John E Duda

Summary

Country: USA

Publications

  1. ncbi request reprint Pathology and neurotransmitter abnormalities of dementia with Lewy bodies
    John E Duda
    Parkinson s Disease Research, Education and Clinical Center, Philadelphia VA Medical Center, Philadelphia, PA 19104, USA
    Dement Geriatr Cogn Disord 17:3-14. 2004
  2. pmc Genetic influences on cognitive decline in Parkinson's disease
    James F Morley
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvalia, USA
    Mov Disord 27:512-8. 2012
  3. pmc Alzheimer's disease pattern of brain atrophy predicts cognitive decline in Parkinson's disease
    Daniel Weintraub
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104 3339, USA
    Brain 135:170-80. 2012
  4. pmc Use of latent variable modeling to delineate psychiatric and cognitive profiles in Parkinson disease
    Shahrzad Mavandadi
    Mental Illness Research, Education and Clinical Center, Philadelphia VA Medical Center, Philadelphia, PA, USA
    Am J Geriatr Psychiatry 17:986-95. 2009
  5. pmc Olfactory dysfunction is associated with neuropsychiatric manifestations in Parkinson's disease
    James F Morley
    Parkinson s Disease Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA
    Mov Disord 26:2051-7. 2011
  6. pmc Neuropathologic substrates of Parkinson disease dementia
    David J Irwin
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Morris K Udall Parkinson s Disease Center of Excellence, Institute on Aging, Philadelphia, PA, USA
    Ann Neurol 72:587-98. 2012
  7. pmc Montreal cognitive assessment performance in patients with Parkinson's disease with "normal" global cognition according to mini-mental state examination score
    Sarra Nazem
    Department of Psychiatry, University of Pennsyvania, Philadelphia, USA
    J Am Geriatr Soc 57:304-8. 2009
  8. pmc Daytime sleepiness is associated with falls in Parkinson's disease
    Meredith Spindler
    Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA Parkinson s Disease Research, Education, and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA
    J Parkinsons Dis 3:387-91. 2013
  9. pmc The Penn Parkinson's Daily Activities Questionnaire-15: Psychometric properties of a brief assessment of cognitive instrumental activities of daily living in Parkinson's disease
    Laura Brennan
    Drexel Neurosciences Institute, Drexel University College of Medicine, 245 N 15th St, 7102 NCB, Philadelphia, PA 19102, USA Department of Psychiatry, University of Pennsylvania School of Medicine, 3615 Chestnut St, 330, Philadelphia, PA 19104, USA
    Parkinsonism Relat Disord 25:21-6. 2016
  10. pmc Neurodegeneration across stages of cognitive decline in Parkinson disease
    Daniel Weintraub
    Department of Psychiatry, University of Pennsylvania, 3615 Chestnut St, Ste 330, Philadelphia, PA 19104, USA
    Arch Neurol 68:1562-8. 2011

Detail Information

Publications59

  1. ncbi request reprint Pathology and neurotransmitter abnormalities of dementia with Lewy bodies
    John E Duda
    Parkinson s Disease Research, Education and Clinical Center, Philadelphia VA Medical Center, Philadelphia, PA 19104, USA
    Dement Geriatr Cogn Disord 17:3-14. 2004
    ..D2 receptor deficiencies in DLB may be the cause of the relative lack of response to levodopa treatment and the severe adverse reaction to neuroleptics in these patients...
  2. pmc Genetic influences on cognitive decline in Parkinson's disease
    James F Morley
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvalia, USA
    Mov Disord 27:512-8. 2012
    ..Clinically, these results suggest that genotyping can provide information about the risk of future cognitive decline for PD patients...
  3. pmc Alzheimer's disease pattern of brain atrophy predicts cognitive decline in Parkinson's disease
    Daniel Weintraub
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104 3339, USA
    Brain 135:170-80. 2012
    ..In addition, an Alzheimer's disease pattern of brain atrophy may be a preclinical biomarker of cognitive decline in Parkinson's disease...
  4. pmc Use of latent variable modeling to delineate psychiatric and cognitive profiles in Parkinson disease
    Shahrzad Mavandadi
    Mental Illness Research, Education and Clinical Center, Philadelphia VA Medical Center, Philadelphia, PA, USA
    Am J Geriatr Psychiatry 17:986-95. 2009
    ..The objective of this study was to use analytic-based approaches to classify psychiatric and cognitive symptoms in PD...
  5. pmc Olfactory dysfunction is associated with neuropsychiatric manifestations in Parkinson's disease
    James F Morley
    Parkinson s Disease Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA
    Mov Disord 26:2051-7. 2011
    ..Future prospective studies are warranted to assess whether hyposmia, a very early feature of Parkinson's disease, might be used to predict the appearance of other common nonmotor symptoms...
  6. pmc Neuropathologic substrates of Parkinson disease dementia
    David J Irwin
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Morris K Udall Parkinson s Disease Center of Excellence, Institute on Aging, Philadelphia, PA, USA
    Ann Neurol 72:587-98. 2012
    ..A study was undertaken to examine the neuropathological substrates of cognitive dysfunction and dementia in Parkinson disease (PD)...
  7. pmc Montreal cognitive assessment performance in patients with Parkinson's disease with "normal" global cognition according to mini-mental state examination score
    Sarra Nazem
    Department of Psychiatry, University of Pennsyvania, Philadelphia, USA
    J Am Geriatr Soc 57:304-8. 2009
    ..To examine Montreal Cognitive Assessment (MoCA) performance in patients with Parkinson's disease (PD) with "normal" global cognition according to Mini-Mental State Examination (MMSE) score...
  8. pmc Daytime sleepiness is associated with falls in Parkinson's disease
    Meredith Spindler
    Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA Parkinson s Disease Research, Education, and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA
    J Parkinsons Dis 3:387-91. 2013
    ..04) and postural instability/gait dysfunction (OR 1.6 95% CI 1.0-2.4, p = 0.03) in non-depressed patients. In conclusion, non-depressed PD patients are 20% more likely to fall for every one unit increase in the ESS measure of sleepiness. ..
  9. pmc The Penn Parkinson's Daily Activities Questionnaire-15: Psychometric properties of a brief assessment of cognitive instrumental activities of daily living in Parkinson's disease
    Laura Brennan
    Drexel Neurosciences Institute, Drexel University College of Medicine, 245 N 15th St, 7102 NCB, Philadelphia, PA 19102, USA Department of Psychiatry, University of Pennsylvania School of Medicine, 3615 Chestnut St, 330, Philadelphia, PA 19104, USA
    Parkinsonism Relat Disord 25:21-6. 2016
    ....
  10. pmc Neurodegeneration across stages of cognitive decline in Parkinson disease
    Daniel Weintraub
    Department of Psychiatry, University of Pennsylvania, 3615 Chestnut St, Ste 330, Philadelphia, PA 19104, USA
    Arch Neurol 68:1562-8. 2011
    ..To assess regions and patterns of brain atrophy in patients with Parkinson disease (PD) with normal cognition (PD-NC), mild cognitive impairment (PD-MCI), and dementia-level cognitive deficits (PDD)...
  11. pmc Patient versus informant reporting of ICD symptoms in Parkinson's disease using the QUIP: validity and variability
    Kimberly Papay
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Parkinsonism Relat Disord 17:153-5. 2011
    ....
  12. doi request reprint Association between dopaminergic medications and nocturnal sleep in early-stage Parkinson's disease
    Lama M Chahine
    Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19107, USA
    Parkinsonism Relat Disord 19:859-63. 2013
    ..We examined the association between dopaminergic medications and subjective and objective nocturnal sleep in PD...
  13. pmc Suicidal and death ideation in Parkinson's disease
    Sarra Nazem
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Mov Disord 23:1573-9. 2008
    ..Comorbid psychiatric disorders, more than PD-related disease variables, are associated with this ideation, highlighting the need for a comprehensive approach to the clinical care of PD patients...
  14. pmc Involuntary emotional expression disorder (IEED) in Parkinson's disease
    Lisa Phuong
    Parkinson s Disease Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA
    Parkinsonism Relat Disord 15:511-5. 2009
    ..To estimate the frequency and correlates of involuntary emotional expression disorder (IEED) in Parkinson's disease (PD) using the Center for Neurologic Study-Lability Scale (CNS-LS) and recently-proposed diagnostic criteria for IEED...
  15. pmc Medication management and neuropsychological performance in Parkinson's disease
    Kevin J Manning
    Department of Psychology, Drexel University, Philadelphia, PA 19104, USA
    Clin Neuropsychol 26:45-58. 2012
    ..A range of neuropsychological abilities is associated with the ability to understand and implement a medication schedule and pillbox in individuals with PD...
  16. pmc Mild cognitive impairment is common in Parkinson's disease patients with normal Mini-Mental State Examination (MMSE) scores
    Eugenia Mamikonyan
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Parkinsonism Relat Disord 15:226-31. 2009
    ..We report on the frequency and characteristics of cognitive deficits in PD patients with intact global cognition based on Mini-Mental State Examination (MMSE) performance...
  17. pmc Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis
    David J Irwin
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Morris K Udall Parkinson s Disease Center of Excellence, Institute on Aging, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA Electronic address
    Lancet Neurol 16:55-65. 2017
    ..We aimed to identify genetic and pathological markers that have the strongest association with these features of clinical heterogeneity in synucleinopathies...
  18. pmc Development and initial testing of the Penn Parkinson's Daily Activities Questionnaire
    Laura Brennan
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Mov Disord 31:126-34. 2016
    ..The questionnaire is an item response theory-based tool for rating cognitive instrumental activities of daily living in PD...
  19. pmc Suicide ideation and behaviours after STN and GPi DBS surgery for Parkinson's disease: results from a randomised, controlled trial
    Daniel Weintraub
    Parkinson s Disease, Research, Education and Clinical Center PADRECC, Philadelphia VA Medical Center, Philadelphia, PA, USA
    J Neurol Neurosurg Psychiatry 84:1113-8. 2013
    ....
  20. pmc Lewy pathology is not the first sign of degeneration in vulnerable neurons in Parkinson disease
    Joshua M Milber
    Parkinson s Disease Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, USA
    Neurology 79:2307-14. 2012
    ..To determine whether evidence of neuronal dysfunction or demise preceded deposition of Lewy pathology in vulnerable neurons in Parkinson disease (PD)...
  21. doi request reprint Neuropsychological correlates of olfactory dysfunction in Parkinson's disease
    James F Morley
    Parkinson s Disease Research, Education and Clinical Center, Philadelphia VA Medical Center and Department of Neurology, University of Pennsylvania School of Medicine Philadelphia, PA 19104, USA
    J Neurol Sci 310:228-30. 2011
    ..In this paper, we will review emerging evidence for a relationship between hyposmia and neuropsychiatric manifestations, discussing the potential pathophysiology together with challenges and opportunities for future research...
  22. pmc Long-term follow-up of impulse control disorders in Parkinson's disease
    Eugenia Mamikonyan
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Mov Disord 23:75-80. 2008
    ....
  23. ncbi request reprint Dimensions of executive function in Parkinson's disease
    Daniel Weintraub
    Parkinson s Disease Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
    Dement Geriatr Cogn Disord 20:140-4. 2005
    ..Executive impairment is common in Parkinson's disease (PD). However, it is unknown which dimensions of executive function are assessed by commonly used neuropsychological instruments and if clinical correlates of specific dimensions exist...
  24. pmc Validation of the questionnaire for impulsive-compulsive disorders in Parkinson's disease
    Daniel Weintraub
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Mov Disord 24:1461-7. 2009
    ..A positive screen should be followed by a comprehensive, clinical interview to determine the range and severity of symptoms, as well as need for clinical management...
  25. pmc Defining and validating a short form Montreal Cognitive Assessment (s-MoCA) for use in neurodegenerative disease
    David R Roalf
    Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA
    J Neurol Neurosurg Psychiatry . 2016
    ..Yet, administration time is too long for many clinical settings...
  26. ncbi request reprint Phenylthiocarbamide (PTC) perception in Parkinson disease
    Paul J Moberg
    Parkinson s Disease Research, Education, and Clinical Center, Philadelphia Veterans Affairs Medical Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cogn Behav Neurol 20:145-8. 2007
    ..To examine phenylthiocarbamide (PTC) sensitivity in Parkinson disease (PD) patients and healthy volunteers to determine whether taster status represented a simple vulnerability marker for PD...
  27. pmc Antidepressant studies in Parkinson's disease: a review and meta-analysis
    Daniel Weintraub
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Mov Disord 20:1161-9. 2005
    ..In addition, PD patients may benefit less from antidepressant treatment, particularly selective serotonin reuptake inhibitors, than do elderly patients without PD...
  28. pmc Frequency and correlates of co-morbid psychosis and depression in Parkinson's disease
    Daniel Weintraub
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
    Parkinsonism Relat Disord 12:427-31. 2006
    ..02), depression with mild-cognitive impairment (P=.03), and their co-occurrence with higher daily levodopa dosages (P<.01). These results suggest that psychosis and depression in PD are distinct neurobehavioral disorders...
  29. pmc High patient satisfaction with telehealth in Parkinson disease: A randomized controlled study
    Jayne R Wilkinson
    Parkinson s Disease Research, Education and Clinical Center PADRECC JRW, MS, SMW, DW, JFM, JED, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA Department of Neurology JRW, MS, DW, JFM, JED, Department of Psychiatry DW, and Department of Physical Medicine Rehabilitation MGS, Perelman School of Medicine of the University of Pennsylvania, Philadelphia and School of Social Policy and Practice SCM, University of Pennsylvania, Philadelphia
    Neurol Clin Pract 6:241-251. 2016
    ..Research suggests that telehealth can lead to increased patient satisfaction, equal or better clinical outcomes, and cost savings, but these outcomes have not been well-studied in PD...
  30. pmc Olfactory impairment predicts cognitive decline in early Parkinson's disease
    Michelle E Fullard
    Parkinson s Disease Research, Education, and Clinical Center PADRECC, Philadelphia VA Medical Center, 3900 Woodland Ave, Philadelphia, PA 19104, USA Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA Electronic address
    Parkinsonism Relat Disord 25:45-51. 2016
    ..To evaluate the association between baseline olfaction and both cross-sectional and longitudinal cognitive assessments, motor symptoms, non-motor symptoms (NMS), and CSF biomarkers in early Parkinson's disease (PD)...
  31. doi request reprint Lower urinary tract symptoms in men with Parkinson disease
    Joanne P Robinson
    Questions or comments about this article may be directed to Joanne P Robinson, PhD RN GCNS BC FAAN, at She is a Dean and Professor at Rutgers, The State University of New Jersey, School of Nursing Camden, Camden, NJ, and an alumna of the Edmond J Safra Foundation Visiting Nurse Faculty Program on Parkinson s Disease Christine W Bradway, PhD RN FAAN, is an Associate Professor at the University of Pennsylvania School of Nursing, Philadelphia, PA, and an alumna of the Edmond J Safra Foundation Visiting Nurse Faculty Program on Parkinson s Disease Lisette Bunting Perry, PhD RN, co directs the Edmond J Safra Foundation Visiting Nurse Faculty Program on Parkinson s Disease and was the Assistant Clinical Director of the Parkinson s Disease Education, and Clinical Center, Veterans Affairs Medical Center, Philadelphia, PA Tamara Avi Itzhak, DSC, is an Associate Professor at the Department of Occupational Therapy, School of Health and Behavioral Sciences, York College, City University of New York, Jamaica, NY Marie Mangino, MSN RN GNP BC, is an alumna of the Edmond J Safra Foundation Visiting Nurse Faculty Program on Parkinson s Disease and directs Vincent Healthcare, Erdenheim, PA Jesse Chittams, MS, is a Biostatistician at University of Pennsylvania School of Nursing, Philadelphia, PA John E Duda, MD, directs the Parkinson s Disease Research, Education, and Clinical Center, Veterans Affairs Medical Center, Germany
    J Neurosci Nurs 45:382-92; quiz E1-2. 2013
    ..The aim of this study was to examine the prevalence, presentation, and predictors of lower urinary tract symptoms (LUTS) in men with idiopathic Parkinson disease (PD)...
  32. pmc Bilateral deep brain stimulation vs best medical therapy for patients with advanced Parkinson disease: a randomized controlled trial
    Frances M Weaver
    Hines VA Hospital, Center for Management of Complex Chronic Care, Hines, Illinois 60141, USA
    JAMA 301:63-73. 2009
    ..Deep brain stimulation is an accepted treatment for advanced Parkinson disease (PD), although there are few randomized trials comparing treatments, and most studies exclude older patients...
  33. pmc Caregiver report of apathy predicts dementia in Parkinson's disease
    Whitney Fitts
    Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Parkinsonism Relat Disord 21:992-5. 2015
    ..However, little is known about its relationship with long-term cognition. We sought to determine if a caregiver-reported apathy measure predicts the development of PD dementia...
  34. doi request reprint Olfaction as a biomarker in Parkinson's disease
    James F Morley
    Parkinson s Disease Research, Education and Clinical Center, Philadelphia VA Medical Center and Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Biomark Med 4:661-70. 2010
    ....
  35. doi request reprint Olfactory system pathology as a model of Lewy neurodegenerative disease
    John E Duda
    Parkinson s Disease Research, Education and Clinical Center MS 127, Philadelphia VA Medical Center, Philadelphia, PA 19104, USA
    J Neurol Sci 289:49-54. 2010
    ..In this report, the known neuropathology of the olfactory system in PD will be reviewed and the advantages of investigating degeneration of the olfactory bulb as a model of Lewy neurodegeneration will be discussed...
  36. ncbi request reprint Co-morbidity of TDP-43 proteinopathy in Lewy body related diseases
    Hanae Nakashima-Yasuda
    Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, HUP Maloney 3rd Floor, Philadelphia, PA 19104 4283, USA
    Acta Neuropathol 114:221-9. 2007
    ..This study expands the concept of TDP-43 proteinopathies by implicating TDP-43 lesions in mechanisms of neurodegeneration in LB disorders...
  37. pmc Pathological α-synuclein distribution in subjects with coincident Alzheimer's and Lewy body pathology
    Jon B Toledo
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    Acta Neuropathol 131:393-409. 2016
    ....
  38. doi request reprint Globus pallidus interna deep brain stimulation for tardive dyskinesia: case report and review of the literature
    Meredith A Spindler
    Parkinson s Disease Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
    Parkinsonism Relat Disord 19:141-7. 2013
    ..Finally, we present an illustrative case of refractory tardive dyskinesia treated with GPi-DBS with 5 years of follow-up and 4 accompanying video segments...
  39. pmc Delayed Parkinson's disease diagnosis among African-Americans: the role of reporting of disability
    Nabila Dahodwala
    Parkinson s Disease Research, Education and Clinical Center, Philadelphia VA Medical Center, Philadelphia, PA, USA
    Neuroepidemiology 36:150-4. 2011
    ..We sought to compare the stage at which African-American and white PD patients present for healthcare, and determine whether perception of disability accounts for racial differences...
  40. ncbi request reprint Striatal dopamine transporter imaging correlates with anxiety and depression symptoms in Parkinson's disease
    Daniel Weintraub
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Nucl Med 46:227-32. 2005
    ..We studied the correlation of striatal dopamine transporter (DAT) imaging with anxiety and depression symptoms in Parkinson's disease (PD)...
  41. ncbi request reprint Concurrence of alpha-synuclein and tau brain pathology in the Contursi kindred
    John E Duda
    Parkinson s Disease Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Pennsylvania, USA
    Acta Neuropathol 104:7-11. 2002
    ..We suggest that it is important to recognize that the neurodegenerative process caused by the Ala53Thr mutation in alpha-synuclein is not identical to that seen in typical idiopathic Parkinson's disease brains...
  42. ncbi request reprint Effect of psychiatric and other nonmotor symptoms on disability in Parkinson's disease
    Daniel Weintraub
    Parkinson s Disease Research, Education and Clinical Center, Veterans Affairs Medical Center, Philadelphia, Pennsylvania, USA
    J Am Geriatr Soc 52:784-8. 2004
    ..To examine the effect of depression and other nonmotor symptoms on functional ability in Parkinson's disease (PD)...
  43. doi request reprint Dietary modifications in Parkinson's disease: A neuroprotective intervention?
    Shital P Shah
    Parkinson s Disease Research, Education and Clinical Center, Corporal Michael J Crescenz VA Medical Center, Philadelphia, PA, USA Electronic address
    Med Hypotheses 85:1002-5. 2015
    ..We hypothesize that phytochemicals in plant-based foods may contribute to neuroprotection in PD and that adopting a plant-based diet may provide symptomatic improvement and alter disease progression in PD. ..
  44. doi request reprint Caregiver tele-support group for Parkinson's disease: A pilot study
    Shital P Shah
    Parkinson s Disease Research, Education and Clinical Center, Philadelphia VA Medical Center, 3900 Woodland Ave, Mail Stop 127, Philadelphia, PA 19104, USA Department of Neurology, University of Pennsylvania Perelman School of Medicine, 300 S 9th Street, 3rd Floor, Philadelphia, PA 19107, USA
    Geriatr Nurs 36:207-11. 2015
    ..Although caregiver burden reduces quality of life of the caregiver, support groups for caregivers have not been studied. Offering a tele-support group to PD caregivers would be an innovative approach to extending a novel resource...
  45. doi request reprint Taste function in early stage treated and untreated Parkinson's disease
    Richard L Doty
    Department of Otorhinolaryngology, Head and Neck Surgery, Smell and Taste Center, Perelman School of Medicine, Hospital of the University of Pennsylvania, 5 Ravdin Pavilion, 3400 Spruce Street, Philadelphia, PA, 19104, USA
    J Neurol 262:547-57. 2015
    ..Conceivably PD-related damage to CN IX releases central inhibition on CN VII at the level of the brainstem, resulting in enhanced taste intensity on the anterior tongue. ..
  46. doi request reprint Motor and non-motor features of Parkinson's disease that predict persistent drug-induced Parkinsonism
    James F Morley
    Parkinson s Disease Research, Education and Clinical Center, Philadelphia VA Medical Center, USA Department of Neurology, University of Pennsylvania, Perelman School of Medicine, USA Electronic address
    Parkinsonism Relat Disord 20:738-42. 2014
    ..Additionally, drug-induced Parkinsonism may, in some cases, represent "unmasking" of incipient Parkinson's disease. Clinical features or tests that distinguish degenerative from pharmacologic Parkinsonism are needed...
  47. doi request reprint Use of hyposmia and other non-motor symptoms to distinguish between drug-induced parkinsonism and Parkinson's disease
    James F Morley
    Parkinson s Disease Research, Education and Clinical Center, Philadelphia VA Medical Center, PA, USA
    J Parkinsons Dis 4:169-73. 2014
    ..In this review, we discuss the rationale and evidence for using pre-clinical manifestations of PD, particularly non-motor symptoms, to distinguish between the conditions. ..
  48. ncbi request reprint Laser light visual cueing for freezing of gait in Parkinson disease: A pilot study with male participants
    Lisette Bunting-Perry
    Parkinson s Disease Research, Education, and Clinical Center, Philadelphia Department of Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
    J Rehabil Res Dev 50:223-30. 2013
    ..No significant differences were observed between the two walking conditions across the three tasks. The laser beam, when applied as a visual cue on a rolling walker, did not diminish FOG in this study...
  49. ncbi request reprint History and prevalence of involuntary emotional expression disorder
    John E Duda
    Parkinson s Disease Research, Education and Clinical Center PADRECC, Philadelphia VA Medical Center, Philadelphia, PA, USA
    CNS Spectr 12:6-10. 2007
    ....
  50. pmc Characterization of antibodies that selectively detect alpha-synuclein in pathological inclusions
    Elisa A Waxman
    Department of Pharmacology, University of Pennsylvania School of Medicine, 3620 Hamilton Walk, 123 John Morgan Building, Philadelphia, PA, 19104, USA
    Acta Neuropathol 116:37-46. 2008
    ....
  51. ncbi request reprint Olfactory dysfunction in Parkinson's disease
    Sarah M Kranick
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Neurosignals 16:35-40. 2008
    ..Ongoing studies of olfactory dysfunction may also reveal potential for use as a medication-independent biomarker of disease progression in addition to use as a biomarker for the diagnosis of PD...
  52. ncbi request reprint Assessing the executive function deficits of patients with Parkinson's disease: utility of the Tower of London-Drexel
    William C Culbertson
    Drexel University, Neuropsychology Program, Philadelphia, PA 19104, USA
    Assessment 11:27-39. 2004
    ..Support was found for the convergent and divergent validity of the TOLDX. The clinical and theoretical implications of the findings are discussed...
  53. ncbi request reprint Recognition and treatment of depression in Parkinson's disease
    Daniel Weintraub
    Parkinson s Disease Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, USA
    J Geriatr Psychiatry Neurol 16:178-83. 2003
    ..Most depressed patients are untreated, and half of antidepressant users remain depressed, suggesting that even when delivered, treatment is often inadequate or ineffective...
  54. ncbi request reprint Tau and 14-3-3 in glial cytoplasmic inclusions of multiple system atrophy
    Benoit I Giasson
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 3rd Floor Maloney Building, Philadelphia, PA 19104, USA
    Acta Neuropathol 106:243-50. 2003
    ....
  55. ncbi request reprint Evidence for impaired encoding and retrieval memory profiles in Parkinson disease
    Daniel Weintraub
    Parkinson s Disease Research, Education and Clinical Center PADRECC, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania, USA
    Cogn Behav Neurol 17:195-200. 2004
    ..Specifically, we sought to ascertain whether the memory performance of PD patients can be categorized as fitting an unimpaired, an impaired retrieval, or an impaired encoding memory profile...
  56. ncbi request reprint Dementia with Lewy bodies
    Ian McKeith
    Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, UK
    Lancet Neurol 3:19-28. 2004
    ..Clear guidance on the management of DLB is urgently needed. Virtually unrecognised 20 years ago, DLB could within this decade be one of the most treatable neurodegenerative disorders of late life...
  57. ncbi request reprint Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein
    Benoit I Giasson
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, 3600 Spruce Street, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Neuron 34:521-33. 2002
    ..These mice demonstrate that A53T alpha-synuclein leads to the formation of toxic filamentous alpha-synuclein neuronal inclusions that cause neurodegeneration...
  58. ncbi request reprint Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases
    John E Duda
    Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Ann Neurol 52:205-10. 2002
    ....
  59. pmc Evaluation of alpha-synuclein immunohistochemical methods used by invited experts
    Thomas G Beach
    Civin Laboratory for Neuropathology, Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
    Acta Neuropathol 116:277-88. 2008
    ..Some methods, however, achieved relatively high sensitivities with optimized formic acid protocols combined with a hydrolytic step. One method was developed that allows high sensitivity with commercially available reagents...