Benjamin B Williams

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. ncbi request reprint High spatial resolution multisite EPR oximetry of transient focal cerebral ischemia in the rat
    Benjamin B Williams
    Dartmouth EPR Center, Department of Radiology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Antioxid Redox Signal 9:1691-8. 2007
  2. pmc Clinical electron paramagnetic resonance (EPR) oximetry using India ink
    Benjamin B Williams
    EPR Center for Viable Systems, Department of Radiology, Dartmouth Medical School, 703 Vail, Hanover, NH 03755, USA
    Adv Exp Med Biol 662:149-56. 2010
  3. pmc Electron paramagnetic resonance dosimetry for a large-scale radiation incident
    Harold M Swartz
    Dartmouth Medical School, Hanover, NH 03755, USA
    Health Phys 103:255-67. 2012
  4. pmc Surface loop resonator design for in vivo EPR tooth dosimetry using finite element analysis
    Jennifer D Pollock
    Dartmouth College, Hanover, NH, USA
    Health Phys 98:339-44. 2010
  5. pmc Physically-based biodosimetry using in vivo EPR of teeth in patients undergoing total body irradiation
    Benjamin B Williams
    Department of Diagnostic Radiology, Dartmouth Physically based Biodosimetry Center for Medical Countermeasures against Radiation, Dartmouth Medical School, Hanover, New Hampshire, USA
    Int J Radiat Biol 87:766-75. 2011
  6. pmc Skeletal muscle and glioma oxygenation by carbogen inhalation in rats: a longitudinal study by EPR oximetry using single-probe implantable oxygen sensors
    Huagang Hou
    Department of Radiology, Geisel School of Medicine, Hanover, NH, 03755, USA
    Adv Exp Med Biol 812:97-103. 2014
  7. pmc The view from the trenches: part 2-technical considerations for EPR screening
    Roberto J Nicolalde
    EPR Center for Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
    Health Phys 98:128-35. 2010
  8. pmc Dosimetry based on EPR spectral analysis of fingernail clippings
    Dean E Wilcox
    Department of Chemistry, Dartmouth College, Hanover, NH 03755, USA
    Health Phys 98:309-17. 2010
  9. pmc Evaluating the Special Needs of The Military for Radiation Biodosimetry for Tactical Warfare Against Deployed Troops: Comparing Military to Civilian Needs for Biodosimetry Methods
    Ann Barry Flood
    EPR Center for the Study of Viable Systems, Radiology Department, Geisel School of Medicine at Dartmouth, Hanover, NH 03755 Department of Radiation Oncology, Emory University School of Medicine, Atlanta, GA Department of Radiation Oncology, College of Medicine, University of Florida, Gainesville, FL Radiation Oncology Division, Geisel School of Medicine at Dartmouth, Hanover, NH 03755 Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, NH 03755
    Health Phys 111:169-82. 2016
  10. doi request reprint Direct and Repeated Clinical Measurements of pO2 for Enhancing Cancer Therapy and Other Applications
    Harold M Swartz
    Department of Radiology, Geisel School of Medicine at Dartmouth, One Medical Center Drive Lebanon, Lebanon, NH, USA
    Adv Exp Med Biol 923:95-104. 2016

Collaborators

Detail Information

Publications27

  1. ncbi request reprint High spatial resolution multisite EPR oximetry of transient focal cerebral ischemia in the rat
    Benjamin B Williams
    Dartmouth EPR Center, Department of Radiology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Antioxid Redox Signal 9:1691-8. 2007
    ..These measurements demonstrate the capabilities of the HSRMS oximetry technique and set the stage for more extensive physiologic studies...
  2. pmc Clinical electron paramagnetic resonance (EPR) oximetry using India ink
    Benjamin B Williams
    EPR Center for Viable Systems, Department of Radiology, Dartmouth Medical School, 703 Vail, Hanover, NH 03755, USA
    Adv Exp Med Biol 662:149-56. 2010
    ..These studies demonstrate the feasibility of EPR oximetry in a clinical setting and the potential for more widespread use in the treatment of these and other oxygen-dependent diseases...
  3. pmc Electron paramagnetic resonance dosimetry for a large-scale radiation incident
    Harold M Swartz
    Dartmouth Medical School, Hanover, NH 03755, USA
    Health Phys 103:255-67. 2012
    ..The authors conclude that electron paramagnetic resonance dosimetry is likely to be a useful part of triage for a large-scale radiation incident...
  4. pmc Surface loop resonator design for in vivo EPR tooth dosimetry using finite element analysis
    Jennifer D Pollock
    Dartmouth College, Hanover, NH, USA
    Health Phys 98:339-44. 2010
    ..The effects of loop positioning in the mouth are examined, and it is shown that the sensitivity to loop position along a row of molars is decreased as the loop is moved away from the teeth...
  5. pmc Physically-based biodosimetry using in vivo EPR of teeth in patients undergoing total body irradiation
    Benjamin B Williams
    Department of Diagnostic Radiology, Dartmouth Physically based Biodosimetry Center for Medical Countermeasures against Radiation, Dartmouth Medical School, Hanover, New Hampshire, USA
    Int J Radiat Biol 87:766-75. 2011
    ..In vivo electron paramagnetic resonance (EPR) spectroscopy of tooth enamel has been developed to meet this need...
  6. pmc Skeletal muscle and glioma oxygenation by carbogen inhalation in rats: a longitudinal study by EPR oximetry using single-probe implantable oxygen sensors
    Huagang Hou
    Department of Radiology, Geisel School of Medicine, Hanover, NH, 03755, USA
    Adv Exp Med Biol 812:97-103. 2014
    ..The heterogeneity of 9L tumors in response to carbogen highlights the need to repeatedly monitor pO₂ to confirm tumor oxygenation so that such changes can be taken into account in planning therapies and interpreting results...
  7. pmc The view from the trenches: part 2-technical considerations for EPR screening
    Roberto J Nicolalde
    EPR Center for Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
    Health Phys 98:128-35. 2010
    ....
  8. pmc Dosimetry based on EPR spectral analysis of fingernail clippings
    Dean E Wilcox
    Department of Chemistry, Dartmouth College, Hanover, NH 03755, USA
    Health Phys 98:309-17. 2010
    ..Second, decomposition of the EPR spectra from irradiated fingernails into MIS and RIS components can be used to isolate and thus quantify the RIS for determining individual exposure dose...
  9. pmc Evaluating the Special Needs of The Military for Radiation Biodosimetry for Tactical Warfare Against Deployed Troops: Comparing Military to Civilian Needs for Biodosimetry Methods
    Ann Barry Flood
    EPR Center for the Study of Viable Systems, Radiology Department, Geisel School of Medicine at Dartmouth, Hanover, NH 03755 Department of Radiation Oncology, Emory University School of Medicine, Atlanta, GA Department of Radiation Oncology, College of Medicine, University of Florida, Gainesville, FL Radiation Oncology Division, Geisel School of Medicine at Dartmouth, Hanover, NH 03755 Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, NH 03755
    Health Phys 111:169-82. 2016
    ..In contrast, simulations based on the civilian scenario revealed that no method could process 50,000 people in 2 d and only two could succeed within 6 d. ..
  10. doi request reprint Direct and Repeated Clinical Measurements of pO2 for Enhancing Cancer Therapy and Other Applications
    Harold M Swartz
    Department of Radiology, Geisel School of Medicine at Dartmouth, One Medical Center Drive Lebanon, Lebanon, NH, USA
    Adv Exp Med Biol 923:95-104. 2016
    ....
  11. pmc Standard error of inverse prediction for dose-response relationship: approximate and exact statistical inference
    Eugene Demidenko
    Dartmouth Physically Based Biodosimetry Center for Medical Countermeasures Against Radiation Dart Dose CMCR, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA
    Stat Med 32:2048-61. 2013
    ..We illustrate our theory with electron paramagnetic resonance tooth dosimetry for a rapid estimation of the radiation dose received in the event of nuclear terrorism...
  12. pmc Advances in in vivo EPR Tooth BIOdosimetry: Meeting the targets for initial triage following a large-scale radiation event
    Ann Barry Flood
    EPR Center for the Study of Viable Systems at Dartmouth, Radiology Dept, Geisel School of Medicine at Dartmouth, Hanover, NH, USA
    Radiat Prot Dosimetry . 2016
    ..In sum, recent advancements allow this prototype to meet or exceed the US Federal Government's recommended targets for POC biodosimetry in large-scale events...
  13. ncbi request reprint FLEXIBLE, WIRELESS, INDUCTIVELY COUPLED SURFACE COIL RESONATOR FOR EPR TOOTH DOSIMETRY
    Wilson Schreiber
    Department of Radiology, EPR Center for the Study of Viable Systems, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA
    Radiat Prot Dosimetry . 2016
    ..This resonator development provides further utility to the dosimeter, and increases the usability of the dosimeter by non-expert operators in the intended use scenario...
  14. pmc Repeated assessment of orthotopic glioma pO(2) by multi-site EPR oximetry: a technique with the potential to guide therapeutic optimization by repeated measurements of oxygen
    Nadeem Khan
    EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
    J Neurosci Methods 204:111-7. 2012
    ..Furthermore, EPR oximetry could be potentially used to enhance the outcome of chemoradiation by scheduling treatments at times of increase in glioma pO(2)...
  15. pmc Implantable resonators--a technique for repeated measurement of oxygen at multiple deep sites with in vivo EPR
    Hongbin Li
    EPR Center for Viable Systems, Department of Radiology, Dartmouth Medical School, 703, Vail, Hanover, NH 03755, USA
    Adv Exp Med Biol 662:265-72. 2010
    ..The technique also is quite useful for following changes in tumor pO(2), including applications with simultaneous measurements in tumors and adjacent normal tissues...
  16. pmc Advances in a framework to compare bio-dosimetry methods for triage in large-scale radiation events
    Ann Barry Flood
    Geisel School of Medicine at Dartmouth, EPR Center, Hanover, NH 03768, USA
    Radiat Prot Dosimetry 159:77-86. 2014
    ....
  17. pmc Repetitive tissue pO2 measurements by electron paramagnetic resonance oximetry: current status and future potential for experimental and clinical studies
    Nadeem Khan
    EPR Center for Viable Systems, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Antioxid Redox Signal 9:1169-82. 2007
    ..We are confident that in vivo EPR oximetry will play a crucial role in the understanding and clinical management of various pathologies in the years to come...
  18. pmc Development of in vivo tooth EPR for individual radiation dose estimation and screening
    Benjamin B Williams
    Dartmouth Medical School, 704 Vail HP7785, Hanover, NH 03755, USA
    Health Phys 98:327-38. 2010
    ..In summary, it seems plausible that the EPR dosimetry techniques will have an important role in retrospective dosimetry for exposures involving large numbers of individuals...
  19. ncbi request reprint Surface Dielectric Resonators for X-band EPR Spectroscopy
    Sergey Petryakov
    Department of Radiology, EPR Center for the Study of Viable Systems, Geisel School of Medicine at Dartmouth, Hanover, NH, USA
    Radiat Prot Dosimetry . 2016
    ..An advantage of this resonator for surface measurements is that the magnetic fields generated by the resonator are inherently shallow, which is desirable for in vivo nail dosimetry...
  20. doi request reprint In vivo EPR tooth dosimetry for triage after a radiation event involving large populations
    Benjamin B Williams
    Department of Radiology, EPR Center for the Study of Viable Systems, Geisel School of Medicine at Dartmouth, Hanover, NH, USA
    Radiat Environ Biophys 53:335-46. 2014
    ..Based on these and previous evaluations of the performance and use of the in vivo tooth dosimetry system, it is concluded that this system could be a very valuable resource to aid in the management of a massive radiological event...
  21. ncbi request reprint Oxygen effects on the EPR signals from wood charcoals: experimental results and the development of a model
    Oleg Y Grinberg
    EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Phys Chem B 111:13316-24. 2007
    ..An attenuated, but similar, EPR response to oxygen by chars when they are immersed in aqueous solution is attributed to water competition with oxygen for adsorption on the char surface...
  22. pmc ROC Analysis for Evaluation of Radiation Biodosimetry Technologies
    Benjamin B Williams
    Department of Medicine, Section of Radiation Oncology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA Department of Radiology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA
    Radiat Prot Dosimetry . 2016
    ..We argue that this methodology should be adopted generally to evaluate the performance of radiation biodosimetry screening assays so that they can be compared in the context of their intended use...
  23. pmc A critical assessment of biodosimetry methods for large-scale incidents
    Harold M Swartz
    The EPR Center for Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
    Health Phys 98:95-108. 2010
    ..In conclusion, biodosimetry techniques have different properties, and knowledge of their properties for meeting the different needs for different stages will result in their most effective use in a nuclear disaster mass-casualty event...
  24. doi request reprint EPR Oximetry for Investigation of Hyperbaric O2 Pre-treatment for Tumor Radiosensitization
    Benjamin B Williams
    Dartmouth EPR Center, Geisel School of Medicine at Dartmouth, Hanover, NH, 03755, USA
    Adv Exp Med Biol 923:367-74. 2016
    ..These results indicate that without direct measurements of pO2 in the tissue of interest, it is likely to be difficult to know the effects of HBO on actual tissue pO2. ..
  25. pmc Cherenkov imaging method for rapid optimization of clinical treatment geometry in total skin electron beam therapy
    Jacqueline M Andreozzi
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755
    Med Phys 43:993-1002. 2016
    ..A method was developed utilizing Cherenkov imaging for rapid and thorough determination of the two gantry angles that produce the most uniform treatment plane during dual-field total skin electron beam therapy (TSET)...
  26. doi request reprint Overview of the principles and practice of biodosimetry
    Harold M Swartz
    EPR Center for the Study of Viable Systems, Geisel School of Medicine at Dartmouth, Hanover, NH, USA
    Radiat Environ Biophys 53:221-32. 2014
    ..Emerging biodosimetric methods can fill this critically important gap...
  27. pmc Radiation dose prediction using data on time to emesis in the case of nuclear terrorism
    Eugene Demidenko
    Section of Biostatistics and Epidemiology, Hanover, New Hampshire, USA
    Radiat Res 171:310-9. 2009
    ..More reliable methods for after-the-fact assessment of radiation dose are needed to complement the use of time to emesis...