Frederic Leblond

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. pmc Analytic expression of fluorescence ratio detection correlates with depth in multi-spectral sub-surface imaging
    F Leblond
    Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, NH 03755, USA
    Phys Med Biol 56:6823-37. 2011
  2. pmc Early-photon fluorescence tomography: spatial resolution improvements and noise stability considerations
    Frederic Leblond
    Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover New Hampshire 03755, USA
    J Opt Soc Am A Opt Image Sci Vis 26:1444-57. 2009
  3. pmc Pre-clinical whole-body fluorescence imaging: Review of instruments, methods and applications
    Frederic Leblond
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    J Photochem Photobiol B 98:77-94. 2010
  4. pmc Toward whole-body optical imaging of rats using single-photon counting fluorescence tomography
    Frederic Leblond
    Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, New Hampshire 03755, USA
    Opt Lett 36:3723-5. 2011
  5. pmc Glioblastoma multiforme treatment with clinical trials for surgical resection (aminolevulinic acid)
    David W Roberts
    Dartmouth Medical School, Hanover, NH, USA
    Neurosurg Clin N Am 23:371-7. 2012
  6. pmc Quantitative, spectrally-resolved intraoperative fluorescence imaging
    Pablo A Valdes
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Sci Rep 2:798. 2012
  7. pmc Combined fluorescence and reflectance spectroscopy for in vivo quantification of cancer biomarkers in low- and high-grade glioma surgery
    Pablo A Valdes
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    J Biomed Opt 16:116007. 2011
  8. pmc Computed tomography-guided time-domain diffuse fluorescence tomography in small animals for localization of cancer biomarkers
    Kenneth M Tichauer
    Thayer School of Engineering, Dartmouth College
    J Vis Exp . 2012
  9. pmc 5-Aminolevulinic acid-induced protoporphyrin IX fluorescence in meningioma: qualitative and quantitative measurements in vivo
    Pablo A Valdes
    Section of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire Thayer School of Engineering, Hanover, New Hampshire Geisel School of Medicine at Dartmouth, Hanover, New Hampshire Departments of Pathology and Neurology, Georgetown University Medical Center, Washington, DC Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada Engineering Physics Department, Ecole Polytechnique de Montreal, Montreal, Quebec, Canada Norris Cotton Cancer Center, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire
    Neurosurgery 10:74-82; discussion 82-3. 2014
  10. pmc Implicit and explicit prior information in near-infrared spectral imaging: accuracy, quantification and diagnostic value
    Brian W Pogue
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Philos Trans A Math Phys Eng Sci 369:4531-57. 2011

Detail Information

Publications22

  1. pmc Analytic expression of fluorescence ratio detection correlates with depth in multi-spectral sub-surface imaging
    F Leblond
    Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, NH 03755, USA
    Phys Med Biol 56:6823-37. 2011
    ..These results suggest that depth assessment of fluorescence contrast can be achieved in fluorescence-guided surgery to allow improved intra-operative delineation of tumor margins...
  2. pmc Early-photon fluorescence tomography: spatial resolution improvements and noise stability considerations
    Frederic Leblond
    Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover New Hampshire 03755, USA
    J Opt Soc Am A Opt Image Sci Vis 26:1444-57. 2009
    ..5 to 2.5 mm) separated by less than 1.5 mm...
  3. pmc Pre-clinical whole-body fluorescence imaging: Review of instruments, methods and applications
    Frederic Leblond
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    J Photochem Photobiol B 98:77-94. 2010
    ....
  4. pmc Toward whole-body optical imaging of rats using single-photon counting fluorescence tomography
    Frederic Leblond
    Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, New Hampshire 03755, USA
    Opt Lett 36:3723-5. 2011
    ....
  5. pmc Glioblastoma multiforme treatment with clinical trials for surgical resection (aminolevulinic acid)
    David W Roberts
    Dartmouth Medical School, Hanover, NH, USA
    Neurosurg Clin N Am 23:371-7. 2012
    ..These developments extend the applicability of this technology to additional tumor histologies and provide the rationale for further instrumentation development...
  6. pmc Quantitative, spectrally-resolved intraoperative fluorescence imaging
    Pablo A Valdes
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Sci Rep 2:798. 2012
    ..The wide-field qFI technique has broad implications for intraoperative surgical guidance because it provides near real-time quantitative assessment of multiple fluorescent biomarkers across the operative field...
  7. pmc Combined fluorescence and reflectance spectroscopy for in vivo quantification of cancer biomarkers in low- and high-grade glioma surgery
    Pablo A Valdes
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    J Biomed Opt 16:116007. 2011
    ..Future work would seek to validate the predictive power of this proof-of-concept study in a separate larger cohort of patients...
  8. pmc Computed tomography-guided time-domain diffuse fluorescence tomography in small animals for localization of cancer biomarkers
    Kenneth M Tichauer
    Thayer School of Engineering, Dartmouth College
    J Vis Exp . 2012
    ..Though demonstrated for fluorescence imaging in a glioma mouse model, the methodology presented in this video can be extended to different tumor models in various small animal models potentially up to the size of a rat...
  9. pmc 5-Aminolevulinic acid-induced protoporphyrin IX fluorescence in meningioma: qualitative and quantitative measurements in vivo
    Pablo A Valdes
    Section of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire Thayer School of Engineering, Hanover, New Hampshire Geisel School of Medicine at Dartmouth, Hanover, New Hampshire Departments of Pathology and Neurology, Georgetown University Medical Center, Washington, DC Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada Engineering Physics Department, Ecole Polytechnique de Montreal, Montreal, Quebec, Canada Norris Cotton Cancer Center, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire
    Neurosurgery 10:74-82; discussion 82-3. 2014
    ..To date, the clinical utility of 5-ALA in meningiomas is not fully understood, with most descriptive studies using qualitative approaches to 5-ALA-PpIX...
  10. pmc Implicit and explicit prior information in near-infrared spectral imaging: accuracy, quantification and diagnostic value
    Brian W Pogue
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Philos Trans A Math Phys Eng Sci 369:4531-57. 2011
    ..Most beneficial inclusion of prior information has been in the inversion/reconstruction process, because it solves the mathematical intractability. However, it is not clear that this is always the most beneficial stage...
  11. pmc Dual-tracer background subtraction approach for fluorescent molecular tomography
    Kenneth M Tichauer
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    J Biomed Opt 18:16003. 2013
    ..The approach is demonstrated in simulations, a phantom study, and in a mouse glioma imaging study, demonstrating substantial improvement over conventional and homogenous background subtraction image reconstruction approaches...
  12. pmc Multiple-gate time domain diffuse fluorescence tomography allows more sparse tissue sampling without compromising image quality
    Robert W Holt
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Opt Lett 37:2559-61. 2012
    ....
  13. pmc Macroscopic optical imaging technique for wide-field estimation of fluorescence depth in optically turbid media for application in brain tumor surgical guidance
    Kolbein K Kolste
    Dartmouth College, Thayer School of Engineering, Hanover, 14 Engineering Drive, New Hampshire 03755, United States
    J Biomed Opt 20:26002. 2015
    ..Wide-field depth estimates are made using optical technology integrated onto a commercial surgical microscope, making this approach feasible for real-world applications...
  14. pmc A microcomputed tomography guided fluorescence tomography system for small animal molecular imaging
    Dax Kepshire
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Rev Sci Instrum 80:043701. 2009
    ..This multimodality imaging system will have a wide range of applications in preclinical cancer research ranging from studies of the tumor microenvironment and treatment efficacy for emerging cancer therapeutics...
  15. pmc Automatic exposure control and estimation of effective system noise in diffuse fluorescence tomography
    Dax L Kepshire
    Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, NH 03755, USA
    Opt Express 17:23272-83. 2009
    ..This fluorophore has very low fluorescence yield, but high biological relevance for tumor imaging, given that it is produced in the mitochondria, and upregulated in many tumor types...
  16. pmc Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker
    Pablo A Valdes
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA
    J Neurosurg 115:11-7. 2011
    ..The authors show that diagnostically significant but visually imperceptible concentrations of PpIX can be quantitatively measured in vivo and used to discriminate normal from neoplastic brain tissue across a range of tumor histologies...
  17. ncbi request reprint Computationally efficient methods for incorporation of spectral priors in 3-d optical tomography
    Subhadra Srinivasan
    Dartmouth College, Thayer School of Engineering, Hanover, NH 03755, USA
    Conf Proc IEEE Eng Med Biol Soc . 2006
    ....
  18. doi request reprint Depth resolution and multiexponential lifetime analyses of reflectance-based time-domain fluorescence data
    Kenneth M Tichauer
    Lawson Health Research Institute, 268 Grosvenor Street, London, Ontario N6A 4V2, Canada
    Appl Opt 50:3962-72. 2011
    ....
  19. pmc Coregistered fluorescence-enhanced tumor resection of malignant glioma: relationships between δ-aminolevulinic acid-induced protoporphyrin IX fluorescence, magnetic resonance imaging enhancement, and neuropathological parameters. Clinical article
    David W Roberts
    Section of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA
    J Neurosurg 114:595-603. 2011
    ....
  20. pmc Radiologic and near-infrared/optical spectroscopic imaging: where is the synergy?
    Brian W Pogue
    Dartmouth College, Hanover, New Hampshire 03755, USA
    AJR Am J Roentgenol 195:321-32. 2010
    ..The purpose of this article is to outline the fundamental limitations and advantages and to review the available systems. The emerging developments and future potential will be summarized...
  21. pmc Raman spectroscopy detects distant invasive brain cancer cells centimeters beyond MRI capability in humans
    Michael Jermyn
    Thayer School of Engineering, Dartmouth College, 14 Engineering Dr, Hanover, NH 03755, USA Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, 3801 University St, Montreal, QC, H3A 2B4, Canada Dept of Engineering Physics, Polytechnique Montréal, CP 6079, Succ Centre Ville, Montreal, QC, H3C 3A7, Canada
    Biomed Opt Express 7:5129-5137. 2016
    ..The detection of distant invasive cancer cells beyond MRI signal has the potential to increase the effectiveness of surgery and directly lengthen patient survival...