Mary A Marovich
Affiliation: Division of Retrovirology
- Preparation of clinical-grade recombinant canarypox-human immunodeficiency virus vaccine-loaded human dendritic cellsMary A Marovich
Division of Retrovirology, US Military HIV Research Program, Rockville, Maryland 20850, USA
J Infect Dis 186:1242-52. 2002..These data support an ongoing HIV vaccine trial comparing conventional vaccine delivery routes with ex vivo vaccine-loaded autologous DCs for immunogenicity in HIV-1-uninfected volunteers...
- ALVAC-HIV vaccines: clinical trial experience focusing on progress in vaccine developmentMary A Marovich
Division of Retrovirology, US Military HIV Research Program, Rockville, Maryland 20850, USA
Expert Rev Vaccines 3:S99-104. 2004..All of these observations have important implications for the future of HIV vaccines and need to be considered in the design of the next generation of products...
- A double-blind randomized phase I clinical trial targeting ALVAC-HIV vaccine to human dendritic cellsMichael A Eller
U S Military HIV Research Program, Rockville, Maryland, United States of America
PLoS ONE 6:e24254. 2011..We explored the concept that direct ex vivo targeting of human dendritic cells (DC) would enhance the immune response compared to either conventional intramuscular or intradermal injections of the vaccine alone...
- Leishmaniasis recidivans recurrence after 43 years: a clinical and immunologic report after successful treatmentM A Marovich
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Clin Infect Dis 33:1076-9. 2001..Combination therapy with intralesional sodium stibogluconate and oral itraconazole was successful and immunologic data suggest that both CD4(+) and CD8(+) T cell subsets had roles in this disease process...
- Human dendritic cells as targets of dengue virus infectionM Marovich
Division of Retrovirology, Walter Reed Army Institute of Research and Henry M Jackson Foundation, Rockville, Maryland 20850, USA
J Investig Dermatol Symp Proc 6:219-24. 2001..Immature dendritic cells exposed to dengue virus produce TNF-alpha protein. Some of these immature dendritic cells undergo TNF-alpha mediated maturation as a consequence of exposure to the dengue virus...
- DC-SIGN (CD209) mediates dengue virus infection of human dendritic cellsBoonrat Tassaneetrithep
Division of Retrovirology, Walter Reed Army Institite of Research and Henry M Jackson Foundation for the Advancement of Military Medicine Diseases, Rockville, MD 20850, USA
J Exp Med 197:823-9. 2003..Viruses produced by dendritic cells are infectious for DC-SIGN- and L-SIGN-bearing THP-1 cells and other permissive cell lines. Therefore, DC-SIGN may be considered as a new target for designing therapies that block dengue infection...
- Role of dendritic cells in antibody-dependent enhancement of dengue virus infectionKobporn Boonnak
Department of Medicine, Uniformed Services University of the Health Sciences, Division of Retrovirology, Department of Vaccine R and D, Walter Reed Army Institute of Research, 13 Taft Ct, Suite 200, Rockville, MD 20850, USA
J Virol 82:3939-51. 2008..Studying the cellular targets of DV infection and their susceptibility to ADE will aid our understanding of complex disease and contribute to the field of vaccine development...
- Phase I safety and immunogenicity evaluation of MVA-CMDR, a multigenic, recombinant modified vaccinia Ankara-HIV-1 vaccine candidateJeffrey R Currier
United States Military HIV Research Program, Rockville, Maryland, United States of America
PLoS ONE 5:e13983. 2010..The HIV sequences were derived from circulating recombinant form CRF01_AE, which predominates in Thailand. The objective was to evaluate safety and immunogenicity of MVA-CMDR in human volunteers in the US and Thailand...
- Cell type specificity and host genetic polymorphisms influence antibody-dependent enhancement of dengue virus infectionKobporn Boonnak
Division of Retrovirology, Walter Reed Army Institute of Research and Henry M Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland 20850, USA
J Virol 85:1671-83. 2011..Our data suggest that ADE effects are cell type specific, are influenced by host genetics, and, depending on relative infection rates, may further contribute to the complexity of DV pathogenesis...
- Heterologous prime-boost regimens using rAd35 and rMVA vectors elicit stronger cellular immune responses to HIV proteins than homologous regimensSilvia Ratto-Kim
United States Military HIV Research Program, Walter Reed Army Institute of Research, Rockville, Maryland, USA
PLoS ONE 7:e45840. 2012..This study supports the rationale for testing heterologous prime-boost regimens in humans...
- Design and evaluation of multi-gene, multi-clade HIV-1 MVA vaccinesPatricia L Earl
Laboratory of Viral Diseases, NIAID, NIH, Bethesda, MD, USA
Vaccine 27:5885-95. 2009..The MVA/CMDR vaccine candidate expressing CRF01_AE genes has elicited HIV-specific T-cell responses in two independent Phase I clinical trials. Further testing of the other rMVA is warranted...
- Single-cell level response of HIV-specific and cytomegalovirus-specific CD4 T cells correlate with viral control in chronic HIV-1 subtype A infectionMichael A Eller
U S Military HIV Research Program, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
J Acquir Immune Defic Syndr 61:9-18. 2012..To study the possible role of T cells associated with better outcome, we examined CD4 and CD8 T-cell responses against HIV-1 and cytomegalovirus (CMV) in Ugandans infected with subtype A HIV-1...
- Human FcγRII cytoplasmic domains differentially influence antibody-mediated dengue virus infectionKobporn Boonnak
Division of Retrovirology, Henry M Jackson Foundation for the Advancement of Military Medicine, Walter Reed Army Institute of Research, Rockville, MD 20850, USA
J Immunol 190:5659-65. 2013....
- Cell type-specific proteasomal processing of HIV-1 Gag-p24 results in an altered epitope repertoireNicholas J Steers
Henry Jackson Foundation for the Advancement of Military Medicine, 1600 East Gude Drive, Rockville, Maryland 20850, USA
J Virol 85:1541-53. 2011..These epitopes have been linked to HIV-1 disease progression. Our results suggest that the source of generation of precursor MHC class I epitopes may be a critical factor for the induction of relevant epitope-specific cytotoxic T cells...
- Human immunodeficiency virus type 1 infection is associated with increased NK cell polyfunctionality and higher levels of KIR3DL1+ NK cells in ugandans carrying the HLA-B Bw4 motifMichael A Eller
Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, 14186 Stockholm, Sweden
J Virol 85:4802-11. 2011..These results indicate that chronic HIV-1 infection is associated with increased NK cell polyfunctionality and elevated levels of KIR3DL1(+) NK cells in Ugandans carrying the HLA-B Bw4 motif...
- Expansion of Inefficient HIV-Specific CD8 T Cells during Acute InfectionMichael A Eller
U S Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA
J Virol 90:4005-16. 2016..These data indicate, for the first time, that early CD4(+)T cell loss coincides with the expansion of a functionally impaired HIV-specific CD8(dim)T cell population less efficient in controlling HIV viremia...
- Mitigation of variation observed in a peripheral blood mononuclear cell (PBMC) based HIV-1 neutralization assay by donor cell poolingLindsay Wieczorek
Military HIV Research Program, Silver Spring, MD, USA Henry M Jackson Foundation, Bethesda, MD, USA
Virology 447:240-8. 2013....
- Peptide impurities in commercial synthetic peptides and their implications for vaccine trial assessmentJeffrey R Currier
U S Military HIV Research Program, Rockville, Maryland 20850, USA
Clin Vaccine Immunol 15:267-76. 2008..We propose a simple schema of biological QA/QC protocols to augment the standard biochemical QA/QC analyses as a means to circumvent this and other problems that can affect cellular immune-based assay outcome and interpretation...
- Defining epitope coverage requirements for T cell-based HIV vaccines: theoretical considerations and practical applicationsJeffrey R Currier
US Military HIV Research Program MHRP, Rockville, MD, USA
J Transl Med 9:212. 2011..Assessment of potential HIV strain coverage by candidate T cell-based vaccines (whether natural sequence or computationally optimized products) is now a critical component in interpreting candidate vaccine suitability...
- Sex differences in soluble markers vary before and after the initiation of antiretroviral therapy in chronically HIV-infected individualsShelly J Krebs
aUS Military HIV Research Program, Silver SpringbHenry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USAcPhramongkutklao Hospital, Bangkok, ThailanddDepartment of Epidemiology and Biostatistics, University of California, San Francisco, California, USAeSEARCH, Thai Red Cross AIDS Research Centre, Bangkok, ThailandfCurrently, International Vaccine Institute, Seoul, KoreagChulalongkorn University, Bangkok, ThailandhCurrently, Vaccine Research and Development Section, Division of AIDS, NIH, Bethesda, MarylandiDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, California, USA Shelly J Krebs and Bonnie M Slike contributed equally to the writing of this article
AIDS 30:1533-42. 2016..To evaluate differences in soluble inflammatory markers between chronically HIV-infected men and women, with or without cognitive impairment, and in response to treatment...
- The Immunology of a Healing Response in Cutaneous Leishmaniasis Treated with Localized Heat or Systemic Antimonial TherapyInès Lakhal-Naouar
Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America
PLoS Negl Trop Dis 9:e0004178. 2015..We hypothesized that different curative immune responses might develop with systemic and local treatment modalities...
- Differential effects of dengue virus on infected and bystander dendritic cellsDupeh R Palmer
Department of Viral Diseases, Walter Reed Army Institute of Research, Naval Research Center, Silver Spring, Maryland, USA
J Virol 79:2432-9. 2005..Taken together, these results constitute an immune evasion strategy used by DV that directly impairs antigen-presenting cell function by maturation blockade and induction of apoptosis...
- A randomized controlled trial of local heat therapy versus intravenous sodium stibogluconate for the treatment of cutaneous Leishmania major infectionNaomi E Aronson
Infectious Diseases Division, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
PLoS Negl Trop Dis 4:e628. 2010..Cutaneous Leishmania major has affected many travelers including military personnel in Iraq and Afghanistan. Optimal treatment for this localized infection has not been defined, but interestingly the parasite is thermosensitive...
- An immunocytometric assay based on dengue infection via DC-SIGN permits rapid measurement of anti-dengue neutralizing antibodiesNicole C Martin
Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
J Virol Methods 134:74-85. 2006..Importantly, serotype-specific neutralizing activity against recently isolated dengue strains with less heterotypic cross-neutralization than laboratory adapted viruses was also demonstrated...
- Specific antibody production by blood B cells is retained in late stage drug-naïve HIV-infected AfricansLydie Beniguel
GIMAP EA3064, Faculte de Medecine, université J Monnet, St Etienne, France
Clin Dev Immunol 11:121-7. 2004....
- Identification of germinal center B cells in blood from HIV-infected drug-naive individuals in Central AfricaLydie Beniguel
CGIMAP EA3064, Faculte de Medecine, Université Jean Monnet, 15 Rue A Paré 42023, Saint Etienne Cedex 2, France
Clin Dev Immunol 11:23-7. 2004..It may impact the management of HIV infection in countries with limited access to HIV drugs and urges consideration for implementation of therapeutic vaccines...