S Collins

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint Overview of clinical perspectives and mechanisms of obesity
    Sheila Collins
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Birth Defects Res A Clin Mol Teratol 73:470-1. 2005
  2. ncbi request reprint Genetic vulnerability to diet-induced obesity in the C57BL/6J mouse: physiological and molecular characteristics
    Sheila Collins
    Department of Pharmacology, Duke University Medical Center, Durham, NC 27710, USA
    Physiol Behav 81:243-8. 2004
  3. ncbi request reprint Learning new tricks from old dogs: beta-adrenergic receptors teach new lessons on firing up adipose tissue metabolism
    Sheila Collins
    CIIT Centers for Health Research, Six Davis Drive, Research Triangle Park, North Carolina 27709, USA
    Mol Endocrinol 18:2123-31. 2004
  4. ncbi request reprint Adrenoceptors, uncoupling proteins, and energy expenditure
    S Collins
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    Exp Biol Med (Maywood) 226:982-90. 2001
  5. ncbi request reprint beta-Adrenergic activation of p38 MAP kinase in adipocytes: cAMP induction of the uncoupling protein 1 (UCP1) gene requires p38 MAP kinase
    W Cao
    Department of Psychiatry and Behavioral Sciences and the Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 276:27077-82. 2001
  6. ncbi request reprint Pharmacologic manipulation of ob expression in a dietary model of obesity
    S Collins
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 271:9437-40. 1996
  7. ncbi request reprint Low plasma leptin in response to dietary fat in diabetes- and obesity-prone mice
    R S Surwit
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    Diabetes 46:1516-20. 1997
  8. ncbi request reprint Diazoxide restores beta3-adrenergic receptor function in diet-induced obesity and diabetes
    R S Surwit
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    Endocrinology 141:3630-7. 2000
  9. ncbi request reprint Direct binding of activated c-Src to the beta 3-adrenergic receptor is required for MAP kinase activation
    W Cao
    Departments of Psychiatry and Behavioral Sciences, Pharmacology, and Medicine and the Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 275:38131-4. 2000
  10. ncbi request reprint CCAAT/enhancer-binding protein alpha is required for transcription of the beta 3-adrenergic receptor gene during adipogenesis
    T M Dixon
    Department of Pharmacology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 276:722-8. 2001

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Overview of clinical perspectives and mechanisms of obesity
    Sheila Collins
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Birth Defects Res A Clin Mol Teratol 73:470-1. 2005
  2. ncbi request reprint Genetic vulnerability to diet-induced obesity in the C57BL/6J mouse: physiological and molecular characteristics
    Sheila Collins
    Department of Pharmacology, Duke University Medical Center, Durham, NC 27710, USA
    Physiol Behav 81:243-8. 2004
    ..This review highlights metabolic and signal transduction features that are altered during the course of disease progression, many of which mirror the human situation...
  3. ncbi request reprint Learning new tricks from old dogs: beta-adrenergic receptors teach new lessons on firing up adipose tissue metabolism
    Sheila Collins
    CIIT Centers for Health Research, Six Davis Drive, Research Triangle Park, North Carolina 27709, USA
    Mol Endocrinol 18:2123-31. 2004
    ....
  4. ncbi request reprint Adrenoceptors, uncoupling proteins, and energy expenditure
    S Collins
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    Exp Biol Med (Maywood) 226:982-90. 2001
    ....
  5. ncbi request reprint beta-Adrenergic activation of p38 MAP kinase in adipocytes: cAMP induction of the uncoupling protein 1 (UCP1) gene requires p38 MAP kinase
    W Cao
    Department of Psychiatry and Behavioral Sciences and the Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 276:27077-82. 2001
    ....
  6. ncbi request reprint Pharmacologic manipulation of ob expression in a dietary model of obesity
    S Collins
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 271:9437-40. 1996
    ....
  7. ncbi request reprint Low plasma leptin in response to dietary fat in diabetes- and obesity-prone mice
    R S Surwit
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    Diabetes 46:1516-20. 1997
    ..From these results, we suggest that the response of leptin to fat feeding may be an important predictor of the development of subsequent obesity...
  8. ncbi request reprint Diazoxide restores beta3-adrenergic receptor function in diet-induced obesity and diabetes
    R S Surwit
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    Endocrinology 141:3630-7. 2000
    ..CLDz was more effective in reducing percent body fat, lowering nonesterified fatty acids, improving glucose tolerance, and reducing feed efficiency than either treatment alone...
  9. ncbi request reprint Direct binding of activated c-Src to the beta 3-adrenergic receptor is required for MAP kinase activation
    W Cao
    Departments of Psychiatry and Behavioral Sciences, Pharmacology, and Medicine and the Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 275:38131-4. 2000
    ..Together, these data describe a novel mechanism of ERK activation by a G protein-coupled receptor in which the intracellular domains directly recruit c-Src...
  10. ncbi request reprint CCAAT/enhancer-binding protein alpha is required for transcription of the beta 3-adrenergic receptor gene during adipogenesis
    T M Dixon
    Department of Pharmacology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 276:722-8. 2001
    ..These results define C/EBP alpha as a key transcriptional regulator of the mouse beta(3)AR gene during adipogenesis...
  11. ncbi request reprint Impaired expression and functional activity of the beta 3- and beta 1-adrenergic receptors in adipose tissue of congenitally obese (C57BL/6J ob/ob) mice
    S Collins
    Department of Medicine Gastroenterology, Duke University Medical Center, Durham, North Carolina 27710
    Mol Endocrinol 8:518-27. 1994
    ....
  12. ncbi request reprint Role of leptin in fat regulation
    S Collins
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 380:677. 1996
  13. ncbi request reprint The beta-adrenergic receptors and the control of adipose tissue metabolism and thermogenesis
    S Collins
    Department of Pharmacology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Recent Prog Horm Res 56:309-28. 2001
    ..The impact of understanding these pathways and their potential role in modulating adaptive thermogenesis is discussed...
  14. ncbi request reprint Regulation of the uncoupling protein gene (Ucp) by beta 1, beta 2, and beta 3-adrenergic receptor subtypes in immortalized brown adipose cell lines
    E M Rohlfs
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 270:10723-32. 1995
    ....
  15. ncbi request reprint Transcriptional regulation of the mouse uncoupling protein-2 gene. Double E-box motif is required for peroxisome proliferator-activated receptor-gamma-dependent activation
    A V Medvedev
    Departments of Psychiatry and Behavioral Sciences and Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 276:10817-23. 2001
    ..Taken together, these data indicate that PPARgamma activates the UCP2 gene indirectly by altering the activity or expression of other transcription factors that bind to the UCP2 promoter...
  16. ncbi request reprint Ecological forecasts: an emerging imperative
    J S Clark
    Department of Biology, Duke University, Durham, NC 27708 USA
    Science 293:657-60. 2001
    ..Interdisciplinary linkages are necessary because of the climate and societal controls on ecosystems, the feedbacks involving social change, and the decision-making relevance of forecasts...
  17. ncbi request reprint Beta-adrenergic receptors and regulation of energy expenditure: a family affair
    Jacques Robidoux
    Departments of Pharmacology, Psychiatry, and Behavioral Sciences, and The Sarah W Stedman Center for Nutritional Studies, Duke University Medical Center, Durham, North Carolina 27710, USA
    Annu Rev Pharmacol Toxicol 44:297-323. 2004
    ..They illustrate how betaAR signaling can orchestrate a coordinated set of intracellular responses for fine control of metabolic balance...
  18. pmc p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene
    Wenhong Cao
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell Biol 24:3057-67. 2004
    ..In conclusion, our findings illustrate that by orchestrating the activity of multiple transcription factors, p38 MAPK is a central mediator of the cAMP signaling mechanism of brown fat that promotes thermogenesis...
  19. pmc Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38alpha MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes
    Jacques Robidoux
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell Biol 25:5466-79. 2005
    ..Therefore, in the brown adipocyte the recently described scaffold protein JIP2 assembles the required factors MKK3 and p38alpha MAPK linking PKA to the control of thermogenic gene expression...
  20. ncbi request reprint beta-Cell mitochondria exhibit membrane potential heterogeneity that can be altered by stimulatory or toxic fuel levels
    Jakob D Wikstrom
    Tufts University, Department of Pharmacology and Experimental Therapeutics, 136 Harrison Ave, Boston, MA 02111, USA
    Diabetes 56:2569-78. 2007
    ..This study offers insight into the different metabolic states of beta-cell mitochondria...
  21. ncbi request reprint Maximal beta3-adrenergic regulation of lipolysis involves Src and epidermal growth factor receptor-dependent ERK1/2 activation
    Jacques Robidoux
    Program in Endocrine Biology, Division of Biological Sciences, CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 281:37794-802. 2006
    ..Together these results illustrate the distinct and complementary roles for PKA and ERK in catecholamine-stimulated lipolysis...
  22. ncbi request reprint An interview with Sheila Collins, Ph.D. Interview by Vicki Glaser
    Sheila Collins
    Assay Drug Dev Technol 3:253-60. 2005
  23. pmc Persistent nuclear factor-kappa B activation in Ucp2-/- mice leads to enhanced nitric oxide and inflammatory cytokine production
    Yushi Bai
    Division of Biological Sciences, Endocrine Biology Program, CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709 2137, USA
    J Biol Chem 280:19062-9. 2005
    ..We conclude that mitochrondrially derived reactive oxygen from Ucp2-/- cells constitutively activates NF-kappa B, resulting in a "primed" state to both potentiate and amplify the inflammatory response upon subsequent stimulation...
  24. ncbi request reprint Resistance to cerebral ischemic injury in UCP2 knockout mice: evidence for a role of UCP2 as a regulator of mitochondrial glutathione levels
    Fabienne de Bilbao
    Department of Psychiatry, University Hospitals Geneva, Geneva, Switzerland
    J Neurochem 89:1283-92. 2004
    ..Moreover, our data imply that UCP2 is not directly involved in the regulation of ROS production but acts by regulating mitochondrial GSH levels in microglia...
  25. pmc Liver X receptor alpha is a transcriptional repressor of the uncoupling protein 1 gene and the brown fat phenotype
    Haibo Wang
    The Hamner Institutes for Health Sciences, 6 Davis Drive, P O Box 12137, Research Triangle Park, NC 27709, USA
    Mol Cell Biol 28:2187-200. 2008
    ..The ability of LXRalpha to dampen energy expenditure in this way provides another mechanism for maintaining a balance between energy storage and utilization...