Division of Retrovirology

Summary

Organization: Division of Retrovirology
Country: USA

Top Publications

  1. ncbi HIV vaccine development: past, present and future
    Merlin L Robb
    US Military HIV Research Program, 1600 Gude Drive, Rockville, MD 20850, USA
    IDrugs 13:852-6. 2010
  2. ncbi Identification of CRF34_01B, a second circulating recombinant form unrelated to and more complex than CRF15_01B, among injecting drug users in northern Thailand
    Sodsai Tovanabutra
    US Military HIV Research Program, Rockville, Maryland 20850, USA
    AIDS Res Hum Retroviruses 23:829-33. 2007
  3. ncbi Impact of antiretroviral treatment on gene expression in peripheral blood mononuclear cells from SIVmac251-infected macaques
    Maryanne T Vahey
    Division of Retrovirology, Walter Reed Army Institute of Research, Washington, DC, USA
    J Infect Dis 196:384-93. 2007
  4. ncbi HyperPack: a software package for the study of levels, contexts, and patterns of APOBEC-mediated hypermutation in HIV
    Gustavo H Kijak
    U S Military HIV Research Program, Henry M Jackson Foundation for the Advancement of Military Medicine, 1600 East Gude Drive, Rockville, MD 20850, USA
    AIDS Res Hum Retroviruses 23:554-7. 2007
  5. ncbi Epidemiology and spatial analysis of malaria in the Northern Peruvian Amazon
    Christian T Bautista
    US Naval Medical Research Center Detachment, Lima, Peru
    Am J Trop Med Hyg 75:1216-22. 2006
  6. ncbi HIV-1, lipid rafts, and antibodies to liposomes: implications for anti-viral-neutralizing antibodies
    Carl R Alving
    Department of Vaccine Production and Delivery, Division of Retrovirology, US Military HIV Research Program, Walter Reed Army Institute of Research, Rockville, MD 20850, USA
    Mol Membr Biol 23:453-65. 2006
  7. ncbi Distinguishing molecular forms of HIV-1 in Asia with a high-throughput, fluorescent genotyping assay, MHAbce v.2
    Gustavo H Kijak
    Henry M Jackson Foundation for the Advancement of Military Medicine US Military HIV Research Program, Rockville, MD 20850, USA
    Virology 358:178-91. 2007
  8. ncbi HIV incidence trends among white and african-american active duty United States Army personnel (1986-2003)
    Christian T Bautista
    Division of Retrovirology, US Military HIV Research Program at the Walter Reed Army Institute of Research, Rockville, MD 20850, USA
    J Acquir Immune Defic Syndr 43:351-5. 2006
  9. ncbi Antibodies to lipids and liposomes: immunology and safety
    Carl R Alving
    Department of Vaccine Production and Delivery, Division of Retrovirology, U S Military HIV Research Program, Walter Reed Army Institute of Research, Rockville, MD 20850, USA
    J Liposome Res 16:157-66. 2006
  10. ncbi Epidemiology of HIV-1 infection in agricultural plantation residents in Kericho, Kenya: preparation for vaccine feasibility studies
    Warren B Sateren
    US Military HIV Research Program at the Walter Reed Army Institute of Research WRAIR, Division of Retrovirology, and the Henry M Jackson Foundation for the Advancement Military Medicine, Inc, Rockville, MD 20850, USA
    J Acquir Immune Defic Syndr 43:102-6. 2006

Scientific Experts

Detail Information

Publications62

  1. ncbi HIV vaccine development: past, present and future
    Merlin L Robb
    US Military HIV Research Program, 1600 Gude Drive, Rockville, MD 20850, USA
    IDrugs 13:852-6. 2010
    ....
  2. ncbi Identification of CRF34_01B, a second circulating recombinant form unrelated to and more complex than CRF15_01B, among injecting drug users in northern Thailand
    Sodsai Tovanabutra
    US Military HIV Research Program, Rockville, Maryland 20850, USA
    AIDS Res Hum Retroviruses 23:829-33. 2007
    ..More comprehensive HIV-1 prevention and treatment programs in IDU can help to limit the growing complexity of HIV-1 strains in Thailand...
  3. ncbi Impact of antiretroviral treatment on gene expression in peripheral blood mononuclear cells from SIVmac251-infected macaques
    Maryanne T Vahey
    Division of Retrovirology, Walter Reed Army Institute of Research, Washington, DC, USA
    J Infect Dis 196:384-93. 2007
    ....
  4. ncbi HyperPack: a software package for the study of levels, contexts, and patterns of APOBEC-mediated hypermutation in HIV
    Gustavo H Kijak
    U S Military HIV Research Program, Henry M Jackson Foundation for the Advancement of Military Medicine, 1600 East Gude Drive, Rockville, MD 20850, USA
    AIDS Res Hum Retroviruses 23:554-7. 2007
    ..HyperPack is a platform-flexible, Java stand-alone application available through http://www.hivresearch.org/hyperpack/...
  5. ncbi Epidemiology and spatial analysis of malaria in the Northern Peruvian Amazon
    Christian T Bautista
    US Naval Medical Research Center Detachment, Lima, Peru
    Am J Trop Med Hyg 75:1216-22. 2006
    ..Modest targeted control efforts directed at identified high-risk areas may have significant impact on malaria transmission in this region...
  6. ncbi HIV-1, lipid rafts, and antibodies to liposomes: implications for anti-viral-neutralizing antibodies
    Carl R Alving
    Department of Vaccine Production and Delivery, Division of Retrovirology, US Military HIV Research Program, Walter Reed Army Institute of Research, Rockville, MD 20850, USA
    Mol Membr Biol 23:453-65. 2006
    ..The possibility is proposed that liposomal lipids, or liposome-protein combinations, could be useful as antigens for inducing broadly neutralizing antibodies to HIV-1...
  7. ncbi Distinguishing molecular forms of HIV-1 in Asia with a high-throughput, fluorescent genotyping assay, MHAbce v.2
    Gustavo H Kijak
    Henry M Jackson Foundation for the Advancement of Military Medicine US Military HIV Research Program, Rockville, MD 20850, USA
    Virology 358:178-91. 2007
    ..MHAbce v.2, with an area of application including China, India, Southeast Asia, and the Pacific Rim, can be used to develop a comprehensive and detailed picture of this important component of the HIV/AIDS pandemic...
  8. ncbi HIV incidence trends among white and african-american active duty United States Army personnel (1986-2003)
    Christian T Bautista
    Division of Retrovirology, US Military HIV Research Program at the Walter Reed Army Institute of Research, Rockville, MD 20850, USA
    J Acquir Immune Defic Syndr 43:351-5. 2006
    ..To analyze HIV incidence rate (IR) trends among white and African-American active duty US Army personnel between 1986 and 2003...
  9. ncbi Antibodies to lipids and liposomes: immunology and safety
    Carl R Alving
    Department of Vaccine Production and Delivery, Division of Retrovirology, U S Military HIV Research Program, Walter Reed Army Institute of Research, Rockville, MD 20850, USA
    J Liposome Res 16:157-66. 2006
    ..Numerous Phase I and II human clinical trials of experimental vaccines containing liposomes and lipid A have shown a high level of safety...
  10. ncbi Epidemiology of HIV-1 infection in agricultural plantation residents in Kericho, Kenya: preparation for vaccine feasibility studies
    Warren B Sateren
    US Military HIV Research Program at the Walter Reed Army Institute of Research WRAIR, Division of Retrovirology, and the Henry M Jackson Foundation for the Advancement Military Medicine, Inc, Rockville, MD 20850, USA
    J Acquir Immune Defic Syndr 43:102-6. 2006
    ..HIV prevention efforts have been implemented, along with further research to characterize this population for future cohort feasibility studies and HIV-1 vaccine efficacy trials...
  11. pmc Seroprevalence of and risk factors for HIV-1 infection among female commercial sex workers in South America
    C T Bautista
    U S Military HIV Research Program at the Walter Reed Army Institute of Research, and the Henry M Jackson Foundation for the Advancement of Military Medicine, Inc, 1 Taft Court, Suite 250, Rockville, MD 20850, USA
    Sex Transm Infect 82:311-6. 2006
    ..Assessment of HIV prevalence and associated risk behaviours among female commercial sex workers (FCSW) across major cities in South America...
  12. pmc CTL epitope distribution patterns in the Gag and Nef proteins of HIV-1 from subtype A infected subjects in Kenya: use of multiple peptide sets increases the detectable breadth of the CTL response
    Jeffrey R Currier
    The US Military HIV Research Program, Rockville, MD 20850, USA
    BMC Immunol 7:8. 2006
    ..While considerable effort has been focused upon mapping and defining immunodominant CTL epitopes in HIV-1 subtype B and subtype C infections, few epitope mapping studies have focused upon subtype A...
  13. ncbi Measurement of cytokine release at the single cell level using the ELISPOT assay
    Josephine H Cox
    U S Military HIV Research Program, Henry M Jackson Foundation for the Advancement of Military Medicine, 13 Taft Court, Rockville, MD 20850, USA
    Methods 38:274-82. 2006
    ..The history, applications, validation process, and future challenges of the ELISPOT assay are discussed in this chapter...
  14. ncbi Complement activation-related pseudoallergy caused by amphiphilic drug carriers: the role of lipoproteins
    Janos Szebeni
    Department of Vaccine Production and Delivery, Division of Retrovirology, Walter Reed Army Institute of Research and Henry Jackson Foundation for Military Medical Research, Silver Spring, MD, USA
    Curr Drug Deliv 2:443-9. 2005
    ..Thus, lipoproteins may be essential in the induction, and they may also play a complex modulatory role in C activation-related pseudoallergy caused amphiphilic drug solvents and carriers...
  15. ncbi A nascent HIV type 1 epidemic among injecting drug users in Kabul, Afghanistan is dominated by complex AD recombinant strain, CRF35_AD
    E Sanders-Buell
    US Military HIV Research Program Division of Retrovirology, Walter Reed Army Institute of Research, Rockville Maryland 20850, USA
    AIDS Res Hum Retroviruses 23:834-9. 2007
    ..2% HIV-1 prevalence, are either CRF35_AD or a related recombinant. Voluntary HIV-1 screening and harm reduction programs in Afghanistan, applied now, could limit the spread of HIV-1, both in IDUs and in other social networks...
  16. ncbi Geographic mapping of HIV infection among civilian applicants for United States military service
    Christian T Bautista
    US Military HIV Research Program, Division of Retrovirology, Walter Reed Army Institute of Research, Rockville, MD 20850, USA
    Health Place 14:608-15. 2008
    ..Among African-Americans, three HIV spatial clusters were found: New York/New Jersey, Washington DC/Virginia, and south and central California. The South accounted for a significant proportion of HIV-infected African-American applicants...
  17. doi Sexual practices, drug use behaviors, and prevalence of HIV, syphilis, hepatitis B and C, and HTLV-1/2 in immigrant and non-immigrant female sex workers in Argentina
    Christian T Bautista
    US Military HIV Research Program at the Walter Reed Army Institute of Research, 1 Taft Court, Suite 250, Rockville, MD 20850, USA
    J Immigr Minor Health 11:99-104. 2009
    ..To study socio-demographics, sexual practices, drug use behaviors, and prevalences of HIV, syphilis, hepatitis B and C, HTLV-1 and HTLV-2 in immigrant (foreigner) and non-immigrant (local/native) female sex workers (FSW)...
  18. pmc Phase I safety and immunogenicity evaluation of MVA-CMDR, a multigenic, recombinant modified vaccinia Ankara-HIV-1 vaccine candidate
    Jeffrey R Currier
    United States Military HIV Research Program, Rockville, Maryland, United States of America
    PLoS ONE 5:e13983. 2010
    ..The HIV sequences were derived from circulating recombinant form CRF01_AE, which predominates in Thailand. The objective was to evaluate safety and immunogenicity of MVA-CMDR in human volunteers in the US and Thailand...
  19. pmc HIV vaccines: lessons learned and the way forward
    Jerome H Kim
    Walter Reed Army Institute of Research, U S Military HIV Research Program, Rockville, Maryland, USA
    Curr Opin HIV AIDS 5:428-34. 2010
    ..An effective HIV vaccine is a global health priority. We describe lessons learned from four HIV vaccine trials that failed to demonstrate efficacy and one that showed modest protection as a pathway forward...
  20. pmc W-curve alignments for HIV-1 genomic comparisons
    Douglas J Cork
    United States Military HIV Research Program, Rockville, Maryland, USA
    PLoS ONE 5:e10829. 2010
    ..The W-curve approach allows us to compare large numbers of samples quickly...
  21. doi Effects of duration of injection drug use and age at first injection on HCV among IDU in Kabul, Afghanistan
    Christian T Bautista
    U S Military HIV Research Program, Walter Reed Army Institute of Research, Division of Retrovirology, Rockville, MD, USA
    J Public Health (Oxf) 32:336-41. 2010
    ..Duration of injection and young age at first injection are common risk factors for HCV in IDU populations. The association of HCV with these time factors was analyzed...
  22. pmc Clinical reactivations of herpes simplex virus type 2 infection and human immunodeficiency virus disease progression markers
    Bulbulgul Aumakhan
    Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
    PLoS ONE 5:e9973. 2010
    ..The natural history of HSV-2 infection and role of HSV-2 reactivations in HIV disease progression are unclear...
  23. doi Evaluation of HIV type 1 strains in men having sex with men and in female sex workers in Mombasa, Kenya
    Sodsai Tovanabutra
    Walter Reed Army Institute of Research, Rockville, MD 20850, USA
    AIDS Res Hum Retroviruses 26:123-31. 2010
    ..Characteristics of a close social network were identified, with extended chains of transmission, novel recombinant strains possibly generated within the network, and a relatively high proportion of recombinant and dual infections...
  24. doi Impact of host cell variation on the neutralization of HIV-1 in vitro
    Victoria R Polonis
    Department of Vaccine Research and Development, Walter Reed Army Institute of Research, Rockville, Maryland, USA
    Curr Opin HIV AIDS 4:400-7. 2009
    ..A commentary on the challenges of standardizing in-vitro neutralization assays using primary cells is included...
  25. doi Neutralizing antibodies induced by liposomal HIV-1 glycoprotein 41 peptide simultaneously bind to both the 2F5 or 4E10 epitope and lipid epitopes
    Gary R Matyas
    Division of Retrovirology, US Military HIV Research Program, Walter Reed Army Institute of Research, Rockville, MD 20850, USA
    AIDS 23:2069-77. 2009
    ....
  26. doi High-throughput genotyping of KIR2DL2/L3, KIR3DL1/S1, and their HLA class I ligands using real-time PCR
    R N Koehler
    Division of Retrovirology, US Military HIV Research Program Henry M Jackson Foundation, Rockville, MD 20850, USA
    Tissue Antigens 74:73-80. 2009
    ..The application of this platform will further clarify the nature and impact of the KIR-HLA epistatic interaction on disease course in large global population-based studies...
  27. doi Lipid binding properties of 4E10, 2F5, and WR304 monoclonal antibodies that neutralize HIV-1
    Gary R Matyas
    Department of Adjuvant and Antigen Research, Division of Retrovirology, U S Military HIV Research Program, Walter Reed Army Institute of Research, 1600 East Gude Drive, Rockville, MD 20850, USA
    Biochim Biophys Acta 1788:660-5. 2009
    ....
  28. pmc CD4+ T-cell decline after the interruption of antiretroviral therapy in ACTG A5170 is predicted by differential expression of genes in the ras signaling pathway
    Maryanne T Vahey
    Division of Retrovirology, The Walter Reed Army Institute of Research, Rockville, Maryland 20850, USA
    AIDS Res Hum Retroviruses 24:1047-66. 2008
    ..These observations identify specific host cell processes associated with differential outcome in this cohort after TI...
  29. doi Variable contexts and levels of hypermutation in HIV-1 proviral genomes recovered from primary peripheral blood mononuclear cells
    Gustavo H Kijak
    Henry M Jackson Foundation for the Advancement of Military Medicine US Military HIV Research Program, 1600 East Gude Drive, Rockville, Maryland 20850, USA
    Virology 376:101-11. 2008
    ..These data suggest considerable complexity in the interplay of host restriction and viral defense during HIV-1 infection...
  30. pmc Serum IgG antibody response to the protective antigen (PA) of Bacillus anthracis induced by anthrax vaccine adsorbed (AVA) among U.S. military personnel
    Darrell E Singer
    Division of Retrovirology, Walter Reed Army Institute of Research, Military HIV Research Program, Rockville, MD, USA
    Vaccine 26:869-73. 2008
    ..95 microg/mL and 45.5%, respectively. The forth dose elicited 100% seroconversion compared to the pre-immunization level. These results should facilitate comparison between different immunization schedules and new vaccines...
  31. pmc In-depth analysis of a heterosexually acquired human immunodeficiency virus type 1 superinfection: evolution, temporal fluctuation, and intercompartment dynamics from the seronegative window period through 30 months postinfection
    F E McCutchan
    US Military HIV Research Program, 1600 E Gude Drive, Rockville, MD 20850, USA
    J Virol 79:11693-704. 2005
    ....
  32. ncbi Complement activation-related pseudoallergy: a new class of drug-induced acute immune toxicity
    Janos Szebeni
    Department of Vaccine Production and Delivery, Division of Retrovirology, Walter Reed Army Institute of Research and Henry Jackson Foundation for Military Medical Research, Silver Spring, MD, USA
    Toxicology 216:106-21. 2005
    ..Overall, the CARPA concept may help in the prediction, prevention and treatment of the acute immune toxicity of numerous state-of-the-art drugs...
  33. ncbi A new circulating recombinant form, CRF15_01B, reinforces the linkage between IDU and heterosexual epidemics in Thailand
    Sodsai Tovanabutra
    Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand
    AIDS Res Hum Retroviruses 19:561-7. 2003
    ..These recombinants must be considered in ongoing or projected efficacy evaluations of HIV-1 vaccines and antiviral therapies...
  34. pmc Human immunodeficiency virus type 1 primary isolate neutralization resistance is associated with the syncytium-inducing phenotype and lower CD4 cell counts in subtype CRF01_AE-infected patients
    Victoria R Polonis
    Armed Forces Research Institute of Medical Sciences, Bangkok 10400, Thailand
    J Virol 77:8570-6. 2003
    ....
  35. ncbi HIV-1 infection among civilian applicants for US military service, 1985 to 2000: epidemiology and geography
    Warren B Sateren
    Division of Retrovirology, Walter Reed Army Institute of Research, U S Military HIV Research Program, 1 Taft Court, Suite 250, Rockville, MD 20850, USA
    J Acquir Immune Defic Syndr 32:215-22. 2003
    ..This study examined demographic and geographic correlates of HIV-1 prevalence among civilian applicants for US military service...
  36. ncbi Among 46 near full length HIV type 1 genome sequences from Rakai District, Uganda, subtype D and AD recombinants predominate
    Matthew E Harris
    Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
    AIDS Res Hum Retroviruses 18:1281-90. 2002
    ..Subtype D comprised more than 70% of all the HIV-1 genomes in Rakai when both pure subtypes and recombinants were considered. Candidate vaccines based on HIV-1 subtype D would be appropriate for evaluation in Rakai District, Uganda...
  37. ncbi Precise mapping of recombination breakpoints suggests a common parent of two BC recombinant HIV type 1 strains circulating in China
    F E McClutchan
    Henry M Jackson Foundation, Rockville, Maryland 20850, USA
    AIDS Res Hum Retroviruses 18:1135-40. 2002
    ..Both CRFs are broadly distributed from north to south in western China and have maintained low interpatient diversity...
  38. ncbi Preparation of clinical-grade recombinant canarypox-human immunodeficiency virus vaccine-loaded human dendritic cells
    Mary A Marovich
    Division of Retrovirology, US Military HIV Research Program, Rockville, Maryland 20850, USA
    J Infect Dis 186:1242-52. 2002
    ..These data support an ongoing HIV vaccine trial comparing conventional vaccine delivery routes with ex vivo vaccine-loaded autologous DCs for immunogenicity in HIV-1-uninfected volunteers...
  39. pmc Comprehensive screening for human immunodeficiency virus type 1 subtype-specific CD8 cytotoxic T lymphocytes and definition of degenerate epitopes restricted by HLA-A0207 and -C(W)0304 alleles
    Jeffrey R Currier
    U S Military HIV Research Program, Rockville, Maryland 20850, USA
    J Virol 76:4971-86. 2002
    ..These findings provide biological validation of HLA supertypes in HIV-1 CTL recognition and support earlier studies of cross-subtype CTL responses during HIV-1 infection...
  40. ncbi Impact of viral infection on the gene expression profiles of proliferating normal human peripheral blood mononuclear cells infected with HIV type 1 RF
    Maryanne T Vahey
    Division of Retrovirology, Walter Reed Army Institute of Research, Washington, DC, USA
    AIDS Res Hum Retroviruses 18:179-92. 2002
    ....
  41. ncbi Diverse BF recombinants have spread widely since the introduction of HIV-1 into South America
    J K Carr
    Henry M Jackson Foundation, Rockville, MD 20850, USA
    AIDS 15:F41-7. 2001
    ..To describe the genetic diversity of HIV-1 in South America by full genome sequencing and analysis...
  42. ncbi Leishmaniasis recidivans recurrence after 43 years: a clinical and immunologic report after successful treatment
    M A Marovich
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Clin Infect Dis 33:1076-9. 2001
    ..Combination therapy with intralesional sodium stibogluconate and oral itraconazole was successful and immunologic data suggest that both CD4(+) and CD8(+) T cell subsets had roles in this disease process...
  43. ncbi The ABC transporter genes of Plasmodium falciparum and drug resistance
    S A Peel
    Department of Molecular Diagnostics and Pathogenesis, Division of Retrovirology Walter Reed Army Institute of Research, Rockville, MD, USA
    Drug Resist Updat 4:66-74. 2001
    ..To date, three full-length ABC transporter genes have been isolated from P. falciparum: two P-glycoprotein-like homologues, pfmdr1 and pfmdr2, and a homologue of the yeast GCN20 gene, pfgcn20...
  44. ncbi Selective increases in HIV-specific neutralizing antibody and partial reconstitution of cellular immune responses during prolonged, successful drug therapy of HIV infection
    J H Kim
    Walter Reed Army Institute of Research, Rockville, Maryland 20850, USA
    AIDS Res Hum Retroviruses 17:1021-34. 2001
    ..In the setting of stable anti-HIV Ab levels, the development of increased NAb in certain individuals suggests that control of the virus by HAART may assist in immune control of HIV...
  45. pmc Human immunodeficiency virus type 1 DNA sequences genetically damaged by hypermutation are often abundant in patient peripheral blood mononuclear cells and may be generated during near-simultaneous infection and activation of CD4(+) T cells
    M Janini
    Henry M Jackson Foundation, Rockville, Maryland 20850, USA
    J Virol 75:7973-86. 2001
    ..Near-simultaneous activation and infection of CD4(+) T cells may represent a window of susceptibility where the informational content of HIV-1 sequences is lost due to hypermutation...
  46. ncbi Detection of high frequencies of HIV-1 cross-subtype reactive CD8 T lymphocytes in the peripheral blood of HIV-1-infected Kenyans
    Jeffrey R Currier
    US Military HIV Research Program, Suite 200, 13 Taft Court, Rockville, MD 20850, USA
    AIDS 17:2149-57. 2003
    ..To quantitate rapidly the frequency of HIV-1 subtype-specific and broadly HIV-1 cross-subtype-reactive CD8 T cells in the peripheral blood of HIV-1-infected individuals from a geographical region of multiple subtype endemicity...
  47. ncbi A cluster of HIV type 1 subtype C sequences from Ethiopia, observed in full genome analysis, is not sustained in subgenomic regions
    Matthew E Harris
    Walter Reed Army Institute of Research, Washington, D C, USA
    AIDS Res Hum Retroviruses 19:1125-33. 2003
    ..Although immunological responses must be considered, from a phylogenetic perspective, there is no compelling support for use of Ethiopian subtype C sequences, compared to other subtype C, as vaccine prototype strains...
  48. ncbi The changing molecular epidemiology of HIV type 1 among northern Thai drug users, 1999 to 2002
    Sodsai Tovanabutra
    Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand
    AIDS Res Hum Retroviruses 20:465-75. 2004
    ..Ongoing molecular surveillance of circulating HIV-1 strains is imperative for the evaluation of HIV vaccine efficacy...
  49. ncbi HIV-1 diversity and prevalence differ between urban and rural areas in the Mbeya region of Tanzania
    Miguel A Arroyo
    US Military HIV Research Program USMHRP, Walter Reed Army Institute of Research, Division of Retrovirology, 1600 East Gude Drive, Silver Spring, MD 20850, USA
    AIDS 19:1517-24. 2005
    ..To characterize HIV-1 strains in a potential vaccine trial cohort (CODE) in the Mbeya region of southwest Tanzania...
  50. ncbi Outbreak of a West African recombinant of HIV-1 in Tashkent, Uzbekistan
    Jean K Carr
    US Military HIV Research Program, Henry M Jackson Foundation, Rockville, MD 20850, USA
    J Acquir Immune Defic Syndr 39:570-5. 2005
    ..This research describes the genetic diversity of HIV-1 in Uzbekistan...
  51. ncbi HIV-1 MN Env 15-mer peptides better detect HIV-1 specific CD8 T cell responses compared with consensus subtypes B and M group 15-mer peptides
    Alleluiah Rutebemberwa
    Henry M Jackson Foundation and the US Military HIV Research Program, Rockville, Maryland 20850, USA
    AIDS 19:1165-72. 2005
    ..To compare the ability of three Env (15-mer) peptide sets derived from the HIV-1 MN, the subtype B consensus, and the group M consensus to detect HIV-1 specific interferon (IFN)-gamma responses in HIV-1 subtype B infected subjects...
  52. pmc Biologic and genetic characterization of a panel of 60 human immunodeficiency virus type 1 isolates, representing clades A, B, C, D, CRF01_AE, and CRF02_AG, for the development and assessment of candidate vaccines
    Bruce K Brown
    The Henry M Jackson Foundation, 13 Taft Court, Suite 200, Rockville, MD 20850, USA
    J Virol 79:6089-101. 2005
    ....
  53. ncbi Immunodominance and cross-reactivity of B5703-restricted CD8 T lymphocytes from HIV type 1 subtype C-infected Ethiopians
    Jeffrey R Currier
    The U S Military HIV Research Program, Rockville, Maryland 20850, USA
    AIDS Res Hum Retroviruses 21:239-45. 2005
    ..Efforts to optimize the cross-reactivity of vaccine-induced CD8 T cells may need to focus on the relative immunogenicity of minor sequence variation...
  54. ncbi Results of an ELISPOT proficiency panel conducted in 11 laboratories participating in international human immunodeficiency virus type 1 vaccine trials
    Josephine H Cox
    U S Military HIV Research Program, Rockville, MD 20850, USA
    AIDS Res Hum Retroviruses 21:68-81. 2005
    ..This study highlights the need for better standardization of protocols and reagents to obtain reliable and reproducible data that may support immunogenicity studies, vaccine regulatory submissions, and licensure...
  55. pmc Seroprevalence of and risk factors for HIV-1 infection among South American men who have sex with men
    C T Bautista
    US Military HIV Research Program and Henry M Jackson Foundation, 1 Taft Court, Suite 250, Rockville, MD 20850, USA
    Sex Transm Infect 80:498-504. 2004
    ..Seeking better understanding of risk behaviours in this region, we determined the seroprevalence, potential risk factors, and geographic distribution of HIV-1 among groups of men who have sex with men (MSM)...
  56. pmc Identification and utilization of inter-species conserved (ISC) probesets on Affymetrix human GeneChip platforms for the optimization of the assessment of expression patterns in non human primate (NHP) samples
    Zhining Wang
    Henry M Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland 20850, USA
    BMC Bioinformatics 5:165. 2004
    ..Appropriate normalization methods were identified that further improve the reliability of human GeneChips for interspecies (human vs NHP) comparisons...
  57. ncbi HIV type 1 subtypes among blood donors in the Mbeya region of southwest Tanzania
    Miguel A Arroyo
    U S Military HIV Research Program USMHRP, Walter Reed Army Research Institute, Division of Retrovirology, Rockville, Maryland 20850, USA
    AIDS Res Hum Retroviruses 20:895-901. 2004
    ..Based on this work, subtype C appears to be the prevalent subtype in southwest Tanzania, followed by a high proportion of intersubtype recombinants...
  58. ncbi HIV type 1 circulating recombinant form CRF09_cpx from west Africa combines subtypes A, F, G, and may share ancestors with CRF02_AG and Z321
    Francine E McCutchan
    Global Molecular Epidemiology Program, Henry M Jackson Foundation, 1600 East Gude Drive, Rockville, Maryland 20850, USA
    AIDS Res Hum Retroviruses 20:819-26. 2004
    ..Although newly identified, at least one infection with CRF09_cpx has already occurred outside of Africa...
  59. ncbi HIV type 1-specific inter- and intrasubtype cellular immune responses in HIV type 1-infected Ugandans
    Alleluiah Rutebemberwa
    Henry M Jackson Foundation, Rockville, Maryland 20850, USA
    AIDS Res Hum Retroviruses 20:763-71. 2004
    ....
  60. ncbi ALVAC-HIV vaccines: clinical trial experience focusing on progress in vaccine development
    Mary A Marovich
    Division of Retrovirology, US Military HIV Research Program, Rockville, Maryland 20850, USA
    Expert Rev Vaccines 3:S99-104. 2004
    ..All of these observations have important implications for the future of HIV vaccines and need to be considered in the design of the next generation of products...
  61. ncbi Development and application of a high-throughput HIV type 1 genotyping assay to identify CRF02_AG in West/West Central Africa
    Gustavo H Kijak
    The Henry M Jackson Foundation, Rockville, Maryland 20850, USA
    AIDS Res Hum Retroviruses 20:521-30. 2004
    ..Together with other regional genotyping assays MHAcrf02 will contribute to the development of a global picture of HIV-1 diversity and geographic distribution, providing a strong foundation for intervention, including vaccine development...
  62. ncbi The AG recombinant IbNG and novel strains of group M HIV-1 are common in Cameroon
    J K Carr
    Henry M Jackson Foundation, Rockville, Maryland 20850, USA
    Virology 286:168-81. 2001
    ..This suggests that there was an ancestral AG recombinant that gave rise to CRF02 AG (IbNG), the successful circulating recombinant form, and to others that were less successful and are now rare...