014
    ....
  28. pmc Pyruvate Dehydrogenase Phosphatase Regulatory Gene Expression Correlates with Exercise Training Insulin Sensitivity Changes
    Matthew D Barberio
    1Research Center for Genetic Medicine, Children s National Medical Center, Durham, NC 2Division of Rheumatology, Department of Medicine, Duke University School of Medicine, Durham, NC 3Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 4Department of Exercise and Nutrition Sciences, George Washington University, Washington, DC 5Division of Cardiology, Department of Medicine, Duke University School of Medicine, Durham, NC and 6Department of Integrative Systems Biology, George Washington University, Washington, DC
    Med Sci Sports Exerc 48:2387-2397. 2016
    ..The purpose of this study was to use global gene expression to identify skeletal muscle genes that correlate with exercise-induced Si changes...
  29. doi request reprint A Novel Protein Glycan-Derived Inflammation Biomarker Independently Predicts Cardiovascular Disease and Modifies the Association of HDL Subclasses with Mortality
    Robert W McGarrah
    Division of Cardiology, Department of Medicine, Duke University School of Medicine, Durham, NC
    Clin Chem 63:288-296. 2017
    ....
  30. pmc Uric acid is a danger signal of increasing risk for osteoarthritis through inflammasome activation
    Anna E Denoble
    Departments of Medicine and Radiology Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 108:2088-93. 2011
    ....