Boris Draznin

Summary

Country: USA

Publications

  1. ncbi request reprint Molecular mechanisms of insulin resistance: serine phosphorylation of insulin receptor substrate-1 and increased expression of p85alpha: the two sides of a coin
    Boris Draznin
    Research Service, 151, Denver VA Medical Center, 1055 Clermont St, CO 80220, USA
    Diabetes 55:2392-7. 2006
  2. pmc Insulin attenuates vascular smooth muscle calcification but increases vascular smooth muscle cell phosphate transport
    Cecilia C Low Wang
    Research Service, Denver Veterans Affairs Medical Center, Denver, CO 80220, United States
    Atherosclerosis 195:e65-75. 2007
  3. pmc Acute effects of different diet compositions on skeletal muscle insulin signalling in obese individuals during caloric restriction
    Cecilia C L Wang
    Research Service, Department of Veterans Affairs, Denver, Colorado, USA
    Metabolism 62:595-603. 2013
  4. ncbi request reprint Inhibition of the phosphatidylinositol 3'-kinase signaling pathway leads to decreased insulin-stimulated adiponectin secretion from 3T3-L1 adipocytes
    Rocio I Pereira
    Research Service, Denver Veterans Affairs Medical Center, Denver, CO 80220, USA
    Metabolism 54:1636-43. 2005
  5. ncbi request reprint Effects of chronic hyperinsulinemia in insulin-resistant patients
    Sergio Muntoni
    Denver, CO 80220, USA
    Curr Diab Rep 8:233-8. 2008
  6. ncbi request reprint Insulin affects vascular smooth muscle cell phenotype and migration via distinct signaling pathways
    Cecilia C Low Wang
    Veterans Affairs Research Service, Denver VA Medical Center, Denver, Colorado 80220, USA
    Diabetes 52:2562-9. 2003
  7. ncbi request reprint Garlic extract methylallyl thiosulfinate blocks insulin potentiation of platelet-derived growth factor-stimulated migration of vascular smooth muscle cells
    Inga Golovchenko
    Research Service of the Veterans Affairs Medical Center, Denver, CO 80220, USA
    Metabolism 52:254-9. 2003
  8. ncbi request reprint Growth hormone regulation of p85alpha expression and phosphoinositide 3-kinase activity in adipose tissue: mechanism for growth hormone-mediated insulin resistance
    Juan Pablo Del Rincon
    Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Diabetes 56:1638-46. 2007
  9. ncbi request reprint Increased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess
    Linda A Barbour
    Department of Medicine, University Colorado Health Sciences Center, Denver, 80262, USA
    J Biol Chem 280:37489-94. 2005
  10. ncbi request reprint Inhibition of phosphatidylinositol 3-kinase enhances mitogenic actions of insulin in endothelial cells
    Monica Montagnani
    Cardiology Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 277:1794-9. 2002

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Molecular mechanisms of insulin resistance: serine phosphorylation of insulin receptor substrate-1 and increased expression of p85alpha: the two sides of a coin
    Boris Draznin
    Research Service, 151, Denver VA Medical Center, 1055 Clermont St, CO 80220, USA
    Diabetes 55:2392-7. 2006
    ..Conceivably, a combination of both increased expression of p85alpha and increased serine phosphorylation of IRS-1 is needed to induce clinically apparent insulin resistance...
  2. pmc Insulin attenuates vascular smooth muscle calcification but increases vascular smooth muscle cell phosphate transport
    Cecilia C Low Wang
    Research Service, Denver Veterans Affairs Medical Center, Denver, CO 80220, United States
    Atherosclerosis 195:e65-75. 2007
    ..This effect of insulin contrasts with its effect to induce phosphate transport in VSMC...
  3. pmc Acute effects of different diet compositions on skeletal muscle insulin signalling in obese individuals during caloric restriction
    Cecilia C L Wang
    Research Service, Department of Veterans Affairs, Denver, Colorado, USA
    Metabolism 62:595-603. 2013
    ..The cellular effects of restricting fat versus carbohydrate during a low-calorie diet are unclear. The aim of this study was to examine acute effects of energy and macronutrient restriction on skeletal muscle insulin signalling in obesity...
  4. ncbi request reprint Inhibition of the phosphatidylinositol 3'-kinase signaling pathway leads to decreased insulin-stimulated adiponectin secretion from 3T3-L1 adipocytes
    Rocio I Pereira
    Research Service, Denver Veterans Affairs Medical Center, Denver, CO 80220, USA
    Metabolism 54:1636-43. 2005
    ....
  5. ncbi request reprint Effects of chronic hyperinsulinemia in insulin-resistant patients
    Sergio Muntoni
    Denver, CO 80220, USA
    Curr Diab Rep 8:233-8. 2008
    ..Conversely, metformin can improve primary and surrogate end points...
  6. ncbi request reprint Insulin affects vascular smooth muscle cell phenotype and migration via distinct signaling pathways
    Cecilia C Low Wang
    Veterans Affairs Research Service, Denver VA Medical Center, Denver, Colorado 80220, USA
    Diabetes 52:2562-9. 2003
    ..Thus, with impaired PI 3-kinase signaling and intact MAPK signaling, as seen in insulin resistance, insulin may lose its ability to maintain VSMC quiescence and instead promote VSMC migration...
  7. ncbi request reprint Garlic extract methylallyl thiosulfinate blocks insulin potentiation of platelet-derived growth factor-stimulated migration of vascular smooth muscle cells
    Inga Golovchenko
    Research Service of the Veterans Affairs Medical Center, Denver, CO 80220, USA
    Metabolism 52:254-9. 2003
    ..MAT also completely inhibited the ability of hyperinsulinemia to potentiate the PDGF-induced VSMC migration. Thus, the purported anti-atherogenic action of garlic may be related to its inhibitory influence on GGTase I...
  8. ncbi request reprint Growth hormone regulation of p85alpha expression and phosphoinositide 3-kinase activity in adipose tissue: mechanism for growth hormone-mediated insulin resistance
    Juan Pablo Del Rincon
    Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Diabetes 56:1638-46. 2007
    ....
  9. ncbi request reprint Increased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess
    Linda A Barbour
    Department of Medicine, University Colorado Health Sciences Center, Denver, 80262, USA
    J Biol Chem 280:37489-94. 2005
    ....
  10. ncbi request reprint Inhibition of phosphatidylinositol 3-kinase enhances mitogenic actions of insulin in endothelial cells
    Monica Montagnani
    Cardiology Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 277:1794-9. 2002
    ..We conclude that inhibition of the metabolic branch of insulin signaling leads to an enhanced mitogenic action of insulin in endothelial cells...
  11. ncbi request reprint Insulin regulation of sterol regulatory element-binding protein-1 expression in L-6 muscle cells and 3T3 L1 adipocytes
    Kristen J Nadeau
    Division of Pediatric Endocrinology, Department of Pediatrics, University of Colorado Health Sciences Center, 1056 East 19th Avenue, Denver, CO 80218, USA
    J Biol Chem 279:34380-7. 2004
    ....
  12. ncbi request reprint Enhanced insulin signaling via Shc in human breast cancer
    Christina A Finlayson
    Department of Surgery, University of Colorado Health Sciences Center, Denver, USA
    Metabolism 52:1606-11. 2003
    ....
  13. ncbi request reprint Human placental growth hormone increases expression of the p85 regulatory unit of phosphatidylinositol 3-kinase and triggers severe insulin resistance in skeletal muscle
    Linda A Barbour
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Endocrinology 145:1144-50. 2004
    ....
  14. ncbi request reprint Phosphatidylinositol 3-kinase redistribution is associated with skeletal muscle insulin resistance in gestational diabetes mellitus
    Jianhua Shao
    Department of Pediatrics, Veterans Affairs Medical Center, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Diabetes 51:19-29. 2002
    ..These defects are unique to pregnancy and suggest that redistribution of PI 3-kinase to the insulin receptor may be a primary defect underlying insulin resistance in skeletal muscle during gestational diabetes...
  15. ncbi request reprint Molecular mechanisms of insulin resistance that impact cardiovascular biology
    Cecilia C Low Wang
    Research Service of the Denver Veterans Affairs Medical Center, Denver, CO, USA
    Diabetes 53:2735-40. 2004
    ..Here we discuss some of the effects of insulin resistance and mechanisms of potentially detrimental influence of hyperinsulinemia in the presence of metabolic insulin resistance...
  16. ncbi request reprint Early growth response gene-1 expression in vascular smooth muscle cells effects of insulin and oxidant stress
    Cecilia C Low Wang
    Research Service, Denver Veterans Affairs Medical Center, Denver, Colorado
    Am J Hypertens 19:366-72. 2006
    ..In this study we examined the effects of insulin and oxidant stress on Egr-1 expression in vascular smooth muscle cells (VSMC), and identified mechanisms for these effects on Egr-1...
  17. ncbi request reprint Increased farnesylation of p21-Ras and neonatal macrosomia in women with gestational diabetes
    Patti Thureen
    Department of Pediatrics, Medicine of the University of Colorado Health Sciences Center, Research Service of the Denver Veterans Affairs Medical Center, Colorado, USA
    J Pediatr 149:871-3. 2006
    ..The ability of fetal hyperinsulinemia to increase the availability of farnesylated p21-Ras may represent one mechanism of the growth-promoting action of insulin during fetal development...
  18. ncbi request reprint Human placental growth hormone causes severe insulin resistance in transgenic mice
    Linda A Barbour
    Department of Medicine, University of Colorado Health Sciences Center, Denver, USA
    Am J Obstet Gynecol 186:512-7. 2002
    ..Our aim was to evaluate the effect of placental growth hormone on insulin sensitivity in vivo using transgenic mice that overexpress the human placental growth hormone gene...
  19. ncbi request reprint Insulin sensitivity determines the effectiveness of dietary macronutrient composition on weight loss in obese women
    Marc Andre Cornier
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
    Obes Res 13:703-9. 2005
    ..To determine whether macronutrient composition of a hypocaloric diet can enhance its effectiveness and whether insulin sensitivity (Si) affects the response to hypocaloric diets...