David J Graber

Summary

Affiliation: Dartmouth Medical School
Country: USA

Publications

  1. pmc Early inflammatory mediator gene expression in two models of traumatic brain injury: ex vivo cortical slice in mice and in vivo cortical impact in piglets
    David J Graber
    Department of Pathology, Geisel School of Medicine at Dartmouth, One Medical Center Drive, Lebanon, NH, 03756, USA
    J Neuroinflammation 12:76. 2015
  2. doi request reprint Anti-inflammatory efficacy of dexamethasone and Nrf2 activators in the CNS using brain slices as a model of acute injury
    David J Graber
    Department of Pathology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Neuroimmune Pharmacol 7:266-78. 2012
  3. doi request reprint Neurodegeneration by activated microglia across a nanofiltration membrane
    David J Graber
    School of Public Health, State University at Albany, Albany, NY 12222, USA
    J Biochem Mol Toxicol 26:45-53. 2012
  4. pmc Strain-dependent variation in the early transcriptional response to CNS injury using a cortical explant system
    David J Graber
    Dept, Pathology, Dartmouth Medical School, Lebanon, New Hampshire, USA
    J Neuroinflammation 8:122. 2011
  5. pmc Efficacy of thalidomide for the treatment of amyotrophic lateral sclerosis: a phase II open label clinical trial
    Elijah W Stommel
    Department of Medicine Section of Neurology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Amyotroph Lateral Scler 10:393-404. 2009
  6. doi request reprint Synthetic triterpenoid CDDO derivatives modulate cytoprotective or immunological properties in astrocytes, neurons, and microglia
    David J Graber
    Department of Pathology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Neuroimmune Pharmacol 6:107-20. 2011
  7. pmc A novel mouse model of Niemann-Pick type C disease carrying a D1005G-Npc1 mutation comparable to commonly observed human mutations
    Robert A Maue
    Department of Physiology and Neurobiology, Dartmouth Medical School, Hanover, NH 03755, USA
    Hum Mol Genet 21:730-50. 2012
  8. pmc Progressive changes in microglia and macrophages in spinal cord and peripheral nerve in the transgenic rat model of amyotrophic lateral sclerosis
    David J Graber
    Department of Pathology, Dartmouth Medical School, One Medical Center Drive, Lebanon, New Hampshire 03756, USA
    J Neuroinflammation 7:8. 2010
  9. doi request reprint Purification and culture of spinal motor neurons from rat embryos
    David J Graber
    Dartmouth Medical School, Department of Pathology, Lebanon, NH 03756, USA
    Cold Spring Harb Protoc 2013:319-26. 2013
  10. doi request reprint Afferent influences on striatal development in organotypic cocultures
    Abigail Snyder-Keller
    David Axelrod Institute, New York State Department of Health, Albany, New York 12208, USA
    Synapse 62:487-500. 2008

Collaborators

Detail Information

Publications12

  1. pmc Early inflammatory mediator gene expression in two models of traumatic brain injury: ex vivo cortical slice in mice and in vivo cortical impact in piglets
    David J Graber
    Department of Pathology, Geisel School of Medicine at Dartmouth, One Medical Center Drive, Lebanon, NH, 03756, USA
    J Neuroinflammation 12:76. 2015
    ..The immunological response during the first 24 hours after traumatic brain injury (TBI) may be a critical therapeutic interval for limiting the secondary neuronal damage that is influenced by enhanced inflammatory mediator expression...
  2. doi request reprint Anti-inflammatory efficacy of dexamethasone and Nrf2 activators in the CNS using brain slices as a model of acute injury
    David J Graber
    Department of Pathology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Neuroimmune Pharmacol 7:266-78. 2012
    ..Short-term CNS explants may provide a more accurate model of in vivo conditions than microglia cultures since the complex tissue microenvironment is maintained...
  3. doi request reprint Neurodegeneration by activated microglia across a nanofiltration membrane
    David J Graber
    School of Public Health, State University at Albany, Albany, NY 12222, USA
    J Biochem Mol Toxicol 26:45-53. 2012
    ..These data describe a novel coculture system for studying diffusible factors and further support nitric oxide production as an important mediator in microglia-induced neuron death...
  4. pmc Strain-dependent variation in the early transcriptional response to CNS injury using a cortical explant system
    David J Graber
    Dept, Pathology, Dartmouth Medical School, Lebanon, New Hampshire, USA
    J Neuroinflammation 8:122. 2011
    ..A cortical explant system was employed as a model for injury to determine whether the immediate transcriptional response to tissue resection revealed differences among three mouse strains...
  5. pmc Efficacy of thalidomide for the treatment of amyotrophic lateral sclerosis: a phase II open label clinical trial
    Elijah W Stommel
    Department of Medicine Section of Neurology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Amyotroph Lateral Scler 10:393-404. 2009
    ..In conclusion, treatment of ALS with the TNF-alpha inhibitor, thalidomide, does not appear to effectively modulate disease progression and can cause adverse effects...
  6. doi request reprint Synthetic triterpenoid CDDO derivatives modulate cytoprotective or immunological properties in astrocytes, neurons, and microglia
    David J Graber
    Department of Pathology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Neuroimmune Pharmacol 6:107-20. 2011
    ....
  7. pmc A novel mouse model of Niemann-Pick type C disease carrying a D1005G-Npc1 mutation comparable to commonly observed human mutations
    Robert A Maue
    Department of Physiology and Neurobiology, Dartmouth Medical School, Hanover, NH 03755, USA
    Hum Mol Genet 21:730-50. 2012
    ....
  8. pmc Progressive changes in microglia and macrophages in spinal cord and peripheral nerve in the transgenic rat model of amyotrophic lateral sclerosis
    David J Graber
    Department of Pathology, Dartmouth Medical School, One Medical Center Drive, Lebanon, New Hampshire 03756, USA
    J Neuroinflammation 7:8. 2010
    ..The purpose of this study was to gain further knowledge by characterizing the immunological changes during disease progression in the spinal cord and peripheral nerve using the more recently developed hmSOD1 rat transgenic model of ALS...
  9. doi request reprint Purification and culture of spinal motor neurons from rat embryos
    David J Graber
    Dartmouth Medical School, Department of Pathology, Lebanon, NH 03756, USA
    Cold Spring Harb Protoc 2013:319-26. 2013
    ..The near-pure lower motor neuron cultures are plated and seeded in defined conditions optimal for survival and can be maintained for several weeks. The expected yield is approximately 70,000 cells per embryonic spinal cord...
  10. doi request reprint Afferent influences on striatal development in organotypic cocultures
    Abigail Snyder-Keller
    David Axelrod Institute, New York State Department of Health, Albany, New York 12208, USA
    Synapse 62:487-500. 2008
    ..These findings demonstrate the importance of afferent innervation in the maturation of striatal neurons in organotypic cultures...
  11. pmc Neuromyelitis optica pathogenesis and aquaporin 4
    David J Graber
    Department of Pathology, Dartmouth Medical School, Lebanon, New Hampshire, USA
    J Neuroinflammation 5:22. 2008
    ..Thus an AQP4 animal model would provide a means to manipulate events which are now associated with NMO and thus demonstrate what set of events or multiplicity of events can push the anti-AQP4 response to be pathogenic...
  12. doi request reprint Purification and culture of spinal motor neurons
    David J Graber
    Dartmouth Medical School, Department of Pathology, Lebanon, NH 03756, USA
    Cold Spring Harb Protoc 2013:310-1. 2013
    ..Disease and trauma that affect lower motor neurons can cause paralysis and, in some cases, death. Studies using primary cultures of these cells have ongoing potential to facilitate a deeper understanding of their biology and function...