Susana N Asin
Affiliation: Dartmouth Medical School
- Estradiol and progesterone regulate HIV type 1 replication in peripheral blood cellsSusana N Asin
V A Medical Center, White River Junction, Vermont 05009, USA
AIDS Res Hum Retroviruses 24:701-16. 2008..An additional indirect mechanism of sex hormone regulation of cytokine and chemokine secretion cannot be excluded...
- Human immunodeficiency virus type 1 infection of human uterine epithelial cells: viral shedding and cell contact-mediated infectivitySusana N Asin
Department of Microbiology, Dartmouth Medical School, Lebanon, New Hampshire, USA
J Infect Dis 187:1522-33. 2003..These data demonstrated that HIV-1 infects human epithelial cells of upper reproductive tract origin and that productive viral infection of epithelial cells may be an important mechanism of transmission of HIV-1 infection in women...
- Transmission of HIV-1 by primary human uterine epithelial cells and stromal fibroblastsSusana N Asin
Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, New Hampshire, USA
J Infect Dis 190:236-45. 2004..These data suggest that uterine cells are targets for productive infection with X4-tropic strains and release unmodified R5-tropic viruses that would then be able to infect submucosal target cells, including T cells and macrophages...
- HIV type 1 infection in women: increased transcription of HIV type 1 in ectocervical tissue explantsSusana N Asin
Veterans Affairs Medical Center, 215 N Main Street, White River Junction, VT 05009, USA
J Infect Dis 200:965-72. 2009..Mucosal surfaces of the female reproductive tract are the main routes of heterosexual transmission of human immunodeficiency virus type 1 (HIV-1), but the contribution of each of the reproductive sites to mucosal transmission is unknown...
- IL-8 decreases HIV-1 transcription in peripheral blood lymphocytes and ectocervical tissue explantsChristiane Rollenhagen
V A Medical Center, White River Junction, VT 05009, USA
J Acquir Immune Defic Syndr 54:463-9. 2010..This is the first report to suggest that IL-8 decreases replication of primary R5-tropic HIV-1 by transcriptional mechanisms...
- HIV-1 infection of the female reproductive tractAlexandra L Howell
VA Medical Center, 215 North Main Street, White River Junction, VT 05009, USA
Curr HIV/AIDS Rep 2:35-8. 2005..This indicates that several mechanisms for viral infection and transmission are present throughout the FRT...
- Blocking CXCL9 Decreases HIV-1 Replication and Enhances the Activity of Prophylactic Antiretrovirals in Human Cervical TissuesSherrill L Macura
Research Service, V A Medical Center, White River Junction, VT Center for Devices and Radiological Health, Food and Drug Administration, Office of Device Evaluation, Silver Spring, MD Division of Select Agents and Toxins, Centers for Disease Control and Prevention, Atlanta, GA Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth, Lebanon, NH CONRAD, Eastern Virginia Medical School, Norfolk, VA Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH and Department of Medicine, Geisel School of Medicine at Dartmouth, Lebanon, NH
J Acquir Immune Defic Syndr 71:474-82. 2016..We report a link between CXCL9 and HIV-1 replication in human cervical tissues and propose CXCL9 as a potential target to enhance the anti-HIV-1 activity of prophylactic antiretrovirals...
- Synergy between IL-8 and GM-CSF in reproductive tract epithelial cell secretions promotes enhanced neutrophil chemotaxisLi Shen
Department of Immunology and Microbiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH 03756, USA
Cell Immunol 230:23-32. 2004..These findings demonstrate that the majority of neutrophil chemoattractant activity produced by FRT EC results from the synergistic effects of IL-8 and GM-CSF...
- Enhancing Interferon Regulatory Factor 7 Mediated Antiviral Responses and Decreasing Nuclear Factor Kappa B Expression Limit HIV-1 Replication in Cervical TissuesChristiane Rollenhagen
Research Service, V A Medical Center, White River Junction, VT, United States of America Department of Medicine, Geisel School of Medicine at Dartmouth, Lebanon, NH, United States of America
PLoS ONE 10:e0131919. 2015....
- Human immunodeficiency virus receptor and coreceptor expression on human uterine epithelial cells: regulation of expression during the menstrual cycle and implications for human immunodeficiency virus infectionGrant R Yeaman
Department of Obstetrics and Gynecology, Vanderbilt University, Nashville, TN, USA
Immunology 109:137-46. 2003..In addition, these studies provide evidence that the uterus, and potentially the entire upper reproductive tract, are important sites for the initial events involved in HIV infection...