- The combination of a potent vitamin D3 analog, EB 1089, with ionizing radiation reduces tumor growth and induces apoptosis of MCF-7 breast tumor xenografts in nude miceSujatha Sundaram
Departments of Surgery, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
Clin Cancer Res 9:2350-6. 2003..The purpose of this research was to evaluate theinfluence of the combination of the vitamin D(3) analogue EB 1089 with fractionated radiation on growth and apoptosis of MCF-7 tumor xenografts in athymic mice...
- QW-1624F2-2, a synthetic analogue of 1,25-dihydroxyvitamin D3, enhances the response to other deltanoids and suppresses the invasiveness of human metastatic breast tumor cellsSujatha Sundaram
Department of Surgery, Dartmouth Medical School, One Medical Center Drive, HB 7850, Lebanon, NH 03756, USA
Mol Cancer Ther 5:2806-14. 2006..QW also blocked the sustained induction of CYP24 expression by 1,25(OH)(2)D(3) and EB 1089, increased the potency of 1,25(OH)(2)D(3) and EB 1089, and inhibited breast tumor cell proliferation and invasion...
- Vitamin D3 and vitamin D3 analogues as an adjunct to cancer chemo-therapy and radiotherapyDavid A Gewirtz
Department of Pharmacology, Virginia Commonwealth University Medical College of Virginia, Richmond, VA 23298, USA
Curr Med Chem Anticancer Agents 2:683-90. 2002..Consequently, Vitamin D(3) and Vitamin D(3) analogues, utilized at concentrations which produce limited hypercalcemia, are likely to prove effective as adjuncts to conventional chemotherapy and radiotherapy...