BRIAN LAZZARO

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. pmc The effect of three environmental conditions on the fitness of cytochrome P450 monooxygenase-mediated permethrin resistance in Culex pipiens quinquefasciatus
    Melissa C Hardstone
    Department of Entomology, Comstock Hall, Cornell University, Ithaca, NY, USA
    BMC Evol Biol 9:42. 2009
  2. pmc Genotype-by-environment interactions and adaptation to local temperature affect immunity and fecundity in Drosophila melanogaster
    Brian P Lazzaro
    Department of Entomology, Cornell University, Ithaca, New York, USA
    PLoS Pathog 4:e1000025. 2008
  3. ncbi request reprint Disease pathology: wasting energy fighting infection
    Brian P Lazzaro
    Department of Entomology, Field of Genetics and Development, Cornell University, Ithaca, New York 15843, USA
    Curr Biol 16:R964-5. 2006
  4. pmc Genetic variation in Drosophila melanogaster resistance to infection: a comparison across bacteria
    Brian P Lazzaro
    Department of Entomology, Field of Ecology and Evolutionary Biology, Cornell University, Ithaca, New York 14853, USA
    Genetics 174:1539-54. 2006
  5. pmc Elevated polymorphism and divergence in the class C scavenger receptors of Drosophila melanogaster and D. simulans
    Brian P Lazzaro
    Department of Entomology, Cornell University, Ithaca, New York 14853, USA
    Genetics 169:2023-34. 2005
  6. ncbi request reprint Genetic basis of natural variation in D. melanogaster antibacterial immunity
    Brian P Lazzaro
    Department of Entomology, 4138 Comstock Hall, Cornell University, Ithaca, NY 14853, USA
    Science 303:1873-6. 2004
  7. doi request reprint Providencia sneebia sp. nov. and Providencia burhodogranariea sp. nov., isolated from wild Drosophila melanogaster
    Punita Juneja
    Department of Entomology, Cornell University, Ithaca, NY 14853, USA
    Int J Syst Evol Microbiol 59:1108-11. 2009
  8. pmc Immunity in a variable world
    Brian P Lazzaro
    Department of Entomology, Cornell University, Ithaca, NY 14850, USA
    Philos Trans R Soc Lond B Biol Sci 364:15-26. 2009
  9. pmc Natural selection on the Drosophila antimicrobial immune system
    Brian P Lazzaro
    Department of Entomology, Cornell University, Ithaca, NY 14853, USA
    Curr Opin Microbiol 11:284-9. 2008
  10. pmc Female and male genetic contributions to post-mating immune defence in female Drosophila melanogaster
    Sarah M Short
    Field of Genetics and Development, Cornell University, Ithaca, NY 14853, USA
    Proc Biol Sci 277:3649-57. 2010

Research Grants

Detail Information

Publications19

  1. pmc The effect of three environmental conditions on the fitness of cytochrome P450 monooxygenase-mediated permethrin resistance in Culex pipiens quinquefasciatus
    Melissa C Hardstone
    Department of Entomology, Comstock Hall, Cornell University, Ithaca, NY, USA
    BMC Evol Biol 9:42. 2009
    ....
  2. pmc Genotype-by-environment interactions and adaptation to local temperature affect immunity and fecundity in Drosophila melanogaster
    Brian P Lazzaro
    Department of Entomology, Cornell University, Ithaca, New York, USA
    PLoS Pathog 4:e1000025. 2008
    ..Both local adaptation to geographically heterogeneous environments and genotype-by-environment interactions may explain the persistence of genetic variation for resistance to infection in natural populations...
  3. ncbi request reprint Disease pathology: wasting energy fighting infection
    Brian P Lazzaro
    Department of Entomology, Field of Genetics and Development, Cornell University, Ithaca, New York 15843, USA
    Curr Biol 16:R964-5. 2006
    ..Drosophila melanogaster infected with Mycobacterium marinum suffer metabolic wasting similar to that seen in humans suffering from tuberculosis. This wasting is linked to insulin signaling and hastens host death...
  4. pmc Genetic variation in Drosophila melanogaster resistance to infection: a comparison across bacteria
    Brian P Lazzaro
    Department of Entomology, Field of Ecology and Evolutionary Biology, Cornell University, Ithaca, New York 14853, USA
    Genetics 174:1539-54. 2006
    ..lactis and E. faecalis, respectively, most of the molecular polymorphisms tested explain <10% of the total variance in bacterial load sustained after infection...
  5. pmc Elevated polymorphism and divergence in the class C scavenger receptors of Drosophila melanogaster and D. simulans
    Brian P Lazzaro
    Department of Entomology, Cornell University, Ithaca, New York 14853, USA
    Genetics 169:2023-34. 2005
    ..Interestingly, Sr-CIII and Sr-CIV are polymorphic for premature stop codons. Sr-CIV is also polymorphic for an in-frame 101-codon deletion and for the absence of one intron...
  6. ncbi request reprint Genetic basis of natural variation in D. melanogaster antibacterial immunity
    Brian P Lazzaro
    Department of Entomology, 4138 Comstock Hall, Cornell University, Ithaca, NY 14853, USA
    Science 303:1873-6. 2004
    ..Variation in these genes, therefore, seems to drive variability in immunocompetence among wild Drosophila...
  7. doi request reprint Providencia sneebia sp. nov. and Providencia burhodogranariea sp. nov., isolated from wild Drosophila melanogaster
    Punita Juneja
    Department of Entomology, Cornell University, Ithaca, NY 14853, USA
    Int J Syst Evol Microbiol 59:1108-11. 2009
    ..nov. (type strain A(T) =DSM 19967(T) =ATCC BAA-1589(T)) and Providencia burhodogranariea sp. nov. (type strain B(T) =DSM 19968(T) =ATCC BAA-1590(T)) are proposed...
  8. pmc Immunity in a variable world
    Brian P Lazzaro
    Department of Entomology, Cornell University, Ithaca, NY 14850, USA
    Philos Trans R Soc Lond B Biol Sci 364:15-26. 2009
    ..Our aim is to describe how environmental and genetic heterogeneities, often excluded from experimentation as 'noise', may determine the evolutionary potential of populations or the potential for interacting species to coevolve...
  9. pmc Natural selection on the Drosophila antimicrobial immune system
    Brian P Lazzaro
    Department of Entomology, Cornell University, Ithaca, NY 14853, USA
    Curr Opin Microbiol 11:284-9. 2008
    ..The distinct evolutionary patterns exhibited by these various classes of immune system genes can be logically connected to the functions of the proteins they encode...
  10. pmc Female and male genetic contributions to post-mating immune defence in female Drosophila melanogaster
    Sarah M Short
    Field of Genetics and Development, Cornell University, Ithaca, NY 14853, USA
    Proc Biol Sci 277:3649-57. 2010
    ..We thus conclude that post-mating immune depression is predominantly a 'female' trait, and find no evidence that it is evolving under sexual conflict...
  11. ncbi request reprint Evolution of genes and genomes on the Drosophila phylogeny
    Andrew G Clark
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Nature 450:203-18. 2007
    ..These may prove to underlie differences in the ecology and behaviour of these diverse species...
  12. ncbi request reprint Dynamic evolution of the innate immune system in Drosophila
    Timothy B Sackton
    Field of Ecology and Evolutionary Biology, Cornell University, Ithaca, New York 14853, USA
    Nat Genet 39:1461-8. 2007
    ....
  13. pmc Haplotype structure and expression divergence at the Drosophila cellular immune gene eater
    Punita Juneja
    Department of Entomology, Cornell University, Ithaca, New York, USA
    Mol Biol Evol 27:2284-99. 2010
    ..Our study presents an instance where gene expression rather than protein structure is thought to drive the adaptive evolution of a pathogen recognition molecule in the immune system...
  14. pmc Genotype and gene expression associations with immune function in Drosophila
    Timothy B Sackton
    Field of Ecology and Evolutionary Biology, Cornell University, Ithaca, New York, United States of America
    PLoS Genet 6:e1000797. 2010
    ..These results show that polymorphism in genes near the top of the immune system signaling cascade can have a disproportionate effect on organismal phenotype due to the amplification of minor effects through the cascade...
  15. doi request reprint Larval food quality affects adult (but not larval) immune gene expression independent of effects on general condition
    Simon Fellous
    Department of Entomology, Cornell University, Ithaca, NY 14853, USA
    Mol Ecol 19:1462-8. 2010
    ..We conclude that the nutritional environment of insect larvae can affect adult immunity by influencing plastic allocation of resources. These influences are less predictable than constraints linked to general condition would be...
  16. ncbi request reprint Molecular population genetics of inducible antibacterial peptide genes in Drosophila melanogaster
    Brian P Lazzaro
    Molecular Biology and Genetics, Cornell University, USA
    Mol Biol Evol 20:914-23. 2003
    ....
  17. pmc The evolutionary costs of immunological maintenance and deployment
    Kurt A McKean
    Department of Biological Sciences, SUNY at Albany, Albany NY 12222, USA
    BMC Evol Biol 8:76. 2008
    ....
  18. pmc DNA sequence polymorphism and divergence at the erect wing and suppressor of sable loci of Drosophila melanogaster and D. simulans
    John M Braverman
    Department of Biology, Georgetown University, Washington, DC 20057 1229, USA
    Genetics 170:1153-65. 2005
    ..The reduction of polymorphism at su(s) combined with the excess of high-frequency variants in D. simulans is inconsistent with the hitchhiking and background-selection models...
  19. ncbi request reprint fRFLP and fAFLP: medium-throughput genotyping by fluorescently post-labeling restriction digestion
    Brian P Lazzaro
    Pennsylvania State University, University Park, USA
    Biotechniques 33:539-40, 542, 545-6. 2002
    ....

Research Grants1

  1. Evolutionary Genomics of Anti-Malaria Genes in Mosquito
    Brian P Lazzaro; Fiscal Year: 2010
    ..Evolutionary patterns in mosquito defense genes will be used to identify proteins that coevolve with malaria parasites. This work may suggest genetic targets that could be manipulated to limit malaria transmission. ..