KENDALL SMITH

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. pmc Immunotherapy with canarypox vaccine and interleukin-2 for HIV-1 infection: termination of a randomized trial
    Kendall A Smith
    The Division of Immunology, Department of Medicine, Weill Medical College of Cornell University, New York, New York, United States of America
    PLoS Clin Trials 2:e5. 2007
  2. pmc DNA array analysis of interleukin-2-regulated immediate/early genes
    Carol Beadling
    Division of Immunology, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    Med Immunol 1:2. 2002
  3. pmc Negative feedback regulation of T cells via interleukin-2 and FOXP3 reciprocity
    Zoran Popmihajlov
    Division of Immunology, Department of Medicine, Weill Medical College, Cornell University, New York, New York, USA
    PLoS ONE 3:e1581. 2008
  4. pmc The structure of IL2 bound to the three chains of the IL2 receptor and how signaling occurs
    Kendall A Smith
    The Division of Immunology, Department of Medicine, Weill Medical College, Cornell University, New York, NY 10021, USA
    Med Immunol 5:3. 2006
  5. pmc Edward jenner and the small pox vaccine
    Kendall A Smith
    Division of Immunology, Department of Medicine, Weill Medical College of Cornell University New York, NY, USA
    Front Immunol 2:21. 2011
  6. pmc Louis pasteur, the father of immunology?
    Kendall A Smith
    The Division of Immunology, Department of Medicine, Weill Medical College, Cornell University New York, NY, USA
    Front Immunol 3:68. 2012
  7. pmc Conditional IL-2 Gene Deletion: Consequences for T Cell Proliferation
    Zoran Popmihajlov
    Division of Immunology, Department of Medicine, Weill Cornell Medical College New York, NY, USA
    Front Immunol 3:102. 2012
  8. pmc Toward a molecular understanding of adaptive immunity: a chronology - part II
    Kendall A Smith
    The Division of Immunology, Department of Medicine, Weill Medical College, Cornell University New York, NY, USA
    Front Immunol 3:364. 2012
  9. pmc Toward a molecular understanding of adaptive immunity: a chronology, part I
    Kendall A Smith
    Division of Immunology, Department of Medicine, Weill Medical College, Cornell University New York, NY, USA
    Front Immunol 3:369. 2012
  10. pmc Optimal clinical trial designs for immune-based therapies in persistent viral infections
    Kendall A Smith
    Weill Medical College of Cornell University Division of Immunology, Department of Medicine 1300 York Avenue, Box 41 New York, NY 10021, USA
    Med Immunol 1:4. 2002

Research Grants

  1. T CELL CYCLE REGULATION BY CYTOKINE-RESPONSIVE GENES
    KENDALL SMITH; Fiscal Year: 2003
  2. INTERLEUKIN 2 IMMUNOTHERAPY FOR HCV INFECTION
    KENDALL SMITH; Fiscal Year: 2004
  3. Hiv Immune Reactivity 'in Vivo' and 'In Vitro'
    KENDALL SMITH; Fiscal Year: 2006

Collaborators

  • Genoveffa Franchini
  • EDWARD J WHERRY
  • A Kinter
  • Zoran Popmihajlov
  • Janos Nacsa
  • Elzbieta Tryniszewska
  • Deborah J Stauber
  • David Venzon
  • Marcin Moniuszko
  • Joseph N Blattman
  • Carol Beadling
  • Heather Morgan
  • Zoie Milligan
  • Dong Xu
  • Erik W Debler
  • Patricia A Horton
  • Ian A Wilson
  • Yvette Edghill-Smith
  • Anna Hryniewicz
  • Wen Po Tsai
  • Rafi Ahmed
  • Jason M Grayson
  • Susan M Kaech
  • David Montefiori
  • Jim Tartaglia
  • Zdenek Hel
  • Mark G Lewis
  • Peter Silvera
  • Robyn Washington Parks

Detail Information

Publications33

  1. pmc Immunotherapy with canarypox vaccine and interleukin-2 for HIV-1 infection: termination of a randomized trial
    Kendall A Smith
    The Division of Immunology, Department of Medicine, Weill Medical College of Cornell University, New York, New York, United States of America
    PLoS Clin Trials 2:e5. 2007
    ..To determine whether immunotherapy of chronic HIV-1 infection can prevent or attenuate viremia upon antiviral discontinuation...
  2. pmc DNA array analysis of interleukin-2-regulated immediate/early genes
    Carol Beadling
    Division of Immunology, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    Med Immunol 1:2. 2002
    ..This approach should allow the discovery of genes regulated by all of the ligand/receptor pairs involved in lymphocyte activation...
  3. pmc Negative feedback regulation of T cells via interleukin-2 and FOXP3 reciprocity
    Zoran Popmihajlov
    Division of Immunology, Department of Medicine, Weill Medical College, Cornell University, New York, New York, USA
    PLoS ONE 3:e1581. 2008
    ....
  4. pmc The structure of IL2 bound to the three chains of the IL2 receptor and how signaling occurs
    Kendall A Smith
    The Division of Immunology, Department of Medicine, Weill Medical College, Cornell University, New York, NY 10021, USA
    Med Immunol 5:3. 2006
    ..What do we know now that we did not know before this structural information was available, and how do these new data help us to develop new therapies?..
  5. pmc Edward jenner and the small pox vaccine
    Kendall A Smith
    Division of Immunology, Department of Medicine, Weill Medical College of Cornell University New York, NY, USA
    Front Immunol 2:21. 2011
    ..Also, the vaccine that Jenner used, which decreased the prevalence of Small Pox worldwide in his own time, and later was used to eradicate Small Pox altogether, is discussed in light of recent data...
  6. pmc Louis pasteur, the father of immunology?
    Kendall A Smith
    The Division of Immunology, Department of Medicine, Weill Medical College, Cornell University New York, NY, USA
    Front Immunol 3:68. 2012
    ..This review chronicles Pasteur's remarkable metamorphosis from organic chemist to microbiologist to immunologist, and from basic science to medicine...
  7. pmc Conditional IL-2 Gene Deletion: Consequences for T Cell Proliferation
    Zoran Popmihajlov
    Division of Immunology, Department of Medicine, Weill Cornell Medical College New York, NY, USA
    Front Immunol 3:102. 2012
    ....
  8. pmc Toward a molecular understanding of adaptive immunity: a chronology - part II
    Kendall A Smith
    The Division of Immunology, Department of Medicine, Weill Medical College, Cornell University New York, NY, USA
    Front Immunol 3:364. 2012
    ..Thus, adaptive immunity receives antigen-specific activation signals from the environment and turns them into antigen non-specific endogenous action signals...
  9. pmc Toward a molecular understanding of adaptive immunity: a chronology, part I
    Kendall A Smith
    Division of Immunology, Department of Medicine, Weill Medical College, Cornell University New York, NY, USA
    Front Immunol 3:369. 2012
    ..This review is the first part of a chronology of our evolution toward a molecular understanding of adaptive immunity...
  10. pmc Optimal clinical trial designs for immune-based therapies in persistent viral infections
    Kendall A Smith
    Weill Medical College of Cornell University Division of Immunology, Department of Medicine 1300 York Avenue, Box 41 New York, NY 10021, USA
    Med Immunol 1:4. 2002
    ..This commentary explores the rationale of using "Diagnostic Treatment Interruptions" of antiviral therapies to determine efficacies of immune-based therapies...
  11. pmc The continuing HIV vaccine saga: naked emperors alongside fairy godmothers
    Kendall A Smith
    The Division of Immunology, Department of Medicine, Weill Medical College, Cornell University, New York, NY USA
    Med Immunol 4:6. 2005
    ..This Commentary summarizes some of the highlights from this meeting, and focuses on some of the developments that appeared particularly promising, as well as those that do not. Unfortunately, the "saga" continues...
  12. pmc Wanted, an Anthrax vaccine: Dead or Alive?
    Kendall A Smith
    The Division of Immunology, Department of Medicine, Weill Medical College, Cornell University, New York, NY, 10021, USA
    Med Immunol 4:5. 2005
    ..This editorial focuses on the history of anthrax as a microbial disease, and the earliest efforts at producing a vaccine for its prevention...
  13. pmc The Classics of Immunology
    Kendall A Smith
    The Division of Immunology Department of Medicine Weill Medical College Cornell University New York, NY 10021 USA
    Med Immunol 4:3. 2005
    ..To begin this process at the very dawn of immunology, we highlight Sir Edward Jenner's first descriptions of the use of cowpox to immunize individuals against the dread disease smallpox...
  14. pmc The HIV vaccine saga
    Kendall A Smith
    The Division of Immunology, Department of Medicine, Weill Medical College, Cornell University, New York, NY 10021, USA
    Med Immunol 2:1. 2003
    ..SAGA: (Old Norse) "a long, continued heroic story that is action-packed, but not especially romantic, and that is historical or legendary or both"...
  15. pmc The quantal theory of how the immune system discriminates between "self and non-self"
    Kendall A Smith
    The Division of Immunology, Department of Medicine, Weill Medical College, Cornell University, New York, New York, United States of America
    Med Immunol 3:3. 2004
    ....
  16. pmc Smallpox: can we still learn from the journey to eradication?
    Kendall A Smith
    The Division of Immunology, Department of Medicine, Weill Medical College, Cornell University, New York, USA
    Indian J Med Res 137:895-9. 2013
    ..Accordingly vaccinia itself, and not modified replication incompetent vaccina, is the hope for use as a vector in the eradication of additional pathogenic microbes from the globe...
  17. pmc Following the cytokine signaling pathway to leukemogenesis: a chronology
    Kendall A Smith
    Department of Medicine, Weill Medical College, Cornell University, New York, New York 10065, USA
    J Clin Invest 118:3564-73. 2008
    ..Based on the paradigm established by these data, it is inescapable that going forward, investigators will operate under the hypothesis that transformation of additional cells and tissues will have a similar pathogenesis...
  18. ncbi request reprint To cure chronic HIV infection, a new therapeutic strategy is needed
    K A Smith
    The Division of Immunology, Department of Medicine, Weill Medical College, Cornell University, New York, NY 10021, USA
    Curr Opin Immunol 13:617-24. 2001
    ....
  19. doi request reprint The quantal theory of immunity and the interleukin-2-dependent negative feedback regulation of the immune response
    Kendall A Smith
    Department of Medicine, The Division of Immunology, Weill Medical College, Cornell University, New York, NY, USA
    Immunol Rev 224:124-40. 2008
    ..In contrast, we found no evidence that FOXP3(+) cells actively suppress IL-2 expression, thereby failing to support the notion that such cells regulate potential effector cells...
  20. ncbi request reprint The quantal theory of immunity
    Kendall A Smith
    The Division of Immunology, Department of Medicine, Weill Medical College, Cornell University, New York, NY 10021, USA
    Cell Res 16:11-9. 2006
    ....
  21. ncbi request reprint Low-dose daily interleukin-2 immunotherapy: accelerating immune restoration and expanding HIV-specific T-cell immunity without toxicity
    K A Smith
    Division of Immunology, Weill Medical College of Cornell University, New York, New York 10021, USA
    AIDS 15:S28-35. 2001
    ..At least two signals are required to promote the proliferative expansion and function of antiviral effector lymphocytes, HIV antigens and IL-2...
  22. ncbi request reprint Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo
    Joseph N Blattman
    Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, USA
    Nat Med 9:540-7. 2003
    ..Thus, timing of IL-2 administration and differentiation status of the T cell are critical parameters in designing IL-2 therapies...
  23. ncbi request reprint Vaccination of macaques with long-standing SIVmac251 infection lowers the viral set point after cessation of antiretroviral therapy
    Elzbieta Tryniszewska
    Basic Research Laboratory, National Cancer Institute, Bethesda, MD 20892, USA
    J Immunol 169:5347-57. 2002
    ..These data provide the proof of concept that therapeutic vaccination before cessation of ART may be a feasible approach in the clinical management of HIV-1 infection...
  24. ncbi request reprint New strategies to combat HIV: augmenting antiviral immunity
    Kendall A Smith
    Division of Immunology, New York Presbyterian Hospital Weill Medical College of Cornell University, New York, USA
    AIDS Read 13:365-9, 382. 2003
  25. ncbi request reprint Contrasting effects of low-dose IL-2 on vaccine-boosted simian immunodeficiency virus (SIV)-specific CD4+ and CD8+ T cells in macaques chronically infected with SIVmac251
    Janos Nacsa
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892, USA
    J Immunol 174:1913-21. 2005
    ..Thus, we conclude that the decrease in virus-specific CD4+ T cell response may be due to IL-2-promoted redistribution of cells from the circulation, or due to Ag-induced cell death, rather than suppression by a T regulatory population...
  26. pmc Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor
    Deborah J Stauber
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 103:2788-93. 2006
    ..The IL-2/gamma(c) interface itself exhibits the smallest buried surface and the fewest hydrogen bonds in the complex, which is consistent with its promiscuous use in other cytokine receptor complexes...

Research Grants3

  1. T CELL CYCLE REGULATION BY CYTOKINE-RESPONSIVE GENES
    KENDALL SMITH; Fiscal Year: 2003
    ..abstract_text> ..
  2. INTERLEUKIN 2 IMMUNOTHERAPY FOR HCV INFECTION
    KENDALL SMITH; Fiscal Year: 2004
    ..This approach should prove beneficial in improving the proportion of patients who recover from HCV infection, and as well, introduce immunologic tests that may be predictive of responsiveness to therapy. ..
  3. Hiv Immune Reactivity 'in Vivo' and 'In Vitro'
    KENDALL SMITH; Fiscal Year: 2006
    ..Thus, this project is designed to determine the capacity of IBTs to control HIV, and to develop laboratory assays that are predictive of effective HIV immunty. ..