Huagang Hou

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. ncbi request reprint Comparison of EPR oximetry and Eppendorf polarographic electrode assessments of rat brain PtO2
    JULIA A O'HARA
    EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
    Physiol Meas 25:1413-23. 2004
  2. ncbi request reprint The effect of oxygen therapy on brain damage and cerebral pO(2) in transient focal cerebral ischemia in the rat
    Huagang Hou
    Department of Radiology, Dartmouth Medical School, Hanover, NH, USA
    Physiol Meas 28:963-76. 2007
  3. pmc Modulation of tumor hypoxia by topical formulations with vasodilators for enhancing therapy
    Zrinka Abramovic
    Laboratory of Biophysics, Jozef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia
    Adv Exp Med Biol 701:75-82. 2011
  4. pmc Sensitization of human cancer cells to gemcitabine by the Chk1 inhibitor MK-8776: cell cycle perturbation and impact of administration schedule in vitro and in vivo
    Ryan Montano
    Department of Pharmacology and Toxicology, Geisel School of Medicine at Dartmouth, Lebanon, NH USA
    BMC Cancer 13:604. 2013
  5. pmc Real-time monitoring of ischemic and contralateral brain pO2 during stroke by variable length multisite resonators
    Huagang Hou
    EPR Center for Viable Systems, Department of Diagnostic Radiology, The Geisel School of Medicine, 48 Lafayette Street, Lebanon, NH 03766 Norris Cotton Cancer Center, One Medical Center Drive, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA Electronic address
    Magn Reson Imaging 32:563-9. 2014
  6. pmc Skeletal muscle and glioma oxygenation by carbogen inhalation in rats: a longitudinal study by EPR oximetry using single-probe implantable oxygen sensors
    Huagang Hou
    Department of Radiology, Geisel School of Medicine, Hanover, NH, 03755, USA
    Adv Exp Med Biol 812:97-103. 2014
  7. pmc Dynamic changes in oxygenation of intracranial tumor and contralateral brain during tumor growth and carbogen breathing: a multisite EPR oximetry with implantable resonators
    Huagang Hou
    EPR Center for the Study of Viable Systems, Department of Radiology, Dartmouth Medical School, Hanover, NH 03755, United States
    J Magn Reson 214:22-8. 2012
  8. pmc Cerebral oxygenation of the cortex and striatum following normobaric hyperoxia and mild hypoxia in rats by EPR oximetry using multi-probe implantable resonators
    Huagang Hou
    EPR Center for Viable Systems, Department of Diagnostic Radiology, Dartmouth Medical School, Hanover, NH 03755, USA
    Adv Exp Med Biol 701:61-7. 2011
  9. pmc Effect of hyperoxygenation on tissue pO2 and its effect on radiotherapeutic efficacy of orthotopic F98 gliomas
    Nadeem Khan
    EPR Center for Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
    Int J Radiat Oncol Biol Phys 78:1193-200. 2010
  10. ncbi request reprint Increased oxygenation of intracranial tumors by efaproxyn (efaproxiral), an allosteric hemoglobin modifier: In vivo EPR oximetry study
    Huagang Hou
    Department of Diagnostic Radiology, EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, NH, USA
    Int J Radiat Oncol Biol Phys 61:1503-9. 2005

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Comparison of EPR oximetry and Eppendorf polarographic electrode assessments of rat brain PtO2
    JULIA A O'HARA
    EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
    Physiol Meas 25:1413-23. 2004
    ....
  2. ncbi request reprint The effect of oxygen therapy on brain damage and cerebral pO(2) in transient focal cerebral ischemia in the rat
    Huagang Hou
    Department of Radiology, Dartmouth Medical School, Hanover, NH, USA
    Physiol Meas 28:963-76. 2007
    ..The ability to measure the pO(2) in several sites provides important information that should help to optimize the design of hyperoxic therapies for stroke...
  3. pmc Modulation of tumor hypoxia by topical formulations with vasodilators for enhancing therapy
    Zrinka Abramovic
    Laboratory of Biophysics, Jozef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia
    Adv Exp Med Biol 701:75-82. 2011
    ..This approach can be potentially used to enhance radiotherapeutic outcome by scheduling radiation doses when an increase in tumor pO(2) is observed after topical applications of BN formulations...
  4. pmc Sensitization of human cancer cells to gemcitabine by the Chk1 inhibitor MK-8776: cell cycle perturbation and impact of administration schedule in vitro and in vivo
    Ryan Montano
    Department of Pharmacology and Toxicology, Geisel School of Medicine at Dartmouth, Lebanon, NH USA
    BMC Cancer 13:604. 2013
    ..Here, we address the importance of appropriate drug scheduling when gemcitabine is combined with the Chk1 inhibitor MK-8776, and the mechanisms involved in the schedule dependence...
  5. pmc Real-time monitoring of ischemic and contralateral brain pO2 during stroke by variable length multisite resonators
    Huagang Hou
    EPR Center for Viable Systems, Department of Diagnostic Radiology, The Geisel School of Medicine, 48 Lafayette Street, Lebanon, NH 03766 Norris Cotton Cancer Center, One Medical Center Drive, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA Electronic address
    Magn Reson Imaging 32:563-9. 2014
    ..Electron paramagnetic resonance (EPR) oximetry using variable length multi-probe implantable resonator (IR), was used to investigate the temporal changes in the ischemic and contralateral brain pO2 during stroke in rats...
  6. pmc Skeletal muscle and glioma oxygenation by carbogen inhalation in rats: a longitudinal study by EPR oximetry using single-probe implantable oxygen sensors
    Huagang Hou
    Department of Radiology, Geisel School of Medicine, Hanover, NH, 03755, USA
    Adv Exp Med Biol 812:97-103. 2014
    ..The heterogeneity of 9L tumors in response to carbogen highlights the need to repeatedly monitor pO₂ to confirm tumor oxygenation so that such changes can be taken into account in planning therapies and interpreting results...
  7. pmc Dynamic changes in oxygenation of intracranial tumor and contralateral brain during tumor growth and carbogen breathing: a multisite EPR oximetry with implantable resonators
    Huagang Hou
    EPR Center for the Study of Viable Systems, Department of Radiology, Dartmouth Medical School, Hanover, NH 03755, United States
    J Magn Reson 214:22-8. 2012
    ..We report a recently developed electron paramagnetic resonance (EPR) oximetry approach with multiple probe implantable resonators (IRs) that allow repeated measurements of oxygen in tissue at depths of greater than 10mm...
  8. pmc Cerebral oxygenation of the cortex and striatum following normobaric hyperoxia and mild hypoxia in rats by EPR oximetry using multi-probe implantable resonators
    Huagang Hou
    EPR Center for Viable Systems, Department of Diagnostic Radiology, Dartmouth Medical School, Hanover, NH 03755, USA
    Adv Exp Med Biol 701:61-7. 2011
    ..In addition, the ability to simultaneously measure the pO(2) in several areas of the brain provides important information that could potentially help differentiate the pO(2) changes that can occur due to global or local mechanisms...
  9. pmc Effect of hyperoxygenation on tissue pO2 and its effect on radiotherapeutic efficacy of orthotopic F98 gliomas
    Nadeem Khan
    EPR Center for Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
    Int J Radiat Oncol Biol Phys 78:1193-200. 2010
    ..We report repeated measurements of orthotopic F98 tumor pO(2) and relate this to the effect of carbogen inhalation on tumor growth when combined with hypofractionated radiotherapy...
  10. ncbi request reprint Increased oxygenation of intracranial tumors by efaproxyn (efaproxiral), an allosteric hemoglobin modifier: In vivo EPR oximetry study
    Huagang Hou
    Department of Diagnostic Radiology, EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, NH, USA
    Int J Radiat Oncol Biol Phys 61:1503-9. 2005
    ..Efaproxiral reduces hemoglobin-oxygen binding affinity, which facilitates oxygen release from hemoglobin into surrounding tissues and potentially increases the pO(2) of the tumors...
  11. pmc Tissue pO2 of orthotopic 9L and C6 gliomas and tumor-specific response to radiotherapy and hyperoxygenation
    Nadeem Khan
    EPR Center for Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
    Int J Radiat Oncol Biol Phys 73:878-85. 2009
    ..3 Gy of radiation and carbogen inhalation on orthotopic 9L and C6 gliomas and on the contralateral brain pO(2) in rats using a new and potentially widely useful method, multisite in vivo electron paramagnetic resonance oximetry...
  12. ncbi request reprint The effects of Efaproxyn (efaproxiral) on subcutaneous RIF-1 tumor oxygenation and enhancement of radiotherapy-mediated inhibition of tumor growth in mice
    Huagang Hou
    Department of Diagnostic Radiology, Dartmouth Medical School, Hanover, NH 03755, USA
    Radiat Res 168:218-25. 2007
    ..This is the first study to demonstrate the ability of efaproxiral to increase tumor oxygenation and to increase the tumor growth inhibition of radiotherapy over 5 days of treatment...
  13. ncbi request reprint The effect of RSR13, a synthetic allosteric modifier of hemoglobin, on brain tissue pO2 (measured by EPR oximetry) following severe hemorrhagic shock in rats
    Minoru Miyake
    EPR Center for the Study of Viable Systems, Department of Radiology, 7785 Vail Dartmouth Medical School, Hanover, NH, USA
    Adv Exp Med Biol 530:319-29. 2003
    ..There was no difference in the blood pressure or heart rate between groups. RSR13 may have useful applications to decrease the effects of acute hemorrhagic hypoxemia by increasing brain oxygenation...
  14. ncbi request reprint Effect of RSR13, an allosteric hemoglobin modifier, on oxygenation in murine tumors: an in vivo electron paramagnetic resonance oximetry and bold MRI study
    Huagang Hou
    Department of Diagnostic Radiology, EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
    Int J Radiat Oncol Biol Phys 59:834-43. 2004
    ....
  15. pmc Synergistic combination of hyperoxygenation and radiotherapy by repeated assessments of tumor pO2 with EPR oximetry
    Huagang Hou
    EPR Center for Viable Systems, Dartmouth Medical School, Hanover, NH, USA
    J Radiat Res 52:568-74. 2011
    ..Repeated tumor pO(2) measurements by EPR oximetry can provide temporal information that could be used to improve therapeutic outcomes by scheduling doses at times of improved tumor oxygenation...
  16. pmc Tumor pO₂ as a surrogate marker to identify therapeutic window during metronomic chemotherapy of 9L gliomas
    Sriram Mupparaju
    EPR Center for Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
    Adv Exp Med Biol 701:107-13. 2011
    ..In vivo EPR oximetry is currently being tested for repeated pO(2) measurements in patients with superficial tumors...
  17. pmc Radiotherapy in conjunction with 7-hydroxystaurosporine: a multimodal approach with tumor pO2 as a potential marker of therapeutic response
    Nadeem Khan
    EPR Center for Viable Systems, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Radiat Res 172:592-7. 2009
    ..This multimodal approach could be used to enhance the outcome of radiotherapy. Furthermore, tumor pO2 could be a potential marker of therapeutic response...
  18. pmc Repeated assessment of orthotopic glioma pO(2) by multi-site EPR oximetry: a technique with the potential to guide therapeutic optimization by repeated measurements of oxygen
    Nadeem Khan
    EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
    J Neurosci Methods 204:111-7. 2012
    ..Furthermore, EPR oximetry could be potentially used to enhance the outcome of chemoradiation by scheduling treatments at times of increase in glioma pO(2)...
  19. pmc Repeated tumor oximetry to identify therapeutic window during metronomic cyclophosphamide treatment of 9L gliomas
    Sriram Mupparaju
    EPR Center for Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
    Oncol Rep 26:281-6. 2011
    ..This vital information could also be used to schedule radiotherapy to enhance therapeutic outcome...
  20. pmc Recurrent low-dose chemotherapy to inhibit and oxygenate head and neck tumors
    Nadeem Khan
    EPR Center for Viable Systems, Department of Radiology, The Geisel School of Medicine, Hanover, NH, 03755, USA
    Adv Exp Med Biol 812:105-11. 2014
    ..EPR oximetry can be used to follow the temporal changes in tumor pO₂ to identify a therapeutic window on treatment with metronomic chemotherapy for potential combination with radiotherapy...
  21. pmc Assessment of the changes in 9L and C6 glioma pO2 by EPR oximetry as a prognostic indicator of differential response to radiotherapy
    Huagang Hou
    EPR Center for Viable Systems, Department of Radiology, Geisel School of Medicine, Hanover, New Hampshire, USA
    Radiat Res 179:343-51. 2013
    ..We propose that the repeated measurement of the oxygen levels in the tumors during radiotherapy can be used to identify responders and to design tumor oxygen guided treatment plans to improve the outcome...
  22. pmc Repeated tumor pO(2) measurements by multi-site EPR oximetry as a prognostic marker for enhanced therapeutic efficacy of fractionated radiotherapy
    Huagang Hou
    Department of Diagnostic Radiology, Dartmouth Medical School, Hanover, NH, USA
    Radiother Oncol 91:126-31. 2009
    ..To investigate the temporal effects of single or fractionated radiotherapy on subcutaneous RIF-1 tumor pO(2) and to determine the therapeutic outcomes when the timing of fractionations is guided by tumor pO(2)...
  23. pmc Advances in probes and methods for clinical EPR oximetry
    Harold M Swartz
    EPR Center for the Study of Viable Systems, The Geisel School of Medicine at Dartmouth, Lebanon, NH, 03766, USA
    Adv Exp Med Biol 812:73-9. 2014
    ..This paper presents an overview of recent developments in our ability to make meaningful measurements of oxygen partial pressures in human subjects under clinical settings. ..
  24. pmc Effect of a topical vasodilator on tumor hypoxia and tumor oxygen guided radiotherapy using EPR oximetry
    Huagang Hou
    EPR Center for Viable Systems, Department of Diagnostic Radiology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Radiat Res 173:651-8. 2010
    ..5% BN formulation led to a significant growth inhibition. EPR oximetry provided dynamic information on the changes in tumor pO(2), which could be used to identify responders and non-responders and schedule therapy during the experiments...
  25. ncbi request reprint The effects of anesthesia on cerebral tissue oxygen tension: use of EPR oximetry to make repeated measurements
    Harold M Swartz
    Department of Diagnostic Radiology, Dartmouth Medical School, 7785 Vail Building Hanover, NH 03755 USA
    Adv Exp Med Biol 530:569-75. 2003
    ..The results indicate that the tissue O2 can be measured directly using EPR oximetry, and data can be obtained non-invasively during the course of anesthesia...
  26. ncbi request reprint Cerebral tissue oxygenation in reversible focal ischemia in rats: multi-site EPR oximetry measurements
    Huagang Hou
    EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, NH, USA
    Physiol Meas 26:131-41. 2005
    ..In addition, the ability simultaneously to measure the pO2 in several sites provides important additional information that should help to differentiate between changes in the PO2 due toglobal or local mechanisms...
  27. ncbi request reprint Simultaneous measurement of rat brain cortex PtO2 using EPR oximetry and a fluorescence fiber-optic sensor during normoxia and hyperoxia
    JULIA A O'HARA
    EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, NH 03755, USA
    Physiol Meas 26:203-13. 2005
    ..26 to 0.95 (carbogen) were similar by the two methods and (4) in some rats breathing carbogen, absolute values of PtO(2) were above the sensitive range of the OxyLite method...
  28. ncbi request reprint High spatial resolution multisite EPR oximetry of transient focal cerebral ischemia in the rat
    Benjamin B Williams
    Dartmouth EPR Center, Department of Radiology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Antioxid Redox Signal 9:1691-8. 2007
    ..These measurements demonstrate the capabilities of the HSRMS oximetry technique and set the stage for more extensive physiologic studies...
  29. pmc Implantable resonators--a technique for repeated measurement of oxygen at multiple deep sites with in vivo EPR
    Hongbin Li
    EPR Center for Viable Systems, Department of Radiology, Dartmouth Medical School, 703, Vail, Hanover, NH 03755, USA
    Adv Exp Med Biol 662:265-72. 2010
    ..The technique also is quite useful for following changes in tumor pO(2), including applications with simultaneous measurements in tumors and adjacent normal tissues...
  30. doi request reprint Modulation of hypoxia by magnetic nanoparticle hyperthermia to augment therapeutic index
    Eunice Y Chen
    Department of Surgery, Geisel School of Medicine, Hanover, NH, USA
    Adv Exp Med Biol 812:87-95. 2014
    ..Future studies will establish tumor pO₂-guided multimodal therapies, such as mNPH and radiation, to improve therapeutic efficacy...
  31. pmc Repetitive tissue pO2 measurements by electron paramagnetic resonance oximetry: current status and future potential for experimental and clinical studies
    Nadeem Khan
    EPR Center for Viable Systems, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Antioxid Redox Signal 9:1169-82. 2007
    ..We are confident that in vivo EPR oximetry will play a crucial role in the understanding and clinical management of various pathologies in the years to come...
  32. ncbi request reprint The dose-dependent effect of RSR13, a synthetic allosteric modifier of hemoglobin, on physiological parameters and brain tissue oxygenation in rats
    Oleg Y Grinberg
    EPR Center for the Study of Viable Systems, Dept of Radiology, Dartmouth Medical School, 7785 Vail, Hanover, NH 03755, USA
    Adv Exp Med Biol 530:287-96. 2003
    ..This capability is likely to be very useful in circumstances where the pO2 of the brain is compromised...
  33. ncbi request reprint Clinical applications of EPR: overview and perspectives
    Harold M Swartz
    Dartmouth Medical School, Hanover, NH 03755, USA
    NMR Biomed 17:335-51. 2004
    ....
  34. ncbi request reprint pO2 and regional blood flow in a rabbit model of limb ischemia
    Oleg Y Grinberg
    EPR Center for the Study of Viable Systems, Dartmouth Medical School, Hanover, NH, USA
    Physiol Meas 25:659-70. 2004
    ..Within two weeks of occlusion the pO2 is recovered to 45% of baseline. This study demonstrates, for the first time, the applicability of EPR oximetry in animals larger than rodents...
  35. pmc Clinical EPR: unique opportunities and some challenges
    Harold M Swartz
    Department of Radiology, Geisel School of Medicine at Dartmouth, Dartmouth College, 48 Lafayette Street, Lebanon, NH 03766 Electronic address
    Acad Radiol 21:197-206. 2014
    ..Further work is in progress to translate this unique technology to routine clinical practice...
  36. ncbi request reprint Changes in oxygenation of intracranial tumors with carbogen: a BOLD MRI and EPR oximetry study
    Jeff F Dunn
    NMR and EPR Research Centers, Department of Diagnostic Radiology, Dartmouth Hitchcock Medical Center, Hanover, New Hampshire, USA
    J Magn Reson Imaging 16:511-21. 2002
    ..To examine, using blood oxygen level dependent (BOLD) MRI and EPR oximetry, the changes in oxygenation of intracranial tumors induced by carbogen breathing...
  37. ncbi request reprint Electron paramagnetic resonance assessment of brain tissue oxygen tension in anesthetized rats
    Huagang Hou
    Department of Diagnostic Radiology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Anesth Analg 96:1467-72, table of contents. 2003
    ....
  38. doi request reprint Direct and Repeated Measurement of Heart and Brain Oxygenation Using In Vivo EPR Oximetry
    Nadeem Khan
    Department of Radiology, EPR Center for the Study of Viable Systems, Geisel School of Medicine at Dartmouth, Norris Cotton Cancer Center, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA
    Methods Enzymol 564:529-52. 2015
    ..Initial feasibility of pO2 measurement in solid tumors of patients has been successfully demonstrated. ..
  39. pmc Monitoring oxygen levels in orthotopic human glioma xenograft following carbogen inhalation and chemotherapy by implantable resonator-based oximetry
    Huagang Hou
    EPR Center for the Study of Viable Systems, Department of Radiology, Geisel School of Medicine at Dartmouth, Hanover, NH Norris Cotton Cancer Center, Dartmouth Hitchcock Medical Center, Lebanon, NH
    Int J Cancer 136:1688-96. 2015
    ..The increase in glioma pO2 of mice breathing carbogen can be used to improve treatment outcome. The treatment with gemcitabine + MK-8776 is a promising strategy that warrants further investigation. ..