W Naidong

Summary

Affiliation: Covance Laboratories
Country: USA

Publications

  1. ncbi request reprint An automatic 96-well solid phase extraction and liquid chromatography-tandem mass spectrometry method for the analysis of morphine, morphine-3-glucuronide and morphine-6-glucuronide in human plasma
    Wilson Z Shou
    Covance Laboratories Inc, 3301 Kinsman Boulevard, Madison, Wisconsin 53704, USA
    J Pharm Biomed Anal 27:143-52. 2002
  2. ncbi request reprint Development and validation of a hydrophilic interaction liquid chromatography-tandem mass spectrometric method for the analysis of paroxetine in human plasma
    Weng Naidong
    Covance Laboratories Inc, 3301 Kinsman Boulevard, Madison, WI 53707, USA
    Biomed Chromatogr 18:28-36. 2004
  3. ncbi request reprint Development and validation of a high-sensitivity liquid chromatography/tandem mass spectrometry (LC/MS/MS) method with chemical derivatization for the determination of ethinyl estradiol in human plasma
    Wilson Z Shou
    Covance Laboratories Inc, 3301 Kinsman Boulevard, Madison, WI 53704, USA
    Biomed Chromatogr 18:414-21. 2004
  4. ncbi request reprint Analysis of omeprazole and 5-OH omeprazole in human plasma using hydrophilic interaction chromatography with tandem mass spectrometry (HILIC-MS/MS)--eliminating evaporation and reconstitution steps in 96-well liquid/liquid extraction
    Qi Song
    Covance Bioanalytical Services, LLC, Indianapolis, IN, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 830:135-42. 2006
  5. ncbi request reprint Bioanalytical liquid chromatography tandem mass spectrometry methods on underivatized silica columns with aqueous/organic mobile phases
    Weng Naidong
    Covance Laboratories Inc, 3301 Kinsman Boulevard, Madison, WI 53704, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 796:209-24. 2003
  6. ncbi request reprint A sensitive LC/MS/MS method using silica column and aqueous-organic mobile phase for the analysis of loratadine and descarboethoxy-loratadine in human plasma
    Weng Naidong
    Covance Laboratories Inc, Department of Bioanalytical Chemistry, 3301 Kinsman Boulevard, Madison, WI 53704, USA
    J Pharm Biomed Anal 32:609-17. 2003
  7. ncbi request reprint Simultaneous development of six LC-MS-MS methods for the determination of multiple analytes in human plasma
    Weng Naidong
    Bioanalytical Chemistry Department, Covance Laboratories, Inc, 3301 Kinsman Boulevard, Madison, WI 53704, USA
    J Pharm Biomed Anal 28:1115-26. 2002
  8. ncbi request reprint Simultaneous determination of hydrocodone and hydromorphone in human plasma by liquid chromatography with tandem mass spectrometric detection
    Yu Luan Chen
    Department of Bioanalytical Chemistry, Covance Laboratories Inc, Madison, WI 53704, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 769:55-64. 2002
  9. ncbi request reprint Liquid chromatography/tandem mass spectrometric bioanalysis using normal-phase columns with aqueous/organic mobile phases - a novel approach of eliminating evaporation and reconstitution steps in 96-well SPE
    Weng Naidong
    Bioanalytical Chemistry Department, Covance Laboratories, Inc, 3301 Kinsman Boulevard, Madison, WI 53704, USA
    Rapid Commun Mass Spectrom 16:1965-75. 2002
  10. ncbi request reprint Importance of injection solution composition for LC-MS-MS methods
    W Naidong
    Covance Laboratories Inc, Department of Bioanalytical Chemistry, 3301 Kinsman Boulevard, Madison, WI 53707, USA
    J Pharm Biomed Anal 26:753-67. 2001

Collaborators

Detail Information

Publications32

  1. ncbi request reprint An automatic 96-well solid phase extraction and liquid chromatography-tandem mass spectrometry method for the analysis of morphine, morphine-3-glucuronide and morphine-6-glucuronide in human plasma
    Wilson Z Shou
    Covance Laboratories Inc, 3301 Kinsman Boulevard, Madison, Wisconsin 53704, USA
    J Pharm Biomed Anal 27:143-52. 2002
    ..The inter-day precision and accuracy of the quality control samples were <8% relative standard deviation (RSD) and <7% relative error (RE) for MOR, <5% RSD and <2% RE for M6G, and <2% RSD and <4% RE for M3G...
  2. ncbi request reprint Development and validation of a hydrophilic interaction liquid chromatography-tandem mass spectrometric method for the analysis of paroxetine in human plasma
    Weng Naidong
    Covance Laboratories Inc, 3301 Kinsman Boulevard, Madison, WI 53707, USA
    Biomed Chromatogr 18:28-36. 2004
    ..0% relative standard deviation (RSD) and <2.9% relative error (RE). This method can be used for supporting therapeutical drug monitoring and pharmacokinetic or drug-drug interaction studies...
  3. ncbi request reprint Development and validation of a high-sensitivity liquid chromatography/tandem mass spectrometry (LC/MS/MS) method with chemical derivatization for the determination of ethinyl estradiol in human plasma
    Wilson Z Shou
    Covance Laboratories Inc, 3301 Kinsman Boulevard, Madison, WI 53704, USA
    Biomed Chromatogr 18:414-21. 2004
    ..5 pg/mL. This high sensitivity method can be used for therapeutic drug monitoring or supporting bio-equivalence and drug-drug interaction studies in human subjects...
  4. ncbi request reprint Analysis of omeprazole and 5-OH omeprazole in human plasma using hydrophilic interaction chromatography with tandem mass spectrometry (HILIC-MS/MS)--eliminating evaporation and reconstitution steps in 96-well liquid/liquid extraction
    Qi Song
    Covance Bioanalytical Services, LLC, Indianapolis, IN, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 830:135-42. 2006
    ..4% relative standard deviation (R.S.D.) and 4.1% relative error (R.E.) for omeprazole, and 4.5% R.S.D. and 5.6% R.E. for 5-OH omeprazole, respectively...
  5. ncbi request reprint Bioanalytical liquid chromatography tandem mass spectrometry methods on underivatized silica columns with aqueous/organic mobile phases
    Weng Naidong
    Covance Laboratories Inc, 3301 Kinsman Boulevard, Madison, WI 53704, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 796:209-24. 2003
    ..Contrary to what is commonly perceived, the silica column demonstrated superior column stability. This technology can be a valuable supplement to the reversed-phase LC-MS/MS...
  6. ncbi request reprint A sensitive LC/MS/MS method using silica column and aqueous-organic mobile phase for the analysis of loratadine and descarboethoxy-loratadine in human plasma
    Weng Naidong
    Covance Laboratories Inc, Department of Bioanalytical Chemistry, 3301 Kinsman Boulevard, Madison, WI 53704, USA
    J Pharm Biomed Anal 32:609-17. 2003
    ..The inter-day precision of the quality control (QC) samples was 3.5-9.4% relative standard deviation (R.S.D.). The inter-day accuracy of the QC samples was 99.0-107.9% of the nominal values...
  7. ncbi request reprint Simultaneous development of six LC-MS-MS methods for the determination of multiple analytes in human plasma
    Weng Naidong
    Bioanalytical Chemistry Department, Covance Laboratories, Inc, 3301 Kinsman Boulevard, Madison, WI 53704, USA
    J Pharm Biomed Anal 28:1115-26. 2002
    ..Recovery of analytes was determined. Matrix effects and interference due to endogenous compounds were investigated. Selection of a potential internal standard was discussed...
  8. ncbi request reprint Simultaneous determination of hydrocodone and hydromorphone in human plasma by liquid chromatography with tandem mass spectrometric detection
    Yu Luan Chen
    Department of Bioanalytical Chemistry, Covance Laboratories Inc, Madison, WI 53704, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 769:55-64. 2002
    ..No detectable carryover was observed when a blank sample was injected immediately after a 2500 ng/ml sample that was 25-fold more concentrated than the upper limit of quantitation (ULOQ)...
  9. ncbi request reprint Liquid chromatography/tandem mass spectrometric bioanalysis using normal-phase columns with aqueous/organic mobile phases - a novel approach of eliminating evaporation and reconstitution steps in 96-well SPE
    Weng Naidong
    Bioanalytical Chemistry Department, Covance Laboratories, Inc, 3301 Kinsman Boulevard, Madison, WI 53704, USA
    Rapid Commun Mass Spectrom 16:1965-75. 2002
    ..These bioanalytical LC/MS/MS methods were validated according to "Guidance for Industry - Bioanalytical Method Validation" recommended by the Food and Drug Administration (FDA) of the United States...
  10. ncbi request reprint Importance of injection solution composition for LC-MS-MS methods
    W Naidong
    Covance Laboratories Inc, Department of Bioanalytical Chemistry, 3301 Kinsman Boulevard, Madison, WI 53707, USA
    J Pharm Biomed Anal 26:753-67. 2001
    ..Poor peak shape was observed when the injection solution had a stronger eluting strength than mobile phase, particularly for early eluting peaks...
  11. ncbi request reprint Novel liquid chromatographic-tandem mass spectrometric methods using silica columns and aqueous-organic mobile phases for quantitative analysis of polar ionic analytes in biological fluids
    W Naidong
    Covance Laboratories, Inc, Madison, WI 53704, USA
    J Chromatogr B Biomed Sci Appl 754:387-99. 2001
    ..Up to a 20-fold sensitivity increase was observed for acidic polar ionic compounds. Silica columns and aqueous-organic mobile phases were used for assaying nicotine, cotinine, and albuterol in biological fluids...
  12. ncbi request reprint Development and validation of a sensitive and robust LC-tandem MS method for the analysis of warfarin enantiomers in human plasma
    W Naidong
    Department of Bioanalytical Chemistry, Covance Laboratories, Inc, 3301 Kinsman Boulevard, Madison, WI 53704, USA
    J Pharm Biomed Anal 25:219-26. 2001
    ..5% RSD and <5.8% bias for R-WAR, respectively. Analyte stability during sample processing and storage were established. Method ruggedness was demonstrated by the reproducible performance from analysis of clinical samples...
  13. ncbi request reprint A highly automated 96-well solid phase extraction and liquid chromatography/tandem mass spectrometry method for the determination of fentanyl in human plasma
    W Z Shou
    Bioanalytical Chemistry, Covance Laboratories Inc, 3301 Kinsman Boulevard, Madison, Wisconsin 53704, USA
    Rapid Commun Mass Spectrom 15:466-76. 2001
    ..The automation of the sample preparation steps not only increased the analysis throughput, but also facilitated the transfer of the method between different bioanalytical laboratories of the same organization...
  14. ncbi request reprint Ultrafast liquid chromatography/tandem mass spectrometry bioanalysis of polar analytes using packed silica columns
    Wilson Z Shou
    Covance Laboratories Inc, 3301 Kinsman Boulevard, Madison, WI 53704, USA
    Rapid Commun Mass Spectrom 16:1613-21. 2002
    ....
  15. ncbi request reprint Determination of S-phenylmercapturic acid in human urine using an automated sample extraction and fast liquid chromatography-tandem mass spectrometric method
    Yinghe Li
    Covance Laboratories Inc, Madison, WI 53704, USA
    Biomed Chromatogr 20:597-604. 2006
    ..With the fully automated sample cleanup procedure and the fast LC-MS/MS analysis, a sample analysis throughput of 384 samples per day could be achieved...
  16. ncbi request reprint Simultaneous determination of norethindrone and ethinyl estradiol in human plasma by high performance liquid chromatography with tandem mass spectrometry--experiences on developing a highly selective method using derivatization reagent for enhancing sensi
    Wenkui Li
    Department of Bioanalytical Chemistry, Covance Laboratories Inc, 3301 Kinsman Blvd Madison, WI 53704, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 825:223-32. 2005
    ..This method could be used for pharmacokinetic and drug-drug interaction studies in human subjects...
  17. ncbi request reprint Simple means to alleviate sensitivity loss by trifluoroacetic acid (TFA) mobile phases in the hydrophilic interaction chromatography-electrospray tandem mass spectrometric (HILIC-ESI/MS/MS) bioanalysis of basic compounds
    Wilson Z Shou
    Covance Laboratories Inc, 3301 Kinsman Boulevard, Madison, WI 53704, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 825:186-92. 2005
    ..This method has been successfully applied to the HILIC-ESI/MS/MS high-throughput analysis of extracted biological samples to support pre-clinical and clinical studies...
  18. ncbi request reprint A novel approach to perform metabolite screening during the quantitative LC-MS/MS analyses of in vitro metabolic stability samples using a hybrid triple-quadrupole linear ion trap mass spectrometer
    Wilson Z Shou
    Covance Laboratories Inc, 3301 Kinsman Boulevard, Madison, Wisconsin 53704, USA
    J Mass Spectrom 40:1347-56. 2005
    ..The time-concentration profiles of identified metabolites were also estimated from the acquired data. This approach has been successfully used to support discovery programs...
  19. ncbi request reprint Automated 96-well solid phase extraction and hydrophilic interaction liquid chromatography-tandem mass spectrometric method for the analysis of cetirizine (ZYRTEC) in human plasma--with emphasis on method ruggedness
    Qi Song
    Covance Bioanalytical Services, LLC, 8211 SciCor Drive, Suite B, Indianapolis, IN 46214, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 814:105-14. 2005
    ..Practical issues of analyzing incurred samples were discussed. This HILIC-MS/MS method for analysis of citirizine in human plasma was successfully used to support clinical studies...
  20. ncbi request reprint Direct injection of 96-well organic extracts onto a hydrophilic interaction chromatography/tandem mass spectrometry system using a silica stationary phase and an aqueous/organic mobile phase
    Weng Naidong
    Rapid Commun Mass Spectrom 18:2963-8. 2004
  21. ncbi request reprint Direct injection of solid-phase extraction eluents onto silica columns for the analysis of polar compounds isoniazid and cetirizine in plasma using hydrophilic interaction chromatography with tandem mass spectrometry
    Austin C Li
    Covance Laboratories, Inc, 3301 Kinsman Blvd, Madison, WI, USA
    Rapid Commun Mass Spectrom 18:2343-50. 2004
    ..Substantial time savings were realized as a result of both the elimination of the evaporation and reconstitution steps and the fast chromatographic analysis...
  22. ncbi request reprint Simultaneous assay of sildenafil and desmethylsildenafil in human plasma using liquid chromatography-tandem mass spectrometry on silica column with aqueous-organic mobile phase
    Angela Eerkes
    Covance Laboratories Inc, Madison, WI 53704, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 768:277-84. 2002
    ..The low limit of quantitation was 1.0 ng/ml for both SIL and DMS. The method was validated to meet the criteria of current industrial guidance for quantitative bioanalytical methods...
  23. ncbi request reprint Post-column infusion study of the 'dosing vehicle effect' in the liquid chromatography/tandem mass spectrometric analysis of discovery pharmacokinetic samples
    Wilson Z Shou
    Covance Laboratories Inc, 3301 Kinsman Boulevard, Madison, WI 53704, USA
    Rapid Commun Mass Spectrom 17:589-97. 2003
    ..A simple but effective means of identifying a 'dosing vehicle effect' is also proposed...
  24. ncbi request reprint Determination of ketoconazole in human plasma by high-performance liquid chromatography-tandem mass spectrometry
    Yu Luan Chen
    Department of Bioanalytical Chemistry, Covance Laboratories Inc, 3301 Kinsman Boulevard, Madison, WI 53704, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 774:67-78. 2002
    ..Three freeze-thaw cycles, keeping plasma samples at ambient for 24 h, storing extracted samples at ambient for 24 h, and storing frozen plasma samples at approximately -20 degrees C for up to 2 months did not show substantial effects...
  25. ncbi request reprint Liquid/liquid extraction using 96-well plate format in conjunction with hydrophilic interaction liquid chromatography-tandem mass spectrometry method for the analysis of fluconazole in human plasma
    Angela Eerkes
    Covance Laboratories Inc, Department of Bioanalytical Chemistry, 3301 Kinsman Boulevard, Madison, WI 53704, USA
    J Pharm Biomed Anal 31:917-28. 2003
    ..The standard curve range was 0.5-100 ng ml(-1). The inter-day precision and accuracy of the quality control samples were <7.1% relative standard deviation and <2.2% relative error...
  26. ncbi request reprint Development, validation and transfer of a hydrophilic interaction liquid chromatography/tandem mass spectrometric method for the analysis of the tobacco-specific nitrosamine metabolite NNAL in human plasma at low picogram per milliliter concentrations
    Jiongwei Pan
    Covance Bioanalytical Chemistry, Madison, WI 53704, USA
    Rapid Commun Mass Spectrom 18:2549-57. 2004
    ..Optimization of enzyme hydrolysis of NNAL-gluc is discussed in detail. The overall recoveries for free and total NNAL and IS were 68.2 and 71.5% (free) and 70.7 and 65.5% (total). No adverse matrix effects were noticed for this assay...
  27. ncbi request reprint Development and validation of a liquid chromatography/tandem mass spectrometry (LC/MS/MS) method for the determination of ribavirin in human plasma and serum
    Wilson Z Shou
    Department of Analytical Chemistry, Covance Laboratories Inc, 3301 Kinsman Boulevard, Madison, WI 53704, USA
    J Pharm Biomed Anal 29:83-94. 2002
    ..Bamethan was used as the internal standard. The protein precipitation extraction has been automated based on 96-well format with the use of robotic liquid handlers to improve the overall throughput of the analysis...
  28. ncbi request reprint The use of chemical derivatization to enhance liquid chromatography/tandem mass spectrometric determination of 1-hydroxypyrene, a biomarker for polycyclic aromatic hydrocarbons in human urine
    Yinghe Li
    Covance Laboratories Inc, 3301 Kinsman Boulevard, Madison, Wisconsin, USA
    Rapid Commun Mass Spectrom 19:3331-8. 2005
    ..This is the first report of using chemical derivatization to enhance MS/MS detection with fast chromatography in the determination of 1-OHP in human urine...
  29. ncbi request reprint Assay and purity control of tetracycline, chlortetracycline and oxytetracycline in animal feeds and premixes by TLC densitometry with fluorescence detection
    Weng Naidong
    Laboratorium voor Farmaceutische Chemie en Analyse van Geneesmiddelen, Faculteit Farmaceutische Wetenschappen, Katholieke Universiteit Leuven, Van Evenstraat 4, B 3000 Leuven, Belgium
    J Pharm Biomed Anal 33:85-93. 2003
    ..2% of the label-claimed TC (40 mg/g) and CTC (200 or 400 mg/g). The LOQ for impurities of oxytetracycline in a premix is 0.1% of the label claimed OTC (100 mg/g)...
  30. ncbi request reprint High-throughput biological sample analysis using on-line turbulent flow extraction combined with monolithic column liquid chromatography/tandem mass spectrometry
    Shaolian Zhou
    DMPK Bioanalytical Chemistry Department, Covance Laboratories Inc, Madison, WI 53704, USA
    Rapid Commun Mass Spectrom 19:2144-50. 2005
    ..It was demonstrated that the total run time for this assay with a baseline separation of two analytes is less than 1.5 min...
  31. ncbi request reprint Hydrophilic interaction liquid chromatographic tandem mass spectrometric determination of atenolol in human plasma
    Wenkui Li
    Covance Laboratories Inc, Madison, WI 53704, USA
    Biomed Chromatogr 19:385-93. 2005
    ..68 and 0.75 min, respectively. The present method could be used for therapeutic drug monitoring, pharmacokinetic and drug--drug interaction studies of beta-blocking agents...
  32. ncbi request reprint Liquid chromatographic-electrospray tandem mass spectrometric determination of clarithromycin in human plasma
    Wenkui Li
    Department of Bioanalytical Chemistry, Covance Laboratories Inc, 3301 Kinsman Blvd, Madison, WI 53704, USA
    Biomed Chromatogr 20:1242-51. 2006
    ..The mean recovery was 81.5 and 78.3%, respectively, for clarithromycin and internal standard...