- Schnurri-3 regulates ERK downstream of WNT signaling in osteoblastsJae Hyuck Shim
Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York 10065, USA
J Clin Invest 123:4010-22. 2013..Inducible knockdown of Shn3 in adult mice resulted in a high-bone mass phenotype, providing evidence that transient blockade of these pathways in adults holds promise as a therapy for osteoporosis...
- Zinc inhibits osteoclast differentiation by suppression of Ca2+-Calcineurin-NFATc1 signaling pathwayKwang Hwan Park
Department of Microbiology, Yonsei University College of Medicine, Seoul, Republic of Korea
Cell Commun Signal 11:74. 2013..7 cells...
- CHMP5 controls bone turnover rates by dampening NF-κB activity in osteoclastsMatthew B Greenblatt
Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115 Department of Medicine and Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065
J Exp Med 212:1283-301. 2015..Thus, CHMP5 tunes NF-κB signaling downstream of RANK in osteoclasts to dampen osteoclast differentiation, osteoblast coupling and bone turnover rates, and disruption of CHMP5 activity results in a PDB-like skeletal disorder. ..