Genomes and Genes
J D Sedgwick
Affiliation: DNAX Research
- Generation of splenic follicular structure and B cell movement in tumor necrosis factor-deficient miceM C Cook
Centenary Institute of Cancer Medicine and Cell Biology, Sydney, NSW, Australia 2050
J Exp Med 188:1503-10. 1998..Thus, TNF is necessary for creating the permissive environment for B cell movement and function, but is not itself responsible for these processes...
- Tumor necrosis factor: a master-regulator of leukocyte movementJ D Sedgwick
DNAX Research Institute, 901 California Avenue, Palo Alto, CA 94304 1104, USA
Immunol Today 21:110-3. 2000
- Increased thymic B cells but maintenance of thymic structure, T cell differentiation and negative selection in lymphotoxin-alpha and TNF gene-targeted miceA P Grech
Centenary Institute of Cancer Medicine and Cell Biology, Newtown, NSW, Australia
Dev Immunol 8:61-74. 2000....
- Distinct roles for lymphotoxin-alpha and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissueH Korner
Centenary Institute of Cancer Medicine and Cell Biology, Sydney, Australia
Eur J Immunol 27:2600-9. 1997....
- Membrane-bound TNF supports secondary lymphoid organ structure but is subservient to secreted TNF in driving autoimmune inflammationS R Ruuls
DNAX, 901 California Avenue, Palo Alto, CA 94304, USA
Immunity 15:533-43. 2001..We conclude that memTNF supports many processes underlying lymphoid tissue structure, but secreted TNF is needed for optimal inflammatory lesion development...
- Structural deficiencies in granuloma formation in TNF gene-targeted mice underlie the heightened susceptibility to aerosol Mycobacterium tuberculosis infection, which is not compensated for by lymphotoxinA G Bean
Centenary Institute of Cancer Medicine and Cell Biology, Newtown, Australia
J Immunol 162:3504-11. 1999..Thus, the enhanced susceptibility of TNF-/- is not compensated for by the presence of LT alpha, and the critical role of TNF is not in the activation of T cells and macrophages but in the local organization of granulomas...
- Lymphotoxin controls alphaEbeta7-integrin expression by peripheral CD8+ T cellsM J Gabor
Centenary Institute of Cancer Medicine and Cell Biology, Sydney, NSW, Australia
Immunol Cell Biol 79:323-31. 2001....
- Central nervous system microglial cell activation and proliferation follows direct interaction with tissue-infiltrating T cell blastsJ D Sedgwick
Centenary Institute of Cancer Medicine and Cell Biology, Royal Prince Alfred Hospital, Camperdown, Sydney, Australia
J Immunol 160:5320-30. 1998..These outcomes are consistent with direct tissue macrophage-T cell interactions in situ that lead to activation, proliferation, and expansion of the responding tissue-resident cell...
- Challenging cytokine redundancy: inflammatory cell movement and clinical course of experimental autoimmune encephalomyelitis are normal in lymphotoxin-deficient, but not tumor necrosis factor-deficient, miceD Sean Riminton
Centenary Institute of Cancer Medicine and Cell Biology, Sydney, New South Wales 2050, Australia
J Exp Med 187:1517-28. 1998..We conclude from these studies that TNF and LT are functionally distinct cytokines in vivo, and despite sharing common receptors, show no redundancy of function nor mutual compensation...
- Tumor necrosis factor-dependent segmental control of MIG expression by high endothelial venules in inflamed lymph nodes regulates monocyte recruitmentM J Janatpour
DNAX Research Institute, Inc, Palo Alto, CA 94304, USA
J Exp Med 194:1375-84. 2001....
- Tumour necrosis factor and lymphotoxin: molecular aspects and role in tissue-specific autoimmunityH Korner
Centenary Institute of Cancer Medicine and Cell Biology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
Immunol Cell Biol 74:465-72. 1996....
- Unlinking tumor necrosis factor biology from the major histocompatibility complex: lessons from human genetics and animal modelsS R Ruuls
DNAX Research Institute, Palo Alto, CA 94304 1104, USA
Am J Hum Genet 65:294-301. 1999
- Down-regulation of the macrophage lineage through interaction with OX2 (CD200)R M Hoek
DNAX Research Institute of Molecular and Cellular Biology, 901 California Avenue, Palo Alto, CA 94304, USA
Science 290:1768-71. 2000..Thus, in diverse tissues OX2 delivers an inhibitory signal for the macrophage lineage...
- Allele-specific PCR analysis for detection of the gld Fas-ligand point mutationR M Hoek
Centenary Institute of Cancer Medicine and Cell Biology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
J Immunol Methods 210:109-12. 1997..This approach permits the screening of back-crossed F1 progeny within one day, using whole blood samples as a source of genomic DNA. The technique is fast, robust, easily learnt, and unambiguous...
- Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleenV N Ngo
Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California 94143, USA
J Exp Med 189:403-12. 1999..Together these findings indicate that LTalpha1beta2 and TNF are required for the development and function of B and T zone stromal cells that make chemokines necessary for lymphocyte compartmentalization in the spleen...
- Induction of intratumoral tumor necrosis factor (TNF) synthesis and hemorrhagic necrosis by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in TNF knockout miceL M Ching
Auckland Cancer Society Research Centre, University of Auckland, New Zealand
Cancer Res 59:3304-7. 1999..TNF protein was undetectable in liver and spleen tissue from TNF knockout mice, but was evident in tissue from TNF-positive mice. These results confirm that DMXAA has the novel ability of inducing tumors to synthesize TNF in situ...
- Tumor necrosis factor sustains the generalized lymphoproliferative disorder (gld) phenotypeH Korner
Interdisziplinäres Zentrum für Klinische Forschung der Universität Erlangen Nürnberg, D 91054 Erlangen, Germany
J Exp Med 191:89-96. 2000..We conclude that TNF is necessary for the full manifestation of the lymphoproliferative disorder, in particular playing a critical role in lymphoaccumulation. Most importantly, absence of TNF protects gld mice against premature death...
- TNF/lymphotoxin-alpha double-mutant mice resist septic arthritis but display increased mortality in response to Staphylococcus aureusO Hultgren
Department of Rheumatology, University of Goteborg, Sweden
J Immunol 161:5937-42. 1998..Our results show the importance of TNF/LT alpha in defense against systemic S. aureus infections and point out the detrimental role of these cytokines as mediators of inflammatory response in S. aureus arthritis...
- Critical points of tumor necrosis factor action in central nervous system autoimmune inflammation defined by gene targetingH Korner
Centenary Institute of Cancer Medicine and Cell Biology, Royal Prince Alfred Hospital, Sydney, New South Wales, 2050 Australia
J Exp Med 186:1585-90. 1997..These results are consistent with the TNF dependence of processes controlling initial leukocyte movement within the CNS. Nevertheless, potent alternative mechanisms exist to mediate all other phases of EAE...
- An essential role for tumor necrosis factor in natural killer cell-mediated tumor rejection in the peritoneumM J Smyth
Cellular Cytotoxicity Laboratory, The Austin Research Institute, Heidelberg, Victoria 3084, Australia
J Exp Med 188:1611-9. 1998..Overall, these data show that NK cells delivering perforin are the major effectors of class I- tumor rejection in the peritoneum, and that TNF is specifically critical for their recruitment to the peritoneum...
- DAP12-deficient mice fail to develop autoimmunity due to impaired antigen primingA B Bakker
Department of Microbiology and Immunology and Cancer Research Institute, University of California, San Francisco 94143, USA
Immunity 13:345-53. 2000..These data suggest that DAP12 signaling may be required for optimal antigen-presenting cell (APC) function or inflammation...
- A chemokine-driven positive feedback loop organizes lymphoid folliclesK M Ansel
Department of Microbiology and Immunology, University of California San Francisco, 94143, USA
Nature 406:309-14. 2000..In germinal centres the feedback loop is overridden, with B-cell lymphotoxin alpha1beta2 expression being induced by a mechanism independent of BLC...
- Multiple deficiencies underlie NK cell inactivity in lymphotoxin-alpha gene-targeted miceM J Smyth
Cellular Cytotoxicity Laboratory, The Austin Research Institute, Heidelberg, Victoria, Australia
J Immunol 163:1350-3. 1999..5- to 3-fold in LT-alpha-deficient mice, as compared with wild-type mice. Combined defects in NK cell development and effector function contribute to compromised NK cell antitumor function in LT-alpha-deficient mice...