Affiliation: Dartmouth-Hitchcock Medical Center
- The late preterm infant and the control of breathing, sleep, and brainstem development: a reviewRobert A Darnall
Department of Physiology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
Clin Perinatol 33:883-914; abstract x. 2006..Research focused on this group of infants will not only further our understanding of brainstem maturation during this high risk period, but will help develop focused plans for their management...
- Eliminating medullary 5-HT neurons delays arousal and decreases the respiratory response to repeated episodes of hypoxia in neonatal rat pupsRobert A Darnall
Department of Physiology and Neurobiology and Department of Pediatrics, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire
J Appl Physiol (1985) 120:514-25. 2016..Thus alterations medullary 5-HT mechanisms might contribute to an arousal deficit and contribute to death in SIDS infants. ..
- Arousal from sleep in response to intermittent hypoxia in rat pups is modulated by medullary raphe GABAergic mechanismsRobert A Darnall
Department of Pediatrics, Dartmouth Medical School, Lebanon, NH 03756, USA
Am J Physiol Regul Integr Comp Physiol 302:R551-60. 2012..Arousal habituation may contribute to sudden infant death syndrome, which is associated with MR serotonergic and GABAergic receptor dysfunction...
- Inhibition of serotonergic neurons in the nucleus paragigantocellularis lateralis fragments sleep and decreases rapid eye movement sleep in the piglet: implications for sudden infant death syndromeRobert A Darnall
Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
J Neurosci 25:8322-32. 2005..Abnormalities in the function of these neurons may alter sleep homeostasis and contribute to the etiology of SIDS...
- The role of CO(2) and central chemoreception in the control of breathing in the fetus and the neonateRobert A Darnall
Departments of Physiology and Neurobiology and Pediatrics, Dartmouth Medical School, Borwell Building, Lebanon, NH 03756, USA
Respir Physiol Neurobiol 173:201-12. 2010....
- Reversible blunting of arousal from sleep in response to intermittent hypoxia in the developing ratR A Darnall
Department of Pediatrics, Dartmouth School of Medicine, Lebanon, New Hampshire, USA
J Appl Physiol (1985) 109:1686-96. 2010..We conclude that exposure to repeated episodes of hypoxia can cause progressive blunting of arousal, which is reversible by altering the exposure times to hypoxia and the period of recovery between hypoxia exposures...
- Prolongation of the laryngeal chemoreflex after inhibition of the rostral ventral medulla in piglets: a role in SIDS?Liesbeth Van Der Velde
Departments of Physiology, Medicine, and Pediatrics, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
J Appl Physiol 94:1883-95. 2003..We conclude that the RVM provides a tonic facilitatory drive to ventilation that limits the duration of the LCR, and loss of this drive may contribute to the SIDS when combined with stimuli that inhibit respiration...
- Characterization of hypoxia-induced ventilatory depression in newborn pigletsRene St-Jacques
Department of Physiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
Exp Physiol 88:509-15. 2003..We conclude that a region of the caudal mesencephalon or pons is necessary for the manifestation of depressions of ventilatory activity in the newborn pig...
- Spontaneous Arousals in "CHIME" Infants at Risk for SIDSROBERT DARNALL; Fiscal Year: 2006..Finally, we will examine the relationships among the level of arousal, post-conceptional age, sleep state, and other infant behaviors such as feeding that are also associated with changes in autonomic activity. ..