Jerome H Kim

Summary

Affiliation: Division of Retrovirology
Country: USA

Publications

  1. ncbi request reprint Specific antibody responses to vaccination with bivalent CM235/SF2 gp120: detection of homologous and heterologous neutralizing antibody to subtype E (CRF01.AE) HIV type 1
    Jerome H Kim
    U S Military HIV Research Program, Rockville, Maryland 20850, USA
    AIDS Res Hum Retroviruses 19:807-16. 2003
  2. doi request reprint Lessons from the RV144 Thai phase III HIV-1 vaccine trial and the search for correlates of protection
    Jerome H Kim
    US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910 email
    Annu Rev Med 66:423-37. 2015
  3. pmc A novel acute HIV infection staging system based on 4th generation immunoassay
    Jintanat Ananworanich
    SEARCH, Pathumwan, Bangkok, Thailand
    Retrovirology 10:56. 2013
  4. ncbi request reprint Selective increases in HIV-specific neutralizing antibody and partial reconstitution of cellular immune responses during prolonged, successful drug therapy of HIV infection
    J H Kim
    Walter Reed Army Institute of Research, Rockville, Maryland 20850, USA
    AIDS Res Hum Retroviruses 17:1021-34. 2001
  5. pmc HIV vaccines: lessons learned and the way forward
    Jerome H Kim
    Walter Reed Army Institute of Research, U S Military HIV Research Program, Rockville, Maryland, USA
    Curr Opin HIV AIDS 5:428-34. 2010
  6. pmc Molecular evolution of the HIV-1 Thai epidemic between the time of RV144 immunogen selection to the execution of the vaccine efficacy trial
    Gustavo H Kijak
    U S Military HIV Research Program, Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA
    J Virol 87:7265-81. 2013
  7. doi request reprint HLA class I, KIR, and genome-wide SNP diversity in the RV144 Thai phase 3 HIV vaccine clinical trial
    Heather A Prentice
    U S Military HIV Research Program MHRP, Walter Reed Army Institute of Research, Silver Spring, MD, USA
    Immunogenetics 66:299-310. 2014
  8. pmc HIV-1 envelope resistance to proteasomal cleavage: implications for vaccine induced immune responses
    Nicholas J Steers
    United States Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America
    PLoS ONE 7:e42579. 2012
  9. doi request reprint Designing the epitope flanking regions for optimal generation of CTL epitopes
    Nicholas J Steers
    United States Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA Henry M Jackson Foundation for the Advancement of Military Medicine, Rockledge, MD 20852, USA
    Vaccine 32:3509-16. 2014
  10. pmc Significant contribution of subtype G to HIV-1 genetic complexity in Nigeria identified by a newly developed subtyping assay specific for subtype G and CRF02_AG
    Richard A Heipertz
    aUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland bEmergency Plan Implementation Committee, Nigerian Ministry of Defense, Abuja, Nigeria cHenry M Jackson Foundation for the Advancement of Military Medicine, Inc, Bethesda, Maryland dUS Military HIV Research Program HJF MRI, Abuja, Nigeria eCentre de Recherches Medicales de Lambarene CERMEL Fondation Internationale de l Hôpital Albert Schweitzer Lambarene, Gabon fUnited States Public Health Service, Rockville, Maryland g45 Nigerian Air Force Hospital, Makurdi, Nigeria hDepartment of Defense HIV Program, Abuja, Nigeria
    Medicine (Baltimore) 95:e4346. 2016

Detail Information

Publications56

  1. ncbi request reprint Specific antibody responses to vaccination with bivalent CM235/SF2 gp120: detection of homologous and heterologous neutralizing antibody to subtype E (CRF01.AE) HIV type 1
    Jerome H Kim
    U S Military HIV Research Program, Rockville, Maryland 20850, USA
    AIDS Res Hum Retroviruses 19:807-16. 2003
    ..Whether the NAb detected by the CM235M4-C4.6/A3R5 system is qualitatively different from those in more traditional NP03/H9 assays will require further study...
  2. doi request reprint Lessons from the RV144 Thai phase III HIV-1 vaccine trial and the search for correlates of protection
    Jerome H Kim
    US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910 email
    Annu Rev Med 66:423-37. 2015
    ..Efficacy trials are now planned in heterosexual populations in southern Africa and men who have sex with men in Thailand. ..
  3. pmc A novel acute HIV infection staging system based on 4th generation immunoassay
    Jintanat Ananworanich
    SEARCH, Pathumwan, Bangkok, Thailand
    Retrovirology 10:56. 2013
    ..Here we evaluated AHI staging based on a 4thG IA (4thG staging)...
  4. ncbi request reprint Selective increases in HIV-specific neutralizing antibody and partial reconstitution of cellular immune responses during prolonged, successful drug therapy of HIV infection
    J H Kim
    Walter Reed Army Institute of Research, Rockville, Maryland 20850, USA
    AIDS Res Hum Retroviruses 17:1021-34. 2001
    ..In the setting of stable anti-HIV Ab levels, the development of increased NAb in certain individuals suggests that control of the virus by HAART may assist in immune control of HIV...
  5. pmc HIV vaccines: lessons learned and the way forward
    Jerome H Kim
    Walter Reed Army Institute of Research, U S Military HIV Research Program, Rockville, Maryland, USA
    Curr Opin HIV AIDS 5:428-34. 2010
    ..An effective HIV vaccine is a global health priority. We describe lessons learned from four HIV vaccine trials that failed to demonstrate efficacy and one that showed modest protection as a pathway forward...
  6. pmc Molecular evolution of the HIV-1 Thai epidemic between the time of RV144 immunogen selection to the execution of the vaccine efficacy trial
    Gustavo H Kijak
    U S Military HIV Research Program, Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA
    J Virol 87:7265-81. 2013
    ....
  7. doi request reprint HLA class I, KIR, and genome-wide SNP diversity in the RV144 Thai phase 3 HIV vaccine clinical trial
    Heather A Prentice
    U S Military HIV Research Program MHRP, Walter Reed Army Institute of Research, Silver Spring, MD, USA
    Immunogenetics 66:299-310. 2014
    ..This will inform subsequent host genetic analyses in the RV144 cohort and provide insight for future genetic association studies in the Thai population. ..
  8. pmc HIV-1 envelope resistance to proteasomal cleavage: implications for vaccine induced immune responses
    Nicholas J Steers
    United States Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America
    PLoS ONE 7:e42579. 2012
    ..Preliminary immunological data from the RV144 phase III trial indicated that the immune responses were biased towards the Env antigen with a dominant CD4+ T-cell response...
  9. doi request reprint Designing the epitope flanking regions for optimal generation of CTL epitopes
    Nicholas J Steers
    United States Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA Henry M Jackson Foundation for the Advancement of Military Medicine, Rockledge, MD 20852, USA
    Vaccine 32:3509-16. 2014
    ..These results highlight the importance of flanking regions in promoting efficient antigen processing and presentation. This concept can have important implications in vaccine design and development strategies. ..
  10. pmc Significant contribution of subtype G to HIV-1 genetic complexity in Nigeria identified by a newly developed subtyping assay specific for subtype G and CRF02_AG
    Richard A Heipertz
    aUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland bEmergency Plan Implementation Committee, Nigerian Ministry of Defense, Abuja, Nigeria cHenry M Jackson Foundation for the Advancement of Military Medicine, Inc, Bethesda, Maryland dUS Military HIV Research Program HJF MRI, Abuja, Nigeria eCentre de Recherches Medicales de Lambarene CERMEL Fondation Internationale de l Hôpital Albert Schweitzer Lambarene, Gabon fUnited States Public Health Service, Rockville, Maryland g45 Nigerian Air Force Hospital, Makurdi, Nigeria hDepartment of Defense HIV Program, Abuja, Nigeria
    Medicine (Baltimore) 95:e4346. 2016
    ..High proportions of samples reacted to a G probe in env gp120 confirms that subtype G infections are abundant and should be considered in strategies for global HIV-1 vaccine development. ..
  11. pmc Effect of cytokines on Siglec-1 and HIV-1 entry in monocyte-derived macrophages: the importance of HIV-1 envelope V1V2 region
    Ousman Jobe
    Henry M Jackson Foundation for the Advancement of Military Medicine, Silver Spring, Maryland, USA Laboratory of Adjuvant and Antigen Research, U S Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA
    J Leukoc Biol 99:1089-106. 2016
    ....
  12. pmc The Number and Complexity of Pure and Recombinant HIV-1 Strains Observed within Incident Infections during the HIV and Malaria Cohort Study Conducted in Kericho, Kenya, from 2003 to 2006
    Erik Billings
    United States Military HIV Research Program Henry M Jackson Foundation, Rockville, Maryland, United States of America
    PLoS ONE 10:e0135124. 2015
    ....
  13. pmc Identification of New Regions in HIV-1 gp120 Variable 2 and 3 Loops that Bind to α4β7 Integrin Receptor
    Kristina K Peachman
    U S Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States of America
    PLoS ONE 10:e0143895. 2015
    ....
  14. pmc CD8 and CD4 epitope predictions in RV144: no strong evidence of a T-cell driven sieve effect in HIV-1 breakthrough sequences from trial participants
    Kalpana Dommaraju
    US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America Henry Jackson Foundation, Bethesda, Maryland, United States of America
    PLoS ONE 9:e111334. 2014
    ..Overall, our results did not reveal a strong differential impact of vaccine-induced T cell responses among breakthrough infections in RV144 participants. ..
  15. pmc Identification of immunodominant CD4-restricted epitopes co-located with antibody binding sites in individuals vaccinated with ALVAC-HIV and AIDSVAX B/E
    Silvia Ratto-Kim
    United States Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, 20910, United States of America
    PLoS ONE 10:e0115582. 2015
    ..There was no correlation between the frequencies of CD4+ fine epitope responses and binding antibody. ..
  16. pmc High-throughput multiplex HLA genotyping by next-generation sequencing using multi-locus individual tagging
    Philip K Ehrenberg
    U, S, Military HIV Research Program MHRP, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD, USA
    BMC Genomics 15:864. 2014
    ..Unambiguous HLA-A, B, C and DRB1 genotypes can be determined for 96 individuals in a single run of the Illumina MiSeq...
  17. doi request reprint Molecular epidemiology of early and acute HIV type 1 infections in the United States Navy and Marine Corps, 2005-2010
    Richard A Heipertz
    1 US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland
    AIDS Res Hum Retroviruses 29:1310-20. 2013
    ..Real-time molecular monitoring of new HIV-1 acquisitions in the Sea Services may have a role in facilitating public health interventions at sites where related HIV-1 infections are identified...
  18. pmc Cell type-specific proteasomal processing of HIV-1 Gag-p24 results in an altered epitope repertoire
    Nicholas J Steers
    Henry Jackson Foundation for the Advancement of Military Medicine, 1600 East Gude Drive, Rockville, Maryland 20850, USA
    J Virol 85:1541-53. 2011
    ..These epitopes have been linked to HIV-1 disease progression. Our results suggest that the source of generation of precursor MHC class I epitopes may be a critical factor for the induction of relevant epitope-specific cytotoxic T cells...
  19. pmc Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2
    Morgane Rolland
    US Military HIV Research Program, Silver Spring, Maryland 20910, USA
    Nature 490:417-20. 2012
    ....
  20. doi request reprint Transfusion-transmitted human T-lymphotropic virus Type I infection in a United States military emergency whole blood transfusion recipient in Afghanistan, 2010
    Shilpa Hakre
    Armed Services Blood Program Office, Falls Church, Virginia San Antonio Military Medical Center, San Antonio, Texas United States Military HIV Research Program, Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland United States Military HIV Research Program, Walter Reed Army Institute of Research, Rockville, Maryland
    Transfusion 53:2176-82. 2013
    ..All recipients of blood collected in combat are tested according to policy soon after and at 3, 6, and 12 months after transfusion...
  21. pmc Human immunodeficiency virus vaccine trials
    Robert J O'Connell
    U S Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    Cold Spring Harb Perspect Med 2:a007351. 2012
    ..We review the clinical trials of HIV vaccines that have provided insight into human immunogenicity or efficacy in preventing HIV-1 infection...
  22. pmc Risk behaviour and time as covariates for efficacy of the HIV vaccine regimen ALVAC-HIV (vCP1521) and AIDSVAX B/E: a post-hoc analysis of the Thai phase 3 efficacy trial RV 144
    Merlin L Robb
    US Military HIV Research Program, Division of Retrovirology, Walter Reed Army Institute of Research, Rockville, MD, USA
    Lancet Infect Dis 12:531-7. 2012
    ..Baseline variables of age, sex, marital status, and risk did not modify vaccine efficacy. We did a post-hoc analysis of the trial's data to investigate behavioural risk and efficacy every 6 months after vaccination...
  23. pmc RecDraw: a software package for the representation of HIV-1 recombinant structures
    Gustavo H Kijak
    US Military HIV Research Program, Rockville, Maryland 20850, USA
    AIDS Res Hum Retroviruses 26:1317-21. 2010
    ..RecDraw is a platform-flexible, Java stand-alone application available through http://www.hivresearch.org/research.php?ServiceID = 5&SubServiceID = 6 ...
  24. pmc Brief Report: Sexual Risk Behaviors of HIV Seroconverters in the US Army, 2012-2014
    Shilpa Hakre
    US Military HIV Research Program, Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD US Army Public Health Command, Aberdeen Proving Ground, MD and US Military HIV Research Program, Walter Reed Army Institute of Research, Bethesda, MD
    J Acquir Immune Defic Syndr 70:456-61. 2015
    ..Don't Ask, Don't Tell repeal allows for risk screening and reduction interventions targeting a newly identifiable risk category in the US Army. At-risk populations need to be identified and assessed for possible unmet health needs. ..
  25. pmc Expansion of Inefficient HIV-Specific CD8 T Cells during Acute Infection
    Michael A Eller
    U S Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA
    J Virol 90:4005-16. 2016
    ..These data indicate, for the first time, that early CD4(+)T cell loss coincides with the expansion of a functionally impaired HIV-specific CD8(dim)T cell population less efficient in controlling HIV viremia...
  26. pmc Centralized HIV Program Oversight: An Investigation of a Case Series of New HIV Infections among US Army Soldiers, 2012 to 2013
    Laura A Pacha
    U S Army Public Health Command, Aberdeen Proving Ground LAP, SLS, SBC U S Military HIV Research Program, Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD SH, OM, EES B, GHK, yl, SLM, PTP, St, U S Army Medical Command, San Antonio, TX MWP, RMM and U S Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD NLM, JHK, SAP, LLJ, PTS
    Medicine (Baltimore) 94:e2093. 2015
    ..Further investigation is underway and will determine whether these findings are generalizable to the Army...
  27. pmc HLA class II genes modulate vaccine-induced antibody responses to affect HIV-1 acquisition
    Heather A Prentice
    U S Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20818, USA
    Sci Transl Med 7:296ra112. 2015
    ..Overall, the underlying genetic findings indicate that HLA class II modulated the quantity, quality, and efficacy of antibody responses in the RV144 trial. ..
  28. pmc Cryptic determinant of α4β7 binding in the V2 loop of HIV-1 gp120
    Boonrat Tassaneetrithep
    Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand United States Military Health Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America
    PLoS ONE 9:e108446. 2014
    ..Accordingly, the anti-V2 antibodies that apparently reduced the risk of infection in the RV144 trial may have functioned by blocking α4β7-mediated HIV-host cell interactions via this cryptic determinant. ..
  29. doi request reprint Hepatitis C genotype distribution and homology among geographically disparate injecting drug users in Afghanistan
    Eric Sanders-Buell
    Department of Molecular Virology and Pathogenesis, United States Military HIV Research Program MHRP, Walter Reed Army Institute of Research, Silver Spring, MD, USA
    J Med Virol 85:1170-9. 2013
    ....
  30. pmc Heterologous prime-boost regimens using rAd35 and rMVA vectors elicit stronger cellular immune responses to HIV proteins than homologous regimens
    Silvia Ratto-Kim
    United States Military HIV Research Program, Walter Reed Army Institute of Research, Rockville, Maryland, USA
    PLoS ONE 7:e45840. 2012
    ..This study supports the rationale for testing heterologous prime-boost regimens in humans...
  31. pmc W-curve alignments for HIV-1 genomic comparisons
    Douglas J Cork
    United States Military HIV Research Program, Rockville, Maryland, USA
    PLoS ONE 5:e10829. 2010
    ..The W-curve approach allows us to compare large numbers of samples quickly...
  32. ncbi request reprint HIV-1 Vpr activates cell cycle inhibitor p21/Waf1/Cip1: a potential mechanism of G2/M cell cycle arrest
    Iqbal H Chowdhury
    Henry M Jackson Foundation for the Advancement of Military Medicine, Rockville 20850, USA
    Virology 305:371-7. 2003
    ..These data demonstrate that HIV-1 Vpr utilizes the cyclin-dependent kinase inhibitor p21, in addition to cdc2, to arrest cells in G2/M...
  33. ncbi request reprint HIV-1 genetic diversity among incident infections in Mbeya, Tanzania
    Erik Billngs
    United States Military HIV Research Program Henry M Jackson Foundation, Laboratory of Molecular Virology and Pathogenesis, Silver Spring, Maryland, United States
    AIDS Res Hum Retroviruses . 2016
    ....
  34. pmc Impact of HIV-1 backbone on neutralization sensitivity: neutralization profiles of heterologous envelope glycoproteins expressed in native subtype C and CRF01_AE backbone
    Agnes Laurence Chenine
    The Henry M Jackson Foundation, Bethesda, Maryland, United States of America Military HIV Research Program, Silver Spring, Maryland, United States of America
    PLoS ONE 8:e76104. 2013
    ....
  35. pmc Inclusion of a CRF01_AE HIV envelope protein boost with a DNA/MVA prime-boost vaccine: Impact on humoral and cellular immunogenicity and viral load reduction after SHIV-E challenge
    Josephine H Cox
    U S Military HIV Program, Rockville, MD, USA
    Vaccine 30:1830-40. 2012
    ..These results demonstrate that a gp140 subunit and inclusion of SIV Gag-Pol may be critical for control of SHIV post challenge...
  36. doi request reprint Class I HLA-A*7401 is associated with protection from HIV-1 acquisition and disease progression in Mbeya, Tanzania
    Rebecca N Koehler
    US Military HIV Research Program, Henry M Jackson Foundation, Rockville, Maryland 20850, USA
    J Infect Dis 202:1562-6. 2010
    ..This observation calls for additional investigation of mechanisms by which HLA-A*74:01 may influence HIV-1 acquisition and control of the infection...
  37. doi request reprint Inhibition of HIV-1 infection of peripheral blood mononuclear cells by a monoclonal antibody that binds to phosphoinositides and induces secretion of β-chemokines
    Gary R Matyas
    Division of Retrovirology, Walter Reed Army Institute of Research, Rockville, MD 20850, USA
    Biochem Biophys Res Commun 402:808-12. 2010
    ....
  38. pmc Virological and immunological characteristics of HIV-infected individuals at the earliest stage of infection
    Jintanat Ananworanich
    SEARCH, The Thai Red Cross AIDS Research Centre, Bangkok, Thailand The Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA United States Military HIV Research Program Walter Reed Army Institute of Research, Silver Spring, MD, USA
    J Virus Erad 2:43-48. 2016
    ..The challenges of identifying acute HIV infection (AHI) have resulted in a lack of critical information on early AHI that constrains the development of therapeutics that are designed to eradicate HIV from the infected host...
  39. doi request reprint Prospects for a Globally Effective HIV-1 Vaccine
    Jean Louis Excler
    U S Military HIV Research Program, Walter Reed Army Institute of Research, Bethesda, MD, USA Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA Electronic address
    Am J Prev Med 49:S307-18. 2015
    ..Although NHP challenge studies may guide vaccine development, human efficacy trials remain key to answer the critical questions leading to the development of a global HIV-1 vaccine for licensure. ..
  40. pmc TFH cells accumulate in mucosal tissues of humanized-DRAG mice and are highly permissive to HIV-1
    Atef Allam
    1 US Military HIV Research Program, Walter Reed Army Institute of Research 2 Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA
    Sci Rep 5:10443. 2015
    ..The novel finding of TFH-cells in the FRT may contribute to the high susceptibility of DRAG mice to HIV-1 infection. This mouse model thus provides new opportunities to study TFH-cells and to evaluate HIV-1 vaccines. ..
  41. doi request reprint Prospects for a globally effective HIV-1 vaccine
    Jean Louis Excler
    U S Military HIV Research Program, Walter Reed Army Institute of Research, Bethesda, MD, USA Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA Electronic address
    Vaccine 33:D4-12. 2015
    ..Although NHP challenge studies may guide vaccine development, human efficacy trials remain key to answer the critical questions leading to the development of a global HIV-1 vaccine for licensure. ..
  42. doi request reprint Circulating HIV-Specific Interleukin-21(+)CD4(+) T Cells Represent Peripheral Tfh Cells with Antigen-Dependent Helper Functions
    Bruce T Schultz
    U S Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA Institute for HIV Research, University Hospital Essen, University Duisburg Essen, 45147 Essen, Germany
    Immunity 44:167-78. 2016
    ..Together, we identify IL-21(+)CD4(+) T cells as pTfh cells, implicating them as key populations in the generation of vaccine-evoked antibody responses...
  43. doi request reprint Standardization of a cytometric p24-capture bead-assay for the detection of main HIV-1 subtypes
    Melanie Merbah
    U S Military HIV Research Program, Walter Reed Army Institute of Research, MD, USA Henry M Jackson Foundation for the Advancement of Military Medicine, MD, USA Electronic address
    J Virol Methods 230:45-52. 2016
    ..This newly developed p24 assay leverages the advantages of the Luminex platform, which include smaller sample volume and simultaneous detection of up to 500 analytes in a single sample, and delivers a valuable tool for the field...
  44. pmc Detection of HIV-1 neutralizing antibodies in a human CD4⁺/CXCR4⁺/CCR5⁺ T-lymphoblastoid cell assay system
    Robert J McLinden
    Military HIV 1 Research Program, WRAIR, Silver Spring, Maryland, United States of America
    PLoS ONE 8:e77756. 2013
    ..The A3R5 cell line provides a novel approach to guide the development and qualification of promising new HIV-1 vaccine immunogens. ..
  45. pmc Distinct gene-expression profiles associated with the susceptibility of pathogen-specific CD4 T cells to HIV-1 infection
    Haitao Hu
    US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD
    Blood 121:1136-44. 2013
    ..Our data suggest a mechanism for the persistence of CMV-specific CD4 response and earlier loss of mucosal Th17-associated TT- and C albicans-specific CD4 response in AIDS...
  46. pmc Nonneutralizing functional antibodies: a new "old" paradigm for HIV vaccines
    Jean Louis Excler
    U S Military HIV Research Program, Bethesda, Maryland, USA Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA
    Clin Vaccine Immunol 21:1023-36. 2014
    ..The induction of high-frequency HIV-specific functional nNAb at high titers may represent an attractive hypothesis-testing strategy in future HIV vaccine efficacy trials. ..
  47. ncbi request reprint An investigation of bloodborne pathogen transmission due to multipatient sharing of insulin pens
    Shilpa Hakre
    Epidemiology and Threat Assessment, U S Military HIV Research Program, Henry M Jackson Foundation for the Advancement of Military Medicine, 6720 A Rockledge Drive, Suite 400, Bethesda, MD 20817, USA
    Mil Med 177:930-8. 2012
    ..Training of hospital staff on correct use of insulin pens should be prioritized and their practices evaluated. Insulin pens should be more clearly labeled for single-patient use...
  48. ncbi request reprint Comparison between env-specific T-cell epitopic responses in HIV-1-uninfected adults immunized with combination of ALVAC-HIV(vCP205) plus or minus rgp160MN/LAI-2 and HIV-1-infected adults
    Silvia Ratto-Kim
    Henry M Jackson Foundation, Rockville, Maryland, USA
    J Acquir Immune Defic Syndr 32:9-17. 2003
    ....
  49. doi request reprint Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisition
    Monica Vaccari
    Animal Models and Vaccine Section, National Cancer Institute, Bethesda, Maryland, USA
    Nat Med 22:762-70. 2016
    ..Whether RAS activation, mucosal ILCs and antibodies to V2 are also important hallmarks of HIV-vaccine efficacy in humans will require further studies. ..
  50. doi request reprint Impact of nucleic acid testing relative to antigen/antibody combination immunoassay on the detection of acute HIV infection
    Mark S de Souza
    aSEARCH bThe Thai Red Cross AIDS Research Centre, Bangkok, Thailand cCooper Human Systems, Nashua, New Hampshire, USA dHIV NAT eDepartment of Retrovirology, Armed Forces Research Institute of Medical Sciences, United States Component, Bangkok, Thailand fUnited States Military HIV Research Program, Bethesda gWalter Reed Army Institute of Research, Silver Spring hThe Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA
    AIDS 29:793-800. 2015
    ..To assess the addition of HIV nucleic acid testing (NAT) to fourth-generation (4thG) HIV antigen/antibody combination immunoassay in improving detection of acute HIV infection (AHI)...
  51. ncbi request reprint Human T-cell leukemia virus type 1 Tax activates cyclin-dependent kinase inhibitor p21/Waf1/Cip1 expression through a p53-independent mechanism: Inhibition of cdk2
    Iqbal H Chowdhury
    Department of Vaccine Development and Research, Henry M Jackson Foundation for the Advancement of Military Medicine, Rockville, MD, USA
    Int J Cancer 107:603-11. 2003
    ..Tax induction of p21 may balance the T-cell proliferation function of Tax and may contribute to the long clinical latency of HTLV-1 infection and the delayed development of adult T-cell leukemia...
  52. ncbi request reprint Strong cellular and humoral anti-HIV Env immune responses induced by a heterologous rhabdoviral prime-boost approach
    Gene S Tan
    Department of Microbiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Virology 331:82-93. 2005
    ..Our results show that it is feasible to elicit robust cellular and humoral anti-HIV responses using two different live attenuated Rhabdovirus vectors to sequentially prime and boost...
  53. ncbi request reprint A phase 1/2 comparative vaccine trial of the safety and immunogenicity of a CRF01_AE (subtype E) candidate vaccine: ALVAC-HIV (vCP1521) prime with oligomeric gp160 (92TH023/LAI-DID) or bivalent gp120 (CM235/SF2) boost
    Prasert Thongcharoen
    Department of Microbiology, Faculty of Medicine, Siriraj Hospital, Bangkok, Thailand
    J Acquir Immune Defic Syndr 46:48-55. 2007
    ..A prime-boost HIV-1 vaccine trial assessing safety and immunogenicity was conducted in Thailand as part of an evaluation of candidate regimens for a phase 3 efficacy trial...
  54. doi request reprint Incidence and characterization of acute HIV-1 infection in a high-risk Thai population
    Jintanat Ananworanich
    Department of Retrovirology, The Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
    J Acquir Immune Defic Syndr 49:151-5. 2008
    ..The objective of this study was to investigate the incidence, demographics, HIV subtype, and genotypic resistance of acute HIV infections in a high-risk Thai population...
  55. ncbi request reprint Prospective analyses of HIV-1-specific proliferative responses, recall antigen proliferative responses, and clinical outcomes in an HIV-1-seropositive cohort
    Silvia Ratto-Kim
    Hawaii AIDS Clinical Research Program, University of Hawaii School of Medicine, Honolulu, 96816, USA
    J Infect Dis 189:1988-95. 2004
    ..It was not known whether this association would be predictive of better clinical outcome in longitudinal studies...
  56. pmc Expression of monocyte markers in HIV-1 infected individuals with or without HIV associated dementia and normal controls in Bangkok Thailand
    Silvia Ratto-Kim
    Hawaii AIDS Clinical Research Program, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, United States
    J Neuroimmunol 195:100-7. 2008
    ..In conclusion it appears that HAD in Thai individuals has a different immunological profile then in North America cohorts...