Affiliation: Craig Rehabilitation Hospital
Location: Englewood, CO, USA
Dr. Falci is a graduate of Georgetown University in Washington, D.C. and completed his neurosurgical residency at Georgetown in 1992. He received his undergraduate training at Princeton University, Princeton, N.J. Dr. Falci initiated and designed the First Transplantation of Embryonic Nerve Cells for Spinal Cord Injury Project at Craig Center for Spinal Cord Research in collaboration with the Spinalis SCI Research Unit, Karolinska Institute, Huddinge University Hospital, Stockholm, and the department of Neurosurgery, University of Uppsala in Sweden. (J. of Neurotrauma, Vol. 14, No. 11, November, 1997)
Specialties include: surgical treatment for posttraumatic spinal cord tethering, postraumatic syringomyelia, posttraumatic neuropathic pain, spinal deformities, spasticity, as well as research in neuropathic pain and stem cell development for spinal cord injury
Current research includes: Neurochemical and Histopathologic Analysis of the Dorsal Root Entry Zone in Spinal Cord Injured Patients with Central Deafferentation Pain, Animal Modeling of neuropathic pain in spinal cord injury, Development of Human Clinical Trial for Administration of Embryonic Stem Cells in Spinal Cord Injury, and Use of Human Embryonic Stem Cells in Restoration of Neurologic Function in Spinal Cord Injured Rats.
- In-vitro and in-vivo studies of human axillary odour and the cutaneous microfloraP J Rennie
Department of Microbiology, Leeds, U K
Br J Dermatol 124:596-602. 1991..Underarm odour was produced exclusively by aerobic coryneform bacteria. Of aerobic coryneforms, 71.4% were odour producers and these were identified as Corynebacterium xerosis...
- Markers of pluripotency and differentiation in human neural precursor cells derived from embryonic stem cells and CNS tissueM Sundberg
Regea Institute for Regenerative Medicine, University of Tampere and Tampere University Hospital, Tampere, Finland
Cell Transplant 20:177-91. 2011..Our data show that transplantation to the subcutaneous tissue or the testes of immunodeficient mice is not a reliable method for evaluation of the tumor risk of remaining pluripotent cells in grafts...
- A phase 2 autologous cellular therapy trial in patients with acute, complete spinal cord injury: pragmatics, recruitment, and demographicsL A T Jones
Proneuron Biotechnologies, Englewood, CO, USA
Spinal Cord 48:798-807. 2010..Post hoc analysis from a randomized controlled cellular therapy trial in acute, complete spinal cord injury (SCI)...
- Posttraumatic spinal cord tethering and syringomyelia: surgical treatment and long-term outcomeScott P Falci
Department of Neurosurgery, Craig Hospital, Englewood, Colorado 80113, USA
J Neurosurg Spine 11:445-60. 2009..Both objective and subjective long-term outcomes were evaluated. To the authors' knowledge, this is the first series of this size correlating long-term patient perception of outcome with long-term objective outcome analyses...
- Human neural stem cells and astrocytes, but not neurons, suppress an allogeneic lymphocyte responseElisabet Akesson
Department of Neurobiology, Division of Neurodegeneration, Care Sciences and Society, Karolinska Institutet, Novum, Stockholm, Sweden
Stem Cell Res 2:56-67. 2009..Thus, human NSCs and their derived astrocytes do not initiate, but instead suppress, an allogeneic response, while they cannot block a graft rejection in a xenogeneic setting...
- Human neural precursor cells continue to proliferate and exhibit low cell death after transplantation to the injured rat spinal cordMia Emgard
Division of Neurodegeneration, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Geriatric Clinic Res Lab, Novum level 5, Stockholm, Sweden
Brain Res 1278:15-26. 2009....
- Neuroimaging in traumatic spinal cord injury: an evidence-based review for clinical practice and researchDaniel Lammertse
Department of Physical Medicine and Rehabilitation, Univeristy of Colorado Denver Health Science Center, Denver Cororado, USA
J Spinal Cord Med 30:205-14. 2007..To perform an evidence-based review of the literature on neuroimaging techniques utilized in spinal cord injury clinical practice and research...
- Long-term culture and neuronal survival after intraspinal transplantation of human spinal cord-derived neurospheresElisabet Akesson
Karolinska Institutet, Division of Neurodegeneration and Neuroinflammation, Department of Neurobiology, Care Sciences and Society, Novum, S 141 86 Stockholm, Sweden
Physiol Behav 92:60-6. 2007....
- Late human cytomegalovirus (HCMV) proteins inhibit differentiation of human neural precursor cells into astrocytesJenny Odeberg
Karolinska Institutet, Department of Medicine, Center for Molecular Medicine, Karolinska University Hospital in Solna, Stockholm, Sweden
J Neurosci Res 85:583-93. 2007..Clearly, HCMV can reduce the capacity of NPCs to differentiate into astrocytes and this effect may provide part of the explanation for the abnormalities in brain development associated with congenital HCMV infection...
- Human cytomegalovirus inhibits neuronal differentiation and induces apoptosis in human neural precursor cellsJenny Odeberg
Neurotec Department, Division of Neurodegeneration and Neuroinflammation, Novum floor 5, SE 141 86 Stockholm, Sweden
J Virol 80:8929-39. 2006..These findings indicate that HCMV has the capacity to reduce the ability of human NPCs to differentiate into neurons, which may offer one explanation for the abnormalities in brain development associated with congenital HCMV infection...
- Cellular composition of long-term human spinal cord- and forebrain-derived neurosphere culturesJing Hua Piao
Neurotec Department, Division of Neurodegeneration and Neuroinflammation, Karolinska Institutet, Stockholm, Sweden
J Neurosci Res 84:471-82. 2006..This could in turn imply that human spinal cord and forebrain NPCs present different repair potentials in in vivo settings...
- Low immunogenicity of in vitro-expanded human neural cells despite high MHC expressionJenny Odeberg
Neurotec Department, Division of Experimental Geriatrics, Karolinska Institutet, Karolinska University Hospital, KFC, 4th Floor, Novum, SE 141 86 Stockholm, Sweden
J Neuroimmunol 161:1-11. 2005..Taken together, these results suggest a low immunogenicity of these cultured human neural cells despite HLA incompatibility and high HLA expression...
- Dorsal root entry zone microcoagulation for spinal cord injury-related central pain: operative intramedullary electrophysiological guidance and clinical outcomeScott Falci
Department of Neurosurgery, Physical Medicine and Rehabilitation, Craig Hospital, Englewood, Colorado, USA
J Neurosurg 97:193-200. 2002..Additionally, electrical data were used to determine if the spinal cord could be somatotopically mapped with regard to this pain of central origin...
- Solid human embryonic spinal cord xenografts in acute and chronic spinal cord cavities: a morphological and functional studyE Akesson
Department of Neurotec, Karolinska Institutet, Huddinge University Hospital, S-141 86, Sweden
Exp Neurol 170:305-16. 2001..In conclusion, solid human embryonic spinal cord tissue transplanted to a cavity in the adult injured spinal cord results in beneficial morphological effects in both the acute and chronic spinal cord lesion...
- MHC antigen expression in human first trimester spinal cord with implications for clinical transplantation proceduresE Akesson
Department of Neurotec, Karolinska Institutet, Huddinge University Hospital, KFC 4th floor, S 141 86, Novum, Sweden
J Neuroimmunol 111:210-4. 2000..In conclusion, we report non-immunogenic expression of HLA antigens in the human first trimester spinal cord...
- Surgical treatment of posttraumatic cystic and tethered spinal cordsS P Falci
Department of Neurosurgery, Craig Hospital, Denver, Colorado, USA
J Spinal Cord Med 22:173-81. 1999..Of this latter group, 64.3% regained a lost function, 62.5% saw improvement in spasticity, 55.6% had substantial improvement in neurogenic pain, and 95.8% felt that surgery prevented further neurologic deterioration...
- Obliteration of a posttraumatic spinal cord cyst with solid human embryonic spinal cord grafts: first clinical attemptS Falci
Department of Neurosurgery, Craig Hospital, Denver, Colorado, USA
J Neurotrauma 14:875-84. 1997..The grafts are well visualized by MRI to the 7-month postoperative follow-up and cyst obliteration is seen in the region where the grafts were placed...
- The diagnosis and treatment of pediatric lumbar spine injuries caused by rear seat lap beltsD L Johnson
Department of Neurosurgery, George Washington University, Washington, District of Columbia
Neurosurgery 26:434-41. 1990..Rear seat lap belts are better than no restraints, but the addition of a shoulder restraint is strongly advocated to reduce lumbar spine injury...
- Caudal granular insular cortex is sufficient and necessary for the long-term maintenance of allodynic behavior in the rat attributable to mononeuropathyAlexander M Benison
Department of Psychology and Neuroscience, University of Colorado, Boulder, Colorado 80309 0345, USA
J Neurosci 31:6317-28. 2011..In addition, using electrophysiological techniques, we reveal a corticospinal loop that could be the anatomical source of the influence of CGIC on allodynia...