Philip C Spinella
Affiliation: Connecticut Children's Medical Center
- Warm fresh whole blood transfusion for severe hemorrhage: U.S. military and potential civilian applicationsPhilip C Spinella
Connecticut Children s Medical Center, Hartford, CT, USA
Crit Care Med 36:S340-5. 2008..S. Army research from Afghanistan and Iraq. We also discuss current indications for its use as well as potential civilian applications for large-scale disasters...
- Risks associated with fresh whole blood and red blood cell transfusions in a combat support hospitalPhilip C Spinella
U S Army Institute of Surgical Research, San Antonio, TX, USA
Crit Care Med 35:2576-81. 2007..Fresh whole blood (FWB) and red blood cells (RBCs) are transfused to injured casualties in combat support hospitals. We evaluated the risks of FWB and RBCs transfused to combat-related casualties...
- The effect of recombinant activated factor VII on mortality in combat-related casualties with severe trauma and massive transfusionPhilip C Spinella
US Army Institute of Surgical Research, San Antonio, Texas, USA
J Trauma 64:286-93; discussion 293-4. 2008....
- Increased mortality associated with the early coagulopathy of trauma in combat casualtiesSarah E Niles
USA MEDDAC Bavaria S E N, Vilseck, Germany
J Trauma 64:1459-63; discussion 1463-5. 2008..We hypothesized that acute coagulopathy (international normalized ratio >/=1.5) in combat casualties was associated with increased injury severity and mortality as is seen in civilian trauma patients...
- Pediatric trauma in an austere combat environmentPhilip C Spinella
Department of Pediatrics PCS, Connecticut Children s Medical Center, Hartford, CT, USA
Crit Care Med 36:S293-6. 2008..S. combat support hospitals and to provide insight into both critical care and noncritical care challenges this presents...
- Balanced massive transfusion ratios in multiple injury patients with traumatic brain injurySigune Peiniger
Department of Trauma and Orthopedic Surgery, University of Witten Herdecke, Cologne Merheim Medical Centre, Ostmerheimerstrasse 200, D 51109 Cologne, Germany
Crit Care 15:R68. 2011....
- Association between length of storage of red blood cell units and outcome of critically ill children: a prospective observational studyOliver Karam
Pediatric Critical Care Unit, CHU Sainte Justine, Universite de Montreal, 3175 chemin de la Cote Sainte Catherine, Montreal, Canada
Crit Care 14:R57. 2010..No prospective study has been conducted in children. Our objectives were to assess the clinical impact of the length of storage of red blood cell units on clinical outcome of critically ill children...
- Survey of transfusion policies at US and Canadian children's hospitals in 2008 and 2009Philip C Spinella
Department of Pediatrics, Connecticut Children s Hospital, Hartford, Connecticut, USA
Transfusion 50:2328-35. 2010..Our objective was to determine the current transfusion policies in US and Canadian children's hospitals for both neonatal and pediatric general populations...
- Resuscitation and transfusion principles for traumatic hemorrhagic shockPhilip C Spinella
University of Connecticut, Pediatric Intensivist, Department of Pediatrics, Department of Surgery, Connecticut Children s Medical Center, Hartford, CT 06106, USA
Blood Rev 23:231-40. 2009..Taken together, the preponderance of data suggests that these concepts may significantly decrease mortality in massively transfused trauma patients...
- Warm fresh whole blood is independently associated with improved survival for patients with combat-related traumatic injuriesPhilip C Spinella
United States Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
J Trauma 66:S69-76. 2009..We hypothesized that warm fresh whole blood (WFWB) transfusion would be associated with improved survival in patients with trauma compared with those transfused only stored component therapy (CT)...
- Effect of plasma and red blood cell transfusions on survival in patients with combat related traumatic injuriesPhilip C Spinella
Connecticut Children s Medical Center, Hartford, CT 06106, USA
J Trauma 64:S69-77; discussion S77-8. 2008..Our objective was to determine the independent effects of plasma and RBC transfusion on survival for patients with combat-related traumatic injuries receiving any blood products...
- The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospitalMatthew A Borgman
Brooke Army Medical Center, Fort Sam Houston, TX, USA
J Trauma 63:805-13. 2007..The risk of death from hemorrhagic shock increases in this population. To treat the coagulopathy of trauma, some have suggested early, aggressive correction using a 1:1 ratio of plasma to red blood cell (RBC) units...
- Ten-year analysis of transfusion in Operation Iraqi Freedom and Operation Enduring Freedom: increased plasma and platelet use correlates with improved survivalHeather F Pidcoke
US Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
J Trauma Acute Care Surg 73:S445-52. 2012....
- Ten years of military pediatric care in Afghanistan and IraqMatthew Borgman
Department of Pediatrics, Brooke Army Medical Center, San Antonio, Texas, USA
J Trauma Acute Care Surg 73:S509-13. 2012..This study's objective was to evaluate the burden and epidemiology of pediatric medical care during the past decade of military operations in Iraq and Afghanistan...
- Fresh whole blood transfusions in coalition military, foreign national, and enemy combatant patients during Operation Iraqi Freedom at a U.S. combat support hospitalPhilip C Spinella
U S Army Institute of Surgical Research, San Antonio, Texas, USA
World J Surg 32:2-6. 2008....
- Coagulopathy and shock on admission is associated with mortality for children with traumatic injuries at combat support hospitalsJason T Patregnani
Connecticut Children s Medical Center, Hartford, CT, USA
Pediatr Crit Care Med 13:273-7. 2012..Our objective was to determine whether coagulopathy and shock on admission are independently associated with mortality in children with traumatic injuries...
- The association of blood component use ratios with the survival of massively transfused trauma patients with and without severe brain injuryK J Brasel
Department of Pediatrics, St Louis Children s Hospital, St Louis, Missouri 63110, USA
J Trauma 71:S343-52. 2011..The effect of blood component ratios on the survival of patients with traumatic brain injury (TBI) has not been studied...
- The ratio of fibrinogen to red cells transfused affects survival in casualties receiving massive transfusions at an army combat support hospitalHarry K Stinger
Brooke Army Medical Center, U S Army Institute of Surgical Research, San Antonio, TX 78234 6200, USA
J Trauma 64:S79-85; discussion S85. 2008..Our objective was to determine whether increased ratios of fibrinogen to red blood cells (RBCs) decreased mortality in combat casualties requiring massive transfusion...
- Freeze-dried plasma at the point of injury: from concept to doctrineElon Glassberg
Surgeon General s Headquarters, Israel Defense Forces, and Department of Military Medicine, Hebrew University, Jerusalem, Israel Department of Pediatrics, Division of Critical Care, Washington University in St Louis, Missouri and US Army Institute of Surgical Research, Fort Sam Houston and Center for Translational Injury Research, Division of Acute Care Surgery, Department of Surgery, University of Texas Health Science Center at Houston, Houston, Texas
Shock 40:444-50. 2013..It is our hope that others will be able to learn from our experience, thus improving trauma casualty care around the world. ..
- Timing and location of blood product transfusion and outcomes in massively transfused combat casualtiesAndrew P Cap
United States Army Institute of Surgical Research, Fort Sam Houston, Texas 78234 6315, USA
J Trauma Acute Care Surg 73:S89-94. 2012..Mortality outcomes associated with early (first 6 hours) resuscitation incorporating platelets, for combat casualties requiring MT, have not been reported...
- Duration of red blood cell storage is associated with increased incidence of deep vein thrombosis and in hospital mortality in patients with traumatic injuriesPhilip C Spinella
Department of Pediatrics, Connecticut Children s Medical Center, 282 Washington Street, Hartford, CT 06106, USA
Crit Care 13:R151. 2009..To determine if duration of RBC storage is associated with adverse outcomes we studied critically ill trauma patients requiring transfusion...
- Increased mortality rates of young children with traumatic injuries at a US army combat support hospital in Baghdad, Iraq, 2004Renee I Matos
Department of Pediatrics, Lackland Air Force Base, TX 78236, USA
Pediatrics 122:e959-66. 2008..The objective of this study was to determine whether age <or=8 y is an independent predictor of mortality in noncoalition trauma patients at a US combat support hospital...
- Remote damage control resuscitation and the Solstrand Conference: defining the need, the language, and a way forwardRobert T Gerhardt
US Army Institute of Surgical Research, Department of Emergency Medicine, San Antonio Military Medical Center, Fort Sam Houston, Texas 78234, USA
Transfusion 53:9S-16S. 2013....
- Thromboelastography to direct the administration of recombinant activated factor VII in a child with traumatic injury requiring massive transfusionCade M Nylund
Department of Pediatrics, Willford Hall Medical Center, San Antonio, TX, USA
Pediatr Crit Care Med 10:e22-6. 2009..To describe the use of thromboelastography (TEG) to direct hemostatic resuscitation in a child with traumatic injury requiring massive transfusion...
- Association of shock, coagulopathy, and initial vital signs with massive transfusion in combat casualtiesClaire R Larson
Department of Surgery, United States Army Institute of Surgical Research, Fort Sam Houston, Texas 78234, USA
J Trauma 69:S26-32. 2010..The objective of this study was to compare the results of an MT prediction model and actual MT incidence in combat casualties...
- Constant challenges and evolution of US military transfusion medicine and blood operations in combatPhilip C Spinella
United States Army Institute of Surgical Research, Ft Sam Houston, TX, USA
Transfusion 52:1146-53. 2012..Blood operations are constrained by many limitations in combat settings. As a result there are many challenges that require innovative solutions...
- The U.S. military wartime pediatric trauma mission: how surgeons and pediatricians are adapting the system to address the needMichael M Fuenfer
Department of Surgery, Walter Reed Army Medical Center, Washington, DC, USA
Mil Med 174:887-91. 2009..This report details how the military medical system is adapting to create a data driven and comprehensive response to optimize the medical and surgical pediatric care being provided...
- Refrigerated platelets for the treatment of acute bleeding: a review of the literature and reexamination of current standardsHeather F Pidcoke
Blood Research Program, US Army Institute of Surgical Research, Fort Sam Houston, Texas Department of Critical Care, Department of Pediatrics, Washington University in St Louis, Missouri Department of Biomedical Engineering, The University of Texas at San Antonio, San Antonio, Texas Norwegian Naval Special Operation Commando and Department of Immunology and Transfusion Medicine, Haukeland University Hospital, Bergen, Norway and Division of Transfusion Medicine, Department of Pathology, Johns Hopkins Hospital, Baltimore, Maryland
Shock 41:51-3. 2014..In summary, a "one-size-fits-all" strategy for PLT storage may not be adequate, and a reexamination of whether cold-stored PLTs should be offered as a widely available therapeutic product may be indicated. ..
- Incidence and acute complications of asymptomatic central venous catheter-related deep venous thrombosis in critically ill childrenEdward Vincent S Faustino
Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
J Pediatr 162:387-91. 2013..To determined the current incidence and acute complications of asymptomatic central venous catheter (CVC)-related deep venous thrombosis (DVT) in critically ill children...
- Fresh whole blood use for hemorrhagic shock: preserving benefit while avoiding complicationsPhilip C Spinella
Department of Pediatrics, Washington University in St Louis, St Louis, MO 63110, USA
Anesth Analg 115:751-8. 2012..We intend this review to stimulate hypothesis generation and clinical investigation in determining when FWB may be indicated and how to optimally process and store FWB to maximize its risk-benefit ratio...
- All plasma products are not created equal: Characterizing differences between plasma productsPhilip C Spinella
From the Division of Critical Care P C S, E F, and Laboratory Medicine P C S, D J D, Department of Pediatrics, Washington University in St Louis St Louis, Missouri US Army Institute of Surgical Research H F P, J K A, A P C, Brooke Army Medical Center, San Antonio, Texas Blood Systems Research Institute S P, P J N, San Francisco and University of California S P, P J N, San Francisco, California and Entegrion O G, Research Triangle Park, North Carolina
J Trauma Acute Care Surg 78:S18-25. 2015..Plasma can be manufactured by multiple methods. Few studies have compared quality parameters between plasma products that may affect efficacy and safety...
- Early management of pediatric vascular injuries through humanitarian surgical care during U.S. military operationsAnahita Dua
Department of Surgery, Center for Translational Injury Research, University of Texas Medical Center, Houston, Tex, USA
J Vasc Surg 58:695-700. 2013..Physiologic data included presenting vital signs (rectal temperature, blood pressure, and heart rate), arterial pH, base deficit, hemoglobin (g/dL), and international normalized ratio...
- Use of a massive transfusion protocol with hemostatic resuscitation for severe intraoperative bleeding in a childAlex M Dressler
Department of Critical Care, Connecticut Children s Medical Center, Hartford, CT 06106, USA
J Pediatr Surg 45:1530-3. 2010..The MT protocol principles, benefits, and postoperative course of the patient are described...
- Emergent endotracheal intubations in children: be careful if it's late when you intubateChristopher L Carroll
Department of Pediatrics, Connecticut Children s Medical Center, Hartford, CT, USA
Pediatr Crit Care Med 11:343-8. 2010..The purpose of this study was to delineate the risks of emergent endotracheal intubations in children...
- Blood far forward: Time to get moving!Andrew P Cap
From the Coagulation Blood Research Program A P C, H F P, US Army Institute of Surgical Research, Fort Sam Houston, Houston, Texas Deployment Medicine International M D P, Gig Harbor, Washington Department of Surgery J F R, Temple University School of Medicine, Philadelphia, Pennsylvania The Trauma and Combat Medicine Branch E G, Surgeon General s HW, Israel Defense Forces, Ramat Gan, Israel Norwegian Naval Special Operations Commando H S E, G S, Bergen, Norway Department of Anaesthesia Intensive Care C K B, T K F, Haukeland University Hospital, Bergen, Norway US Army Special Operations Command S K, Fort Bragg, North Carolina Advanced Tactical and Emergency Medicine P T, United Kingdom Department of Anesthesiology R S, Division of Trauma Anesthesiology, Medical Director of Perfusion Cell Salvage Services, R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, Maryland Ranger Regiment E M, A F, Fort Benning, Georgia Department of Emergency Medicine K R W, University of Michigan, Michigan Center for Integrative Research in Critical Care, Ann Arbor, Michigan Department of Pediatrics P C S, Division of Pediatric Critical Care
J Trauma Acute Care Surg 78:S2-6. 2015....
- Isolated pediatric burn injury in Iraq and AfghanistanMatthew A Borgman
1Department of Pediatrics, San Antonio Military Medical Center, Fort Sam Houston, TX 2Division of Critical Care, Department of Pediatrics, Washington University in St Louis, St Louis, MO
Pediatr Crit Care Med 16:e23-7. 2015..To characterize the epidemiology of burn injury in pediatric patients and identify factors associated with mortality based on burn severity...
- Symposium on fresh whole blood for severe hemorrhagic shock: from in-hospital to far forward resuscitationsPhilip C Spinella
Department of Pediatrics, Division of Critical Care, Washington University in St Louis, St Louis, MO 63110, USA
Transfus Apher Sci 46:113-7. 2012..The meeting concluded with a discussion of the THOR network's three-year research program...
- Severity of head injury is associated with increased risk of coagulopathy in combat casualtiesAndrew Peter Cap
US Army Institute of Surgical Research, Fort Sam Houston, Texas 78234, USA
J Trauma 71:S78-81. 2011..This has not been reported in a large series of combat casualties in which penetrating injuries predominate...
- New or Progressive Multiple Organ Dysfunction Syndrome in Pediatric Severe Sepsis: A Sepsis Phenotype With Higher Morbidity and MortalityJohn C Lin
1Division of Critical Care Medicine, Department of Pediatrics, Washington University School of Medicine, St Louis, MO 2Department of Anesthesiology and Critical Care, The Children s Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 3Division of Critical Care Medicine, Department of Pediatrics, University of Montreal, Montreal, QC, Canada 4Pediatric Critical Care Medicine, Departments of Pediatrics and Public Health Sciences, Penn State University College of Medicine, Hershey, PA
Pediatr Crit Care Med 18:8-16. 2017..To describe the epidemiology, morbidity, and mortality of new or progressive multiple organ dysfunction syndrome in children with severe sepsis...
- Whole blood: back to the futurePhilip C Spinella
aDepartment of Pediatrics, Division of Critical Care, Washington University in St Louis, St Louis, Missouri bU S Army Institute of Surgical Research, JBSA FT Sam Houston, Houston, Texas, USA
Curr Opin Hematol 23:536-542. 2016..We present data comparing whole blood with blood components and summarize the data that support increased availability of whole blood for patients with life-threatening bleeding...
- Clearly defining pediatric massive transfusion: cutting through the fog and friction with combat dataLucas P Neff
From the Department of Surgery L P N, David Grant Medical Center, Travis Air Force Base, Fairfield, California Departments of Surgery J W C, M J E and Pediatrics M A B, San Antonio Military Medical Center, Fort Sam Houston, San Antonio, Texas Department of Surgery L P N, J W C, Uniformed Services University of the Health Sciences, Bethesda, Maryland and Department of Pediatrics P C S, Washington University School of Medicine, St Louis, Missouri and The Academic Department of Military Surgery and Trauma J J M, Royal Centre for Defence Medicine, Birmingham, United Kingdom
J Trauma Acute Care Surg 78:22-8; discussion 28-9. 2015..Massive transfusion (MT) in pediatric patients remains poorly defined. Using the largest existing registry of transfused pediatric trauma patients, we sought a data-driven MT threshold...
- Simulation training for surgical residents in pediatric trauma scenariosJill Popp
University of Connecticut School of Medicine, Connecticut Children s Medical Center, Hartford, USA
Conn Med 76:159-62. 2012..The goal of this study was to evaluate whether high-fidelity simulation training improved surgery residents' knowledge and self-efficacy in relation to pediatric trauma scenarios...
- Care of pediatric neurosurgical patients in Iraq in 2007: clinical and ethical experience of a field hospitalJonathan E Martin
Department of Surgery, Division of Neurosurgery, University of Connecticut School of Medicine, Connecticut Children s Medical Center, Hartford, Connecticut 06106, USA
J Neurosurg Pediatr 6:250-6. 2010..The authors reviewed their experience with pediatric neurosurgical patients at a field hospital in Iraq in 2007 to provide insight into the management of this patient population...
- Survival after prolonged pediatric extracorporeal membrane oxygenation support for adenoviral pneumoniaTaslim F Allibhai
Department of Pediatrics, Wilford Hall USAF Medical Center, Lackland AFB, San Antonio, TX 78236 5300, USA
J Pediatr Surg 43:e9-e11. 2008..Our experience suggests that there may be use for prolonged ECMO support in children despite severe adenoviral pneumonia...
- Damage control mechanical ventilation: ventilator induced lung injury and lung protective strategies in childrenPhilip C Spinella
Department of Pediatrics, Wilford Hall Medical Center, 2200 Bergquist Drive Suite 1, Lackland AFB TX, 78236 5300, USA
J Trauma 62:S82-3. 2007
- Pediatric trauma: experience of a combat support hospital in IraqRebecca McGuigan
Martin Army Community Hospital, Fort Benning, GA 31905, USA
J Pediatr Surg 42:207-10. 2007..The purpose of this article is to report the experience of the 31st CSH treating pediatric trauma patients...
- Pediatric care as part of the US Army medical mission in the global war on terrorism in Afghanistan and Iraq, December 2001 to December 2004Mark W Burnett
Camp Taji, Iraq
Pediatrics 121:261-5. 2008..Our objective in this report was to describe the epidemiologic features of and workload associated with pediatric admissions to 12 US Army military hospitals deployed to Iraq and Afghanistan...
- S-100beta protein--serum levels in children with brain neoplasms and its potential as a tumor markerAnil Rajendra
Department of Anesthesiology and Critical Care Medicine, The Children s Hospital of Philadelphia, PA 19104, USA
J Neurooncol 67:345-9. 2004..To determine if serum S-100beta levels are elevated in children with brain neoplasms and if it can be used as a tumor marker for children with brain neoplasms...
- Cerebrospinal fluid levels of S-100beta in children and its elevation in pediatric meningitisPhilip C Spinella
Department of Anesthesiology, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
Pediatr Crit Care Med 5:53-7. 2004..To describe normal cerebrospinal fluid (CSF) levels of S-100beta in children and determine whether CSF S-100beta levels are elevated in pediatric meningitis...
- S-100beta protein-serum levels in healthy children and its association with outcome in pediatric traumatic brain injuryPhilip C Spinella
Department of Anesthesiology, The Children s Hospital of Philadelphia, PA, USA
Crit Care Med 31:939-45. 2003..To describe normal serum levels of S-100beta in healthy children and determine whether serum S-100beta levels after traumatic brain injury are associated with outcome...