E Cantu

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint Pulmonary xenotransplantation: rapidly progressing into the unknown
    Edward Cantu
    Department of Surgery, Duke University Medical Center, Durham, NC, USA
    Am J Transplant 4:25-35. 2004
  2. ncbi request reprint Prolonged function of macrophage, von Willebrand factor-deficient porcine pulmonary xenografts
    E Cantu
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Transplant 7:66-75. 2007
  3. pmc Gene set enrichment analysis identifies key innate immune pathways in primary graft dysfunction after lung transplantation
    E Cantu
    Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Am J Transplant 13:1898-904. 2013
  4. pmc Characterization of the innate immune response to chronic aspiration in a novel rodent model
    James Z Appel
    Transplant Immunobiology Laboratory, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Respir Res 8:87. 2007
  5. ncbi request reprint Depletion of pulmonary intravascular macrophages prevents hyperacute pulmonary xenograft dysfunction
    Edward Cantu
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Transplantation 81:1157-64. 2006
  6. ncbi request reprint Role of flow cytometry to define unacceptable HLA antigens in lung transplant recipients with HLA-specific antibodies
    James Z Appel
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Transplantation 81:1049-57. 2006
  7. ncbi request reprint The role of antibodies and von Willebrand factor in discordant pulmonary xenotransplantation
    Christine L Lau
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Transplant 3:1065-75. 2003
  8. ncbi request reprint Hepatitis B core antibody positive donors as a safe and effective therapeutic option to increase available organs for lung transplantation
    Matthew G Hartwig
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Transplantation 80:320-5. 2005
  9. ncbi request reprint J. Maxwell Chamberlain Memorial Paper. Early fundoplication prevents chronic allograft dysfunction in patients with gastroesophageal reflux disease
    Edward Cantu
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Ann Thorac Surg 78:1142-51; discussion 1142-51. 2004
  10. ncbi request reprint Economic evaluation of everolimus vs. azathioprine at one year after de novo heart transplantation
    Jasmina I Radeva
    Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Durham, NC 27715, USA
    Clin Transplant 19:122-9. 2005

Research Grants

Detail Information

Publications11

  1. ncbi request reprint Pulmonary xenotransplantation: rapidly progressing into the unknown
    Edward Cantu
    Department of Surgery, Duke University Medical Center, Durham, NC, USA
    Am J Transplant 4:25-35. 2004
    ..This progress provides a basis for future work and for a hope that the shortage of human lungs for transplantation will not always be a matter of life and death...
  2. ncbi request reprint Prolonged function of macrophage, von Willebrand factor-deficient porcine pulmonary xenografts
    E Cantu
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Transplant 7:66-75. 2007
    ..These data provide initial evidence that vWF plays a role in the 'delayed' (24 h) dysfunction observed in pulmonary xenotransplantation using PIM depleted hMCP organs...
  3. pmc Gene set enrichment analysis identifies key innate immune pathways in primary graft dysfunction after lung transplantation
    E Cantu
    Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Am J Transplant 13:1898-904. 2013
    ..162), NLRP3 (1.135), IL1α (0.952), IL6 (0.931) and CCL4 (0.842). Gene set enrichment analyses implicate inflammasome-mediated and innate immune signaling pathways as key mediators of the development of PGD in lung transplant patients...
  4. pmc Characterization of the innate immune response to chronic aspiration in a novel rodent model
    James Z Appel
    Transplant Immunobiology Laboratory, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Respir Res 8:87. 2007
    ..A novel rodent model of chronic aspiration was therefore developed in order to investigate the resulting innate immune response in the lung...
  5. ncbi request reprint Depletion of pulmonary intravascular macrophages prevents hyperacute pulmonary xenograft dysfunction
    Edward Cantu
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Transplantation 81:1157-64. 2006
    ..Recent findings have suggested that donor pulmonary intravascular macrophages may play a critical role in the hyperacute dysfunction of pulmonary xenografts...
  6. ncbi request reprint Role of flow cytometry to define unacceptable HLA antigens in lung transplant recipients with HLA-specific antibodies
    James Z Appel
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Transplantation 81:1049-57. 2006
    ..A virtual crossmatch strategy using flow cytometry, which enables precise determination of HLA-specific antibody specificity, was compared to prospective crossmatching in sensitized lung transplant candidates...
  7. ncbi request reprint The role of antibodies and von Willebrand factor in discordant pulmonary xenotransplantation
    Christine L Lau
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Transplant 3:1065-75. 2003
    ..These findings suggest that porcine vWF plays a major role in the pathogenesis of pulmonary xenograft dysfunction, and suggests promising strategies to treat lung xenograft dysfunction...
  8. ncbi request reprint Hepatitis B core antibody positive donors as a safe and effective therapeutic option to increase available organs for lung transplantation
    Matthew G Hartwig
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Transplantation 80:320-5. 2005
    ..We hypothesized that isolated HBcAb+ donors represent minimal risk of viral transmission in vaccinated lung transplant (LTx) recipients...
  9. ncbi request reprint J. Maxwell Chamberlain Memorial Paper. Early fundoplication prevents chronic allograft dysfunction in patients with gastroesophageal reflux disease
    Edward Cantu
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Ann Thorac Surg 78:1142-51; discussion 1142-51. 2004
    ..We hypothesized that treatment of reflux with early fundoplication would prevent bronchiolitis obliterans syndrome and improve survival...
  10. ncbi request reprint Economic evaluation of everolimus vs. azathioprine at one year after de novo heart transplantation
    Jasmina I Radeva
    Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Durham, NC 27715, USA
    Clin Transplant 19:122-9. 2005
    ..We compared within-trial costs and resource use over 1 yr of follow-up in de novo heart transplant patients randomized to everolimus 1.5 mg/d (n = 209), everolimus 3.0 mg/d (n = 211), or azathioprine (n = 214)...
  11. ncbi request reprint Improved results treating lung allograft failure with venovenous extracorporeal membrane oxygenation
    Matthew G Hartwig
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 80:1872-9; discussion 1879-80. 2005
    ..We hypothesized that venovenous membrane oxygenation provides a safer alternative than venoarterial support for lung recipients suffering from primary graft failure...

Research Grants1

  1. Role of coagulation and pulmonary xenograft injury
    Edward Cantu; Fiscal Year: 2003
    ..abstract_text> ..