Yuxin Yin

Summary

Affiliation: Columbia University
Country: USA

Publications

  1. ncbi request reprint PAC1 phosphatase is a transcription target of p53 in signalling apoptosis and growth suppression
    Yuxin Yin
    Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, New York 10032, USA
    Nature 422:527-31. 2003
  2. pmc Human RAD9 checkpoint control/proapoptotic protein can activate transcription of p21
    Yuxin Yin
    Center for Radiological Research, Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 101:8864-9. 2004
  3. doi request reprint PTEN: a new guardian of the genome
    Y Yin
    Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Oncogene 27:5443-53. 2008
  4. ncbi request reprint p53 kingdom, a new prospect for its control mechanism and apoptotic defense
    Yuxin Yin
    Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, New York 10032, USA
    Cell Cycle 2:279-80. 2003
  5. doi request reprint DUSP1 is controlled by p53 during the cellular response to oxidative stress
    Yu Xin Liu
    Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Mol Cancer Res 6:624-33. 2008
  6. ncbi request reprint Dual specificity phosphatase 1/CL100 is a direct transcriptional target of E2F-1 in the apoptotic response to oxidative stress
    Jianli Wang
    Department of Radiation Oncology, Center for Radiological Research, College of Physicians and Surgeons, Columbia University Medical Center, 630 West 168th Street, New York, NY 10032, USA
    Cancer Res 67:6737-44. 2007
  7. ncbi request reprint TAp73 is a downstream target of p53 in controlling the cellular defense against stress
    Jianli Wang
    Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 282:29152-62. 2007
  8. pmc PTEN regulates PLK1 and controls chromosomal stability during cell division
    Zhong Zhang
    a Department of Radiation Oncology, Weill Medical Medicine, Cornell University, New York, NY, USA
    Cell Cycle 15:2476-85. 2016
  9. pmc PTEN regulates DNA replication progression and stalled fork recovery
    Jinxue He
    Department of Radiation Oncology, Weill Medical College of Cornell University, New York 10065, USA
    Nat Commun 6:7620. 2015
  10. pmc PTEN regulates EG5 to control spindle architecture and chromosome congression during mitosis
    Jinxue He
    Department of Radiation Oncology, Weill Medical College of Cornell University, New York, New York 10065, USA
    Nat Commun 7:12355. 2016

Collaborators

  • Fan Yang
  • Howard B Lieberman
  • Richard Baer
  • Adam J Ratner
  • Charis Eng
  • M Prakash Hande
  • Eric Hall
  • Jinxue He
  • Jianli Wang
  • Wen Hong Shen
  • Wen H Shen
  • Zhong Zhang
  • Jingyi Yang
  • Xi Kang
  • Yu Xin Liu
  • Qi Yuan
  • Kristy L Lamb
  • TingTing Gu
  • Y Jenny Jin
  • Zhuo Sun
  • Zhu Hong Chen
  • Jorge L Aguilar
  • Jingjing Wu
  • Paul W Brandt-Rauf
  • Andrew R Marks
  • Meng Ouyang
  • Anetta Wronska
  • Mindy M Kim
  • Steven R Reiken
  • Brent W Osborne
  • Sheng Qi Hou
  • Alain Lacampagne
  • Gaetano Santulli
  • Hongbo Hao
  • K S Clifford Chao
  • Pan Wang
  • Chuanxin Huang
  • Shiming He
  • Hui Liang
  • Michael A McNutt
  • Minglu Zhu
  • Ritwij Kulkarni
  • Sandeep Soman
  • Alexander Kikuchi
  • Tara M Randis
  • Jianfen Guo
  • David P Yin
  • Adayabalam S Balajee
  • Hong Wu
  • Alan C Wong
  • Pier Paolo Pandolfi
  • M Prakash Hande
  • Yan J Jin
  • Victor B Zhurkin
  • Tom K Hei
  • Changhong Qiao
  • Gregory G Freund
  • Keith W Kelley
  • Robert H McCusker
  • Suzanne R Broussard
  • Robert Dantzer

Detail Information

Publications20

  1. ncbi request reprint PAC1 phosphatase is a transcription target of p53 in signalling apoptosis and growth suppression
    Yuxin Yin
    Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, New York 10032, USA
    Nature 422:527-31. 2003
    ..Identification of a palindromic motif as a p53-binding site may reveal a novel mechanism whereby p53 regulates its target genes...
  2. pmc Human RAD9 checkpoint control/proapoptotic protein can activate transcription of p21
    Yuxin Yin
    Center for Radiological Research, Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 101:8864-9. 2004
    ..Furthermore, hRAD9 might regulate other cellular processes as well by modulating transcription of multiple down-stream target genes...
  3. doi request reprint PTEN: a new guardian of the genome
    Y Yin
    Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Oncogene 27:5443-53. 2008
    ..Thus, we propose that PTEN is a new guardian of the genome. In this review, we will discuss new discoveries on the role of PTEN in tumor suppression and explore mechanisms by which PTEN maintains genomic stability...
  4. ncbi request reprint p53 kingdom, a new prospect for its control mechanism and apoptotic defense
    Yuxin Yin
    Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, New York 10032, USA
    Cell Cycle 2:279-80. 2003
  5. doi request reprint DUSP1 is controlled by p53 during the cellular response to oxidative stress
    Yu Xin Liu
    Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Mol Cancer Res 6:624-33. 2008
    ..Our results reveal a mechanism whereby p53 selectively regulates target genes and suggest a way in which subgroups of those target genes might be controlled independently...
  6. ncbi request reprint Dual specificity phosphatase 1/CL100 is a direct transcriptional target of E2F-1 in the apoptotic response to oxidative stress
    Jianli Wang
    Department of Radiation Oncology, Center for Radiological Research, College of Physicians and Surgeons, Columbia University Medical Center, 630 West 168th Street, New York, NY 10032, USA
    Cancer Res 67:6737-44. 2007
    ..Interestingly, E2F-1 is acetylated following oxidative stress. Our findings show that E2F-1 is a transcriptional activator of DUSP1 and that DUSP1 is a link between E2F-1 and MAP kinases...
  7. ncbi request reprint TAp73 is a downstream target of p53 in controlling the cellular defense against stress
    Jianli Wang
    Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 282:29152-62. 2007
    ..Our data reveal a new pathway for cellular protection against oxidative damage and provide evidence that TAp73 is a stress-response gene and a downstream effector in the p53 pathway...
  8. pmc PTEN regulates PLK1 and controls chromosomal stability during cell division
    Zhong Zhang
    a Department of Radiation Oncology, Weill Medical Medicine, Cornell University, New York, NY, USA
    Cell Cycle 15:2476-85. 2016
    ..Inhibition of PLK1 activity or overexpression of a non-phosphorylatable PLK1 mutant reduces the polyploid cell population. These data reveal a new mechanism by which PTEN controls genomic stability during cell division. ..
  9. pmc PTEN regulates DNA replication progression and stalled fork recovery
    Jinxue He
    Department of Radiation Oncology, Weill Medical College of Cornell University, New York 10065, USA
    Nat Commun 6:7620. 2015
    ..These data highlight the interplay of PTEN with Rad51 in promoting stalled fork restart. We propose that loss of PTEN may initiate a replication stress cascade that progressively deteriorates through the cell cycle. ..
  10. pmc PTEN regulates EG5 to control spindle architecture and chromosome congression during mitosis
    Jinxue He
    Department of Radiation Oncology, Weill Medical College of Cornell University, New York, New York 10065, USA
    Nat Commun 7:12355. 2016
    ..We propose that PTEN functions to equilibrate mitotic phosphorylation for proper spindle formation and faithful genomic transmission. ..
  11. ncbi request reprint A molecular link between E2F-1 and the MAPK cascade
    Jianli Wang
    Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 282:18521-31. 2007
    ..Characterization of MKP-2 as a cell death mediator may lead to the development of new strategies for cancer treatment...
  12. ncbi request reprint A novel function for human Rad9 protein as a transcriptional activator of gene expression
    Howard B Lieberman
    Center for Radiological Research, Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, 630 W 168th St, New York, New York 10032, USA
    Cell Cycle 3:1008-10. 2004
    ..In this review, the newly defined ability of Rad9 to transactivate p21 and other downstream target genes is discussed in terms of the activities already associated with this protein...
  13. pmc PTEN interacts with histone H1 and controls chromatin condensation
    Zhu Hong Chen
    Institute of Systems Biomedicine, Department of Pathology, School of Basic Medical Sciences, Beijing Key Laboratory of Tumor Systems Biology, Peking Tsinghua Center for Life Sciences, Peking University Health Science Center, Beijing 100191, China Department of Radiation Oncology, Weill Medical College of Cornell University, New York, NY 10065, USA
    Cell Rep 8:2003-14. 2014
    ..Our results demonstrate that PTEN controls chromatin condensation, thus influencing gene expression. We propose that PTEN regulates global gene transcription profiling through histones and chromatin remodeling...
  14. pmc PTEN C-terminal deletion causes genomic instability and tumor development
    Zhuo Sun
    Institute of Systems Biomedicine, Department of Pathology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, PRC Department of Radiation Oncology, Weill Medical College of Cornell University, New York, NY 10065, USA
    Cell Rep 6:844-54. 2014
    ..Our data highlight the essential role of the PTEN C terminus in the maintenance of genomic stability and suppression of tumorigenesis. ..
  15. pmc Phosphatase-dependent regulation of epithelial mitogen-activated protein kinase responses to toxin-induced membrane pores
    Jorge L Aguilar
    Department of Pediatrics, Columbia University, New York, New York, United States of America
    PLoS ONE 4:e8076. 2009
    ..Epithelial regulation of MAPK signaling in response to membrane disruption involves distinct pathways and may require different strategies for therapeutic interventions...
  16. ncbi request reprint Essential role for nuclear PTEN in maintaining chromosomal integrity
    Wen Hong Shen
    Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Cell 128:157-70. 2007
    ..We propose that PTEN acts as a guardian of genome integrity...
  17. pmc Maintenance of normal blood pressure is dependent on IP3R1-mediated regulation of eNOS
    Qi Yuan
    Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons of Columbia University Medical Center, New York, NY 10032 Wu Center for Molecular Cardiology, College of Physicians and Surgeons of Columbia University Medical Center, New York, NY 10032
    Proc Natl Acad Sci U S A 113:8532-7. 2016
    ..Our results demonstrate that IP3R1 plays a crucial role in the EC-mediated vasorelaxation and the maintenance of normal BP. ..
  18. ncbi request reprint Mitogen-activated protein kinase phosphatase 2: a novel transcription target of p53 in apoptosis
    Wen Hong Shen
    Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Cancer Res 66:6033-9. 2006
    ..These data suggest that p53 regulates distinct genes via different binding mechanisms and that MKP2 is an essential target of p53 in signaling apoptosis...
  19. ncbi request reprint A novel mechanism for p53 to regulate its target gene ECK in signaling apoptosis
    Y Jenny Jin
    Department of Radiation Oncology College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Mol Cancer Res 4:769-78. 2006
    ..Our findings show that p53 is a transcriptional regulator of ECK in mediating apoptosis. The discovery of the novel p53-binding motif in the promoter may lead to the identification of a new class of p53 target genes...
  20. ncbi request reprint Tumor necrosis factor alpha inhibits cyclin A expression and retinoblastoma hyperphosphorylation triggered by insulin-like growth factor-I induction of new E2F-1 synthesis
    Wen Hong Shen
    Laboratory of Immunophysiology, Department of Animal Sciences, University of Illinois, Urbana, Illinois 61801, USA
    J Biol Chem 279:7438-46. 2004
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