Hong Wen Deng

Summary

Affiliation: Creighton University
Country: USA

Publications

  1. ncbi request reprint Heterogeneity of bone mineral density across skeletal sites and its clinical implications
    H W Deng
    Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, NE 68131, USA
    J Clin Densitom 1:339-53. 1998
  2. pmc Inferring Deleterious-Mutation Parameters in Natural Daphnia Populations
    Hong Wen Deng
    Osteoporosis Research Center and Dept of Biomedical Sciences, Creighton University 601 N 30th St, Suite 6787, Omaha, NE 68131 USA
    Biol Proced Online 1:1-9. 1998
  3. pmc Inbreeding depression and inferred deleterious-mutation parameters in Daphnia
    H W Deng
    Department of Biology, University of Oregon, Eugene 97403, USA
    Genetics 147:147-55. 1997
  4. ncbi request reprint Evidence for a major gene for bone mineral density/content in human pedigrees identified via probands with extreme bone mineral density
    H W Deng
    Osteoporosis Research Center, Creighton University, Omaha, USA
    Ann Hum Genet 66:61-74. 2002
  5. ncbi request reprint Gene mapping and identification for osteoporosis
    H W Deng
    Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
    J Musculoskelet Neuronal Interact 4:91-100. 2004
  6. ncbi request reprint Determination of bone size of hip, spine, and wrist in human pedigrees by genetic and lifestyle factors
    Hong Wen Deng
    Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
    J Clin Densitom 5:45-56. 2002
  7. pmc A genomewide linkage scan for quantitative-trait loci for obesity phenotypes
    Hong Wen Deng
    Osteoporosis Research Center, and Department of Biomedical Sciences, Creighton University, Omaha, NE, USA
    Am J Hum Genet 70:1138-51. 2002
  8. ncbi request reprint Searching for obesity genes: progress and prospects
    Yong Jun Liu
    Osteoporosis Research Center, Creighton University Medical Center, Omaha, Nebraska 68131, USA
    Drugs Today (Barc) 41:345-62. 2005
  9. ncbi request reprint The power of the transmission disequilibrium test (TDT) with both case-parent and control-parent trios
    H W Deng
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, P R China
    Genet Res 78:289-302. 2001
  10. ncbi request reprint Transmission disequilibrium test with discordant sib pairs when parents are available
    Hong Wen Deng
    Department of Biomedical Sciences, Creighton University, 601 N 30th St, Suite 6787, Omaha, NE 68131, USA
    Hum Genet 110:451-61. 2002

Collaborators

Detail Information

Publications112 found, 100 shown here

  1. ncbi request reprint Heterogeneity of bone mineral density across skeletal sites and its clinical implications
    H W Deng
    Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, NE 68131, USA
    J Clin Densitom 1:339-53. 1998
    ..If only one site is chosen, measurement of the hip is preferred to measurement of the spine...
  2. pmc Inferring Deleterious-Mutation Parameters in Natural Daphnia Populations
    Hong Wen Deng
    Osteoporosis Research Center and Dept of Biomedical Sciences, Creighton University 601 N 30th St, Suite 6787, Omaha, NE 68131 USA
    Biol Proced Online 1:1-9. 1998
    ..On average, and (^ indicates an estimate) are 0.84, 0.30, 0.14 and 4.6E-4 respectively. For the true values, the and are lower bounds, and and upper bounds...
  3. pmc Inbreeding depression and inferred deleterious-mutation parameters in Daphnia
    H W Deng
    Department of Biology, University of Oregon, Eugene 97403, USA
    Genetics 147:147-55. 1997
    ..04) is discussed. It is shown that different reproductive modes do not affect gene frequency at mutation-selection equilibrium if mutational effects on fitness are multiplicative and not completely recessive...
  4. ncbi request reprint Evidence for a major gene for bone mineral density/content in human pedigrees identified via probands with extreme bone mineral density
    H W Deng
    Osteoporosis Research Center, Creighton University, Omaha, USA
    Ann Hum Genet 66:61-74. 2002
    ..This study indicates a promising aspect of studies to identify a major gene for BMD/BMC variation in our pedigrees identified via extreme probands...
  5. ncbi request reprint Gene mapping and identification for osteoporosis
    H W Deng
    Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
    J Musculoskelet Neuronal Interact 4:91-100. 2004
    ..The purpose of the presentation is to introduce to the medical researchers how and what modern genetics can do to disentangle the mist of an array of genetics factors, the major determinants, for BMD...
  6. ncbi request reprint Determination of bone size of hip, spine, and wrist in human pedigrees by genetic and lifestyle factors
    Hong Wen Deng
    Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
    J Clin Densitom 5:45-56. 2002
    ..48 (0.09), 0.64 (0.08), and 0.60 (0.09) for bone size at the hip, spine, and wrist...
  7. pmc A genomewide linkage scan for quantitative-trait loci for obesity phenotypes
    Hong Wen Deng
    Osteoporosis Research Center, and Department of Biomedical Sciences, Creighton University, Omaha, NE, USA
    Am J Hum Genet 70:1138-51. 2002
    ....
  8. ncbi request reprint Searching for obesity genes: progress and prospects
    Yong Jun Liu
    Osteoporosis Research Center, Creighton University Medical Center, Omaha, Nebraska 68131, USA
    Drugs Today (Barc) 41:345-62. 2005
    ..In this article, we discuss the current status and future perspectives for the genetic dissection of obesity, with a focus on the most striking or representative findings...
  9. ncbi request reprint The power of the transmission disequilibrium test (TDT) with both case-parent and control-parent trios
    H W Deng
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, P R China
    Genet Res 78:289-302. 2001
    ..The relative power of the TDTDC and TDTD depends largely upon a number of parameters identified in the study. This study provides a basis for efficient use of control-parent trios in DSL identification...
  10. ncbi request reprint Transmission disequilibrium test with discordant sib pairs when parents are available
    Hong Wen Deng
    Department of Biomedical Sciences, Creighton University, 601 N 30th St, Suite 6787, Omaha, NE 68131, USA
    Hum Genet 110:451-61. 2002
    ..Importantly, the TDT(DS) not only may be more powerful, it also has the advantage of being able to test for segregation distortion that may yield false linkage/association in the TDT(D)...
  11. ncbi request reprint The effects of selected sampling on the transmission disequilibrium test of a quantitative trait locus
    Hong Wen Deng
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, P R China
    Genet Res 79:161-74. 2002
    ..Our study is useful as a practical guideline on how to perform the TDT efficiently in practice by taking advantage of the extensive databases accumulated that are enriched with people of extreme phenotypic values...
  12. ncbi request reprint A whole-genome linkage scan suggests several genomic regions potentially containing QTLs underlying the variation of stature
    Hong Wen Deng
    Osteoporosis Research Center, Creighton University, Omaha, Nebraska 68131, USA
    Am J Med Genet 113:29-39. 2002
    ..Based on our findings, further confirmation and fine-mapping studies are to be pursued on expanded samples and/or with denser markers for eventual identification of major functional genes involved in human height variation...
  13. ncbi request reprint A whole-genome linkage scan suggests several genomic regions potentially containing quantitative trait Loci for osteoporosis
    Hong Wen Deng
    Osteoporosis Research Center, Department of Biomedical Sciences, Creighton University, 601 North 30th Street, Omaha, Nebraska 68131, USA
    J Clin Endocrinol Metab 87:5151-9. 2002
    ....
  14. pmc Estimation of deleterious genomic mutation parameters in natural populations by accounting for variable mutation effects across loci
    Hong Wen Deng
    Osteoporosis Research Center and Department of Biological Sciences, Creighton University, Omaha, Nebraska 68131, USA
    Genetics 162:1487-500. 2002
    ..Importantly, this method is the first one to characterize cov(h, s) for DGM...
  15. ncbi request reprint Several genomic regions potentially containing QTLs for bone size variation were identified in a whole-genome linkage scan
    Hong Wen Deng
    Osteoporosis Research Center and Department of Biomedical Research, Creighton University, Omaha, Nebraska 68131, USA
    Am J Med Genet A 119:121-31. 2003
    ..The two studies may form a basis for further exploration with larger samples and/or denser markers for confirmation and fine mapping studies to eventually identify major functional genes and the associated etiology for osteoporosis...
  16. ncbi request reprint Robust indices of Hardy-Weinberg disequilibrium for QTL fine mapping
    Hong Wen Deng
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, PR China
    Hum Hered 56:160-5. 2003
    ..Our results show that when marker allele frequencies vary across loci, the new measures presented here are more robust and powerful...
  17. ncbi request reprint LOD score exclusion analyses for candidate QTLs using random population samples
    Hong Wen Deng
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, PR China
    Genetica 119:303-15. 2003
    ..The approach is applied to test the importance of Vitamin D receptor (VDR) gene as a potential QTL underlying the variation of bone mass, an important determinant of osteoporosis...
  18. ncbi request reprint Relevance of the genes for bone mass variation to susceptibility to osteoporotic fractures and its implications to gene search for complex human diseases
    Hong Wen Deng
    Osteoporosis Research Center, Creighton University, 601 N 30th St Suite 6787, Omaha, NE 68131, USA
    Genet Epidemiol 22:12-25. 2002
    ..This study may have significant implications for the common practice of gene search for complex diseases through underlying risk factors (usually quantitative traits)...
  19. ncbi request reprint Characterization of genetic and lifestyle factors for determining variation in body mass index, fat mass, percentage of fat mass, and lean mass
    H W Deng
    Osteoporosis Research Center, Creighton University, 601 N 30th Street, Suite 6787, Omaha, NE 68131, USA
    J Clin Densitom 4:353-61. 2001
    ..This study warrants further genetic linkage analyses to search for genes for the obesity-related phenotypes measured by DXA in our population...
  20. pmc Population admixture may appear to mask, change or reverse genetic effects of genes underlying complex traits
    H W Deng
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, People s Republic of China
    Genetics 159:1319-23. 2001
    ..By employing a simple population genetics model, we explore the effects and the conditions of population admixture in masking, changing, or even reversing true genetic effects of genes underlying complex traits...
  21. pmc Conditions for positive and negative correlations between fitness and heterozygosity in equilibrium populations
    H W Deng
    Osteoporosis Research Center, Creighton University, Omaha, Nebraska 68131, USA
    Genetics 148:1333-40. 1998
    ..Although our emphasis is on equilibrium populations and for biallelic genetic systems, the basic conclusions are generalized to non-equilibrium populations and for multi-allelic situations...
  22. pmc Estimating within-locus nonadditive coefficient and discriminating dominance versus overdominance as the genetic cause of heterosis
    H W Deng
    Osteoporosis Research Center, Department of Medicine, Creighton University, Omaha, Nebraska 68131, USA
    Genetics 148:2003-14. 1998
    ....
  23. ncbi request reprint Inferring the major genomic mode of dominance and overdominance
    H W Deng
    ORC, Dept of Medicine, Creighton University, Omaha, NE 68131, USA
    Genetica 102:559-67. 1998
    ..Well-corroborated data in Drosophila and recently emerging data in mice and humans all suggest dominance as the major genomic mode...
  24. pmc Characterization of deleterious mutations in outcrossing populations
    H W Deng
    Osteoporosis Research Center and Department of Biological Sciences, Creighton University, Omaha, Nebraska 68131, USA
    Genetics 150:945-56. 1998
    ..Simulations accounting for environmental variance of fitness suggest that, under full-sib mating, our extension can achieve reasonably well an estimation with sample sizes of only approximately 2000-3000...
  25. ncbi request reprint Change of bone mass in postmenopausal Caucasian women with and without hormone replacement therapy is associated with vitamin D receptor and estrogen receptor genotypes
    H W Deng
    Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
    Hum Genet 103:576-85. 1998
    ....
  26. ncbi request reprint On the experimental design and data analysis of mutation accumulation experiments
    H W Deng
    Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
    Genet Res 73:147-64. 1999
    ..These results should not only be useful for planning efficient M-A experiments, but also may help empiricists in deciding to adopt the M-A approach with manageable labour, time and resources...
  27. ncbi request reprint Recovery of mutations of different sizes from a population sample of DNA sequences under variable mutation rates across sites
    H W Deng
    Osteoporosis Research Center, Creighton University, Omaha, Nebraska 68131, USA
    Mol Biol Evol 16:1098-104. 1999
    ....
  28. ncbi request reprint Genetic determination of variation and covariation of peak bone mass at the hip and spine
    H W Deng
    Osteoporosis Research Center, Creighton University, Omaha, NE, USA
    J Clin Densitom 2:251-63. 1999
    ..The problem of shared environmental effects notwithstanding, we conclude that much of the PBM variation and covariation at the hip and spine is determined genetically...
  29. ncbi request reprint Association of VDR and estrogen receptor genotypes with bone mass in postmenopausal Caucasian women: different conclusions with different analyses and the implications
    H W Deng
    Department of Medicine, Creighton University, Omaha, Nebraska 68131, USA
    Osteoporos Int 9:499-507. 1999
    ..These findings may offer a partial explanation for some of the earlier inconsistent results of association studies on BMD with VDR and ER genotypes...
  30. ncbi request reprint Effect of polygenes on Xiong's transmission disequilibrium test of a QTL in nuclear families with multiple children
    H W Deng
    Osteoporosis Research Center, Creighton University, 601 N 30th St, Omaha, NE 68131, USA
    Genet Epidemiol 21:243-65. 2001
    ..They should also be of practical values in providing guidance on the recruitment of nuclear families with multiple children with the TDT(G)...
  31. ncbi request reprint LOD score exclusion analyses for candidate genes using random population samples
    H W Deng
    Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
    Ann Hum Genet 65:313-29. 2001
    ..The usefulness of the approach is demonstrated by an application to test the importance of vitamin D receptor and estrogen receptor genes underlying the differential risk to osteoporotic fractures...
  32. pmc Population admixture: detection by Hardy-Weinberg test and its quantitative effects on linkage-disequilibrium methods for localizing genes underlying complex traits
    H W Deng
    Osteoporosis Research Center, Creighton University, 601 N 30th St, Omaha, NE 68131, USA
    Genetics 157:885-97. 2001
    ....
  33. ncbi request reprint Determination of bone mineral density of the hip and spine in human pedigrees by genetic and life-style factors
    H W Deng
    Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
    Genet Epidemiol 19:160-77. 2000
    ..Weight invariably affected BMD of the hip and spine in both sexes. Age effects were significant for hip BMD, but not for male spine BMD...
  34. ncbi request reprint Fragment size difference between multiplex and singleplex PCR products and their practical implications
    H W Deng
    Creighton University, Omaha, NE, USA
    Biotechniques 29:298-304, 307-8. 2000
    ..Therefore, the potential size difference between multiplex and singleplex reactions needs to be investigated. This investigation is essential to employ multiplex PCR supplemented with singleplex PCR in gene mapping and DNA typing...
  35. ncbi request reprint Association of estrogen receptor-alpha genotypes with body mass index in normal healthy postmenopausal Caucasian women
    H W Deng
    Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, Nebraska 68131, USA
    J Clin Endocrinol Metab 85:2748-51. 2000
    ..The importance of the ER-alpha genotypes on BMI should be confirmed by further studies using methods robust to the potential problem of population substructuring that may confound the conclusions of population association studies...
  36. pmc QTL fine mapping by measuring and testing for Hardy-Weinberg and linkage disequilibrium at a series of linked marker loci in extreme samples of populations
    H W Deng
    Osteoporosis Research Center, Creighton University, Omaha, NE, 68131, USA
    Am J Hum Genet 66:1027-45. 2000
    ..This means that many statistical genetic methods developed for searching for susceptibility loci of complex diseases can be directly adopted and/or extended to QTL mapping for quantitative traits...
  37. ncbi request reprint Tests of linkage and association of the COL1A2 gene with bone phenotypes' variation in Chinese nuclear families
    F Y Deng
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, People s Republic of China
    Bone 33:614-9. 2003
    ..Due to the limited number of sib pairs in this sample, we did not find evidence of linkage. In summary, the MspI polymorphism is likely to be in linkage disequilibrium with a nearby functional mutation affecting BMD and bone area...
  38. pmc Patterns of linkage disequilibrium and haplotype distribution in disease candidate genes
    Ji Rong Long
    Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
    BMC Genet 5:11. 2004
    ..The adequacy of association studies for complex diseases depends critically on the existence of linkage disequilibrium (LD) between functional alleles and surrounding SNP markers...
  39. ncbi request reprint Bone mineral density and five prominent candidate genes in Chinese men: associations, interaction effects and their implications
    Shu Feng Lei
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, PR China
    Maturitas 51:199-206. 2005
    ..The present study evaluated the relationship of COL1A2, BGP, IL-6, AHSG and PTH genes defined by MspI, HindIII, BsrBI, SacI and BstBI restriction enzymes, respectively, with BMD in Chinese males...
  40. ncbi request reprint Estrogen receptor alpha and vitamin D receptor gene polymorphisms and bone mineral density: association study of healthy pre- and postmenopausal Chinese women
    Yuan Yuan Zhang
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, PR China
    Biochem Biophys Res Commun 308:777-83. 2003
    ..02), and PX carriers had lower hip BMD than the non-carriers (p=0.04). Our data suggest that the ER-alpha and VDR genes may be associated with the BMD variation in Chinese women...
  41. ncbi request reprint Association between COL1A1 gene polymorphisms and bone size in Caucasians
    Ji Rong Long
    Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
    Eur J Hum Genet 12:383-8. 2004
    ..011 and 0.010, respectively. In conclusion, the COL1A1 gene may have some effects on bone size variation at the wrist, but not at the spine or hip in our Caucasian nuclear families...
  42. ncbi request reprint Mapping quantitative trait loci for cross-sectional geometry at the femoral neck
    Hui Shen
    Osteoporosis Research Center, Creighton University, Omaha, Nebraska 68131, USA
    J Bone Miner Res 20:1973-82. 2005
    ..Potential quantitative trait loci were detected at several genomic regions, such as 10q26, 20p12-q12, and chromosome X...
  43. ncbi request reprint APOE haplotypes influence bone mineral density in Caucasian males but not females
    Ji Rong Long
    Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
    Calcif Tissue Int 75:299-304. 2004
    ..008) for the total hip BMD. These data suggested that in our studied Caucasian population, APOE may have effects on BMD variation in males but not females. Further studies with a larger sample size are required to confirm such results...
  44. ncbi request reprint Potential effect of inter-genic action on peak bone mass (PBM) in Chinese females
    Fei Yan Deng
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha 410081, China
    Yi Chuan Xue Bao 32:1003-10. 2005
    ..The population-level statistical analysis indicates that IL6 x ERP and AHSG x IL6 have significant inter-genic effect on the genetic determination of PBM in Chinese females...
  45. ncbi request reprint Polymorphisms of four bone mineral density candidate genes in Chinese populations and comparison with other populations of different ethnicity
    Shu Feng Lei
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Hunan, P R China
    J Bone Miner Metab 21:34-42. 2003
    ....
  46. ncbi request reprint Bone mineral density in elderly Chinese: effects of age, sex, weight, height, and body mass index
    Shu Feng Lei
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Hunan, PR China
    J Bone Miner Metab 22:71-8. 2004
    ..Weight accounted for most of the effect of two correlated variables (weight and height) on BMD in our sample...
  47. ncbi request reprint Contribution of genotype and ethnicity to bone mineral density variation in Caucasians and Chinese: a test for five candidate genes for bone mass
    Volodymyr Dvornyk
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha 410081, China
    Chin Med J (Engl) 118:1235-44. 2005
    ....
  48. ncbi request reprint The -1997 G/T polymorphism in the COLIA1 upstream regulatory region is associated with hip bone mineral density (BMD) in Chinese nuclear families
    Yuan Yuan Zhang
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, 410081 Changsha, Hunan, P R China
    Calcif Tissue Int 76:107-12. 2005
    ....
  49. ncbi request reprint Association between VDR ApaI polymorphism and hip bone mineral density can be modified by body mass index: a study on postmenopausal Chinese women
    Hong Xu
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha 410081, China
    Acta Biochim Biophys Sin (Shanghai) 37:61-7. 2005
    ..Our findings may partially explain the earlier inconsistent association results concerning the VDR gene and BMD, and highlight the importance of incorporating covariates such as BMI into osteoporosis association studies...
  50. ncbi request reprint Tests of linkage and/or association of TGF-beta1 and COL1A1 genes with bone mass
    Ji Rong Long
    Osteoporosis Research Center, Creighton University, 601 N 30th Street, Suite 6787, Omaha, NE 68131, USA
    Osteoporos Int 16:86-92. 2005
    ..021) in male offspring families. Further studies with denser markers and larger sample size are required to eventually define the relationship between these two genes with bone mass at the spine and hip...
  51. ncbi request reprint Association tests of interleukin-6 (IL-6) and type II tumor necrosis factor receptor (TNFR2) genes with bone mineral density in Caucasians using a re-sampling approach
    Peng Xiao
    Osteoporosis Research Center, Department of Biomedical Sciences, School of Medicine, Creighton University, Omaha, NE 68131, USA
    Hum Genet 117:340-8. 2005
    ..Our results have significant implications for association studies and interpretation of non-reproducible association findings...
  52. ncbi request reprint Tests of linkage and/or association of genes for vitamin D receptor, osteocalcin, and parathyroid hormone with bone mineral density
    Hong Wen Deng
    Osteoporosis Research Center, Creighton University, Omaha, Nebraska 68131, USA
    J Bone Miner Res 17:678-86. 2002
    ..This is the first study in the broad field of bone genetics that tests candidate genes as QTLs for BMD by testing simultaneously for association alone, for linkage alone, and for association and linkage (via the TDT)...
  53. ncbi request reprint Parathyroid hormone gene with bone phenotypes in Chinese
    Xiao Gang Zhou
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, PR China
    Biochem Biophys Res Commun 307:666-71. 2003
    ..Our data do not support the PTH gene as a quantitative trait locus (QTL) underlying the bone phenotypic variation in the Chinese population...
  54. doi request reprint Quantitative trait loci mapping
    Dong Hai Xiong
    Osteoporosis Research Center, Creighton University, Omaha, NE, USA
    Methods Mol Biol 455:203-35. 2008
    ..The main focus of this chapter is technical issues although statistical issues are also covered to certain extent. Finally, we summarize the limitations of the current QTL approaches and discuss the solutions to certain problems...
  55. ncbi request reprint Receiver-operating characteristic analyses of body mass index, waist circumference and waist-to-hip ratio for obesity: Screening in young adults in central south of China
    Fang Yang
    Laboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, PR China
    Clin Nutr 25:1030-9. 2006
    ..Our aim was to identify the usefulness of BMI, waist circumference (WC) and waist-to-hip ratio (WHR) in screening for obesity in an Asian population...
  56. ncbi request reprint Tests of linkage and association of PTH/PTHrP receptor type 1 gene with bone mineral density and height in Caucasians
    Yuan Yuan Zhang
    Osteoporosis Research Center, Creighton University Medical Center, 601 N 30th Street, Suite 6787, Omaha, NE 68131, USA
    J Bone Miner Metab 24:36-41. 2006
    ..05). Our findings suggest that the PTHR1 gene may be important for PBMD, height variation, or both, although the significance is dampened by correction for multiple testing...
  57. ncbi request reprint Correlation and prediction of trunk fat mass with four anthropometric indices in Chinese males
    Su Mei Xiao
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, PR China
    Br J Nutr 96:949-55. 2006
    ....
  58. pmc Is a gene important for bone resorption a candidate for obesity? An association and linkage study on the RANK (receptor activator of nuclear factor-kappaB) gene in a large Caucasian sample
    Lan Juan Zhao
    Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, NE 68131, USA
    Hum Genet 120:561-70. 2006
    ..021 for lean mass, 0.016 for BMI, and 0.006 for PFM. The haplotype data analyses provide further association evidence. In conclusion, for the first time, our results suggest that RANK is a novel candidate for determination of obesity...
  59. ncbi request reprint Interaction effects between estrogen receptor alpha and vitamin D receptor genes on age at menarche in Chinese women
    Hong Xu
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hu nan Normal University, Changsha 410081, China
    Acta Pharmacol Sin 26:860-4. 2005
    ..To evaluate whether estrogen receptor alpha (ER-alpha) and vitamin D receptor (VDR) genes are associated with the age at menarche in Chinese women...
  60. ncbi request reprint Bivariate whole genome linkage analysis for femoral neck geometric parameters and total body lean mass
    Fei Yan Deng
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China
    J Bone Miner Res 22:808-16. 2007
    ..A genome-wide bivariate analysis was conducted for femoral neck GPs and TBLM in a large white sample. We found QTLs shared by GPs and TBLM in the total sample and the sex-specific samples. QTLs with potential pleiotropy were also disclosed...
  61. ncbi request reprint Association analysis of estrogen receptor alpha gene polymorphisms with cross-sectional geometry of the femoral neck in Caucasian nuclear families
    Dong Hai Xiong
    Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, 601 N 30th St Suite 6787, Omaha, NE 68131, USA
    Osteoporos Int 16:2113-22. 2005
    ..Therefore, we concluded that polymorphisms in the ER-alpha gene were nominally associated with femoral neck (FN) geometry variables estimated from DXA. Such genetic effects on hip geometry were not sex specific...
  62. pmc Gene expression profiling in monocytes and SNP association suggest the importance of the STAT1 gene for osteoporosis in both Chinese and Caucasians
    Xiang Ding Chen
    Laboratory of Molecular and Statistical Genetics and Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, Hunan, Peoples Republic of China
    J Bone Miner Res 25:339-55. 2010
    ..We also revealed a significant association of the STAT1 gene with BMD variation in the 1000 Caucasians. Thus we conclude that the STAT1 gene is important in human circulating monocytes in the etiology of osteoporosis...
  63. ncbi request reprint Race and sex differences and contribution of height: a study on bone size in healthy Caucasians and Chinese
    Yuan Yuan Zhang
    Osteoporosis Research Center, Creighton University, Omaha, Nebraska 68131, USA
    Am J Hum Biol 17:568-75. 2005
    ..We conclude that height is a major predictor for BS, and its contributions vary across sex, race, and skeletal site...
  64. pmc Current limitations of SNP data from the public domain for studies of complex disorders: a test for ten candidate genes for obesity and osteoporosis
    Volodymyr Dvornyk
    Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, 601 N, 30th St, Suite 6730, Omaha, NE 68131, USA
    BMC Genet 5:4. 2004
    ..However, their utility for such studies of diseases with ethnic-dependent background has never been evaluated...
  65. ncbi request reprint Estrogen receptor alpha gene relationship with peak bone mass and body mass index in Chinese nuclear families
    Wei xia Jian
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, 410081 Changsha, Hunan, PR China
    J Hum Genet 50:477-82. 2005
    ..Our study does not support an association of the ER-alpha gene with BMD and BMI in the Chinese population...
  66. ncbi request reprint Genome-wide scan identified QTLs underlying femoral neck cross-sectional geometry that are novel studied risk factors of osteoporosis
    Dong Hai Xiong
    Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, Nebraska, USA
    J Bone Miner Res 21:424-37. 2006
    ..We found significant linkage of FNCS parameters to 20q12 and Xq25, plus significant epistatic interactions and sex-specific QTLs influencing FNCS geometry variation...
  67. ncbi request reprint Genome scan for QTLs underlying bone size variation at 10 refined skeletal sites: genetic heterogeneity and the significance of phenotype refinement
    Qing Yang Huang
    Osteoporosis Research Center, Creighton University, Omaha, Nebraska 68131, USA
    Physiol Genomics 17:326-31. 2004
    ..93) to bone size in one skeletal site. Our results indicated that the low power of QTLs mapping for composite phenotypic measurements may result from genetic heterogeneity of complex traits...
  68. ncbi request reprint Molecular studies of identification of genes for osteoporosis: the 2002 update
    Yao Zhong Liu
    Department of Biomedical Sciences, Creighton University, 601 N 30th St, Suite 6787, Omaha, Nebraska 68131, USA
    J Endocrinol 177:147-96. 2003
    ..The format adopted by this review should be ideal for accommodating future new advances and studies in a fairly young field that is still developing rapidly...
  69. ncbi request reprint Tests of linkage and/or association of the LEPR gene polymorphisms with obesity phenotypes in Caucasian nuclear families
    Yong Jun Liu
    Osteoporosis Research Center, Creighton University, Omaha, Nebraska 68131, USA
    Physiol Genomics 17:101-6. 2004
    ..Our results suggest that the LEPR gene polymorphisms contribute to variation in obesity phenotypes...
  70. ncbi request reprint Linkage exclusion analysis of two candidate regions on chromosomes 7 and 11: leptin and UCP2/UCP3 are not QTLs for obesity in US Caucasians
    Jing Jing Guo
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, PR China
    Biochem Biophys Res Commun 332:602-8. 2005
    ..Our results suggest that the LEP and UCP2/UCP3 genes are unlikely to have a substantial effect on variation in obesity phenotypes in this particular US Caucasian population...
  71. ncbi request reprint Association and linkage analyses of interleukin-6 gene 634C/G polymorphism and bone phenotypes in Chinese
    Shu Feng Lei
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, 410081 P R China
    J Bone Miner Metab 23:323-8. 2005
    ..Our results, together with the findings from other studies, indicate that the IL-6 gene, although important for postmenopausal bone loss, may have a limited impact on peak bone mass variation in a Chinese population...
  72. ncbi request reprint The (CA)n polymorphism of the TNFR2 gene is associated with peak bone density in Chinese nuclear families
    Hong Xu
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, 410081, People s Republic of China
    J Hum Genet 50:301-4. 2005
    ..007). About 3.14% of lumbar spine BMD variation can be explained by the CA16 allele. In summary, our results suggest that the TNFR2 gene may play an important role in determining lumbar spine BMD variation in Chinese women...
  73. ncbi request reprint Establishment of peak bone mineral density in Southern Chinese males and its comparisons with other males from different regions of China
    Li Jun Tan
    Laboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, Hunan, PR China
    J Bone Miner Metab 25:114-21. 2007
    ..In conclusion, the PBMD at the spine and hip may be used as normal reference data for Southern Chinese males in Changsha instead of documented PBMD from other regions of China and the manufacturer's reference data...
  74. ncbi request reprint Linkage and association analyses of the UCP3 gene with obesity phenotypes in Caucasian families
    Yong Jun Liu
    Osteoporosis Research Center, Creighton University Medical Center, Omaha, Nebraska, USA
    Physiol Genomics 22:197-203. 2005
    ..003). In haplotype analyses, we also observed evidence of linkage (P = 0.002) and association (P = 0.035) with BMI. In summary, our results suggest that UCP3 gene polymorphisms may contribute to BMI variation in this Caucasian population...
  75. ncbi request reprint The (GT)n polymorphism and haplotype of the COL1A2 gene, but not the (AAAG)n polymorphism of the PTHR1 gene, are associated with bone mineral density in Chinese
    Shu Feng Lei
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, 410081, Peoples Republic of China
    Hum Genet 116:200-7. 2005
    ..On the other hand, no significant within-family association, population stratification and total-family association between the PTHR1 polymorphism and BMD were found in our Chinese population...
  76. pmc Accurate haplotype inference for multiple linked single-nucleotide polymorphisms using sibship data
    Peng Yuan Liu
    Osteoporosis Research Center, Creighton University, Omaha, Nebraska 68131, USA
    Genetics 174:499-509. 2006
    ..The utility of our method was illustrated with an application to the analyses of haplotypes of three candidate genes for osteoporosis...
  77. pmc Bivariate whole genome linkage analyses for total body lean mass and BMD
    Xiang Li Wang
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China
    J Bone Miner Res 23:447-52. 2008
    ..We found some QTLs shared by TBLM and BMD in the entire sample and the sex-specific subgroups, and QTLs with potential pleiotropy were disclosed...
  78. ncbi request reprint Evidence for a major gene underlying bone size variation in the Chinese
    Peng Yuan Liu
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, People s Republic of China
    Am J Hum Biol 16:68-77. 2004
    ....
  79. ncbi request reprint AHSG gene polymorphisms are associated with bone mineral density in Caucasian nuclear families
    Yan Jun Yang
    Laboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of the Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, Hunan, 410081, PR China
    Eur J Epidemiol 22:527-32. 2007
    ..To investigate the role of alpha2-HS glycoprotein (AHSG) gene on bone mineral density (BMD) variation...
  80. pmc Robust and comprehensive analysis of 20 osteoporosis candidate genes by very high-density single-nucleotide polymorphism screen among 405 white nuclear families identified significant association and gene-gene interaction
    Dong Hai Xiong
    Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, Nebraska, USA
    J Bone Miner Res 21:1678-95. 2006
    ..Our efforts led to the prioritization of those osteoporosis genes and the detection of gene-gene interactions...
  81. ncbi request reprint A major gene model of adult height is suggested in Chinese
    Miao Xin Li
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, 410081, China
    J Hum Genet 49:148-53. 2004
    ....
  82. ncbi request reprint Linkage exclusion mapping with bone size in 79 Caucasian pedigrees
    Xiang Ding Chen
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, 410081, China
    J Bone Miner Metab 24:337-43. 2006
    ....
  83. ncbi request reprint Genetic determination and correlation of body mass index and bone mineral density at the spine and hip in Chinese Han ethnicity
    Fei Yan Deng
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, 410081, Hunan, People s Republic of China
    Osteoporos Int 17:119-24. 2006
    ..In addition, BMD at the spine and hip shares more genetic effect (pleiotropy) than BMI and BMD do in Chinese Han ethnicity, though the effects are significant for both...
  84. ncbi request reprint Low-density lipoprotein receptor-related protein 5 (LRP5) gene polymorphisms are associated with bone mass in both Chinese and whites
    Dong Hai Xiong
    Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, NE, USA
    J Bone Miner Res 22:385-93. 2007
    ..These data support the concept that LRP5 variation can contribute to minor and major variation in bone structure...
  85. ncbi request reprint A follow-up linkage study for quantitative trait loci contributing to obesity-related phenotypes
    Yong Jun Liu
    Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, Nebraska 68131, USA
    J Clin Endocrinol Metab 89:875-82. 2004
    ..24 in two-point analysis and an MLS of 0.92 in multipoint analysis in all 79 pedigrees. Our data support that 1p36, 2q14, and 6q27 are promising regions that may harbor QTLs for obesity phenotypes...
  86. ncbi request reprint A bivariate whole-genome linkage scan suggests several shared genomic regions for obesity and osteoporosis
    Zi Hui Tang
    Laboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, People s Republic of China
    J Clin Endocrinol Metab 92:2751-7. 2007
    ..BFM and BMD, as the respective measure for obesity and osteoporosis, are phenotypically and genetically correlated. However, specific genomic regions accounting for their genetic correlation are unknown...
  87. ncbi request reprint Genetic and environmental correlations between bone mineral density and bone size in Caucasians
    Yuan Chen
    Laboratory of Molecular and Statistical Genetics, College of Life Science, Hunan Normal University, Changsha, Hunan 410081, PR China
    Hum Biol 79:15-24. 2007
    ..6% at the spine, hip, and their joint variable, respectively. The results suggest that it may be important to choose both BMD and BS, especially at the hip, as surrogate phenotypes for osteoporosis genetic studies in Caucasians...
  88. ncbi request reprint Estrogen receptor alpha gene polymorphisms and peak bone density in Chinese nuclear families
    Yue juan Qin
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Hunan, China
    J Bone Miner Res 18:1028-35. 2003
    ..In conclusion, this study suggests that the ER-alpha gene may have minor effects on PBD variation in our Chinese population...
  89. ncbi request reprint Interaction effects between estrogen receptor alpha gene, vitamin D receptor gene, age, and sex on bone mineral density in Chinese
    Jirong Long
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, 410081 Changsha, Hunan, PR China
    J Hum Genet 48:514-9. 2003
    ..05), and it accounted for 0.6% BMD variation. These interaction effects were largely dependent on gender groups, suggesting there may exist ER-VDR-sex, ER-age-sex, and VDR-age-sex complex interactions in our Chinese sample...
  90. ncbi request reprint Evaluating the correlation and prediction of trunk fat mass with five anthropometric indices in Chinese females aged 20-40 years
    Cheng Jiang
    Laboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, P R China
    Nutr Metab Cardiovasc Dis 17:676-83. 2007
    ..The early measurement of FM(trunk) has potential importance to evaluate trunk obesity. We sought to evaluate the correlation and predication of FM(trunk) with five anthropometric indices in Chinese females...
  91. ncbi request reprint High heritability of bone size at the hip and spine in Chinese
    Wei xia Jian
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, 410081 Changsha Hunan, PR China
    J Hum Genet 49:87-91. 2004
    ..The significantly and moderately high h2 values for bone size demonstrated in this study warrant a subsequent genetic study to search for the genes or genomic regions underlying the phenotype in Chinese...
  92. ncbi request reprint The genetic, environmental and phenotypic correlations of bone phenotypes at the spine and hip in Chinese
    Yan Bo Wang
    Laboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, Hunan, PR China
    Ann Hum Biol 33:500-9. 2006
    ....
  93. ncbi request reprint Molecular and genetic mechanisms of obesity: implications for future management
    Yong Jun Liu
    Osteoporosis Research Center, Creighton University, 601 N 30th St, Suite 6787, Omaha, NE 68131, USA
    Curr Mol Med 3:325-40. 2003
    ..Finally, the implications of the recent advances in the understanding of molecular genetic mechanisms of body weight regulation on prevention and therapeutic intervention of obesity will be discussed...
  94. ncbi request reprint Hotelling's T2 multivariate profiling for detecting differential expression in microarrays
    Yan Lu
    Osteoporosis Research Center, Creighton University 601 N 30th Street, Suite 6787, Omaha, NE 68131, USA
    Bioinformatics 21:3105-13. 2005
    ..Extensive bioinformatics analyses and cross-validation of DEGs identified in the application datasets showed the significant advantages of our new algorithm...
  95. ncbi request reprint Genetic and environmental correlations between bone phenotypes and anthropometric indices in Chinese
    Yan Jun Yang
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China
    Osteoporos Int 16:1134-40. 2005
    ..It may have implications for population studies of candidate genes that underlie the complex bone phenotypes and for the development of strategies for therapeutic application...
  96. ncbi request reprint The VDR, COL1A1, PTH, and PTHR1 gene polymorphisms are not associated with bone size and height in Chinese nuclear families
    Shu Feng Lei
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, 410081, PR China
    J Bone Miner Metab 23:501-5. 2005
    ..Our results do not support that the VDR, COL1A1, PTH, and PTHR1 genes have an important influence on the variation in BS and height in our Chinese population...
  97. ncbi request reprint Structure and molecular phylogeny of sasA genes in cyanobacteria: insights into evolution of the prokaryotic circadian system
    Volodymyr Dvornyk
    Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, USA
    Mol Biol Evol 21:1468-76. 2004
    ....
  98. pmc Polymorphisms of the tumor necrosis factor-alpha receptor 2 gene are associated with obesity phenotypes among 405 Caucasian nuclear families
    Lan Juan Zhao
    Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
    Hum Genet 124:171-7. 2008
    ..The results suggest that the TNFR2 gene polymorphisms contribute to the variation of obesity phenotypes...
  99. doi request reprint Anthropometric indices as the predictors of trunk obesity in Chinese young adults: receiver operating characteristic analyses
    Li Ming Li
    Laboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, Hunan, PR China
    Ann Hum Biol 35:342-8. 2008
    ..Trunk obesity has adverse health implications in adults, but valid and practical methods to correctly measure trunk obesity in China are insufficient...
  100. doi request reprint Evidence for major pleiotropic effects on bone size variation from a principal component analysis of 451 Caucasian families
    Li Jun Tan
    Laboratory of Molecular and Statistical Genetics, Hunan Normal University, Changsha 410081, China
    Acta Pharmacol Sin 29:745-51. 2008
    ..To identify pleiotropic quantitative trait loci (QTL) influencing bone size (BS) at different skeletal sites in Caucasians...
  101. ncbi request reprint Role of genetics in osteoporosis
    Robert R Recker
    Osteoporis Research Center, Creighton University, Omaha, NE 68131, USA
    Endocrine 17:55-66. 2002
    ..We focus on linkage studies in humans and quantitative trait loci mapping in mice to supplement the already extensive reviews of association studies made by many investigators for candidate genes...